Detailed information for compound 705947

Basic information

Technical information
  • TDR Targets ID: 705947
  • Name: N-[2-[2-(3-fluorophenyl)-1,3-thiazol-4-yl]eth yl]-3,4-dimethoxybenzenesulfonamide
  • MW: 422.494 | Formula: C19H19FN2O4S2
  • H donors: 1 H acceptors: 3 LogP: 3.62 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1OC)S(=O)(=O)NCCc1csc(n1)c1cccc(c1)F
  • InChi: 1S/C19H19FN2O4S2/c1-25-17-7-6-16(11-18(17)26-2)28(23,24)21-9-8-15-12-27-19(22-15)13-4-3-5-14(20)10-13/h3-7,10-12,21H,8-9H2,1-2H3
  • InChiKey: ZULVBXOXMJZNPI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-[2-(3-fluorophenyl)thiazol-4-yl]ethyl]-3,4-dimethoxy-benzenesulfonamide
  • N-[2-[2-(3-fluorophenyl)-4-thiazolyl]ethyl]-3,4-dimethoxybenzenesulfonamide
  • N-[2-[2-(3-fluorophenyl)-1,3-thiazol-4-yl]ethyl]-3,4-dimethoxy-benzenesulfonamide
  • G573-0086
  • NCGC00131884-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0115 0.0351 0.0345
Brugia malayi Immunoglobulin I-set domain containing protein 0.0047 0.003 0.0036
Brugia malayi Protein kinase domain containing protein 0.0056 0.0071 0.0084
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0108 0.0316 0.0373
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0253 0.1007 0.2804
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0181 0.0667 0.0787
Schistosoma mansoni serine/threonine protein kinase 0.0181 0.0667 0.0787
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0091 0.0107
Brugia malayi hypothetical protein 0.0056 0.0071 0.0084
Echinococcus multilocularis insulin receptor 0.0599 0.2654 0.3122
Loa Loa (eye worm) hypothetical protein 0.0047 0.003 0.0036
Brugia malayi hypothetical protein 0.0108 0.0316 0.0373
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0253 0.1007 0.2804
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0071 0.0084
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0093 0.0247 0.0283
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0792 0.3573 1
Loa Loa (eye worm) hypothetical protein 0.0116 0.0358 0.0422
Loa Loa (eye worm) hypothetical protein 0.0108 0.0316 0.0373
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 0.0792 0.3573 0.4207
Brugia malayi Immunoglobulin I-set domain containing protein 0.0047 0.003 0.0036
Loa Loa (eye worm) hypothetical protein 0.0047 0.003 0.0036
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0108 0.0316 0.0373
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.1048 0.4789 0.4786
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0264 0.1061 0.1243
Echinococcus granulosus tyrosine protein kinase Btk29A 0.007 0.0137 0.0131
Echinococcus granulosus tyrosine protein kinase Fyn 0.0129 0.0418 0.0411
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0599 0.2654 0.2649
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0071 0.0084
Echinococcus granulosus defective proboscis extension response 0.0108 0.0316 0.031
Brugia malayi Immunoglobulin I-set domain containing protein 0.0047 0.003 0.0036
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0071 0.0084
Brugia malayi Immunoglobulin I-set domain containing protein 0.0047 0.003 0.0036
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0056 0.0071 0.0064
Entamoeba histolytica protein kinase, putative 0.0096 0.026 0.1619
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0136 0.0453 0.0526
Brugia malayi Immunoglobulin I-set domain containing protein 0.0047 0.003 0.0036
Echinococcus multilocularis tyrosine protein kinase Abl 0.015 0.0516 0.06
Echinococcus multilocularis c src tyrosine kinase 0.007 0.0137 0.0154
Brugia malayi Tyrosine-protein kinase abl-1 0.015 0.0516 0.0608
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0047 0.003 0.0027
Schistosoma mansoni tyrosine kinase 0.007 0.0137 0.0162
Brugia malayi Furin-like cysteine rich region family protein 0.1824 0.8485 1
Echinococcus multilocularis lachesin 0.0047 0.003 0.0027
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.007 0.0137 0.0154
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0599 0.2654 0.3122
Loa Loa (eye worm) hypothetical protein 0.0504 0.2204 0.2598
Echinococcus granulosus tyrosine protein kinase Lyn 0.0135 0.0445 0.0438
Echinococcus multilocularis Immunoglobulin 0.0108 0.0316 0.0365
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0371 0.157 0.4384
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0093 0.0247 0.1534
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0136 0.0453 0.0526
Loa Loa (eye worm) hypothetical protein 0.0108 0.0316 0.0373
Schistosoma mansoni cell adhesion molecule 0.0047 0.003 0.0036
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0181 0.0667 0.0787
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0129 0.0418 0.0485
Schistosoma mansoni fructose-16-bisphosphatase-related 0.0792 0.3573 0.4211
Echinococcus granulosus neuroglian 0.0047 0.003 0.0023
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0093 0.0247 0.024
Echinococcus granulosus lachesin 0.0047 0.003 0.0023
Loa Loa (eye worm) phosphatidylinositol 3 0.0093 0.0247 0.0291
Trypanosoma cruzi cdc2-related kinase 1 0.0181 0.0667 0.1852
Plasmodium falciparum protein serine/threonine kinase-1 0.0253 0.1007 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0129 0.0418 0.0485
Brugia malayi Prion-like- 0.0047 0.003 0.0036
Plasmodium falciparum protein kinase 5 0.0181 0.0667 0.6606
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0093 0.0247 0.0673
Echinococcus granulosus dual specificity 0.0371 0.157 0.1565
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0047 0.003 0.0027
Brugia malayi Protein kinase domain containing protein 0.0181 0.0667 0.0787
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0253 0.1007 0.2804
Leishmania major protein kinase, putative 0.0253 0.1007 0.2804
Loa Loa (eye worm) hypothetical protein 0.0047 0.003 0.0036
Loa Loa (eye worm) hypothetical protein 0.0203 0.0768 0.0905
Schistosoma mansoni tyrosine kinase 0.0056 0.0071 0.0084
Echinococcus granulosus insulin receptor 0.0599 0.2654 0.2649
Echinococcus granulosus fructose 16 bisphosphatase 1 0.0792 0.3573 0.3569
Loa Loa (eye worm) hypothetical protein 0.0056 0.0071 0.0084
Brugia malayi Protein kinase domain containing protein 0.0056 0.0071 0.0084
Trypanosoma cruzi cdc2-related kinase 3 0.0181 0.0667 0.1852
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0253 0.1007 0.1187
Schistosoma mansoni microtubule-associated protein tau 0.0709 0.3177 0.3744
Echinococcus granulosus Immunoglobulin 0.0108 0.0316 0.031
Echinococcus granulosus tyrosine protein kinase Src42A 0.0078 0.0176 0.0169
Echinococcus multilocularis tyrosine protein kinase shark 0.0056 0.0071 0.0076
Echinococcus granulosus dual specificity protein kinase clk2 0.0253 0.1007 0.1001
Loa Loa (eye worm) TK/ALK protein kinase 0.0267 0.1074 0.1266
Trypanosoma brucei fructose-1,6-bisphosphatase 0.0792 0.3573 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0153 0.053 0.0625
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0091 0.0107
Loa Loa (eye worm) hypothetical protein 0.0365 0.1543 0.1819
Toxoplasma gondii sedoheptulose-1,7-bisphosphatase 0.0295 0.1206 0.3362
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0071 0.0084
Leishmania major protein kinase, putative 0.0253 0.1007 0.2804
Brugia malayi SH2 domain containing protein 0.0056 0.0071 0.0084
Loa Loa (eye worm) hypothetical protein 0.1054 0.4817 0.5678
Brugia malayi fructose-1,6-bisphosphatase 0.0792 0.3573 0.4211
Loa Loa (eye worm) TK/EGFR protein kinase 0.1824 0.8485 1
Loa Loa (eye worm) hypothetical protein 0.0139 0.0465 0.0548
Echinococcus granulosus tyrosine protein kinase otk 0.0047 0.003 0.0023
Echinococcus multilocularis tyrosine protein kinase Srms 0.0115 0.0351 0.0406
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0056 0.0071 0.0076
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0129 0.0418 0.0485
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0093 0.0247 0.0673
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0129 0.0418 0.0485
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0371 0.157 0.4384
Loa Loa (eye worm) hypothetical protein 0.0504 0.2204 0.2598
Entamoeba histolytica hypothetical protein 0.0371 0.157 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0093 0.0247 0.0291
Echinococcus multilocularis dual specificity protein kinase clk2 0.0253 0.1007 0.1179
Loa Loa (eye worm) hypothetical protein 0.0365 0.1543 0.1819
Entamoeba histolytica protein kinase domain containing protein 0.0371 0.157 1
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0053 0.0057 0.0067
Schistosoma mansoni protein kinase 0.0043 0.0007 0.0008
Schistosoma mansoni tyrosine kinase 0.0136 0.0453 0.0534
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0047 0.003 0.0023
Loa Loa (eye worm) hypothetical protein 0.0068 0.0127 0.015
Trypanosoma brucei cdc2-related kinase 1 0.0181 0.0667 0.1852
Loa Loa (eye worm) TK/ROR protein kinase 0.0053 0.0057 0.0067
Trichomonas vaginalis CMGC family protein kinase 0.0253 0.1007 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.003 0.0036
Onchocerca volvulus 0.0056 0.0071 0.0206
Echinococcus granulosus c src tyrosine kinase 0.007 0.0137 0.0131
Toxoplasma gondii fructose-bisphospatase I 0.0295 0.1206 0.3362
Brugia malayi Peroxidasin 0.0047 0.003 0.0036
Loa Loa (eye worm) hypothetical protein 0.0108 0.0316 0.0373
Echinococcus granulosus tyrosine protein kinase HCK 0.0096 0.026 0.0253
Brugia malayi Immunoglobulin I-set domain containing protein 0.0047 0.003 0.0036
Schistosoma mansoni tyrosine kinase 0.0084 0.0206 0.0243
Schistosoma mansoni tyrosine kinase 0.1011 0.4614 0.5438
Schistosoma mansoni tyrosine kinase 0.1011 0.4614 0.5438
Trichomonas vaginalis CMGC family protein kinase 0.0181 0.0667 0.5535
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0253 0.1007 0.2804
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0087 0.022 0.136
Loa Loa (eye worm) hypothetical protein 0.0155 0.0542 0.0639
Echinococcus multilocularis cyclin dependent kinase 0.0181 0.0667 0.0779
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0181 0.0667 0.0661
Onchocerca volvulus 0.0056 0.0071 0.0206
Schistosoma mansoni tyrosine kinase 0.0599 0.2654 0.3128
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0371 0.157 0.4384
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0139 0.0465 0.0459
Brugia malayi Immunoglobulin I-set domain containing protein 0.0047 0.003 0.0036
Echinococcus multilocularis cyclin dependent kinase 1 0.0181 0.0667 0.0779
Schistosoma mansoni serine/threonine protein kinase 0.0181 0.0667 0.0787
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0295 0.1206 0.3362
Schistosoma mansoni cell adhesion molecule 0.0047 0.003 0.0036
Loa Loa (eye worm) hypothetical protein 0.0047 0.003 0.0036
Echinococcus granulosus roundabout 2 0.0155 0.0542 0.0536
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0071 0.0084
Brugia malayi cell division control protein 2 homolog 0.0181 0.0667 0.0787
Schistosoma mansoni septate junction protein 0.0047 0.003 0.0036
Echinococcus multilocularis 0.0638 0.284 0.3342
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0253 0.1007 0.2804
Echinococcus granulosus peroxidasin 0.0047 0.003 0.0023
Echinococcus granulosus hemicentin 1 0.0047 0.003 0.0023
Schistosoma mansoni tyrosine kinase 0.0129 0.0418 0.0492
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0071 0.0084
Loa Loa (eye worm) TK protein kinase 0.0153 0.053 0.0625
Loa Loa (eye worm) TK protein kinase 0.0096 0.026 0.0307
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0136 0.0453 0.0446
Leishmania major 0.0792 0.3573 1
Echinococcus granulosus cyclin dependent kinase 5 0.0181 0.0667 0.0661
Brugia malayi Fibronectin type III domain containing protein 0.0108 0.0316 0.0373
Schistosoma mansoni vesicular amine transporter 0.0108 0.0316 0.0373
Entamoeba histolytica cell division protein kinase 2, putative 0.0181 0.0667 0.4224
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0129 0.0418 0.0411
Onchocerca volvulus 0.0056 0.0071 0.0206
Echinococcus granulosus fibroblast growth factor receptor 4 0.0136 0.0453 0.0446
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0181 0.0667 0.1852
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0047 0.003 0.0036
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0181 0.0667 0.1852
Loa Loa (eye worm) hypothetical protein 0.0108 0.0316 0.0373
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0108 0.0316 0.0365
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0071 0.0084
Toxoplasma gondii fructose-bisphospatase II 0.0792 0.3573 1
Schistosoma mansoni tyrosine kinase 0.0129 0.0418 0.0492
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0371 0.157 0.4384
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0091 0.0107
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0093 0.0247 0.1534
Brugia malayi Immunoglobulin I-set domain containing protein 0.0108 0.0316 0.0373
Brugia malayi SH2 domain containing protein 0.0056 0.0071 0.0084
Trichomonas vaginalis CMGC family protein kinase 0.0181 0.0667 0.5535
Echinococcus granulosus twitchin 0.013 0.0421 0.0414
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0047 0.003 0.0036
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0253 0.1007 0.2804
Plasmodium vivax serine/threonine kinase-1, putative 0.0253 0.1007 1
Echinococcus multilocularis tyrosine protein kinase Blk 0.0115 0.0351 0.0406
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0253 0.1007 0.2804
Echinococcus granulosus tyrosine protein kinase Src64B 0.0129 0.0418 0.0411
Schistosoma mansoni serine/threonine protein kinase 0.0253 0.1007 0.1187
Echinococcus granulosus epidermal growth factor receptor 0.1824 0.8485 0.8484
Schistosoma mansoni tyrosine kinase 0.1048 0.4789 0.5645
Schistosoma mansoni nephrin 0.0124 0.0394 0.0464
Echinococcus granulosus hypothetical protein 0.0247 0.098 0.0973
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.1054 0.4817 0.4814
Loa Loa (eye worm) hypothetical protein 0.0155 0.0542 0.0639
Brugia malayi Immunoglobulin I-set domain containing protein 0.0047 0.003 0.0036
Schistosoma mansoni cell adhesion molecule 0.0139 0.0465 0.0548
Echinococcus multilocularis tyrosine kinase 0.0056 0.0071 0.0076
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.1054 0.4817 0.5674
Echinococcus multilocularis hemicentin 1 0.0047 0.003 0.0027
Schistosoma mansoni tyrosine kinase 0.0245 0.0969 0.1142
Echinococcus multilocularis tyrosine protein kinase HCK 0.0096 0.026 0.0299
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0129 0.0418 0.0485
Schistosoma mansoni tyrosine kinase 0.1048 0.4789 0.5645
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0093 0.0247 0.0291
Echinococcus multilocularis epidermal growth factor receptor 0.1048 0.4789 0.5641
Trichomonas vaginalis CMGC family protein kinase 0.0181 0.0667 0.5535
Schistosoma mansoni protein kinase 0.0043 0.0007 0.0008
Onchocerca volvulus Tyrosine kinase homolog 0.0465 0.2016 1
Schistosoma mansoni septate junction protein 0.0047 0.003 0.0036
Echinococcus granulosus tyrosine protein kinase Fyn 0.0129 0.0418 0.0411
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0792 0.3573 1
Schistosoma mansoni tyrosine kinase 0.1011 0.4614 0.5438
Echinococcus multilocularis neuroglian 0.0047 0.003 0.0027
Loa Loa (eye worm) SRC-1 0.0129 0.0418 0.0492
Loa Loa (eye worm) TK/INSR protein kinase 0.0599 0.2654 0.3128
Brugia malayi Protein kinase domain containing protein 0.0253 0.1007 0.1187
Brugia malayi protein-tyrosine kinase 0.0115 0.0351 0.0414
Echinococcus multilocularis neuroglian 0.0124 0.0394 0.0456
Echinococcus multilocularis microtubule associated protein 2 0.0709 0.3177 0.3739
Onchocerca volvulus 0.0056 0.0071 0.0206
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0129 0.0418 0.0485
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.007 0.0137 0.0162
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0047 0.003 0.0027
Echinococcus multilocularis roundabout 2 0.0155 0.0542 0.0632
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0047 0.003 0.0036
Loa Loa (eye worm) TK/ABL protein kinase 0.0264 0.1061 0.125
Schistosoma mansoni serine/threonine protein kinase 0.0253 0.1007 0.1187
Loa Loa (eye worm) hypothetical protein 0.0108 0.0316 0.0373
Schistosoma mansoni tyrosine kinase 0.1824 0.8485 1
Echinococcus granulosus tyrosine kinase 0.0115 0.0351 0.0345
Echinococcus multilocularis cyclin dependent kinase 5 0.0181 0.0667 0.0779
Loa Loa (eye worm) TK protein kinase 0.0115 0.0351 0.0414
Entamoeba histolytica hypothetical protein 0.0093 0.0247 0.1534
Schistosoma mansoni neuroglian 0.0047 0.003 0.0036
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0071 0.0084
Entamoeba histolytica protein kinase, putative 0.0371 0.157 1
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0295 0.1206 0.3362
Giardia lamblia Kinase, CMGC CDK 0.0181 0.0667 0.5535
Giardia lamblia Kinase, CMGC CDK 0.0181 0.0667 0.5535
Schistosoma mansoni cell adhesion molecule 0.0047 0.003 0.0036
Schistosoma mansoni nephrin 0.0047 0.003 0.0036
Brugia malayi hypothetical protein 0.0504 0.2204 0.2598
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0181 0.0667 0.1852
Trypanosoma cruzi cdc2-related kinase 3 0.0181 0.0667 0.1852
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0181 0.0667 0.0787
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0588 0.26 0.3065
Echinococcus granulosus roundabout 2 0.0047 0.003 0.0023
Loa Loa (eye worm) hypothetical protein 0.0047 0.003 0.0036
Echinococcus granulosus tyrosine protein kinase Srms 0.0056 0.0071 0.0064
Echinococcus granulosus tyrosine protein kinase ABL1 0.0264 0.1061 0.1054
Onchocerca volvulus 0.0056 0.0071 0.0206
Echinococcus multilocularis cyclin dependent kinase 1 0.0181 0.0667 0.0779
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0129 0.0418 0.0411
Echinococcus granulosus tyrosine protein kinase shark 0.0056 0.0071 0.0064
Echinococcus granulosus tyrosine kinase 0.0056 0.0071 0.0064
Echinococcus granulosus tyrosine protein kinase Blk 0.0115 0.0351 0.0345
Echinococcus granulosus epidermal growth factor receptor 0.1048 0.4789 0.4786
Loa Loa (eye worm) hypothetical protein 0.0247 0.098 0.1155
Onchocerca volvulus 0.0412 0.1764 0.8727
Brugia malayi Immunoglobulin I-set domain containing protein 0.0588 0.26 0.3065
Brugia malayi Protein kinase domain containing protein 0.0599 0.2654 0.3128
Brugia malayi SRC-1 0.0129 0.0418 0.0492
Schistosoma mansoni roundabout 0.0047 0.003 0.0036
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0047 0.003 0.0036
Brugia malayi Protein kinase domain containing protein 0.0056 0.0071 0.0084
Trypanosoma brucei sedoheptulose-1,7-bisphosphatase 0.0295 0.1206 0.3362
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.1054 0.4817 0.5678
Schistosoma mansoni tyrosine kinase 0.0599 0.2654 0.3128
Echinococcus multilocularis Immunoglobulin 0.0108 0.0316 0.0365
Echinococcus multilocularis epidermal growth factor receptor 0.1824 0.8485 1
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0071 0.0084
Schistosoma mansoni tyrosine kinase 0.0056 0.0071 0.0084
Brugia malayi Protein kinase domain containing protein 0.0267 0.1075 0.1267
Echinococcus granulosus cyclin dependent kinase 0.0181 0.0667 0.0661
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0129 0.0418 0.0485
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0371 0.157 0.1851
Echinococcus multilocularis roundabout 2 0.0047 0.003 0.0027
Brugia malayi Immunoglobulin I-set domain containing protein 0.0047 0.003 0.0036
Echinococcus multilocularis 0.0247 0.098 0.1147
Schistosoma mansoni tyrosine kinase 0.007 0.0137 0.0162
Brugia malayi Protein kinase domain containing protein 0.0056 0.0071 0.0084
Schistosoma mansoni protein kinase 0.0043 0.0007 0.0008
Loa Loa (eye worm) fructose-1,6-bisphosphatase 0.0792 0.3573 0.4211
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0047 0.003 0.0027
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0047 0.003 0.0027
Echinococcus granulosus tyrosine protein kinase Src42A 0.0129 0.0418 0.0411
Echinococcus granulosus cyclin dependent kinase 1 0.0181 0.0667 0.0661
Schistosoma mansoni titin 0.0047 0.003 0.0036
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0056 0.0071 0.0411
Loa Loa (eye worm) hypothetical protein 0.0047 0.003 0.0036
Trypanosoma cruzi cdc2-related kinase 1 0.0181 0.0667 0.1852
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0053 0.0057 0.005
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0071 0.0084
Echinococcus multilocularis dual specificity 0.0371 0.157 0.1844
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0046 0.0054
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0053 0.0057 0.0059
Onchocerca volvulus 0.0056 0.0071 0.0206
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0129 0.0418 0.0485
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0047 0.003 0.0036
Echinococcus multilocularis roundabout 2 0.0047 0.003 0.0027
Brugia malayi Protein kinase domain containing protein 0.0056 0.0071 0.0084
Loa Loa (eye worm) hypothetical protein 0.0108 0.0316 0.0373
Loa Loa (eye worm) hypothetical protein 0.006 0.0091 0.0107
Brugia malayi Protein kinase domain containing protein 0.0371 0.157 0.1851
Echinococcus granulosus contactin 0.0047 0.003 0.0023
Loa Loa (eye worm) hypothetical protein 0.0047 0.003 0.0036
Echinococcus multilocularis peroxidasin 0.0047 0.003 0.0027
Echinococcus granulosus neuroglian 0.0124 0.0394 0.0387
Brugia malayi Tyrosine-protein kinase abl-1 0.0128 0.0415 0.049
Echinococcus granulosus microtubule associated protein 2 0.0709 0.3177 0.3172
Echinococcus granulosus tyrosine protein kinase Fyn 0.0129 0.0418 0.0411
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0129 0.0418 0.0485
Trypanosoma brucei cdc2-related kinase 3 0.0181 0.0667 0.1852
Schistosoma mansoni serine/threonine protein kinase 0.0371 0.157 0.1851
Giardia lamblia Kinase, CMGC CLK 0.0253 0.1007 1
Entamoeba histolytica cell division protein kinase 2, putative 0.0181 0.0667 0.4224
Echinococcus multilocularis tyrosine protein kinase otk 0.0047 0.003 0.0027
Echinococcus multilocularis hemicentin 1 0.0047 0.003 0.0027
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0078 0.0176 0.0199
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0115 0.0351 0.0406
Entamoeba histolytica protein kinase, putative 0.0371 0.157 1
Loa Loa (eye worm) hypothetical protein 0.0176 0.064 0.0755
Echinococcus granulosus roundabout 2 0.0047 0.003 0.0023

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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