Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Carbonic anhydrase IV | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase I | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase II | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.0547 | 0.0547 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0214 | 0.1753 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0101 | 0.0618 | 0.0551 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0618 | 0.0618 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0214 | 0.1753 | 0.1753 |
Leishmania major | carbonic anhydrase-like protein | 0.0214 | 0.1753 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0101 | 0.0618 | 0.0618 |
Entamoeba histolytica | hypothetical protein | 0.0094 | 0.0547 | 0.5 |
Trichomonas vaginalis | protein arginine N-methyltransferase, putative | 0.0094 | 0.0547 | 0.5 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0101 | 0.0618 | 0.0618 |
Echinococcus granulosus | methyltransferase protein 5 | 0.0094 | 0.0547 | 0.0479 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0214 | 0.1753 | 0.1753 |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.0618 | 0.0618 |
Trichomonas vaginalis | protein arginine N-methyltransferase, putative | 0.0094 | 0.0547 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0101 | 0.0618 | 0.0618 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0101 | 0.0618 | 0.0618 |
Trypanosoma brucei | RNA helicase, putative | 0.0206 | 0.1674 | 0.9342 |
Loa Loa (eye worm) | protein arginine N-methyltransferase | 0.0094 | 0.0547 | 0.0547 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0214 | 0.1753 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0214 | 0.1753 | 0.1753 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0618 | 0.0618 |
Echinococcus granulosus | protein arginine N methyltransferase 7 | 0.0094 | 0.0547 | 0.0479 |
Brugia malayi | Protein arginine N-methyltransferase | 0.0094 | 0.0547 | 0.0547 |
Schistosoma mansoni | hypothetical protein | 0.0206 | 0.1674 | 0.1674 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0101 | 0.0618 | 0.0618 |
Echinococcus granulosus | carbonic anhydrase II | 0.0214 | 0.1753 | 0.1694 |
Echinococcus multilocularis | protein arginine N methyltransferase 7 | 0.0094 | 0.0547 | 0.0479 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0618 | 0.0618 |
Brugia malayi | hypothetical protein | 0.0094 | 0.0547 | 0.0547 |
Loa Loa (eye worm) | Carm1-pending protein | 0.104 | 1 | 1 |
Plasmodium falciparum | carbonic anhydrase | 0.0101 | 0.0618 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0094 | 0.0547 | 0.0547 |
Echinococcus multilocularis | carbonic anhydrase | 0.0101 | 0.0618 | 0.0551 |
Schistosoma mansoni | carbonic anhydrase | 0.0101 | 0.0618 | 0.0618 |
Echinococcus multilocularis | carbonic anhydrase | 0.0101 | 0.0618 | 0.0551 |
Echinococcus granulosus | carbonic anhydrase | 0.0101 | 0.0618 | 0.0551 |
Echinococcus multilocularis | histone arginine methyltransferase CARMER | 0.104 | 1 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0101 | 0.0618 | 0.0618 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0101 | 0.0618 | 0.0618 |
Entamoeba histolytica | arginine N-methyltransferase protein, putative | 0.0094 | 0.0547 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0101 | 0.0618 | 0.0076 |
Echinococcus granulosus | carbonic anhydrase | 0.0101 | 0.0618 | 0.0551 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0101 | 0.0618 | 0.0618 |
Echinococcus granulosus | histone arginine methyltransferase CARMER | 0.104 | 1 | 1 |
Brugia malayi | plexin A | 0.0046 | 0.0071 | 0.0071 |
Schistosoma mansoni | protein arginine n-methyltransferase | 0.104 | 1 | 1 |
Onchocerca volvulus | 0.0946 | 0.9066 | 1 | |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0214 | 0.1753 | 0.1753 |
Trichomonas vaginalis | protein arginine N-methyltransferase, putative | 0.0094 | 0.0547 | 0.5 |
Toxoplasma gondii | histone arginine methyltransferase PRMT4/CARM1 | 0.104 | 1 | 1 |
Loa Loa (eye worm) | plexin A | 0.0046 | 0.0071 | 0.0071 |
Echinococcus granulosus | carbonic anhydrase | 0.0101 | 0.0618 | 0.0551 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0101 | 0.0618 | 0.0618 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0214 | 0.1753 | 0.1753 |
Entamoeba histolytica | arginine N-methyltransferase 1, putative | 0.0094 | 0.0547 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0214 | 0.1753 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0214 | 0.1753 | 0.1694 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0214 | 0.1753 | 0.1753 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 210 nM | Binding affinity against human carbonic anhydrase I (hCA I) | ChEMBL. | 11425561 |
Ki (binding) | = 210 nM | Binding affinity against human carbonic anhydrase I (hCA I) | ChEMBL. | 11425561 |
Ki (binding) | = 450 nM | Binding affinity against human carbonic anhydrase II (hCA -II) | ChEMBL. | 11425561 |
Ki (binding) | = 450 nM | Binding affinity against human carbonic anhydrase II (hCA -II) | ChEMBL. | 11425561 |
Ki (binding) | = 600 nM | Compound was evaluated for binding affinity against bovine carbonic anhydrase IV (bCA IV) | ChEMBL. | 11425561 |
Ki (binding) | = 600 nM | Compound was evaluated for binding affinity against bovine carbonic anhydrase IV (bCA IV) | ChEMBL. | 11425561 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.