TDR Targets

Basic information

Technical information

TDR Targets ID: 705608
Name: N-(2,5-dimethoxyphenyl)-N'-(2-methylpropyl)-1 -phenylpyrazolo[4,5-e]pyrimidine-4,6-diamine
MW: 418.492 | Formula: C23H26N6O2
H donors: 2 H acceptors: 3 LogP: 5.31 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(c(c1)Nc1nc(NCC(C)C)nc2c1cnn2c1ccccc1)OC
InChi: 1S/C23H26N6O2/c1-15(2)13-24-23-27-21(26-19-12-17(30-3)10-11-20(19)31-4)18-14-25-29(22(18)28-23)16-8-6-5-7-9-16/h5-12,14-15H,13H2,1-4H3,(H2,24,26,27,28)
InChiKey: NZXQVBLECOKVTD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(2,5-dimethoxyphenyl)-N'-isobutyl-1-phenyl-pyrazolo[4,5-e]pyrimidine-4,6-diamine
N-(2,5-dimethoxyphenyl)-N'-isobutyl-1-phenylpyrazolo[4,5-e]pyrimidine-4,6-diamine
[4-[(2,5-dimethoxyphenyl)amino]-1-phenyl-pyrazolo[5,4-d]pyrimidin-6-yl]-isobutyl-amine
N-(2,5-dimethoxyphenyl)-N'-(2-methylpropyl)-1-phenyl-pyrazolo[4,5-e]pyrimidine-4,6-diamine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0174
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0115	0.2377	1
Leishmania major	lysyl-tRNA synthetase, putative	0.0024	0.0283	0.0869
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0455	0.1621
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0033	0.0495	0.0414
Brugia malayi	lysyl-tRNA synthetase	0.0024	0.0283	0.0836
Trichomonas vaginalis	6-phosphofructokinase, putative	0.0031	0.0455	0.1621
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.0588	0.2201
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0036	0.0566	0.0982
Leishmania major	metacaspase, putative	0.0018	0.0161	0.0337
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0031	0.0455	0.1916
Trichomonas vaginalis	phosphofructokinase, putative	0.0115	0.2377	1
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0032	0.0468	0.1678
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0493	0.1785
Echinococcus granulosus	6 phosphofructokinase	0.0115	0.2377	1
Schistosoma mansoni	serine/threonine protein kinase	0.0033	0.0494	0.1791
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0449	1	1
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0493	0.1785
Loa Loa (eye worm)	6-phosphofructokinase	0.0115	0.2377	0.9618
Onchocerca volvulus	Cell death protein 3 homolog	0.0061	0.1131	1
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0493	0.1785
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0494	0.1791
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0161	0.0337
Echinococcus multilocularis	mitogen activated protein kinase	0.0055	0.099	0.3953
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0018	0.0161	0.0119
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0055	0.099	0.3953
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0714	0.2771
Echinococcus multilocularis	caspase	0.0018	0.0161	0.0337
Entamoeba histolytica	pyrophosphate-dependent phosphofructokinase	0.0031	0.0455	0.0823
Schistosoma mansoni	caspase-7 (C14 family)	0.0061	0.1131	0.4567
Trichomonas vaginalis	glucose transporter, putative	0.0033	0.0493	0.1785
Trypanosoma cruzi	metacaspase 5, putative	0.0018	0.0161	0.0337
Trypanosoma cruzi	metacaspase, putative	0.0018	0.0161	0.0337
Leishmania major	ATP-dependent phosphofructokinase	0.0115	0.2377	1
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0455	0.1621
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0032	0.0468	0.1678
Mycobacterium ulcerans	sugar transporter	0.0015	0.0084	0.0352
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0033	0.0493	0.1785
Mycobacterium ulcerans	esterase/lipase LipP	0.0036	0.0566	0.2382
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0566	0.2104
Trypanosoma cruzi	hexose transporter, putative	0.0018	0.0153	0.0304
Leishmania major	glucose transporter, lmgt2	0.0033	0.0493	0.1785
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0032	0.0468	0.1613
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0171	0.3656	0.3602
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0566	0.2161
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0033	0.0494	0.1865
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0865	0.3406
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.0493	0.1785
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0024	0.0283	0.0869
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0455	0.1621
Trypanosoma cruzi	metacaspase, putative	0.0018	0.0161	0.0337
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0493	0.1785
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0115	0.2377	1
Echinococcus multilocularis	apoptotic protease activating factor 1	0.0043	0.0714	0.275
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0033	0.0495	0.0414
Brugia malayi	6-phosphofructokinase	0.0115	0.2377	0.9612
Brugia malayi	beta-lactamase	0.0036	0.0566	0.2022
Onchocerca volvulus		0.0043	0.0714	0.6022
Trypanosoma brucei	glucose transporter 2A	0.0033	0.0493	0.1785
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0037	0.0588	0.2201
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.0865	0.3406
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0865	0.3406
Trypanosoma brucei	Metacaspase-4	0.0018	0.0161	0.0337
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0033	0.0494	0.1865
Echinococcus granulosus	caspase 8	0.0018	0.0161	0.0337
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.0588	0.2201
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0049	0.0865	0.3391
Mycobacterium tuberculosis	Probable lipase LipE	0.0036	0.0566	0.0982
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0055	0.099	0.3953
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0033	0.0495	0.0414
Trichomonas vaginalis	glucose transporter, putative	0.0033	0.0493	0.1785
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0468	0.1758
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0018	0.0161	0.0337
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0106	0.2158	0.9047
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0494	0.1791
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0106	0.2158	0.9047
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.0493	0.1785
Brugia malayi	Cell death protein 3 precursor	0.0061	0.1131	0.439
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0566	0.2161
Echinococcus multilocularis	caspase 8	0.0018	0.0161	0.0337
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0033	0.0495	0.0633
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0018	0.0161	0.0337
Giardia lamblia	Prolyl-tRNA synthetase	0.0032	0.0468	0.4245
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0015	0.0084	0.0352
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0566	0.2104
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0033	0.0495	0.0633
Toxoplasma gondii	ABC1 family protein	0.0036	0.0566	0.0743
Leishmania major	glucose transporter, lmgt1	0.0033	0.0493	0.1785
Toxoplasma gondii	lysine-tRNA ligase	0.0024	0.0283	0.0307
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0055	0.099	0.3953
Brugia malayi	phosphofructokinase	0.0115	0.2377	0.9612
Trypanosoma cruzi	metacaspase 5, putative	0.0018	0.0161	0.0337
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0171	0.3656	0.3602
Echinococcus granulosus	apoptotic protease activating factor 1	0.0043	0.0714	0.275
Trypanosoma cruzi	hexose transporter	0.0033	0.0493	0.1785
Loa Loa (eye worm)	MH2 domain-containing protein	0.0119	0.2469	1
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0493	0.1785
Mycobacterium ulcerans	beta-lactamase	0.0036	0.0566	0.2382
Plasmodium vivax	metacaspase 1, putative	0.0018	0.0161	0.0078
Brugia malayi	6-phosphofructokinase	0.0115	0.2377	0.9612
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0161	0.0337
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0033	0.0495	0.0414
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0566	0.0982
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0566	0.0982
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0036	0.0566	0.2382
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0018	0.0161	0.0337
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.0493	0.1785
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0566	0.2161
Schistosoma mansoni	6-phosphofructokinase	0.0115	0.2377	1
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0033	0.0494	0.1791
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0174
Plasmodium vivax	hypothetical protein, conserved	0.0018	0.0161	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0174
Trypanosoma brucei	protein kinase, putative	0.0055	0.099	0.3953
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0024	0.0283	0.0869
Entamoeba histolytica	protein kinase, putative	0.0033	0.0494	0.1009
Plasmodium vivax	6-phosphofructokinase, putative	0.0031	0.0455	0.0375
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0566	0.2161
Schistosoma mansoni	protein kinase	0.0033	0.0494	0.1791
Toxoplasma gondii	facilitative glucose transporter GT1	0.0106	0.2158	0.3196
Plasmodium falciparum	protein kinase 7	0.0299	0.6575	0.6546
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0174
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.0865	0.3406
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0566	0.2161
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0084	0.0174
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0115	0.2377	1
Plasmodium falciparum	metacaspase-like protein	0.0018	0.0161	0.0078
Leishmania major	protein kinase, putative	0.0033	0.0494	0.1791
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0055	0.099	0.3953
Loa Loa (eye worm)	sugar transporter	0.0015	0.0084	0.0174
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0021	0.0217	0.058
Trypanosoma cruzi	metacaspase, putative	0.0018	0.0161	0.0337
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0055	0.099	0.3953
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0493	0.1785
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0566	0.2161
Echinococcus granulosus	calcium dependent protein kinase	0.003	0.0438	0.1544
Schistosoma mansoni	protein kinase	0.0033	0.0494	0.1791
Schistosoma mansoni	glucose transport protein	0.0106	0.2158	0.9047
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0049	0.0865	0.3274
Plasmodium falciparum	hexose transporter	0.0106	0.2158	0.2092
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0174
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.023	0.4995	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0566	0.2104
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0033	0.0495	0.0414
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0493	0.1785
Echinococcus granulosus	lysyl tRNA synthetase	0.0024	0.0283	0.0869
Plasmodium falciparum	metacaspase 1	0.0018	0.0161	0.0078
Entamoeba histolytica	phosphofructokinase, putative	0.0115	0.2377	1
Brugia malayi	hypothetical protein	0.0043	0.0714	0.2643
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0174
Mycobacterium tuberculosis	Probable lipase LipD	0.0036	0.0566	0.0982
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0036	0.0566	0.0982
Echinococcus granulosus	caspase 3 apoptosis cysteine peptidase	0.0018	0.0161	0.0337
Schistosoma mansoni	glucose transport protein	0.0106	0.2158	0.9047
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.0566	0.2104
Echinococcus granulosus	caspase 2	0.0061	0.1131	0.4567
Loa Loa (eye worm)	sugar transporter	0.0106	0.2158	0.8718
Echinococcus multilocularis	lysyl tRNA synthetase	0.0024	0.0283	0.0869
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0493	0.1785
Schistosoma mansoni	glucose transport protein	0.0106	0.2158	0.9047
Plasmodium vivax	lysine--tRNA ligase, putative	0.0024	0.0283	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0174
Trypanosoma brucei	metacaspase	0.0018	0.0161	0.0337
Mycobacterium tuberculosis	Probable hydrolase	0.0036	0.0566	0.0982
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0161	0.0492
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0566	0.2104
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0055	0.099	0.3953
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0033	0.0495	0.0633
Schistosoma mansoni	serine/threonine protein kinase	0.0055	0.099	0.3953
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0566	0.2104
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0031	0.0455	0.0375
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.002	0.0202	0.0241
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0455	0.1621
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0084	0.0174
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0033	0.0494	0.1721
Trypanosoma brucei	glucose transporter 1E	0.0033	0.0493	0.1785
Plasmodium vivax	hexose transporter	0.0106	0.2158	0.2092
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0566	0.2104
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0106	0.2158	0.9047
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.0493	0.1785
Echinococcus multilocularis	General substrate transporter	0.0091	0.1819	0.7566
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0566	0.2104
Schistosoma mansoni	caspase-3 (C14 family)	0.0018	0.0161	0.0337
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0106	0.2158	0.9047
Loa Loa (eye worm)	6-phosphofructokinase	0.0115	0.2377	0.9618
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0024	0.0283	0.0373
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0494	0.1791
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0494	0.1865
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0468	0.1758
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.0865	0.3406
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.0566	0.1675
Mycobacterium leprae	Probable lipase LipE	0.0036	0.0566	0.1675
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0033	0.0495	0.0414
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0333	0.1199
Echinococcus multilocularis	calcium dependent protein kinase	0.003	0.0438	0.1544
Echinococcus granulosus	General substrate transporter	0.0091	0.1819	0.7566
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0566	0.0982
Toxoplasma gondii	phosphofructokinase PFKII	0.0031	0.0455	0.0573
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0493	0.1785
Plasmodium falciparum	lysine--tRNA ligase	0.0024	0.0283	0.0201
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0024	0.0283	0.1191
Echinococcus multilocularis	caspase 3, apoptosis cysteine peptidase	0.0018	0.0161	0.0337
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0033	0.0494	0.1791
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0018	0.0161	0.0337
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0031	0.0455	0.0375
Loa Loa (eye worm)	hypothetical protein	0.0061	0.1131	0.4487
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0494	0.1791
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0455	0.1621
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0032	0.0468	0.1678
Entamoeba histolytica	hypothetical protein	0.0038	0.0616	0.1588
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0566	0.2161
Schistosoma mansoni	caspase-7 (C14 family)	0.0018	0.0161	0.0337
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0018	0.0161	0.0337
Onchocerca volvulus		0.0036	0.0566	0.4607
Brugia malayi	beta-lactamase family protein	0.0036	0.0566	0.2022
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0174
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0037	0.0588	0.2201
Trypanosoma brucei	metacaspase MCA2	0.0018	0.0161	0.0337
Entamoeba histolytica	protein kinase, putative	0.0033	0.0494	0.1009
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0038	0.0616	0.232
Trichomonas vaginalis	esterase, putative	0.0036	0.0566	0.2104
Plasmodium falciparum	proline--tRNA ligase	0.0037	0.0588	0.0509
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0018	0.0161	0.0119
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0494	0.1791
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0032	0.0468	0.1678
Trichomonas vaginalis	phosphofructokinase, putative	0.0115	0.2377	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0865	0.3406
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0055	0.099	0.3953
Leishmania major	glucose transporter, lmgt3	0.0033	0.0493	0.1785
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0033	0.0495	0.0414
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0032	0.0468	0.1226
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0566	0.2022
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0566	0.2161
Entamoeba histolytica	hypothetical protein	0.0038	0.0616	0.1588
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0161	0.0337
Entamoeba histolytica	hypothetical protein	0.0038	0.0616	0.1588
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0283	0.0995
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0493	0.1785
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0033	0.0495	0.0414
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0031	0.0455	1
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0106	0.2158	0.9047
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0493	0.1785
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0055	0.099	0.3907
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0024	0.0283	0.0869
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0566	0.2104
Echinococcus granulosus	caspase	0.0018	0.0161	0.0337
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0015	0.0084	0.0352
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0106	0.2158	0.9047
Toxoplasma gondii	protein kinase, putative	0.0299	0.6575	1
Brugia malayi	MH2 domain containing protein	0.0119	0.2469	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0106	0.2158	0.9047
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0174
Echinococcus multilocularis	caspase 2	0.0061	0.1131	0.4567
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0493	0.1785
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.0493	0.1785
Mycobacterium ulcerans	integral membrane transport protein	0.0015	0.0084	0.0352
Loa Loa (eye worm)	transcription factor SMAD2	0.0119	0.2469	1
Mycobacterium ulcerans	6-phosphofructokinase	0.0115	0.2377	1
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0018	0.0161	0.0119
Echinococcus granulosus	mitogen activated protein kinase 3	0.0055	0.099	0.3953
Trichomonas vaginalis	conserved hypothetical protein	0.0106	0.2158	0.9047
Brugia malayi	Cam kinase protein 1	0.0033	0.0494	0.1721
Schistosoma mansoni	lysyl-tRNA synthetase	0.0024	0.0283	0.0869
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0106	0.2158	0.9047
Brugia malayi	mucosa associated lymphoid tissue lymphoma translocation protein 1	0.0018	0.0161	0.0324
Schistosoma mansoni	lysyl-tRNA synthetase	0.0024	0.0283	0.0869
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0174
Entamoeba histolytica	phosphofructokinase, putative	0.0115	0.2377	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0566	0.2104
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.002	0.0202	0.0241
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0032	0.0468	0.1613
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.0493	0.1785
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0024	0.0283	0.1191
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0018	0.0161	0.0337
Trichomonas vaginalis	CMGC family protein kinase	0.0055	0.099	0.3953
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.0588	0.2201
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0115	0.2377	0.4669
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.0031	0.0455	0.0573
Giardia lamblia	Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit	0.0031	0.0455	0.4101
Mycobacterium ulcerans	lipase LipD	0.0036	0.0566	0.2382
Giardia lamblia	Kinase, CMGC MAPK	0.0055	0.099	1
Brugia malayi	hypothetical protein	0.0038	0.0616	0.223
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0032	0.0468	0.0885
Echinococcus granulosus	mitogen activated protein kinase	0.0055	0.099	0.3953
Schistosoma mansoni	protein kinase	0.0033	0.0494	0.1791
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0036	0.0566	0.0982
Echinococcus multilocularis	6 phosphofructokinase	0.0115	0.2377	1
Onchocerca volvulus		0.0036	0.0566	0.4607
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0032	0.0468	0.1678
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0031	0.0455	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0566	0.2104
Mycobacterium tuberculosis	Probable esterase LipL	0.0036	0.0566	0.0982
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0055	0.099	0.3953
Trypanosoma brucei	metacaspase 5, putative	0.0018	0.0161	0.0337
Mycobacterium ulcerans	hypothetical protein	0.0036	0.0566	0.2382
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0493	0.1785
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0174
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0055	0.099	0.1396
Trichomonas vaginalis	phosphofructokinase, putative	0.0115	0.2377	1
Trichomonas vaginalis	CMGC family protein kinase	0.0055	0.099	0.3953
Giardia lamblia	Lysyl-tRNA synthetase	0.0024	0.0283	0.2199
Schistosoma mansoni	hypothetical protein	0.0106	0.2158	0.9047
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0171	0.3656	0.5503
Entamoeba histolytica	hypothetical protein	0.0038	0.0616	0.1588
Trypanosoma cruzi	metacaspase, putative	0.0018	0.0161	0.0337
Plasmodium vivax	6-phosphofructokinase, putative	0.0031	0.0455	0.0375
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0494	0.1791
Trichomonas vaginalis	CAMK family protein kinase	0.0033	0.0494	0.1791
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0015	0.0084	0.5
Chlamydia trachomatis	lysine--tRNA ligase	0.0024	0.0283	0.6214
Toxoplasma gondii	6-phosphofructokinase	0.0031	0.0455	0.0573
Plasmodium vivax	proline--tRNA ligase, putative	0.0037	0.0588	0.0509
Onchocerca volvulus		0.0036	0.0566	0.4607
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0161	0.0337
Leishmania major	hypothetical protein, conserved	0.0036	0.0566	0.2104
Brugia malayi	Sugar transporter family protein	0.0106	0.2158	0.8695
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0566	0.0487
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0115	0.2377	1
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0161	0.0337
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0018	0.0161	0.0337
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0161	0.0337
Schistosoma mansoni	6-phosphofructokinase	0.0115	0.2377	1
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0018	0.0161	0.0337
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.0865	0.3406
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0174
Schistosoma mansoni	hypothetical protein	0.0043	0.0714	0.275
Loa Loa (eye worm)	phosphofructokinase	0.0115	0.2377	0.9618
Schistosoma mansoni	subfamily C14A unassigned peptidase (C14 family)	0.0018	0.0161	0.0337
Trichomonas vaginalis	CMGC family protein kinase	0.0055	0.099	0.3953
Brugia malayi	beta-lactamase family protein	0.0036	0.0566	0.2022
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0033	0.0495	0.0414
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0455	0.1621
Trichomonas vaginalis	phosphofructokinase, putative	0.0115	0.2377	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0174
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0494	0.1791
Trypanosoma brucei	metacaspase MCA3	0.0018	0.0161	0.0337
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0018	0.0161	0.0337
Trichomonas vaginalis	CMGC family protein kinase	0.0055	0.099	0.3953
Schistosoma mansoni	hypothetical protein	0.0038	0.0616	0.232
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0566	0.2104
Entamoeba histolytica	phosphofructokinase, putative	0.0115	0.2377	1
Brugia malayi	MAP kinase sur-1	0.0055	0.099	0.38
Schistosoma mansoni	transcription factor LCR-F1	0.0038	0.0616	0.232
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0037	0.0588	0.0778
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0038	0.0616	0.232

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 705608