Detailed information for compound 712126

Basic information

Technical information
  • TDR Targets ID: 712126
  • Name: N-tert-butyl-2-[4-[(2-phenylethylamino)methyl ]phenoxy]acetamide
  • MW: 340.459 | Formula: C21H28N2O2
  • H donors: 2 H acceptors: 1 LogP: 3.55 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NC(C)(C)C)COc1ccc(cc1)CNCCc1ccccc1
  • InChi: 1S/C21H28N2O2/c1-21(2,3)23-20(24)16-25-19-11-9-18(10-12-19)15-22-14-13-17-7-5-4-6-8-17/h4-12,22H,13-16H2,1-3H3,(H,23,24)
  • InChiKey: ZKEPIWSXBKOKJI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-tert-butyl-2-[4-[(2-phenylethylamino)methyl]phenoxy]ethanamide
  • STK280320
  • AP-970/42168131
  • N-(tert-butyl)-2-(4-{[(2-phenylethyl)amino]methyl}phenoxy)acetamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica hypothetical protein 0.0024 0.0097 0.0448
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0109 0.0083
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0053 0.0108
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0109 0.0189
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0028 0.0136 0.0139
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0118 0.0136
Mycobacterium ulcerans hypothetical protein 0.0025 0.0102 0.0162
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0053 0.0108
Schistosoma mansoni chloride channel protein 0.0025 0.0102 0.0103
Echinococcus granulosus SNF4:AMP activated protein kinase gamma subunit 0.0025 0.0102 0.0103
Echinococcus multilocularis 5' AMP activated protein kinase subunit gamma 0.0025 0.0102 0.005
Loa Loa (eye worm) hypothetical protein 0.0025 0.0099 0.0155
Schistosoma mansoni intermediate filament proteins 0.0054 0.0458 0.0841
Trypanosoma brucei GMP reductase 0.0419 0.4877 1
Onchocerca volvulus 0.0054 0.0458 0.2185
Mycobacterium tuberculosis Probable cystathionine beta-synthase Cbs (serine sulfhydrase) (beta-thionase) (hemoprotein H-450) 0.0025 0.0102 0.0187
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0053 0.0108
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0419 0.4877 1
Brugia malayi hypothetical protein 0.0073 0.0681 0.1397
Echinococcus multilocularis musashi 0.0054 0.0458 0.0408
Trypanosoma brucei Voltage-gated Chloride channel Like 3 0.0025 0.0102 0.0068
Echinococcus granulosus survival motor neuron protein 1 0.0246 0.2775 0.5643
Mycobacterium leprae conserved hypothetical protein 0.0025 0.0102 0.0007
Brugia malayi Flap endonuclease-1 0.0028 0.0136 0.028
Brugia malayi CLC chloride channel protein 0.0025 0.0102 0.0209
Leishmania major hypothetical protein, conserved 0.0026 0.0109 0.0083
Loa Loa (eye worm) hypothetical protein 0.0026 0.0109 0.0177
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0419 0.4877 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0391 0.0701
Echinococcus granulosus lamin dm0 0.0054 0.0458 0.0841
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0618 0.1171
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0053 0.0108
Brugia malayi Voltage gated chloride channel family protein 0.0025 0.0102 0.0209
Echinococcus multilocularis muscleblind protein 0.0156 0.1694 0.165
Schistosoma mansoni survival motor neuron protein 0.005 0.0407 0.0735
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0618 0.1171
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0681 0.1303
Loa Loa (eye worm) hypothetical protein 0.0025 0.0102 0.0162
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.007 0.0143
Brugia malayi GMP reductase 0.0174 0.191 0.3917
Onchocerca volvulus Putative GMP reductase 0.0174 0.191 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0446 0.0871
Brugia malayi chloride channel protein 7 0.0025 0.0102 0.0209
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0053 0.006
Loa Loa (eye worm) hypothetical protein 0.0246 0.2775 0.5669
Echinococcus multilocularis SNF4:AMP activated protein kinase gamma subunit 0.0025 0.0102 0.005
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0025 0.0102 0.0187
Schistosoma mansoni ran 0.0022 0.007 0.0035
Echinococcus granulosus tar DNA binding protein 0.0067 0.0618 0.1171
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0099 0.0478
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0053 0.0108
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0025 0.0102 0.0103
Brugia malayi intermediate filament protein 0.0054 0.0458 0.094
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0391 0.034
Toxoplasma gondii CBS family protein 0.0025 0.0102 0.0068
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0099 0.018
Brugia malayi Importin beta-1 subunit 0.003 0.0166 0.0341
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0053 0.0108
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0153 0.0314
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0199 0.2212 0.4509
Leishmania major guanosine monophosphate reductase 0.0419 0.4877 1
Schistosoma mansoni hypothetical protein 0.0073 0.0681 0.1303
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0618 0.1171
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0391 0.0701
Loa Loa (eye worm) GMP reductase 0.0174 0.191 0.3887
Echinococcus granulosus importin subunit beta 1 0.003 0.0166 0.0235
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.007 0.0101
Trypanosoma cruzi chloride channel protein, putative 0.0025 0.0102 0.0068
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0053 0.006
Plasmodium falciparum flap endonuclease 1 0.0028 0.0136 0.0248
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0028 0.0136 0.0139
Mycobacterium tuberculosis Conserved protein 0.0025 0.0102 0.0187
Mycobacterium ulcerans hypothetical protein 0.0025 0.0102 0.0162
Mycobacterium tuberculosis Conserved protein 0.0025 0.0102 0.0187
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0099 0.0061
Brugia malayi steroid hormone receptor 0.0021 0.0053 0.0108
Chlamydia trachomatis CBS domain-containing protein 0.0025 0.0102 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0102 0.0162
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0428 0.0833
Onchocerca volvulus 0.005 0.0407 0.191
Plasmodium vivax flap endonuclease 1, putative 0.0028 0.0136 0.0248
Trypanosoma cruzi GMP reductase 0.0419 0.4877 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0024 0.0025
Onchocerca volvulus 0.0025 0.0102 0.0267
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0053 0.006
Echinococcus granulosus H:Cl exchange transporter 3 0.0025 0.0102 0.0103
Entamoeba histolytica hypothetical protein 0.0073 0.0681 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0099 0.0155
Schistosoma mansoni chloride channel protein 0.0025 0.0102 0.0103
Loa Loa (eye worm) hypothetical protein 0.0025 0.0102 0.0162
Leishmania major chloride channel protein, putative 0.0025 0.0102 0.0068
Echinococcus multilocularis H(+):Cl() exchange transporter 3 0.0025 0.0102 0.005
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0419 0.4877 1
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0166 0.0201
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0053 0.006
Trypanosoma brucei AMP-activated protein kinase, gamma regulatory subunit 0.0025 0.0102 0.0068
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0395 0.4576 1
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0618 0.1171
Schistosoma mansoni protein kinase subunit gamma 0.0025 0.0102 0.0103
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0109 0.0083
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0118 0.0066
Entamoeba histolytica Flap nuclease, putative 0.0028 0.0136 0.1093
Entamoeba histolytica hypothetical protein 0.0073 0.0681 1
Loa Loa (eye worm) chloride channel protein 7 0.0025 0.0102 0.0162
Trypanosoma cruzi GMP reductase 0.0419 0.4877 1
Trypanosoma brucei Voltage-gated Chloride channel Like 1 0.0025 0.0102 0.0068
Echinococcus multilocularis survival motor neuron protein 1 0.0246 0.2775 0.2737
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0109 0.0189
Schistosoma mansoni hypothetical protein 0.005 0.0407 0.0735
Mycobacterium tuberculosis Hypoxic response protein 1 Hrp1 0.0025 0.0102 0.0187
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0681 0.1303
Echinococcus multilocularis lamin 0.0054 0.0458 0.0408
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0391 0.0701
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0053 0.0108
Loa Loa (eye worm) IMP dehydrogenase 1 0.0419 0.4877 1
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0618 0.1171
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0053 0.0108
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0097 0.4095
Echinococcus granulosus H:Cl exchange transporter 4 0.0025 0.0102 0.0103
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0109 0.0083
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0099 0.0155
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0099 0.0061
Brugia malayi ancient conserved domain protein 2 0.0025 0.0102 0.0209
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0419 0.4877 0.485
Echinococcus multilocularis tar DNA binding protein 0.0067 0.0618 0.0568
Echinococcus granulosus AMP activated protein kinase gamma regulatory 0.0025 0.0102 0.0103
Schistosoma mansoni lamin 0.0054 0.0458 0.0841
Loa Loa (eye worm) STAT protein 0.0155 0.1679 0.341
Mycobacterium ulcerans cystathionine beta-synthase 0.0025 0.0102 0.0162
Loa Loa (eye worm) hypothetical protein 0.0035 0.0229 0.0424
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0099 0.0155
Leishmania major hypothetical protein, conserved 0.0025 0.0102 0.0068
Echinococcus granulosus H:Cl exchange transporter 7 0.0025 0.0102 0.0103
Brugia malayi RNA binding protein 0.0067 0.0618 0.1266
Schistosoma mansoni chloride channel protein 0.0025 0.0102 0.0103
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0053 0.0108
Loa Loa (eye worm) hypothetical protein 0.0021 0.0053 0.006
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0028 0.0136 0.0139
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0391 0.0801
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0053 0.0108
Loa Loa (eye worm) RNA binding protein 0.0067 0.0618 0.1224
Trypanosoma cruzi chloride channel protein, putative 0.0025 0.0102 0.0068
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0097 0.4095
Brugia malayi Muscleblind-like protein 0.0156 0.1694 0.3473
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0099 0.0155
Echinococcus multilocularis lamin dm0 0.0054 0.0458 0.0408
Leishmania major inosine-5-monophosphate dehydrogenase 0.0419 0.4877 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0106 0.017
Brugia malayi nuclear receptor NHR-88 0.0021 0.0053 0.0108
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0099 0.0061
Echinococcus granulosus intermediate filament protein 0.0054 0.0458 0.0841
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0395 0.4576 1
Echinococcus multilocularis geminin 0.0176 0.1932 0.1889
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0053 0.0108
Schistosoma mansoni hypothetical protein 0.0176 0.1932 0.3896
Loa Loa (eye worm) hypothetical protein 0.0021 0.0053 0.006
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0419 0.4877 1
Echinococcus granulosus muscleblind protein 0.0156 0.1694 0.3402
Entamoeba histolytica hypothetical protein 0.0073 0.0681 1
Echinococcus granulosus 5' AMP activated protein kinase subunit gamma 0.0025 0.0102 0.0103
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.007 0.0035
Loa Loa (eye worm) hypothetical protein 0.0052 0.0428 0.0833
Loa Loa (eye worm) loechrig isoform VII 0.0025 0.0102 0.0162
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0458 0.094
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0391 0.034
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0099 0.0203
Plasmodium vivax importin-beta 2, putative 0.003 0.0166 0.0313
Chlamydia trachomatis GutQ/KpsF family sugar-phosphate isomerase 0.0025 0.0102 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0099 0.0478
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0053 0.0108
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.0618 0.1266
Echinococcus multilocularis flap endonuclease 1 0.0028 0.0136 0.0084
Echinococcus multilocularis H(+):Cl() exchange transporter 7 0.0025 0.0102 0.005
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0419 0.4877 1
Trypanosoma cruzi Domain of unknown function DUF21, putative 0.0025 0.0102 0.0068
Giardia lamblia Flap structure-specific endonuclease 0.0028 0.0136 1
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0419 0.4877 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0097 0.0057
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0419 0.4877 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0166 0.0294
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0099 0.0155
Loa Loa (eye worm) hypothetical protein 0.0021 0.0053 0.006
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0428 0.0877
Loa Loa (eye worm) hypothetical protein 0.0156 0.1694 0.3442
Schistosoma mansoni hypothetical protein 0.0322 0.3702 0.7565
Loa Loa (eye worm) hypothetical protein 0.0021 0.0053 0.006
Echinococcus granulosus geminin 0.0176 0.1932 0.3896
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0395 0.4576 0.9379
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0391 0.0756
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0419 0.4877 1
Mycobacterium tuberculosis Probable conserved transmembrane alanine and leucine rich protein 0.0025 0.0102 0.0187
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0153 0.0267
Toxoplasma gondii chloride transporter, chloride channel (ClC) family protein 0.0025 0.0102 0.0068
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0053 0.006
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0109 0.0083
Leishmania major CBS domain protein, conserved 0.0025 0.0102 0.0068
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0099 0.0203
Echinococcus multilocularis snurportin 1 0.0322 0.3702 0.3669
Schistosoma mansoni hypothetical protein 0.0035 0.0229 0.0366
Leishmania major importin beta-1 subunit, putative 0.0024 0.0097 0.0057
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0458 0.0896
Brugia malayi ecdysteroid receptor 0.0021 0.0053 0.0108
Loa Loa (eye worm) hypothetical protein 0.0025 0.0099 0.0155
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0025 0.0102 0.0187
Mycobacterium ulcerans hypothetical protein 0.0025 0.0099 0.0155
Schistosoma mansoni hypothetical protein 0.0176 0.1932 0.3896
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0053 0.0108
Echinococcus multilocularis muscleblind protein 1 0.0156 0.1694 0.165
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0053 0.0108
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0428 0.0877
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0099 0.0155
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0681 0.0632
Mycobacterium ulcerans transcriptional regulator 0.0025 0.0102 0.0162
Giardia lamblia 5-AMP-activated protein kinase, gamma-1 subunit 0.0025 0.0102 0.4859
Loa Loa (eye worm) hypothetical protein 0.0054 0.0458 0.0896
Plasmodium falciparum importin beta, putative 0.003 0.0166 0.0313
Echinococcus granulosus flap endonuclease 1 0.0028 0.0136 0.0174
Toxoplasma gondii CBS domain-containing protein 0.0025 0.0102 0.0068
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0407 0.0835
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0025 0.0102 0.0187
Toxoplasma gondii CBS domain-containing protein 0.0025 0.0102 0.0068
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0028 0.0136 0.0139
Brugia malayi hypothetical protein 0.0246 0.2775 0.569
Trypanosoma cruzi AMP-activated protein kinase, gamma regulatory subunit 0.0025 0.0102 0.0068
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.022 0.2466 0.4954
Schistosoma mansoni flap endonuclease-1 0.0025 0.0104 0.0107
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0053 0.006
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.007 0.0101
Schistosoma mansoni lamin 0.0054 0.0458 0.0841
Brugia malayi TAR-binding protein 0.0067 0.0618 0.1266
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.022 0.2466 0.5045
Entamoeba histolytica hypothetical protein 0.0073 0.0681 1
Plasmodium falciparum protein MAM3, putative 0.0025 0.0102 0.0173
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0053 0.006
Loa Loa (eye worm) hypothetical protein 0.0025 0.0106 0.017
Brugia malayi RNA, U transporter 1 0.0086 0.084 0.1722
Brugia malayi CBS domain containing protein 0.0025 0.0102 0.0209
Toxoplasma gondii IMP dehydrogenas 0.0419 0.4877 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0099 0.018
Echinococcus multilocularis importin subunit beta 1 0.003 0.0166 0.0114
Chlamydia trachomatis Mg++ transporter 0.0025 0.0102 1
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0025 0.0102 0.0103
Brugia malayi loechrig isoform VII 0.0025 0.0102 0.0209
Giardia lamblia Manganese-dependent inorganic pyrophosphatase, putative 0.0025 0.0102 0.4859
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0419 0.4877 1
Onchocerca volvulus 0.0025 0.0099 0.0249
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0391 0.0701
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0199 0.2212 0.4422
Treponema pallidum Mg2+ transport protein (mgtE) 0.0025 0.0102 0.5
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0097 0.4095
Brugia malayi ancient conserved domain protein 4 0.0025 0.0102 0.0209
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.007 0.0095
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0099 0.0203
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0099 0.0478
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0391 0.0701
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0053 0.006
Trypanosoma cruzi AMP-activated protein kinase, gamma regulatory subunit 0.0025 0.0102 0.0068
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.0618 0.1224
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0229 0.047
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0174 0.191 0.3917
Brugia malayi hypothetical protein 0.0026 0.0109 0.0224
Brugia malayi nuclear hormone receptor 0.0021 0.0053 0.0108
Loa Loa (eye worm) hypothetical protein 0.0156 0.1694 0.3442
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0053 0.0108
Loa Loa (eye worm) hypothetical protein 0.0021 0.0053 0.006
Treponema pallidum hemolysin (tlyC) 0.0025 0.0102 0.5
Trypanosoma cruzi chloride channel protein, putative 0.0025 0.0102 0.0068
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0053 0.0108
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0099 0.0155
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0419 0.4877 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0109 0.0189
Loa Loa (eye worm) flap endonuclease-1 0.0028 0.0136 0.0233
Leishmania major chloride channel protein, putative 0.0025 0.0102 0.0068
Schistosoma mansoni importin beta-1 0.003 0.0166 0.0235
Onchocerca volvulus 0.0054 0.0458 0.2185
Loa Loa (eye worm) chloride channel 3 0.0025 0.0102 0.0162
Echinococcus multilocularis H(+):Cl() exchange transporter 4 0.0025 0.0102 0.005
Loa Loa (eye worm) hypothetical protein 0.0021 0.0053 0.006
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0166 0.0201
Giardia lamblia Manganese-dependent inorganic pyrophosphatase, putative 0.0025 0.0102 0.4859
Loa Loa (eye worm) hypothetical protein 0.0025 0.0102 0.0162
Schistosoma mansoni ran 0.0022 0.007 0.0035
Mycobacterium ulcerans hypothetical protein 0.0025 0.0102 0.0162
Trypanosoma cruzi chloride channel protein, putative 0.0025 0.0102 0.0068
Giardia lamblia Hypothetical protein 0.0025 0.0102 0.4859
Loa Loa (eye worm) hypothetical protein 0.0026 0.0118 0.0195
Echinococcus granulosus lamin 0.0054 0.0458 0.0841
Loa Loa (eye worm) TAR-binding protein 0.0067 0.0618 0.1224
Mycobacterium leprae Probable cystathionine beta-synthase CBS (Serine sulfhydrase) (Beta-thionase) (Hemoprotein H-450) 0.0025 0.0102 0.0007
Trichomonas vaginalis flap endonuclease-1, putative 0.0028 0.0136 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0053 0.006
Echinococcus granulosus snurportin 1 0.0322 0.3702 0.7565
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0025 0.0102 0.0103
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0458 0.0896
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0419 0.4877 1
Brugia malayi STAT protein, DNA binding domain containing protein 0.0155 0.1679 0.3442
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0166 0.0201
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0174 0.191 0.3917
Loa Loa (eye worm) hypothetical protein 0.0021 0.0053 0.006
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0322 0.3702 0.7579
Mycobacterium tuberculosis Conserved protein 0.0025 0.0102 0.0187
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.007 0.0017
Loa Loa (eye worm) hypothetical protein 0.0025 0.0099 0.0155

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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