Detailed information for compound 708338

Basic information

Technical information
  • TDR Targets ID: 708338
  • Name: 2-[1-(4-ethylphenyl)-2,5-dioxopyrrolidin-3-yl ]sulfanylpyridine-3-carboxylic acid
  • MW: 356.396 | Formula: C18H16N2O4S
  • H donors: 1 H acceptors: 5 LogP: 2.63 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1ccc(cc1)N1C(=O)CC(C1=O)Sc1ncccc1C(=O)O
  • InChi: 1S/C18H16N2O4S/c1-2-11-5-7-12(8-6-11)20-15(21)10-14(17(20)22)25-16-13(18(23)24)4-3-9-19-16/h3-9,14H,2,10H2,1H3,(H,23,24)
  • InChiKey: RBVQGZPCFNGEKB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[1-(4-ethylphenyl)-2,5-dioxo-pyrrolidin-3-yl]sulfanylpyridine-3-carboxylic acid
  • 2-[[1-(4-ethylphenyl)-2,5-dioxo-3-pyrrolidinyl]thio]-3-pyridinecarboxylic acid
  • 2-[[1-(4-ethylphenyl)-2,5-diketo-pyrrolidin-3-yl]thio]nicotinic acid
  • ST5327400

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major metacaspase, putative 0.0065 0.0776 0.7701
Schistosoma mansoni caspase-7 (C14 family) 0.0153 0.2495 0.3941
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.132 0.132
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0127 0.1984 0.2032
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0041 0.0305 0.0256
Echinococcus granulosus caspase 2 0.0153 0.2495 0.3965
Onchocerca volvulus Huntingtin homolog 0.0136 0.216 0.3218
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0776 0.0598
Mycobacterium tuberculosis Probable lipase LipE 0.0077 0.1008 0.0939
Loa Loa (eye worm) hypothetical protein 0.0077 0.1008 0.1008
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0065 0.0776 0.0598
Schistosoma mansoni jumonji domain containing protein 0.0062 0.0721 0.0957
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.019 0.1883
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0246 0.0058
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0059 0.0656 0.0656
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0246 0.0058
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.019 0.019
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.1008 0.0834
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0246 0.2444
Mycobacterium tuberculosis Probable dehydrogenase 0.0114 0.1735 0.1753
Loa Loa (eye worm) hypothetical protein 0.0077 0.1008 0.1008
Plasmodium vivax hypothetical protein, conserved 0.0077 0.1008 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.2588 0.4099
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0059 0.0656 0.0545
Loa Loa (eye worm) glutaminase 2 0.0303 0.5429 0.5429
Trypanosoma brucei metacaspase 5, putative 0.0065 0.0776 0.7701
Trypanosoma cruzi metacaspase, putative 0.0065 0.0776 0.7701
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0062 0.0721 0.0993
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0065 0.0776 0.0598
Brugia malayi beta-lactamase family protein 0.0077 0.1008 0.1008
Loa Loa (eye worm) hypothetical protein 0.0172 0.2855 0.2855
Schistosoma mansoni hypothetical protein 0.0338 0.6095 1
Loa Loa (eye worm) inositol-1 0.0038 0.0246 0.0246
Trichomonas vaginalis glucosylceramidase, putative 0.0353 0.6391 0.6322
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0065 0.0776 0.1049
Brugia malayi beta-lactamase family protein 0.0077 0.1008 0.1008
Loa Loa (eye worm) glutathione reductase 0.005 0.0483 0.0483
Trichomonas vaginalis glucosylceramidase, putative 0.0372 0.6762 0.6699
Trichomonas vaginalis glutaminase, putative 0.0303 0.5429 0.534
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0148 0.24 0.3781
Loa Loa (eye worm) inward rectifying k channel family protein 1 0.0172 0.2855 0.2855
Toxoplasma gondii thioredoxin reductase 0.005 0.0483 0.1691
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0246 0.0197
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0246 0.2444
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0057 0.0613 0.0774
Echinococcus granulosus geminin 0.0338 0.6095 1
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0041 0.0305 0.0256
Trichomonas vaginalis glucosylceramidase, putative 0.0538 1 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0077 0.1008 0.1473
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0077 0.1008 0.1469
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0246 0.0862
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.019 0.019
Trypanosoma brucei metacaspase MCA2 0.0065 0.0776 0.7701
Mycobacterium ulcerans esterase/lipase LipP 0.0077 0.1008 0.1469
Leishmania major hypothetical protein, conserved 0.0077 0.1008 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0721 0.0957
Brugia malayi Muscleblind-like protein 0.0153 0.2501 0.2501
Mycobacterium leprae Probable lipase LipE 0.0077 0.1008 0.3814
Plasmodium vivax thioredoxin reductase, putative 0.005 0.0483 0.4792
Echinococcus granulosus caspase 8 0.0065 0.0776 0.1085
Plasmodium falciparum glutathione reductase 0.005 0.0483 0.6223
Schistosoma mansoni caspase-3 (C14 family) 0.014 0.2234 0.3503
Trypanosoma brucei trypanothione reductase 0.005 0.0483 0.4792
Brugia malayi acetyltransferase, GNAT family protein 0.0148 0.24 0.24
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.1008 0.0834
Onchocerca volvulus 0.0077 0.1008 0.1371
Schistosoma mansoni inositol monophosphatase 0.0038 0.0246 0.0158
Loa Loa (eye worm) hypothetical protein 0.0077 0.1008 0.1008
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.1008 0.0834
Brugia malayi hypothetical protein 0.0136 0.216 0.216
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0077 0.1008 0.1008
Leishmania major trypanothione reductase 0.005 0.0483 0.4792
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0776 0.0598
Brugia malayi Pre-SET motif family protein 0.0033 0.0152 0.0152
Schistosoma mansoni caspase-7 (C14 family) 0.014 0.2234 0.3503
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0231 0.4015 0.4015
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0152 0.004
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0286 0.0186
Trypanosoma brucei hypothetical protein, conserved 0.0077 0.1008 1
Plasmodium falciparum metacaspase 1 0.0065 0.0776 1
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.0656 0.0884
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.132 0.1964
Echinococcus multilocularis caspase 0.014 0.2234 0.3503
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0305 0.0256
Mycobacterium tuberculosis Probable esterase LipL 0.0077 0.1008 0.0939
Echinococcus multilocularis ubiquitin specific protease 41 0.0041 0.0305 0.0256
Loa Loa (eye worm) hypothetical protein 0.0065 0.0776 0.0776
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0147 0.2368 0.2462
Echinococcus multilocularis caspase 2 0.0153 0.2495 0.3941
Onchocerca volvulus 0.0091 0.1289 0.1821
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0065 0.0776 0.2718
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0065 0.0776 0.0598
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.5366 0.5276
Brugia malayi Glycosyl hydrolases family 31 protein 0.0158 0.2588 0.2588
Echinococcus granulosus apoptotic protease activating factor 1 0.0088 0.1224 0.1836
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.1008 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.132 0.1964
Brugia malayi Thioredoxin reductase 0.005 0.0483 0.0483
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0246 0.2444
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.132 0.1964
Toxoplasma gondii hypothetical protein 0.0172 0.2855 1
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0776 0.0598
Echinococcus multilocularis lysine specific demethylase 5A 0.0062 0.0721 0.0957
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0059 0.0656 0.6509
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.0656 0.079
Schistosoma mansoni alpha-glucosidase 0.0136 0.2159 0.3376
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.1008 0.1439
Trichomonas vaginalis esterase, putative 0.0077 0.1008 0.0834
Plasmodium falciparum metacaspase-like protein 0.0065 0.0776 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0147 0.2368 1
Echinococcus multilocularis caspase 3 0.0075 0.0964 0.1365
Echinococcus granulosus ubiquitin specific protease 41 0.0041 0.0305 0.0295
Mycobacterium leprae conserved hypothetical protein 0.0077 0.1008 0.3814
Onchocerca volvulus Glucosylceramidase homolog 0.0353 0.6391 1
Mycobacterium ulcerans beta-lactamase 0.0077 0.1008 0.1469
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0357 0.354
Schistosoma mansoni hypothetical protein 0.0088 0.1224 0.1804
Trypanosoma cruzi metacaspase, putative 0.0065 0.0776 0.7701
Toxoplasma gondii ABC1 family protein 0.0077 0.1008 0.353
Echinococcus granulosus caspase 3 0.0075 0.0964 0.14
Schistosoma mansoni alpha glucosidase 0.0035 0.019 0.0063
Loa Loa (eye worm) hypothetical protein 0.0088 0.1224 0.1224
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.5366 0.5276
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.1008 0.0834
Echinococcus multilocularis apoptotic protease activating factor 1 0.0088 0.1224 0.1804
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0246 0.0058
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0065 0.0776 0.0598
Onchocerca volvulus 0.0263 0.4638 0.719
Trypanosoma brucei metacaspase MCA3 0.0065 0.0776 0.7701
Echinococcus multilocularis caspase 8 0.0065 0.0776 0.1049
Mycobacterium ulcerans lipase LipD 0.0077 0.1008 0.1469
Trichomonas vaginalis glucosylceramidase, putative 0.0353 0.6391 0.6322
Schistosoma mansoni glutaminase 0.0303 0.5429 0.8878
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0114 0.1735 0.1753
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0152 0.0534
Trichomonas vaginalis glucosylceramidase, putative 0.0353 0.6391 0.6322
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0114 0.1735 0.1753
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.5366 0.5276
Onchocerca volvulus 0.0088 0.1224 0.1718
Onchocerca volvulus Cell death protein 3 homolog 0.0153 0.2495 0.3754
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0305 0.0295
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0776 0.0598
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0065 0.0776 0.2718
Trichomonas vaginalis glucosylceramidase, putative 0.0353 0.6391 0.6322
Loa Loa (eye worm) hypothetical protein 0.0033 0.0152 0.0152
Brugia malayi hypothetical protein 0.0088 0.1224 0.1224
Trypanosoma brucei Metacaspase-4 0.0065 0.0776 0.7701
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0065 0.0776 0.0776
Brugia malayi jmjC domain containing protein 0.0062 0.0721 0.0721
Trypanosoma cruzi metacaspase 5, putative 0.0065 0.0776 0.7701
Plasmodium vivax SET domain protein, putative 0.0033 0.0152 0.1513
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.019 0.0102
Echinococcus granulosus muscleblind protein 0.0153 0.2501 0.3976
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0305 0.0256
Plasmodium vivax glutathione reductase, putative 0.005 0.0483 0.4792
Trichomonas vaginalis glucosylceramidase, putative 0.0538 1 1
Loa Loa (eye worm) hypothetical protein 0.0172 0.2855 0.2855
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.03 0.5366 1
Loa Loa (eye worm) hypothetical protein 0.0136 0.216 0.216
Brugia malayi glutaminase DH11.1 0.0303 0.5429 0.5429
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.5366 0.5276
Trichomonas vaginalis glucosylceramidase, putative 0.0538 1 1
Brugia malayi Pre-SET motif family protein 0.0231 0.4015 0.4015
Mycobacterium ulcerans hypothetical protein 0.0077 0.1008 0.1469
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.5366 0.5276
Echinococcus granulosus lysine specific demethylase 5A 0.0062 0.0721 0.0993
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0246 0.2444
Trichomonas vaginalis glucosylceramidase, putative 0.0538 1 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0492 0.9102 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0305 0.3025
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0286 0.3683
Echinococcus multilocularis muscleblind protein 1 0.0153 0.2501 0.3952
Trichomonas vaginalis glucosylceramidase, putative 0.0538 1 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0065 0.0776 0.0598
Trichomonas vaginalis glucosylceramidase, putative 0.0353 0.6391 0.6322
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0077 0.1008 0.1008
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.019 0.1883
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.132 0.1996
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0041 0.0305 0.3025
Trichomonas vaginalis glucosylceramidase, putative 0.0372 0.6762 0.6699
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0357 0.017
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0357 0.125
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0483 0.0556
Trypanosoma brucei metacaspase 0.0065 0.0776 0.7701
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0305 0.3025
Plasmodium vivax hypothetical protein, conserved 0.0065 0.0776 0.7701
Loa Loa (eye worm) hypothetical protein 0.0077 0.1008 0.1008
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0065 0.0776 0.0598
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.1008 0.0834
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.0656 0.0847
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.019 0.1883
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0041 0.0305 0.0222
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.019 0.0664
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0246 0.5
Loa Loa (eye worm) hypothetical protein 0.0041 0.0305 0.0305
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.014 0.2234 0.3529
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0127 0.1984 0.8251
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.1008 0.1439
Plasmodium falciparum thioredoxin reductase 0.005 0.0483 0.6223
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0776 0.0598
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0305 0.0295
Loa Loa (eye worm) glutaminase 0.0303 0.5429 0.5429
Mycobacterium tuberculosis Conserved protein 0.0077 0.1008 0.0939
Echinococcus multilocularis geminin 0.0338 0.6095 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.0656 0.079
Brugia malayi Inositol-1 0.0038 0.0246 0.0246
Loa Loa (eye worm) hypothetical protein 0.0172 0.2855 0.2855
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0065 0.0776 0.0598
Loa Loa (eye worm) hypothetical protein 0.0153 0.2501 0.2501
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0148 0.24 0.3781
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.5366 0.5276
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0059 0.0656 0.0847
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.1008 1
Schistosoma mansoni hypothetical protein 0.0338 0.6095 1
Trichomonas vaginalis set domain proteins, putative 0.0263 0.4638 0.4535
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0246 0.0109
Loa Loa (eye worm) hypothetical protein 0.0153 0.2495 0.2495
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0357 0.0382
Brugia malayi beta-lactamase 0.0077 0.1008 0.1008
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.019 0.0063
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0538 1 1
Brugia malayi glutathione reductase 0.005 0.0483 0.0483
Brugia malayi Cell death protein 3 precursor 0.0153 0.2495 0.2495
Loa Loa (eye worm) hypothetical protein 0.0153 0.2501 0.2501
Echinococcus multilocularis muscleblind protein 0.0153 0.2501 0.3952
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0077 0.1008 0.0939
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0305 0.3025
Schistosoma mansoni lipoxygenase 0.0057 0.0613 0.0774
Giardia lamblia Fructose-bisphosphate aldolase 0.03 0.5366 1
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0041 0.0305 0.0037
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.132 0.1964
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0246 0.0158
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.5366 0.5276
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0065 0.0776 0.2718
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0055 0.0578 0.0578
Mycobacterium tuberculosis Probable reductase 0.0114 0.1735 0.1753
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0065 0.0776 0.0598
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.03 0.5366 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0127 0.1984 0.2032
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0041 0.0305 0.0305
Trypanosoma cruzi metacaspase, putative 0.0065 0.0776 0.7701
Echinococcus multilocularis beta LACTamase domain containing family member 0.0077 0.1008 0.1439
Loa Loa (eye worm) acetyltransferase 0.0148 0.24 0.24
Mycobacterium tuberculosis Probable hydrolase 0.0077 0.1008 0.0939
Loa Loa (eye worm) beta-lactamase 0.0077 0.1008 0.1008
Plasmodium vivax metacaspase 1, putative 0.0065 0.0776 0.7701
Schistosoma mansoni inositol monophosphatase 0.0038 0.0246 0.0158
Trichomonas vaginalis glucosylceramidase, putative 0.0353 0.6391 0.6322
Onchocerca volvulus 0.0077 0.1008 0.1371
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0483 0.4792
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0057 0.0613 0.0811
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.2588 0.4099
Trypanosoma cruzi metacaspase 5, putative 0.0065 0.0776 0.7701
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0776 0.0598
Trichomonas vaginalis glucosylceramidase, putative 0.0353 0.6391 0.6322
Trichomonas vaginalis glucosylceramidase, putative 0.0538 1 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0721 0.0721
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0147 0.2368 0.4095
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0158 0.2588 0.2588
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.0483 0.0352
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0357 0.017
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.5366 0.5276
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.132 0.1964
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0077 0.1008 0.0939
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0305 0.0117
Trypanosoma brucei glucosidase, putative 0.0035 0.019 0.1883
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0305 0.0117
Treponema pallidum fructose-bisphosphate aldolase 0.03 0.5366 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.132 0.1996
Echinococcus granulosus caspase 0.014 0.2234 0.3529
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0077 0.1008 0.0939
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0114 0.1735 0.1753
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.132 0.132
Onchocerca volvulus 0.0077 0.1008 0.1371
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0065 0.0776 0.0598
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0062 0.0721 0.0957
Echinococcus granulosus lysosomal alpha glucosidase 0.0158 0.2588 0.4122
Loa Loa (eye worm) hypothetical protein 0.0136 0.216 0.216
Mycobacterium ulcerans glutaminase 0.0303 0.5429 1
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.014 0.2234 0.3503
Loa Loa (eye worm) hypothetical protein 0.0077 0.1008 0.1008
Mycobacterium tuberculosis Probable lipase LipD 0.0077 0.1008 0.0939
Onchocerca volvulus Huntingtin homolog 0.0136 0.216 0.3218
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0114 0.1735 0.712
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0483 0.0594
Loa Loa (eye worm) hypothetical protein 0.0077 0.1008 0.1008
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0721 0.0957
Schistosoma mansoni alpha-glucosidase 0.0136 0.2159 0.3376
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0114 0.1735 0.1753
Mycobacterium tuberculosis Probable oxidoreductase 0.0127 0.1984 0.2032
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0357 0.125
Trypanosoma cruzi metacaspase, putative 0.0065 0.0776 0.7701
Loa Loa (eye worm) thioredoxin reductase 0.005 0.0483 0.0483
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0305 0.0117
Mycobacterium tuberculosis Conserved protein 0.0077 0.1008 0.0939
Brugia malayi jmjC domain containing protein 0.0062 0.0721 0.0721
Mycobacterium tuberculosis Conserved protein 0.0077 0.1008 0.0939
Echinococcus granulosus histone acetyltransferase KAT2B 0.0144 0.2319 0.367

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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