TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 267.306 | Formula: C14H9N3OS
H donors: 1 H acceptors: 3 LogP: 3.16 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: Oc1c2cnc3c(c2nn1c1cscc1)cccc3
InChi: 1S/C14H9N3OS/c18-14-11-7-15-12-4-2-1-3-10(12)13(11)16-17(14)9-5-6-19-8-9/h1-8,18H
InChiKey: TYBRIRFWCPYXTE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	trypanothione reductase, putative	0.0047	0.0224	0.3129
Plasmodium falciparum	thioredoxin reductase	0.0047	0.0224	0.0224
Leishmania major	glucose transporter, lmgt3	0.0102	0.0621	0.868
Echinococcus granulosus	Threonyl tRNA synthetase C	0.0018	0.0015	0.0032
Leishmania major	myo-inositol/proton symporter (MIT)	0.0046	0.0217	0.3029
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0098	0.0597	0.2629
Schistosoma mansoni	hypothetical protein	0.0554	0.3919	0.7983
Brugia malayi	hypothetical protein	0.002	0.0024	0.0106
Schistosoma mansoni	ran	0.0025	0.0062	0.0126
Echinococcus granulosus	synaptic vesicle 2 protein	0.0046	0.0217	0.0441
Leishmania major	GTP-binding protein, putative	0.0025	0.0062	0.0868
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0046	0.0217	0.0809
Brugia malayi	Latrophilin receptor protein 2	0.0067	0.0371	0.1637
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0217	0.0956
Echinococcus granulosus	snurportin 1	0.036	0.2503	0.5098
Brugia malayi	Doublecortin family protein	0.002	0.0024	0.0106
Mycobacterium ulcerans	sugar transporter	0.0046	0.0217	0.235
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0115	0.0715	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.01	0.0611	0.1246
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0025	0.0062	0.0868
Brugia malayi	glycyl-tRNA synthetase	0.0018	0.0015	0.0068
Schistosoma mansoni	hypothetical protein	0.036	0.2503	0.5098
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0025	0.0062	0.0062
Schistosoma mansoni	glucose transport protein	0.0327	0.2265	0.4615
Trypanosoma cruzi	sugar transporter, putative	0.0046	0.0217	0.3029
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.01	0.0612	0.0925
Trypanosoma cruzi	hexose transporter, putative	0.0056	0.0286	0.3993
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0529	0.3734	0.5643
Schistosoma mansoni	hypothetical protein	0.002	0.0024	0.0049
Schistosoma mansoni	lysyl-tRNA synthetase	0.0073	0.0413	0.0842
Plasmodium falciparum	calcium-dependent protein kinase 5	0.01	0.0612	0.0612
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0046	0.0217	0.0374
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0217	0.0809
Echinococcus granulosus	calcium dependent protein kinase	0.0094	0.0566	0.1154
Echinococcus multilocularis	RUN	0.002	0.0024	0.0042
Echinococcus multilocularis	importin subunit beta 1	0.0034	0.0127	0.0219
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0115	0.0715	1
Brugia malayi	MH2 domain containing protein	0.0119	0.0751	0.331
Trypanosoma cruzi	glucose transporter, putative	0.0046	0.0217	0.3029
Echinococcus multilocularis	Polycystic kidney disease protein	0.002	0.0024	0.0042
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0107	0.0662	0.7188
Plasmodium vivax	glycine--tRNA ligase, putative	0.0018	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0217	0.0809
Plasmodium vivax	calcium-dependent protein kinase, putative	0.01	0.0612	0.0612
Trichomonas vaginalis	sugar transporter, putative	0.0102	0.0621	0.274
Entamoeba histolytica	protein kinase, putative	0.01	0.0611	0.2987
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0143	0.0921	1
Echinococcus multilocularis	glycyl tRNA synthetase	0.0018	0.0015	0.0027
Trichomonas vaginalis	sugar transporter, putative	0.0102	0.0621	0.274
Echinococcus multilocularis	snurportin 1	0.036	0.2503	0.4323
Onchocerca volvulus		0.0046	0.0217	0.0857
Brugia malayi	Sugar transporter family protein	0.0046	0.0217	0.0955
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0292	0.2011	0.8875
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0597	0.2337
Echinococcus granulosus	lipoxygenase domain containing protein	0.002	0.0024	0.0049
Plasmodium vivax	CDK-related protein kinase 6, putative	0.139	1	1
Echinococcus granulosus	importin subunit beta 1	0.0034	0.0127	0.0259
Schistosoma mansoni	glucose transport protein	0.0327	0.2265	0.4615
Mycobacterium ulcerans	threonyl-tRNA synthetase	0.0018	0.0015	0.0168
Plasmodium vivax	threonine--tRNA ligase, putative	0.0018	0.0015	0.0015
Plasmodium falciparum	calcium-dependent protein kinase 4	0.01	0.0612	0.0612
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0046	0.0217	0.3029
Echinococcus granulosus	solute carrier family 22	0.0046	0.0217	0.0441
Plasmodium falciparum	importin beta, putative	0.0034	0.0127	0.0127
Schistosoma mansoni	protein kinase	0.01	0.0611	0.1246
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0217	0.0809
Treponema pallidum	prolyl-tRNA synthetase	0.0035	0.0134	0.0666
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0217	0.0956
Echinococcus multilocularis	transcription factor eb	0.0126	0.0801	0.1383
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0046	0.0217	0.0809
Schistosoma mansoni	rab6-interacting	0.002	0.0024	0.0049
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0217	0.0956
Brugia malayi	Helix-loop-helix DNA-binding domain containing protein	0.0126	0.0801	0.3528
Loa Loa (eye worm)	sugar transporter	0.0327	0.2265	0.9046
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0217	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0102	0.0621	0.274
Loa Loa (eye worm)	hypothetical protein	0.01	0.0611	0.2396
Plasmodium vivax	proline--tRNA ligase, putative	0.0115	0.0715	0.0715
Schistosoma mansoni	lysyl-tRNA synthetase	0.0073	0.0413	0.0842
Toxoplasma gondii	thioredoxin reductase	0.0047	0.0224	0.0338
Mycobacterium tuberculosis	Probable dehydrogenase	0.0107	0.0662	0.7188
Trypanosoma cruzi	hexose transporter	0.0102	0.0621	0.868
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0107	0.0662	0.7188
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0529	0.3734	0.3734
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.01	0.0611	0.1056
Brugia malayi	Major Facilitator Superfamily protein	0.0046	0.0217	0.0955
Trypanosoma brucei	glycyl-tRNA synthetase, putative	0.0018	0.0015	0.0216
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0217	0.0956
Treponema pallidum	fructose-bisphosphate aldolase	0.0292	0.2011	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0213	0.143	0.6303
Trypanosoma brucei	glucose transporter, putative	0.0102	0.0621	0.868
Plasmodium vivax	sugar transporter, putative	0.0046	0.0217	0.0217
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0292	0.2011	1
Schistosoma mansoni	glycyl-tRNA synthetase	0.0018	0.0015	0.0032
Echinococcus granulosus	lipoxygenase domain containing protein	0.002	0.0024	0.0049
Echinococcus granulosus	microtubule associated protein 2	0.069	0.4909	1
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0217	0.0956
Echinococcus multilocularis	Threonyl tRNA synthetase, C	0.0018	0.0015	0.0027
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0102	0.0621	0.868
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0035	0.0134	0.1454
Giardia lamblia	Threonyl-tRNA synthetase	0.0018	0.0015	0.0077
Trichomonas vaginalis	glucose transporter, putative	0.0102	0.0621	0.274
Chlamydia trachomatis	lysine--tRNA ligase	0.0073	0.0413	1
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.01	0.0612	0.0925
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0067	0.0371	0.0757
Trypanosoma brucei	importin beta-1 subunit, putative	0.0034	0.0127	0.1774
Schistosoma mansoni	hypothetical protein	0.0067	0.0371	0.0757
Toxoplasma gondii	protein kinase, putative	0.0925	0.6617	1
Loa Loa (eye worm)	helix-loop-helix DNA-binding domain-containing protein	0.0126	0.0796	0.3138
Schistosoma mansoni	ran	0.0025	0.0062	0.0126
Brugia malayi	probable proline-trna synthetase - fission yeast, putative	0.0018	0.0015	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0217	0.0809
Echinococcus granulosus	solute carrier family 22	0.0046	0.0217	0.0441
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0102	0.0621	0.868
Trichomonas vaginalis	ran, putative	0.0025	0.0062	0.0274
Schistosoma mansoni	sugar transporter	0.0046	0.0217	0.0441
Plasmodium falciparum	calcium-dependent protein kinase 2	0.01	0.0612	0.0612
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0119	0.075	0.8134
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0073	0.0413	0.5782
Echinococcus granulosus	neuropeptide receptor A26	0.0541	0.3819	0.778
Trypanosoma cruzi	hexose transporter, putative	0.0102	0.0621	0.868
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0413	0.16
Onchocerca volvulus		0.0046	0.0217	0.0857
Trypanosoma cruzi	hexose transporter, putative	0.0102	0.0621	0.868
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0217	0.0956
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.01	0.0611	0.2396
Brugia malayi	glutathione reductase	0.0047	0.0224	0.0986
Brugia malayi	hypothetical protein	0.002	0.0024	0.0106
Plasmodium falciparum	protein kinase 7	0.0925	0.6617	0.6617
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0327	0.2265	0.4615
Onchocerca volvulus		0.0046	0.0217	0.0857
Giardia lamblia	Fructose-bisphosphate aldolase	0.0292	0.2011	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0327	0.2265	0.3913
Onchocerca volvulus		0.0046	0.0217	0.0857
Trichomonas vaginalis	sugar transport protein, putative	0.0046	0.0217	0.0956
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0098	0.0597	0.1031
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0217	0.0956
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0067	0.0371	0.1637
Echinococcus multilocularis	lysyl tRNA synthetase	0.0073	0.0413	0.0714
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0292	0.2011	0.8875
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0067	0.0371	0.1431
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0046	0.0217	0.235
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0217	0.0956
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0025	0.0062	0.0868
Trypanosoma brucei	glucose transporter, putative	0.0102	0.0621	0.868
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0067	0.0371	0.0757
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0217	0.0956
Echinococcus multilocularis	solute carrier family 22	0.0046	0.0217	0.0374
Echinococcus multilocularis	microtubule associated protein 2	0.069	0.4909	0.8479
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0217	0.0956
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.01	0.0612	0.0612
Onchocerca volvulus		0.0046	0.0217	0.0857
Brugia malayi	Sugar transporter family protein	0.0327	0.2265	0.9985
Trichomonas vaginalis	conserved hypothetical protein	0.0102	0.0621	0.274
Schistosoma mansoni	sugar transporter	0.0046	0.0217	0.0441
Trichomonas vaginalis	conserved hypothetical protein	0.0102	0.0621	0.274
Brugia malayi	lysyl-tRNA synthetase	0.0073	0.0413	0.1822
Loa Loa (eye worm)	transcription factor SMAD2	0.0119	0.0751	0.2958
Plasmodium falciparum	lysine--tRNA ligase	0.0073	0.0413	0.0413
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0292	0.2011	0.8875
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0046	0.0217	0.0217
Trypanosoma brucei	threonyl-tRNA synthetase, putative	0.0018	0.0015	0.0216
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0025	0.0062	0.0868
Trypanosoma cruzi	hexose transporter, putative	0.0102	0.0621	0.868
Schistosoma mansoni	rab6-interacting	0.002	0.0024	0.0049
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0119	0.075	0.8134
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0073	0.0413	0.1825
Plasmodium falciparum	glutathione reductase	0.0047	0.0224	0.0224
Giardia lamblia	Sugar-proton symporter	0.0046	0.0217	0.1077
Trypanosoma brucei	glucose transporter, putative	0.0102	0.0621	0.868
Schistosoma mansoni	hypothetical protein	0.0554	0.3919	0.7983
Echinococcus multilocularis	neuropeptide s receptor	0.0541	0.3819	0.6597
Trypanosoma brucei	glucose transporter, putative	0.0102	0.0621	0.868
Entamoeba histolytica	hypothetical protein	0.0073	0.0413	0.1995
Chlamydia trachomatis	threonine--tRNA ligase	0.0018	0.0015	0.0374
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0217	0.0956
Giardia lamblia	Prolyl-tRNA synthetase	0.0098	0.0597	0.2967
Leishmania major	threonyl-tRNA synthetase, putative	0.0018	0.0015	0.0216
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0217	0.0956
Echinococcus multilocularis	geminin	0.0554	0.3919	0.6769
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.01	0.0611	0.1056
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0119	0.075	0.8102
Loa Loa (eye worm)	hypothetical protein	0.0328	0.2269	0.9061
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0292	0.2011	0.8875
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0025	0.0062	0.0126
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0327	0.2265	0.4615
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0217	0.0956
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0217	0.0956
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0217	0.0956
Echinococcus multilocularis	solute carrier family 22	0.0046	0.0217	0.0374
Trichomonas vaginalis	threonyl-tRNA synthetase, putative	0.0018	0.0015	0.0068
Trichomonas vaginalis	CAMK family protein kinase	0.01	0.0611	0.2699
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0217	0.0956
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0047	0.0224	0.0386
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0217	0.0956
Onchocerca volvulus		0.0328	0.2269	1
Plasmodium vivax	lysine--tRNA ligase, putative	0.0073	0.0413	0.0413
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0062	0.0333	0.3508
Schistosoma mansoni	hypothetical protein	0.0067	0.0371	0.0757
Leishmania major	trypanothione reductase	0.0047	0.0224	0.3129
Brugia malayi	Sugar transporter family protein	0.0046	0.0217	0.0955
Brugia malayi	RNA, U transporter 1	0.0096	0.058	0.2554
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0098	0.0597	0.6414
Schistosoma mansoni	lipoxygenase	0.0117	0.0735	0.1498
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0327	0.2265	0.3913
Mycobacterium tuberculosis	Probable reductase	0.0107	0.0662	0.7188
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0098	0.0597	0.2913
Leishmania major	lysyl-tRNA synthetase, putative	0.0073	0.0413	0.5782
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0046	0.0217	0.235
Echinococcus granulosus	glycyl tRNA synthetase	0.0018	0.0015	0.0032
Schistosoma mansoni	microtubule-associated protein tau	0.069	0.4909	1
Trypanosoma brucei	glucose transporter, putative	0.0102	0.0621	0.868
Brugia malayi	major facilitator superfamily protein	0.0046	0.0217	0.0955
Leishmania major	protein kinase, putative	0.01	0.0611	0.8549
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0217	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0217	0.0956
Giardia lamblia	Glycyl-tRNA synthetase	0.0018	0.0015	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0217	0.0809
Schistosoma mansoni	hypothetical protein	0.0145	0.094	0.1915
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0217	0.0809
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0217	0.0809
Trypanosoma brucei	sugar transporter, putative	0.0046	0.0217	0.3029
Toxoplasma gondii	HEAT repeat-containing protein	0.0034	0.0127	0.0192
Mycobacterium tuberculosis	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase)	0.0018	0.0015	0.0168
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0046	0.0217	0.0441
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0292	0.2011	0.8875
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0107	0.0662	0.7188
Giardia lamblia	Lysyl-tRNA synthetase	0.0073	0.0413	0.2057
Trypanosoma brucei	glucose transporter 1E	0.0102	0.0621	0.868
Schistosoma mansoni	hypothetical protein	0.0067	0.0371	0.0757
Schistosoma mansoni	polycystin 1-related	0.002	0.0024	0.0049
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0529	0.3734	0.3734
Echinococcus multilocularis	lipoxygenase domain containing protein	0.002	0.0024	0.0042
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0098	0.0597	0.1215
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0064	0.0348	0.1536
Trypanosoma brucei	glucose transporter, putative	0.0102	0.0621	0.868
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0067	0.0371	0.0642
Trypanosoma brucei	importin beta-1 subunit, putative	0.0034	0.0127	0.1774
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0046	0.0217	0.235
Wolbachia endosymbiont of Brugia malayi	prolyl-tRNA synthetase	0.0018	0.0015	0.0715
Mycobacterium ulcerans	glycyl-tRNA synthetase	0.0018	0.0015	0.0168
Leishmania major	glucose transporter, lmgt2	0.0102	0.0621	0.868
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0213	0.143	0.5688
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.036	0.2503	1
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0217	0.0956
Toxoplasma gondii	glycyl-tRNA synthetase	0.0018	0.0015	0.0023
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0018	0.0015	0.0216
Loa Loa (eye worm)	MH2 domain-containing protein	0.0119	0.0751	0.2958
Trichomonas vaginalis	myo-inositol transporter, putative	0.0046	0.0217	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0217	0.0956
Brugia malayi	hypothetical protein	0.0046	0.0217	0.0955
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0098	0.0597	0.2629
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0143	0.0921	1
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0796	0.3138
Schistosoma mansoni	protein kinase	0.01	0.0611	0.1246
Echinococcus granulosus	General substrate transporter	0.0281	0.193	0.3932
Schistosoma mansoni	protein kinase	0.01	0.0611	0.1246
Toxoplasma gondii	sugar transporter ST2	0.0046	0.0217	0.0327
Onchocerca volvulus		0.0046	0.0217	0.0857
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0217	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0217	0.0809
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.01	0.0611	0.1246
Plasmodium falciparum	hexose transporter	0.0327	0.2265	0.2265
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0027	0.008	0.0355
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0217	0.0956
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0025	0.0062	0.0309
Onchocerca volvulus		0.0046	0.0217	0.0857
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0117	0.0735	0.127
Schistosoma mansoni	importin beta-1	0.0034	0.0127	0.0259
Toxoplasma gondii	facilitative glucose transporter GT1	0.0327	0.2265	0.3424
Wolbachia endosymbiont of Brugia malayi	threonyl-tRNA synthetase	0.0018	0.0015	0.0715
Echinococcus granulosus	solute carrier family 22	0.0046	0.0217	0.0441
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.01	0.0612	0.0612
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0117	0.0735	0.1498
Trypanosoma brucei	trypanothione reductase	0.0047	0.0224	0.3129
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.01	0.0611	0.1056
Schistosoma mansoni	hypothetical protein	0.0327	0.2265	0.4615
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0217	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0217	0.0956
Brugia malayi	latrophilin 2 splice variant baaae	0.0145	0.094	0.4143
Toxoplasma gondii	lysine-tRNA ligase	0.0073	0.0413	0.0625
Mycobacterium ulcerans	integral membrane transport protein	0.0046	0.0217	0.235
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0067	0.0371	0.0642
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0046	0.0217	0.0374
Trypanosoma brucei	glucose transporter, putative	0.0102	0.0621	0.868
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.01	0.0612	0.0612
Echinococcus granulosus	solute carrier family 22	0.0046	0.0217	0.0441
Echinococcus multilocularis	neuropeptide receptor A26	0.0541	0.3819	0.6597
Schistosoma mansoni	hypothetical protein	0.0067	0.0371	0.0757
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0115	0.0715	0.1081
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0217	0.0809
Echinococcus granulosus	neuropeptide s receptor	0.0541	0.3819	0.778
Brugia malayi	Thioredoxin reductase	0.0047	0.0224	0.0986
Echinococcus multilocularis	solute carrier family 22	0.0046	0.0217	0.0374
Onchocerca volvulus	Putative transporter	0.0046	0.0217	0.0857
Toxoplasma gondii	transporter, major facilitator family protein	0.0046	0.0217	0.0327
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.01	0.0611	0.1246
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0292	0.2011	0.8875
Brugia malayi	Cam kinase protein 1	0.01	0.0611	0.2695
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0217	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0597	0.2337
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0046	0.0217	0.235
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0025	0.0062	0.0062
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0217	0.0956
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.01	0.0611	0.2396
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0217	0.0956
Toxoplasma gondii	threonyl-tRNA synthetase family protein	0.0018	0.0015	0.0023
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0811	0.5789	1
Trypanosoma cruzi	hexose transporter, putative	0.0046	0.0217	0.3029
Trypanosoma brucei	glucose transporter 2A	0.0102	0.0621	0.868
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0217	0.0956
Brugia malayi	threonyl-tRNA synthetase, cytoplasmic	0.0018	0.0015	0.0068
Schistosoma mansoni	glucose transport protein	0.0327	0.2265	0.4615
Giardia lamblia	Hexose transporter	0.0046	0.0217	0.1077
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0217	0.0809
Chlamydia trachomatis	proline--tRNA ligase	0.0035	0.0134	0.3241
Plasmodium falciparum	threonine--tRNA ligase	0.0018	0.0015	0.0015
Plasmodium falciparum	calcium-dependent protein kinase 1	0.01	0.0612	0.0612
Loa Loa (eye worm)	hypothetical protein	0.0213	0.143	0.5688
Loa Loa (eye worm)	hypothetical protein	0.002	0.0024	0.0035
Leishmania major	importin beta-1 subunit, putative	0.0027	0.008	0.1125
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0107	0.0662	0.714
Onchocerca volvulus		0.0046	0.0217	0.0857
Onchocerca volvulus		0.0046	0.0217	0.0857
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0102	0.0621	0.868
Toxoplasma gondii	sugar transporter ST1	0.0046	0.0217	0.0327
Echinococcus granulosus	transcription factor eb	0.0126	0.0801	0.1631
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0217	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0217	0.0956
Loa Loa (eye worm)	hypothetical protein	0.008	0.0462	0.1797
Brugia malayi	hypothetical protein	0.0046	0.0217	0.0955
Schistosoma mansoni	sugar transporter	0.0046	0.0217	0.0441
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0025	0.0062	0.0094
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0217	0.0956
Plasmodium vivax	multidomain scavenger receptor, putative	0.002	0.0024	0.0024
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0327	0.2265	0.4615
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0327	0.2265	0.3913
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0046	0.0217	0.0441
Entamoeba histolytica	protein kinase, putative	0.01	0.0611	0.2987
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0073	0.0413	0.4487
Loa Loa (eye worm)	hypothetical protein	0.002	0.0024	0.0035
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0217	0.0956
Echinococcus granulosus	geminin	0.0554	0.3919	0.7983
Echinococcus multilocularis	GPCR, family 2	0.0067	0.0371	0.0642
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0062	0.0333	0.3617
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.01	0.0611	0.1056
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0102	0.0621	0.868
Brugia malayi	Major Facilitator Superfamily protein	0.0046	0.0217	0.0955
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0027	0.008	0.1125
Onchocerca volvulus		0.0046	0.0217	0.0857
Echinococcus multilocularis	calcium dependent protein kinase	0.0094	0.0566	0.0978
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0217	0.0956
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0073	0.0413	0.4393
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0062	0.0333	0.3617
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0217	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0217	0.0809
Echinococcus granulosus	thioredoxin glutathione reductase	0.0047	0.0224	0.0456
Leishmania major	glucose transporter, lmgt1	0.0102	0.0621	0.868
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0217	0.0956
Brugia malayi	Major Facilitator Superfamily protein	0.0046	0.0217	0.0955
Mycobacterium tuberculosis	Probable oxidoreductase	0.0119	0.075	0.8134
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0018	0.0015	0.0216
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0327	0.2265	0.3913
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0371	0.1431
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.01	0.0612	0.0925
Echinococcus multilocularis	General substrate transporter	0.0281	0.193	0.3334
Trichomonas vaginalis	glucose transporter, putative	0.0046	0.0217	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0127	0.0448
Onchocerca volvulus		0.0046	0.0217	0.0857
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0217	0.0809
Plasmodium falciparum	proline--tRNA ligase	0.0115	0.0715	0.0715
Echinococcus granulosus	Polycystic kidney disease protein	0.002	0.0024	0.0049
Echinococcus multilocularis	solute carrier family 22	0.0046	0.0217	0.0374
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0027	0.008	0.0355
Leishmania major	hypothetical protein, conserved	0.0046	0.0217	0.3029
Brugia malayi	hypothetical protein	0.0328	0.2269	1
Schistosoma mansoni	loxhd1	0.002	0.0024	0.0049
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0025	0.0062	0.0107
Plasmodium vivax	thioredoxin reductase, putative	0.0047	0.0224	0.0224
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0115	0.0715	1
Onchocerca volvulus		0.0046	0.0217	0.0857
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.004	0.0175	0.0641
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0327	0.2265	0.4615
Echinococcus granulosus	lysyl tRNA synthetase	0.0073	0.0413	0.0842
Trichomonas vaginalis	importin beta-1, putative	0.0027	0.008	0.0355
Loa Loa (eye worm)	thioredoxin reductase	0.0047	0.0224	0.0837
Plasmodium falciparum	LCCL domain-containing protein	0.002	0.0024	0.0024
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0098	0.0597	0.2633
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0143	0.0921	1
Onchocerca volvulus		0.0046	0.0217	0.0857
Trypanosoma brucei	glucose transporter, putative	0.0102	0.0621	0.868
Schistosoma mansoni	serine/threonine protein kinase	0.01	0.0611	0.1246
Entamoeba histolytica	Ran family GTPase	0.0025	0.0062	0.0234
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0217	0.0809
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.01	0.0611	0.1246
Brugia malayi	major facilitator superfamily protein	0.0046	0.0217	0.0955
Onchocerca volvulus		0.0046	0.0217	0.0857
Onchocerca volvulus		0.0046	0.0217	0.0857
Onchocerca volvulus		0.0046	0.0217	0.0857
Loa Loa (eye worm)	glutathione reductase	0.0047	0.0224	0.0837
Schistosoma mansoni	lipoxygenase	0.0082	0.0478	0.0975
Plasmodium vivax	importin-beta 2, putative	0.0034	0.0127	0.0127
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0098	0.0597	0.1215
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0046	0.0217	1
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0098	0.0597	0.1215
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0292	0.2011	0.8875
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0047	0.0224	0.2428
Entamoeba histolytica	hypothetical protein	0.0027	0.008	0.0326
Trichomonas vaginalis	glucose transporter, putative	0.0102	0.0621	0.274
Treponema pallidum	threonyl-tRNA synthetase	0.0018	0.0015	0.0077
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0213	0.143	0.6303
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0217	0.0956
Schistosoma mansoni	sugar transporter	0.0046	0.0217	0.0441
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0073	0.0413	0.4487
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.01	0.0611	0.2695
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0217	0.0809
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0217	0.0956
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0292	0.2011	0.8875
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0115	0.0715	1
Plasmodium falciparum	calcium-dependent protein kinase 3	0.01	0.0612	0.0612
Echinococcus multilocularis	lipoxygenase domain containing protein	0.002	0.0024	0.0042
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0025	0.0062	0.0187
Brugia malayi	Importin beta-1 subunit	0.0034	0.0127	0.0559
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0025	0.0062	0.0274
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0073	0.0413	0.5782
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0217	0.0809
Trichomonas vaginalis	conserved hypothetical protein	0.0327	0.2265	1
Loa Loa (eye worm)	sugar transporter	0.0046	0.0217	0.0809
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0115	0.0715	1
Brugia malayi	hypothetical protein	0.0046	0.0217	0.0955
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0217	0.0956
Loa Loa (eye worm)	doublecortin family protein	0.002	0.0024	0.0035
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.01	0.0611	0.8549
Echinococcus granulosus	GPCR family 2	0.0067	0.0371	0.0757
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0292	0.2011	1
Plasmodium vivax	hexose transporter	0.0327	0.2265	0.2265
Toxoplasma gondii	sugar transporter ST3	0.0046	0.0217	0.0327
Schistosoma mansoni	glucose transporter	0.0046	0.0217	0.0441
Echinococcus granulosus	RUN	0.002	0.0024	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0145	0.094	0.3717
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0107	0.0662	0.7188
Plasmodium vivax	glutathione reductase, putative	0.0047	0.0224	0.0224

Activities

Activity type	Activity value	Assay description	Source	Reference
ED50 (functional)	= 2.49 mg kg-1	Inverse agonist activity of orally administered compound against a subcutaneous dose of 90 mg/kg of PTZ-induced convulsions in mice	ChEMBL.	2842502
ED50 (functional)	= 7.62 mg kg-1	Inverse agonist activity of orally administered compound against a subcutaneous dose of 75 mg/kg of PTZ-induced convulsions in mice	ChEMBL.	2842502
Ki (binding)	= 0.73 nM	Binding affinity against benzodiazepine (BZ) receptor by displacing [3H]-diazepam in cerebral cortex of Wistar rats	ChEMBL.	2842502

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 174220

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 70691