TDR Targets

Basic information

Technical information

TDR Targets ID: 705981
Name: N-[2-[2-(4-chlorophenyl)-1,3-thiazol-4-yl]eth yl]-2,3-dihydro-1,4-benzodioxine-7-sulfonamid e
MW: 436.932 | Formula: C19H17ClN2O4S2
H donors: 1 H acceptors: 3 LogP: 3.92 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(cc1)c1scc(n1)CCNS(=O)(=O)c1ccc2c(c1)OCCO2
InChi: 1S/C19H17ClN2O4S2/c20-14-3-1-13(2-4-14)19-22-15(12-27-19)7-8-21-28(23,24)16-5-6-17-18(11-16)26-10-9-25-17/h1-6,11-12,21H,7-10H2
InChiKey: ZZQQXGARQPRGQF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[2-[2-(4-chlorophenyl)thiazol-4-yl]ethyl]-2,3-dihydro-1,4-benzodioxine-7-sulfonamide
N-[2-[2-(4-chlorophenyl)-4-thiazolyl]ethyl]-2,3-dihydro-1,4-benzodioxine-7-sulfonamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0019	0.0276	0.0493
Schistosoma mansoni	DNA polymerase eta	0.0019	0.0276	0.0221
Loa Loa (eye worm)	MH2 domain-containing protein	0.0016	0.0156	0.0156
Echinococcus multilocularis	musashi	0.0026	0.0604	0.1078
Toxoplasma gondii	Erv1 / Alr family protein	0.0033	0.0922	0.4137
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0051	0.1702	1
Onchocerca volvulus		0.0026	0.0604	0.5
Mycobacterium tuberculosis	Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase)	0.0021	0.0372	0.0168
Mycobacterium ulcerans	4-aminobutyrate aminotransferase	0.0021	0.0372	0.0168
Loa Loa (eye worm)	MH2 domain-containing protein	0.0236	1	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0604	0.0604
Brugia malayi	MH1 domain containing protein	0.0016	0.0156	0.0094
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.0635	0.4772
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0276	0.0215
Trichomonas vaginalis	acetylornithine aminotransferase, putative	0.0147	0.6022	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0583	0.0583
Mycobacterium tuberculosis	Probable aminotransferase	0.0147	0.6022	1
Mycobacterium tuberculosis	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA	0.0147	0.6022	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0276	0.1546
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0276	0.1546
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0016	0.0156	0.0278
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0138	0.5606	0.5578
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0604	0.0604
Mycobacterium ulcerans	ornithine aminotransferase RocD1 and RocD2	0.0021	0.0372	0.0168
Echinococcus multilocularis	mitogen activated protein kinase	0.0051	0.1702	0.3035
Plasmodium vivax	FAD-linked sulfhydryl oxidase ERV1, putative	0.0033	0.0922	1
Echinococcus granulosus	dna polymerase eta	0.0019	0.0276	0.0493
Loa Loa (eye worm)	hepatopoietin HPO2	0.0033	0.0922	0.0922
Toxoplasma gondii	LsmAD domain-containing protein	0.0027	0.0635	0.1974
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.1702	0.2481
Brugia malayi	intermediate filament protein	0.0026	0.0604	0.0546
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0138	0.5606	0.5606
Echinococcus granulosus	mitogen activated protein kinase 3	0.0051	0.1702	0.3035
Mycobacterium tuberculosis	Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at)	0.0021	0.0372	0.0168
Trypanosoma brucei	protein kinase, putative	0.0051	0.1702	1
Mycobacterium ulcerans	hypothetical protein	0.0147	0.6022	1
Echinococcus multilocularis	Smad4	0.0016	0.0156	0.0278
Loa Loa (eye worm)	MH1 domain-containing protein	0.0016	0.0156	0.0156
Trypanosoma brucei	DNA polymerase eta, putative	0.0019	0.0276	0.1546
Brugia malayi	4-aminobutyrate aminotransferase, mitochondrial precursor	0.0021	0.0372	0.0312
Echinococcus granulosus	mitogen activated protein kinase	0.0051	0.1702	0.3035
Mycobacterium tuberculosis	Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase)	0.0021	0.0372	0.0168
Trypanosoma brucei	unspecified product	0.0019	0.0276	0.1546
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0019	0.0276	0.0276
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0138	0.5606	1
Trypanosoma brucei	PAB1-binding protein , putative	0.0027	0.0635	0.3673
Leishmania major	hypothetical protein, conserved	0.0027	0.0635	0.2516
Echinococcus multilocularis	dna polymerase eta	0.0019	0.0276	0.0493
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0051	0.1702	1
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.1702	0.2481
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0138	0.5606	1
Loa Loa (eye worm)	Smad1	0.0016	0.0156	0.0156
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0276	0.0276
Mycobacterium leprae	PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA	0.0147	0.6022	1
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 4	0.0033	0.0922	0.4533
Schistosoma mansoni	lamin	0.0026	0.0604	0.0823
Trypanosoma cruzi	ERV/ALR sulfhydryl oxidase domain-containing protein	0.0033	0.0922	0.4533
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0051	0.1702	0.3035
Loa Loa (eye worm)	transcription factor SMAD2	0.0236	1	1
Echinococcus multilocularis	lamin dm0	0.0026	0.0604	0.1078
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0604	0.0546
Echinococcus granulosus	FAD linked sulfhydryl oxidase ALR	0.0033	0.0922	0.1645
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0276	0.1546
Mycobacterium ulcerans	acetylornithine aminotransferase	0.0021	0.0372	0.0168
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0276	0.1546
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0051	0.1702	1
Echinococcus multilocularis	ornithine aminotransferase	0.0021	0.0372	0.0664
Chlamydia trachomatis	glutamate-1-semialdehyde-2,1-aminomutase	0.0021	0.0372	0.5
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0051	0.1702	0.1702
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 4	0.0033	0.0922	0.4533
Echinococcus granulosus	dna polymerase kappa	0.0019	0.0276	0.0493
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0051	0.1702	1
Brugia malayi	MH2 domain containing protein	0.0016	0.0156	0.0094
Onchocerca volvulus		0.0026	0.0604	0.5
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0051	0.1702	1
Brugia malayi	hypothetical protein	0.0027	0.0635	0.0576
Schistosoma mansoni	serine/threonine protein kinase	0.0051	0.1702	0.2836
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.0635	0.4772
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0276	0.1546
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0635	0.2516
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0604	0.0604
Brugia malayi	MAP kinase sur-1	0.0051	0.1702	0.165
Mycobacterium ulcerans	4-aminobutyrate aminotransferase	0.0021	0.0372	0.0168
Brugia malayi	MH2 domain containing protein	0.0016	0.0156	0.0094
Brugia malayi	hypothetical protein	0.0017	0.021	0.0149
Toxoplasma gondii	Erv1 / Alr family protein	0.0033	0.0922	0.4137
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0276	0.1546
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0019	0.0276	0.5
Schistosoma mansoni	lamin	0.0026	0.0604	0.0823
Echinococcus multilocularis	FAD linked sulfhydryl oxidase ALR	0.0033	0.0922	0.1645
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0604	0.0823
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0051	0.1702	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0276	0.1546
Trypanosoma brucei	ERV/ALR sulfhydryl oxidase domain-containing protein	0.0033	0.0922	0.5378
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0276	0.1546
Echinococcus granulosus	lamin	0.0026	0.0604	0.1078
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0016	0.0156	0.0278
Echinococcus multilocularis	Aminotransferase class III	0.0021	0.0372	0.0664
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0138	0.5606	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0138	0.5606	1
Plasmodium vivax	ataxin-2 like protein, putative	0.0027	0.0635	0.4772
Echinococcus multilocularis	smad	0.0016	0.0156	0.0278
Mycobacterium ulcerans	adenosylmethionine-8-amino-7-oxononanoate aminotransferase	0.0147	0.6022	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0276	0.1546
Echinococcus granulosus	ornithine aminotransferase	0.0021	0.0372	0.0664
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0019	0.0276	0.0221
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0019	0.0276	0.0221
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0062	0.0062
Echinococcus granulosus	Smad4	0.0016	0.0156	0.0278
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0019	0.0276	0.0493
Echinococcus granulosus	Aminotransferase class III	0.0021	0.0372	0.0664
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0138	0.5606	1
Wolbachia endosymbiont of Brugia malayi	acetylornithine transaminase protein	0.0021	0.0372	0.5
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0635	0.2516
Mycobacterium tuberculosis	Probable acetylornithine aminotransferase ArgD	0.0021	0.0372	0.0168
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.1702	0.2481
Echinococcus multilocularis	dna polymerase kappa	0.0019	0.0276	0.0493
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0276	0.1546
Leishmania major	hypothetical protein, conserved	0.0033	0.0922	0.4533
Brugia malayi	Smad1	0.0016	0.0156	0.0094
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0276	0.1546
Echinococcus granulosus	lamin dm0	0.0026	0.0604	0.1078
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0138	0.5606	1
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.1702	0.2481
Echinococcus multilocularis	lamin	0.0026	0.0604	0.1078
Brugia malayi	Augmenter of liver regeneration	0.0033	0.0922	0.0866
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0635	0.0635
Echinococcus granulosus	mothers against decapentaplegic 5	0.0016	0.0156	0.0278
Plasmodium falciparum	FAD-linked sulfhydryl oxidase ERV1, putative	0.0033	0.0922	1
Giardia lamblia	Kinase, CMGC MAPK	0.0051	0.1702	1
Brugia malayi	MH1 domain containing protein	0.0016	0.0156	0.0094
Echinococcus granulosus	smad	0.0016	0.0156	0.0278
Schistosoma mansoni	ornithine--oxo-acid transaminase	0.0021	0.0372	0.0397
Mycobacterium ulcerans	glutamate-1-semialdehyde aminotransferase	0.0021	0.0372	0.0168
Echinococcus granulosus	intermediate filament protein	0.0026	0.0604	0.1078
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0051	0.1702	1
Mycobacterium ulcerans	L-lysine aminotransferase	0.0021	0.0372	0.0168
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0276	0.1546
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0016	0.0156	0.0278
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0051	0.1702	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0276	0.1546
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0138	0.5606	1
Echinococcus multilocularis	ornithine aminotransferase	0.0021	0.0372	0.0664
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0276	0.0215

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 705981