Detailed information for compound 732045

Basic information

Technical information
  • TDR Targets ID: 732045
  • Name: 2-[4-(2,1,3-benzoxadiazol-7-ylmethyl)-1-(3-me thylbutyl)piperazin-2-yl]ethanol
  • MW: 332.441 | Formula: C18H28N4O2
  • H donors: 1 H acceptors: 3 LogP: 2.25 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCC1CN(CCN1CCC(C)C)Cc1cccc2c1non2
  • InChi: 1S/C18H28N4O2/c1-14(2)6-8-22-10-9-21(13-16(22)7-11-23)12-15-4-3-5-17-18(15)20-24-19-17/h3-5,14,16,23H,6-13H2,1-2H3
  • InChiKey: OUOJPWZJYRZWPF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[4-(2,1,3-benzoxadiazol-7-ylmethyl)-1-isopentyl-piperazin-2-yl]ethanol
  • 2-[4-(2,1,3-benzoxadiazol-7-ylmethyl)-1-isopentyl-2-piperazinyl]ethanol
  • 2-[4-(benzofurazan-4-ylmethyl)-1-isoamyl-piperazin-2-yl]ethanol
  • 2-[4-(2,1,3-benzoxadiazol-4-ylmethyl)-1-(3-methylbutyl)piperazin-2-yl]ethanol
  • MLS000734349
  • SMR000317259

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0065 0.0582 0.2583
Brugia malayi hypothetical protein 0.0013 0.0005 0.0024
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0067 0.0597 0.0597
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0031 0.0201 0.5052
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0024
Echinococcus granulosus neuropeptide receptor 0.0013 0.0005 0.0011
Giardia lamblia Lysyl-tRNA synthetase 0.0048 0.0399 0.6849
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0201 0.0894
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0066 0.113
Brugia malayi hypothetical protein 0.0146 0.1474 0.6539
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0249 0.1076
Brugia malayi Major Facilitator Superfamily protein 0.0031 0.0201 0.0894
Toxoplasma gondii transporter, major facilitator family protein 0.0031 0.0201 0.0305
Onchocerca volvulus 0.0031 0.0201 0.1335
Trypanosoma brucei glucose transporter, putative 0.0067 0.0606 0.8651
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0076 0.0701 1
Schistosoma mansoni hypothetical protein 0.0013 0.0005 0.0024
Plasmodium falciparum protein kinase 7 0.0613 0.6612 0.6612
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0351 0.3724 0.5632
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0606 0.269
Plasmodium falciparum calcium-dependent protein kinase 1 0.0067 0.0597 0.0597
Echinococcus granulosus g protein coupled receptor 0.0013 0.0005 0.0011
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0024
Schistosoma mansoni opsin-like receptor 0.0013 0.0005 0.0024
Toxoplasma gondii sugar transporter ST2 0.0031 0.0201 0.0305
Brugia malayi hypothetical protein 0.0013 0.0005 0.0024
Leishmania major glucose transporter, lmgt3 0.0067 0.0606 0.8651
Brugia malayi Serotonin receptor 0.0013 0.0005 0.0024
Trypanosoma cruzi hexose transporter, putative 0.0037 0.027 0.386
Brugia malayi hypothetical protein 0.0031 0.0201 0.0894
Schistosoma mansoni amine GPCR 0.0013 0.0005 0.0024
Brugia malayi Tachykinin-like peptides receptor 99D 0.0013 0.0005 0.0024
Schistosoma mansoni histamine h1 receptor 0.0013 0.0005 0.0024
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0024
Toxoplasma gondii lysine-tRNA ligase 0.0048 0.0399 0.0603
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0024
Brugia malayi beta-lactamase 0.0035 0.0249 0.1106
Echinococcus granulosus solute carrier family 22 0.0031 0.0201 0.041
Trichomonas vaginalis sugar transporter, putative 0.0067 0.0606 0.269
Schistosoma mansoni hypothetical protein 0.0013 0.0005 0.0024
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0249 0.1106
Mycobacterium ulcerans integral membrane transport protein 0.0031 0.0201 0.5052
Onchocerca volvulus 0.0031 0.0201 0.1335
Echinococcus granulosus biogenic amine 5HT receptor 0.0013 0.0005 0.0011
Echinococcus granulosus solute carrier family 22 0.0031 0.0201 0.041
Trypanosoma brucei glucose transporter, putative 0.0067 0.0606 0.8651
Onchocerca volvulus 0.0035 0.0249 0.1661
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0065 0.0582 0.2583
Brugia malayi Sugar transporter family protein 0.0031 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0201 0.0894
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0013 0.0005 0.0024
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0201 0.0894
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0249 0.1076
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0201 0.0894
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0066 0.5542
Brugia malayi G protein-coupled receptor F59B2.13 0.0013 0.0005 0.0024
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0066 0.1102
Echinococcus multilocularis neuropeptide receptor A26 0.0458 0.4907 1
Plasmodium vivax proline--tRNA ligase, putative 0.0076 0.0701 0.0701
Brugia malayi Serotonin receptor 0.0013 0.0005 0.0024
Schistosoma mansoni protein kinase 0.0066 0.0597 0.2648
Echinococcus multilocularis g protein coupled receptor 0.0013 0.0005 0.0011
Schistosoma mansoni protein kinase 0.0066 0.0597 0.2648
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0024
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0067 0.0597 0.0903
Echinococcus multilocularis General substrate transporter 0.0187 0.1918 0.3908
Loa Loa (eye worm) hypothetical protein 0.0065 0.0582 0.2583
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0005 0.0011
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0013 0.0005 0.0011
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0013 0.0005 0.0024
Echinococcus granulosus synaptic vesicle 2 protein 0.0031 0.0201 0.041
Echinococcus granulosus geminin 0.0164 0.1669 0.3401
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0201 0.0894
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0005 0.0024
Schistosoma mansoni ap endonuclease 0.0018 0.0066 0.0292
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0372 0.1651
Echinococcus multilocularis solute carrier family 22 0.0031 0.0201 0.041
Trypanosoma brucei THT1 - hexose transporter, putative 0.0067 0.0606 0.8651
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0217 0.2253 0.4592
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0066 0.0134
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0024
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0066 0.0597 0.2648
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0076 0.0701 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0249 0.1106
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0031 0.0201 0.041
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0201 0.0894
Brugia malayi Major Facilitator Superfamily protein 0.0031 0.0201 0.0894
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0065 0.0582 0.2583
Trypanosoma brucei THT1 - hexose transporter, putative 0.0067 0.0606 0.8651
Plasmodium falciparum lysine--tRNA ligase 0.0048 0.0399 0.0399
Brugia malayi putative neuropeptide receptor NPR1 0.0013 0.0005 0.0024
Loa Loa (eye worm) hypothetical protein 0.0031 0.0201 0.0894
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0013 0.0005 0.0011
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0048 0.0399 0.5689
Schistosoma mansoni sugar transporter 0.0031 0.0201 0.0894
Schistosoma mansoni hypothetical protein 0.0164 0.1669 0.7405
Schistosoma mansoni amine GPCR 0.0013 0.0005 0.0024
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0067 0.0606 0.269
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0013 0.0005 0.0011
Mycobacterium ulcerans hypothetical protein 0.0035 0.0249 0.6253
Echinococcus granulosus neuropeptide Y receptor 0.0013 0.0005 0.0011
Schistosoma mansoni sugar transporter 0.0031 0.0201 0.0894
Echinococcus multilocularis sex peptide receptor 0.0013 0.0005 0.0011
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0031 0.0201 0.0869
Loa Loa (eye worm) beta-lactamase 0.0035 0.0249 0.1106
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0013 0.0005 0.0024
Brugia malayi GnHR receptor homolog 0.0013 0.0005 0.0024
Trypanosoma brucei glucose transporter, putative 0.0067 0.0606 0.8651
Trichomonas vaginalis sugar transport protein, putative 0.0031 0.0201 0.0894
Schistosoma mansoni hypothetical protein 0.0013 0.0005 0.0024
Trypanosoma brucei glucose transporter, putative 0.0067 0.0606 0.8651
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0201 0.0894
Loa Loa (eye worm) hypothetical protein 0.0035 0.0249 0.1106
Loa Loa (eye worm) hypothetical protein 0.0035 0.0249 0.1106
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0027 0.016 0.0709
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0201 0.0894
Echinococcus multilocularis neuropeptide Y receptor 0.0013 0.0005 0.0011
Brugia malayi Sugar transporter family protein 0.0217 0.2253 1
Trichomonas vaginalis sugar transporter, putative 0.0067 0.0606 0.269
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0013 0.0005 0.0011
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0013 0.0005 0.0024
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0249 0.1106
Brugia malayi Dopamine receptor protein 1 0.0013 0.0005 0.0024
Onchocerca volvulus 0.0031 0.0201 0.1335
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0066 0.0597 0.8517
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0024
Echinococcus multilocularis fmrfamide receptor 0.0013 0.0005 0.0011
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0024
Schistosoma mansoni adenoreceptor 0.0013 0.0005 0.0024
Onchocerca volvulus 0.0031 0.0201 0.1335
Loa Loa (eye worm) hypothetical protein 0.0031 0.0201 0.0894
Loa Loa (eye worm) hypothetical protein 0.0031 0.0201 0.0894
Trichomonas vaginalis glucose transporter, putative 0.0031 0.0201 0.0894
Loa Loa (eye worm) hypothetical protein 0.0031 0.0201 0.0894
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0042 0.0333 0.1477
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0201 0.0894
Trypanosoma brucei glucose transporter 2A 0.0067 0.0606 0.8651
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0249 0.1076
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0201 0.0894
Brugia malayi beta-lactamase family protein 0.0035 0.0249 0.1106
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0024
Plasmodium vivax sugar transporter, putative 0.0031 0.0201 0.0201
Brugia malayi larval opioid receptor 0.0013 0.0005 0.0024
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0201 0.0894
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0597 0.2648
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0024
Brugia malayi hypothetical protein 0.0013 0.0005 0.0024
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0249 0.4283
Trypanosoma cruzi hexose transporter, putative 0.0067 0.0606 0.8651
Schistosoma mansoni amine GPCR 0.0013 0.0005 0.0024
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0217 0.2253 0.4592
Brugia malayi neuropeptide F receptor 0.0013 0.0005 0.0024
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0249 0.6253
Onchocerca volvulus 0.0031 0.0201 0.1335
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0005 0.0024
Plasmodium falciparum hexose transporter 0.0217 0.2253 0.2253
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0372 0.1651
Loa Loa (eye worm) hypothetical protein 0.0031 0.0201 0.0894
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0005 0.0011
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0041 0.0318 0.1374
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0005 0.0011
Leishmania major lysyl-tRNA synthetase, putative 0.0048 0.0399 0.5689
Schistosoma mansoni neuropeptide F-like receptor 0.0013 0.0005 0.0024
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0024
Echinococcus granulosus dro:myosuppressin receptor 0.0013 0.0005 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0217 0.2253 1
Brugia malayi Major Facilitator Superfamily protein 0.0031 0.0201 0.0894
Brugia malayi hypothetical protein 0.0013 0.0005 0.0024
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0041 0.0318 0.5469
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0024
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0249 0.1076
Plasmodium falciparum calcium-dependent protein kinase 3 0.0067 0.0597 0.0597
Echinococcus granulosus General substrate transporter 0.0187 0.1918 0.3908
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0201 0.0894
Toxoplasma gondii protein kinase, putative 0.0613 0.6612 1
Echinococcus multilocularis g-protein coupled receptor 0.0013 0.0005 0.0011
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0076 0.0701 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0024
Echinococcus granulosus alpha 1A adrenergic receptor 0.0013 0.0005 0.0011
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0249 0.3558
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0201 0.0894
Schistosoma mansoni neuropeptide receptor 0.0013 0.0005 0.0024
Onchocerca volvulus 0.0031 0.0201 0.1335
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0249 0.1106
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0013 0.0005 0.0024
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0024
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0024
Echinococcus granulosus neuropeptide Y receptor 0.0013 0.0005 0.0011
Loa Loa (eye worm) hypothetical protein 0.0031 0.0201 0.0894
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0066 0.0939
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0023 0.0119 0.2978
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0076 0.0701 0.106
Trypanosoma cruzi hexose transporter, putative 0.0067 0.0606 0.8651
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0024
Chlamydia trachomatis proline--tRNA ligase 0.0023 0.0119 0.2978
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0005 0.0024
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0005 0.0011
Loa Loa (eye worm) hypothetical protein 0.0031 0.0201 0.0894
Echinococcus multilocularis solute carrier family 22 0.0031 0.0201 0.041
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0217 0.2253 0.4592
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0372 0.1651
Onchocerca volvulus 0.0146 0.1474 1
Echinococcus granulosus somatostatin receptor 0.0013 0.0005 0.0011
Loa Loa (eye worm) hypothetical protein 0.0048 0.0399 0.1769
Onchocerca volvulus 0.0031 0.0201 0.1335
Brugia malayi AKH receptor 0.0013 0.0005 0.0024
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0048 0.0399 0.1769
Echinococcus granulosus g-protein coupled receptor 0.0013 0.0005 0.0011
Mycobacterium ulcerans sugar transporter 0.0031 0.0201 0.5052
Schistosoma mansoni neuropeptide F-like receptor 0.0013 0.0005 0.0024
Entamoeba histolytica protein kinase, putative 0.0066 0.0597 1
Trypanosoma cruzi sugar transporter, putative 0.0031 0.0201 0.2874
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0005 0.0011
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0201 0.0894
Echinococcus granulosus tm gpcr rhodopsin 0.0013 0.0005 0.0011
Schistosoma mansoni opsin-like receptor 0.0013 0.0005 0.0024
Trichomonas vaginalis glucose transporter, putative 0.0067 0.0606 0.269
Schistosoma mansoni neuropeptide f receptor 76f 0.0013 0.0005 0.0024
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0217 0.2253 0.4592
Toxoplasma gondii sugar transporter ST1 0.0031 0.0201 0.0305
Loa Loa (eye worm) hypothetical protein 0.0031 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0201 0.0894
Echinococcus granulosus allatostatin A receptor 0.0013 0.0005 0.0011
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0024
Leishmania major protein kinase, putative 0.0066 0.0597 0.8517
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0024
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0013 0.0005 0.0011
Brugia malayi G-protein coupled receptor 0.0013 0.0005 0.0024
Echinococcus granulosus orexin receptor type 2 0.0013 0.0005 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0201 0.0894
Echinococcus granulosus solute carrier family 22 0.0031 0.0201 0.041
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.2317 1
Echinococcus multilocularis g protein coupled receptor 0.0013 0.0005 0.0011
Brugia malayi hypothetical protein 0.0013 0.0005 0.0024
Echinococcus granulosus neuropeptide receptor A26 0.0458 0.4907 1
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0201 0.0894
Echinococcus multilocularis g protein coupled receptor 0.0013 0.0005 0.0011
Echinococcus multilocularis neuropeptides capa receptor 0.0013 0.0005 0.0011
Toxoplasma gondii ABC1 family protein 0.0035 0.0249 0.0377
Onchocerca volvulus 0.0035 0.0249 0.1661
Echinococcus multilocularis neuropeptide receptor 0.0013 0.0005 0.0011
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0066 0.3266
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0013 0.0005 0.0011
Echinococcus granulosus hypothetical protein 0.0013 0.0005 0.0011
Brugia malayi hypothetical protein 0.0031 0.0201 0.0894
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0005 0.0024
Trypanosoma brucei glucose transporter, putative 0.0067 0.0606 0.8651
Trichomonas vaginalis myo-inositol transporter, putative 0.0031 0.0201 0.0894
Echinococcus granulosus 7tm_1 domain containing protein 0.0013 0.0005 0.0011
Brugia malayi hypothetical protein 0.0013 0.0005 0.0024
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0066 0.0597 0.1216
Plasmodium falciparum calcium-dependent protein kinase 5 0.0067 0.0597 0.0597
Onchocerca volvulus 0.0031 0.0201 0.1335
Loa Loa (eye worm) hypothetical protein 0.0031 0.0201 0.0894
Loa Loa (eye worm) hypothetical protein 0.0035 0.0249 0.1106
Echinococcus multilocularis serotonin receptor 0.0013 0.0005 0.0011
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0024
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0066 0.0597 0.1216
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0065 0.0582 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0024
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0048 0.0399 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0217 0.2253 0.4592
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0249 0.1076
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0066 0.0597 0.1216
Schistosoma mansoni glucose transport protein 0.0217 0.2253 1
Brugia malayi putative neuropeptide receptor 0.0013 0.0005 0.0024
Echinococcus multilocularis synaptic vesicle 2 protein 0.0031 0.0201 0.041
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0201 0.0894
Plasmodium falciparum calcium-dependent protein kinase 4 0.0067 0.0597 0.0597
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0013 0.0005 0.0024
Echinococcus multilocularis serotonin receptor 0.0013 0.0005 0.0011
Schistosoma mansoni ap endonuclease 0.0018 0.0066 0.0292
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0013 0.0005 0.0011
Mycobacterium tuberculosis Conserved protein 0.0035 0.0249 0.1076
Giardia lamblia Prolyl-tRNA synthetase 0.0065 0.0582 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0066 0.0939
Onchocerca volvulus 0.0031 0.0201 0.1335
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0013 0.0005 0.0024
Trichomonas vaginalis glucose transporter, putative 0.0067 0.0606 0.269
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0067 0.0597 0.0903
Onchocerca volvulus 0.0031 0.0201 0.1335
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0249 0.1076
Brugia malayi hypothetical protein 0.0013 0.0005 0.0024
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0013 0.0005 0.0024
Echinococcus granulosus G protein coupled receptor 139 0.0013 0.0005 0.0011
Schistosoma mansoni biogenic amine (5HT) receptor 0.0013 0.0005 0.0024
Schistosoma mansoni lysyl-tRNA synthetase 0.0048 0.0399 0.1769
Schistosoma mansoni neuropeptide receptor 0.0013 0.0005 0.0024
Trichomonas vaginalis CAMK family protein kinase 0.0066 0.0597 0.2648
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0065 0.0582 0.2583
Onchocerca volvulus 0.0031 0.0201 0.1335
Echinococcus granulosus neuropeptide receptor 0.0013 0.0005 0.0011
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0201 0.0894
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0024
Plasmodium vivax hexose transporter 0.0217 0.2253 0.2253
Echinococcus granulosus fmrfamide receptor 0.0013 0.0005 0.0011
Toxoplasma gondii exonuclease III APE 0.0018 0.0066 0.0099
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0201 0.0894
Schistosoma mansoni biogenic amine (5HT) receptor 0.0013 0.0005 0.0024
Mycobacterium tuberculosis Conserved protein 0.0035 0.0249 0.1076
Echinococcus granulosus biogenic amine 5HT receptor 0.0013 0.0005 0.0011
Trypanosoma brucei sugar transporter, putative 0.0031 0.0201 0.2874
Schistosoma mansoni sugar transporter 0.0031 0.0201 0.0894
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0005 0.0011
Loa Loa (eye worm) neuropeptide F receptor 0.0013 0.0005 0.0024
Schistosoma mansoni hypothetical protein 0.0164 0.1669 0.7405
Echinococcus multilocularis somatostatin receptor 0.0013 0.0005 0.0011
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0066 0.0939
Echinococcus granulosus solute carrier family 22 0.0031 0.0201 0.041
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0005 0.0011
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0067 0.0597 0.0903
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0031 0.0201 0.5052
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0076 0.0701 1
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0217 0.2253 0.4592
Plasmodium falciparum mitogen-activated protein kinase 2 0.0351 0.3724 0.3724
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0249 0.3558
Schistosoma mansoni biogenic amine receptor 0.0013 0.0005 0.0024
Brugia malayi major facilitator superfamily protein 0.0031 0.0201 0.0894
Echinococcus multilocularis G-protein coupled receptor, putative 0.0013 0.0005 0.0011
Schistosoma mansoni glucose transport protein 0.0217 0.2253 1
Trypanosoma brucei glucose transporter, putative 0.0067 0.0606 0.8651
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0031 0.0201 1
Echinococcus granulosus tm gpcr rhodopsin 0.0013 0.0005 0.0011
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0041 0.0318 0.1374
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0024
Echinococcus multilocularis allatostatin A receptor 0.0013 0.0005 0.0011
Onchocerca volvulus Putative transporter 0.0031 0.0201 0.1335
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0065 0.0582 0.2583
Echinococcus granulosus peptide allatostatin:somatostatin 0.0013 0.0005 0.0011
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0201 0.0894
Chlamydia trachomatis lysine--tRNA ligase 0.0048 0.0399 1
Loa Loa (eye worm) sugar transporter 0.0217 0.2253 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0005 0.0011
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0066 0.0597 0.2648
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0013 0.0005 0.0011
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0067 0.0597 0.0597
Echinococcus granulosus tachykinin peptides receptor 99D 0.0013 0.0005 0.0011
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0013 0.0005 0.0024
Brugia malayi ORL1-like opioid receptor 0.0013 0.0005 0.0024
Echinococcus granulosus 7TM GPCR rhodopsin 0.0013 0.0005 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0201 0.0894
Trypanosoma cruzi glucose transporter, putative 0.0031 0.0201 0.2874
Toxoplasma gondii facilitative glucose transporter GT1 0.0217 0.2253 0.3408
Schistosoma mansoni hypothetical protein 0.0217 0.2253 1
Echinococcus multilocularis calcium dependent protein kinase 0.0062 0.0552 0.1124
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0065 0.0582 0.9752
Loa Loa (eye worm) TYRA-2 protein 0.0013 0.0005 0.0024
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0013 0.0005 0.0011
Treponema pallidum prolyl-tRNA synthetase 0.0023 0.0119 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0005 0.0011
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0249 0.1106
Schistosoma mansoni growth hormone secretagogue receptor 0.0013 0.0005 0.0024
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0201 0.2874
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0024
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0066 0.0597 0.2648
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0201 0.0894
Echinococcus granulosus g protein coupled receptor 0.0013 0.0005 0.0011
Brugia malayi Cam kinase protein 1 0.0066 0.0597 0.2648
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0013 0.0005 0.0011
Loa Loa (eye worm) hypothetical protein 0.0066 0.0597 0.2648
Trypanosoma cruzi hexose transporter 0.0067 0.0606 0.8651
Schistosoma mansoni sugar transporter 0.0031 0.0201 0.0894
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0066 0.0292
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0201 0.0894
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0249 0.6253
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0024
Echinococcus granulosus sex peptide receptor 0.0013 0.0005 0.0011
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0013 0.0005 0.0011
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0066 0.0597 0.1216
Brugia malayi G-protein coupled receptor 0.0013 0.0005 0.0024
Brugia malayi G protein-coupled receptor 0.0013 0.0005 0.0024
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0013 0.0005 0.0011
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0065 0.0582 0.1186
Mycobacterium leprae Probable lipase LipE 0.0035 0.0249 0.4283
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0024
Echinococcus granulosus tm gpcr rhodopsin 0.0013 0.0005 0.0011
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0013 0.0005 0.0024
Schistosoma mansoni amine GPCR 0.0013 0.0005 0.0024
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0024
Echinococcus multilocularis solute carrier family 22 0.0031 0.0201 0.041
Leishmania major hypothetical protein, conserved 0.0035 0.0249 0.3558
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0067 0.0597 0.0597
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0013 0.0005 0.0024
Schistosoma mansoni glucose transporter 0.0031 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0201 0.0894
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0005 0.0011
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0013 0.0005 0.0024
Brugia malayi Sugar transporter family protein 0.0031 0.0201 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0201 0.0894
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0024
Brugia malayi Dopamine receptor 0.0013 0.0005 0.0024
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0201 0.0894
Onchocerca volvulus 0.0031 0.0201 0.1335
Loa Loa (eye worm) hypothetical protein 0.0031 0.0201 0.0894
Echinococcus multilocularis neuropeptide FF receptor 2 0.0013 0.0005 0.0011
Echinococcus multilocularis fmrfamide receptor 0.0013 0.0005 0.0011
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0024
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0201 0.0894
Schistosoma mansoni lysyl-tRNA synthetase 0.0048 0.0399 0.1769
Giardia lamblia Sugar-proton symporter 0.0031 0.0201 0.346
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0201 0.0894
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0372 0.0758
Brugia malayi lysyl-tRNA synthetase 0.0048 0.0399 0.1769
Schistosoma mansoni myosin xvIII 0.0013 0.0005 0.0024
Brugia malayi hypothetical protein 0.0013 0.0005 0.0024
Plasmodium falciparum proline--tRNA ligase 0.0076 0.0701 0.0701
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0065 0.0582 0.1186
Echinococcus multilocularis solute carrier family 22 0.0031 0.0201 0.041
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0606 0.269
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0249 0.0508
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0048 0.0399 0.6849
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0065 0.0582 0.2583
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0024
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0013 0.0005 0.0011
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0066 0.0597 0.1216
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0005 0.0011
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0024
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0024
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0005 0.0024
Brugia malayi major facilitator superfamily protein 0.0031 0.0201 0.0894
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0005 0.0011
Loa Loa (eye worm) hypothetical protein 0.0053 0.0448 0.1987
Echinococcus multilocularis lysyl tRNA synthetase 0.0048 0.0399 0.0812
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0013 0.0005 0.0024
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0048 0.0399 0.5689
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0066 0.0597 0.1216
Brugia malayi hypothetical protein 0.0031 0.0201 0.0894
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0005 0.0011
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0076 0.0701 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0024
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0013 0.0005 0.0024
Brugia malayi sulfakinin receptor protein 0.0013 0.0005 0.0024
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0005 0.0024
Brugia malayi neuropeptide F receptor 0.0013 0.0005 0.0024
Schistosoma mansoni biogenic amine receptor 0.0013 0.0005 0.0024
Brugia malayi follicle stimulating hormone receptor 0.0013 0.0005 0.0024
Echinococcus granulosus g protein coupled receptor 0.0013 0.0005 0.0011
Schistosoma mansoni protein kinase 0.0066 0.0597 0.2648
Onchocerca volvulus 0.0031 0.0201 0.1335
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0372 0.0758
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0372 0.1651
Loa Loa (eye worm) major facilitator superfamily transporter 0.0031 0.0201 0.0894
Echinococcus multilocularis neuropeptides capa receptor 0.0013 0.0005 0.0011
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0249 0.1076
Schistosoma mansoni neuropeptide receptor 0.0013 0.0005 0.0024
Leishmania major glucose transporter/membrane transporter D2, putative 0.0067 0.0606 0.8651
Loa Loa (eye worm) hypothetical protein 0.0031 0.0201 0.0894
Brugia malayi hypothetical protein 0.0013 0.0005 0.0024
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0005 0.0024
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0024
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0024
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0024
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0013 0.0005 0.0011
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0201 0.0894
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0013 0.0005 0.0011
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0013 0.0005 0.0024
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0005 0.0011
Brugia malayi hypothetical protein 0.0013 0.0005 0.0024
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0031 0.0201 0.0201
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0024
Echinococcus granulosus lysyl tRNA synthetase 0.0048 0.0399 0.0812
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0201 0.0894
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0013 0.0005 0.0011
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0031 0.0201 0.0869
Loa Loa (eye worm) G-protein coupled receptor 0.0013 0.0005 0.0024
Loa Loa (eye worm) hypothetical protein 0.0035 0.0249 0.1106
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0351 0.3724 0.3724
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0066 0.0597 0.1216
Echinococcus granulosus neuropeptide s receptor 0.0458 0.4907 1
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0031 0.0201 0.0894
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0249 0.1106
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0066 0.0292
Trypanosoma cruzi hexose transporter, putative 0.0067 0.0606 0.8651
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0066 0.165
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0013 0.0005 0.0011
Schistosoma mansoni hypothetical protein 0.0013 0.0005 0.0024
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0024
Brugia malayi Melatonin receptor type 1A 0.0013 0.0005 0.0024
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0024
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0372 0.1651
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0013 0.0005 0.0011
Trypanosoma brucei THT1 - hexose transporter, putative 0.0067 0.0606 0.8651
Echinococcus multilocularis neuropeptide receptor 0.0013 0.0005 0.0011
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0066 0.0939
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0024
Brugia malayi Dopamine receptor protein 2 0.0013 0.0005 0.0024
Echinococcus multilocularis neuropeptide s receptor 0.0458 0.4907 1
Trypanosoma brucei glucose transporter, putative 0.0067 0.0606 0.8651
Toxoplasma gondii sugar transporter ST3 0.0031 0.0201 0.0305
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0013 0.0005 0.0011
Giardia lamblia Hexose transporter 0.0031 0.0201 0.346
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0024
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0048 0.0399 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0249 0.1106
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0024
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0013 0.0005 0.0024
Leishmania major glucose transporter, lmgt2 0.0067 0.0606 0.8651
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0013 0.0005 0.0024
Leishmania major hypothetical protein, conserved 0.0031 0.0201 0.2874
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0031 0.0201 0.2874
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0013 0.0005 0.0024
Trypanosoma brucei glucose transporter, putative 0.0067 0.0606 0.8651
Echinococcus multilocularis G protein coupled receptor 139 0.0013 0.0005 0.0011
Echinococcus granulosus serotonin receptor 0.0013 0.0005 0.0011
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0066 0.0284
Plasmodium vivax calcium-dependent protein kinase, putative 0.0067 0.0597 0.0597
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0024
Loa Loa (eye worm) hypothetical protein 0.0146 0.1474 0.6539
Echinococcus granulosus calcium dependent protein kinase 0.0062 0.0552 0.1124
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0013 0.0005 0.0024
Loa Loa (eye worm) melatonin receptor type 1A 0.0013 0.0005 0.0024
Brugia malayi RE15519p 0.0013 0.0005 0.0024
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0066 0.0066
Echinococcus multilocularis geminin 0.0164 0.1669 0.3401
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0201 0.0894
Echinococcus granulosus neuropeptides capa receptor 0.0013 0.0005 0.0011
Loa Loa (eye worm) hypothetical protein 0.0035 0.0249 0.1106
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0005 0.0024
Mycobacterium ulcerans lipase LipD 0.0035 0.0249 0.6253
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0249 0.3558
Schistosoma mansoni glucose transport protein 0.0217 0.2253 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0024
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0249 0.1106
Plasmodium vivax CDK-related protein kinase 6, putative 0.0921 1 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0013 0.0005 0.0011
Loa Loa (eye worm) neuropeptide F receptor 0.0013 0.0005 0.0024
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0013 0.0005 0.0024
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0201 0.0894
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0217 0.2253 0.4592
Onchocerca volvulus 0.0031 0.0201 0.1335
Schistosoma mansoni alpha-1 adrenergic receptor 0.0013 0.0005 0.0024
Plasmodium vivax lysine--tRNA ligase, putative 0.0048 0.0399 0.0399
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0201 0.0894
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0066 0.0292
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0201 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0201 0.0894
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0013 0.0005 0.0011
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0066 0.0134
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0372 0.0758
Schistosoma mansoni amine GPCR 0.0013 0.0005 0.0024
Echinococcus multilocularis orexin receptor type 2 0.0013 0.0005 0.0011
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0013 0.0005 0.0024
Loa Loa (eye worm) sugar transporter 0.0031 0.0201 0.0894
Onchocerca volvulus 0.0035 0.0249 0.1661
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0066 0.0292
Loa Loa (eye worm) major facilitator superfamily transporter 0.0031 0.0201 0.0894
Echinococcus granulosus Sugar transporter ERD6 protein 0.0031 0.0201 0.041
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0005 0.0011
Echinococcus granulosus neuropeptides capa receptor 0.0013 0.0005 0.0011
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0201 0.0894
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0217 0.2253 0.4592
Loa Loa (eye worm) hypothetical protein 0.0031 0.0201 0.0894
Mycobacterium ulcerans beta-lactamase 0.0035 0.0249 0.6253
Leishmania major myo-inositol/proton symporter (MIT) 0.0031 0.0201 0.2874
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0066 0.0066
Leishmania major glucose transporter, lmgt1 0.0067 0.0606 0.8651
Loa Loa (eye worm) G-protein coupled receptor 0.0013 0.0005 0.0024
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0249 0.0508
Onchocerca volvulus 0.0031 0.0201 0.1335
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0024
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0066 0.0597 0.1216
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0201 0.0894
Entamoeba histolytica protein kinase, putative 0.0066 0.0597 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0013 0.0005 0.0024
Schistosoma mansoni biogenic amine receptor 0.0013 0.0005 0.0024
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0024
Schistosoma mansoni opsin-like receptor 0.0013 0.0005 0.0024
Echinococcus multilocularis dro:myosuppressin receptor 0.0013 0.0005 0.0011
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0201 0.0894
Onchocerca volvulus 0.0031 0.0201 0.1335
Trichomonas vaginalis esterase, putative 0.0035 0.0249 0.1106
Loa Loa (eye worm) hypothetical protein 0.0035 0.0249 0.1106
Entamoeba histolytica hypothetical protein 0.0048 0.0399 0.6679
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0013 0.0005 0.0024
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0005 0.0024
Loa Loa (eye worm) hypothetical protein 0.0031 0.0201 0.0894
Loa Loa (eye worm) hypothetical protein 0.0031 0.0201 0.0894
Mycobacterium tuberculosis Conserved protein 0.0035 0.0249 0.1076
Schistosoma mansoni neuropeptide receptor 0.0013 0.0005 0.0024
Brugia malayi beta-lactamase family protein 0.0035 0.0249 0.1106
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0372 0.0758
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0249 0.0249
Trypanosoma brucei glucose transporter 1E 0.0067 0.0606 0.8651
Echinococcus multilocularis neuropeptide Y receptor 0.0013 0.0005 0.0011
Loa Loa (eye worm) hypothetical protein 0.0031 0.0201 0.0894
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0249 0.1106
Plasmodium falciparum calcium-dependent protein kinase 2 0.0067 0.0597 0.0597

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) 22.3872 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.