Detailed information for compound 734579

Basic information

Technical information
  • TDR Targets ID: 734579
  • Name: 4,6-bis(4-methoxyphenyl)-2-[2-oxo-2-(2-oxochr omen-3-yl)ethyl]sulfanylpyridine-3-carbonitri le
  • MW: 534.582 | Formula: C31H22N2O5S
  • H donors: 0 H acceptors: 4 LogP: 6.25 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc(cc1)c1nc(SCC(=O)c2cc3ccccc3oc2=O)c(c(c1)c1ccc(cc1)OC)C#N
  • InChi: 1S/C31H22N2O5S/c1-36-22-11-7-19(8-12-22)24-16-27(20-9-13-23(37-2)14-10-20)33-30(26(24)17-32)39-18-28(34)25-15-21-5-3-4-6-29(21)38-31(25)35/h3-16H,18H2,1-2H3
  • InChiKey: WGIRWSDIFIOVQM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4,6-bis(4-methoxyphenyl)-2-[2-oxo-2-(2-oxochromen-3-yl)ethyl]sulfanyl-pyridine-3-carbonitrile
  • 4,6-bis(4-methoxyphenyl)-2-[[2-oxo-2-(2-oxo-3-chromenyl)ethyl]thio]-3-pyridinecarbonitrile
  • 2-[[2-keto-2-(2-ketochromen-3-yl)ethyl]thio]-4,6-bis(4-methoxyphenyl)nicotinonitrile
  • BAS 01279515
  • Oprea1_844489
  • CBKinase1_012488
  • Oprea1_607504
  • STOCK1S-28704
  • ZINC02030105
  • CBKinase1_000088
  • AE-848/33836036

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0166 0.0346
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.1272 0.1453
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0261 0.1143
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.1272 0.3037
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0041 0.0616 0.0807
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0275 0.0301
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0275 0.269
Loa Loa (eye worm) hypothetical protein 0.0071 0.1272 0.1453
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0041 0.0616 0.0807
Echinococcus granulosus importin subunit beta 1 0.0031 0.0401 0.0524
Entamoeba histolytica hypothetical protein 0.0037 0.0536 0.1409
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.016 0.3166 0.4145
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0549 0.1362
Mycobacterium ulcerans lipase LipD 0.0071 0.1272 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0043 0.0668 0.1754
Mycobacterium tuberculosis Conserved hypothetical protein 0.0039 0.0584 0.0505
Toxoplasma gondii hypothetical protein 0.0039 0.0584 0.3096
Toxoplasma gondii CAAX amino terminal protease family protein 0.0039 0.0584 0.3096
Echinococcus multilocularis dna polymerase eta 0.002 0.0166 0.0217
Echinococcus granulosus histone acetyltransferase KAT2B 0.0047 0.0752 0.0984
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.1272 0.1238
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.1272 0.1272
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0261 0.0299
Entamoeba histolytica hypothetical protein 0.0025 0.0277 0.0727
Schistosoma mansoni hypothetical protein 0.0105 0.1997 0.2615
Plasmodium vivax hypothetical protein, conserved 0.0071 0.1272 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0261 0.0263
Plasmodium vivax protease, putative 0.0039 0.0584 0.397
Echinococcus granulosus histone acetyltransferase KAT2B 0.0156 0.307 0.4019
Plasmodium vivax SET domain protein, putative 0.0061 0.1038 0.795
Entamoeba histolytica hypothetical protein 0.0037 0.0536 0.1409
Treponema pallidum hypothetical protein 0.0039 0.0584 1
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.019 0.3808 0.4984
Brugia malayi Pre-SET motif family protein 0.0061 0.1038 0.1186
Loa Loa (eye worm) hypothetical protein 0.0061 0.1038 0.1186
Trypanosoma cruzi peptidase with unknown catalytic mechanism (family U48) 0.019 0.3808 1
Mycobacterium tuberculosis Conserved protein 0.0071 0.1272 0.1238
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0277 0.5664 0.7415
Echinococcus multilocularis muscleblind protein 0.03 0.6156 0.8058
Leishmania major hypothetical protein, conserved 0.0071 0.1272 0.3037
Echinococcus granulosus snurportin 1 0.0327 0.6736 0.8818
Entamoeba histolytica hypothetical protein 0.0037 0.0536 0.1409
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0549 0.1443
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0166 0.0189
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.1272 0.1272
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0549 0.1053
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.1038 0.1359
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0261 0.0687
Loa Loa (eye worm) hypothetical protein 0.0018 0.0131 0.015
Loa Loa (eye worm) hypothetical protein 0.0105 0.1997 0.2281
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0549 0.0468
Schistosoma mansoni ap endonuclease 0.0038 0.0549 0.0719
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0401 0.0968
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0549 0.7793
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.1038 0.1359
Loa Loa (eye worm) hypothetical protein 0.0041 0.0616 0.0704
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0261 0.0687
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0166 0.0059
Schistosoma mansoni hypothetical protein 0.0327 0.6736 0.8818
Schistosoma mansoni hypothetical protein 0.0049 0.0788 0.1031
Echinococcus granulosus CAAX prenyl protease 2 0.019 0.3808 0.4984
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.1038 0.1359
Echinococcus multilocularis GPCR, family 2 0.0049 0.0788 0.1031
Mycobacterium tuberculosis Probable integral membrane protein 0.0039 0.0584 0.0505
Brugia malayi hypothetical protein 0.0016 0.0088 0.01
Schistosoma mansoni inositol transporter 0.0041 0.0616 0.0807
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0166 0.0304
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.1038 0.1359
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0549 0.0719
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0327 0.6736 0.7694
Loa Loa (eye worm) hypothetical protein 0.0049 0.0788 0.09
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0549 0.0719
Loa Loa (eye worm) hypothetical protein 0.019 0.3808 0.4349
Entamoeba histolytica CAAX amino terminal protease family 0.0039 0.0584 0.1534
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0549 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0277 0.5664 0.7415
Mycobacterium ulcerans integral membrane protein 0.0039 0.0584 0.397
Chlamydia trachomatis hypothetical protein 0.0039 0.0584 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0154 0.304 0.3472
Loa Loa (eye worm) hypothetical protein 0.0025 0.0275 0.0315
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.1272 0.3277
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0166 0.0346
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0536 0.0702
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0401 0.1256
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0549 0.0549
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0277 0.5664 0.7415
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0166 0.0346
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0788 0.1031
Loa Loa (eye worm) acetyltransferase 0.016 0.3166 0.3617
Echinococcus multilocularis snurportin 1 0.0327 0.6736 0.8818
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0261 0.1143
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0536 0.0702
Trichomonas vaginalis bromodomain-containing protein, putative 0.0047 0.0752 0.0752
Echinococcus granulosus muscleblind protein 0.03 0.6156 0.8058
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.1272 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.1272 0.1238
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0549 0.3667
Loa Loa (eye worm) hypothetical protein 0.0071 0.1272 0.1453
Entamoeba histolytica CAAX amino terminal protease family 0.0039 0.0584 0.1534
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.1272 0.1665
Trypanosoma brucei unspecified product 0.002 0.0166 0.0346
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.1272 0.1665
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0401 0.0968
Toxoplasma gondii hypothetical protein 0.0039 0.0584 0.3096
Loa Loa (eye worm) hypothetical protein 0.0018 0.0131 0.015
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.1038 0.1359
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0041 0.0616 0.3422
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.099 0.1297
Loa Loa (eye worm) hypothetical protein 0.0018 0.0131 0.015
Loa Loa (eye worm) hypothetical protein 0.002 0.0166 0.0189
Brugia malayi hypothetical protein 0.0025 0.0275 0.0315
Schistosoma mansoni DNA polymerase eta 0.002 0.0166 0.0217
Echinococcus multilocularis solute carrier family 5 0.0041 0.0616 0.0807
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0788 0.1031
Mycobacterium ulcerans hypothetical protein 0.0024 0.0261 0.1143
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.1272 0.1272
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.1272 0.1665
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0261 0.1143
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0788 0.1031
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0275 0.269
Schistosoma mansoni hypothetical protein 0.0037 0.0536 0.0702
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0788 0.09
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0166 0.0346
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0275 0.0636
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.1038 0.7653
Loa Loa (eye worm) hypothetical protein 0.0071 0.1272 0.1453
Onchocerca volvulus 0.0061 0.1038 0.1038
Schistosoma mansoni hypothetical protein 0.017 0.3384 0.4429
Toxoplasma gondii exonuclease III APE 0.0038 0.0549 0.2749
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.1272 0.1453
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0166 0.0346
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0261 0.1143
Brugia malayi acetyltransferase, GNAT family protein 0.016 0.3166 0.3617
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0277 0.5664 0.647
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.1272 0.1238
Trichomonas vaginalis set domain proteins, putative 0.048 1 1
Onchocerca volvulus 0.0041 0.0616 0.0616
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0166 0.0166
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0277 0.5664 0.7415
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0166 0.0346
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0277 0.0277
Schistosoma mansoni hypothetical protein 0.0049 0.0788 0.1031
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0047 0.0752 0.478
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0166 0.0346
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0549 0.3667
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0166 0.0346
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0041 0.0616 0.0807
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.1272 0.1238
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0401 0.0524
Brugia malayi GH02984p 0.037 0.764 0.8726
Brugia malayi Importin beta-1 subunit 0.0031 0.0401 0.0458
Brugia malayi hypothetical protein 0.0037 0.0536 0.0613
Loa Loa (eye worm) hypothetical protein 0.03 0.6156 0.7031
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0277 0.0277
Schistosoma mansoni ap endonuclease 0.0038 0.0549 0.0719
Loa Loa (eye worm) hypothetical protein 0.0154 0.304 0.3472
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0275 0.0301
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.1038 0.1359
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0047 0.0752 0.478
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0166 0.0435
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0261 0.0687
Trypanosoma cruzi CAAX prenyl protease 2, putative 0.019 0.3808 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0261 0.1143
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0154 0.304 0.3472
Onchocerca volvulus 0.0071 0.1272 0.1272
Trichomonas vaginalis Clan U, family U48, CaaX prenyl peptidase 2-like 0.019 0.3808 0.3808
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0166 0.0217
Loa Loa (eye worm) hypothetical protein 0.0018 0.0131 0.015
Schistosoma mansoni sodium/solute symporter 0.0041 0.0616 0.0807
Brugia malayi beta-lactamase family protein 0.0071 0.1272 0.1453
Mycobacterium leprae Probable lipase LipE 0.0071 0.1272 1
Trichomonas vaginalis esterase, putative 0.0071 0.1272 0.1272
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.1272 0.1238
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.019 0.3808 0.4984
Schistosoma mansoni hypothetical protein 0.0049 0.0788 0.1031
Onchocerca volvulus 0.0071 0.1272 0.1272
Giardia lamblia Histone acetyltransferase GCN5 0.0043 0.0668 0.1378
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0549 0.0628
Echinococcus granulosus dna polymerase kappa 0.002 0.0166 0.0217
Echinococcus granulosus sodium:myo inositol cotransporter 0.0041 0.0616 0.0807
Loa Loa (eye worm) hypothetical protein 0.03 0.6156 0.7031
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0047 0.0752 0.0752
Echinococcus multilocularis dna polymerase kappa 0.002 0.0166 0.0217
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0549 0.0549
Schistosoma mansoni importin beta-1 0.0031 0.0401 0.0524
Schistosoma mansoni hypothetical protein 0.0049 0.0788 0.1031
Mycobacterium tuberculosis Conserved protein 0.0071 0.1272 0.1238
Loa Loa (eye worm) hypothetical protein 0.0071 0.1272 0.1453
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0261 0.0263
Loa Loa (eye worm) beta-lactamase 0.0071 0.1272 0.1453
Plasmodium falciparum importin beta, putative 0.0031 0.0401 0.502
Echinococcus granulosus solute carrier family 5 0.0041 0.0616 0.0807
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0549 0.1053
Loa Loa (eye worm) hypothetical protein 0.0024 0.0261 0.0299
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0166 0.0166
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.1272 1
Schistosoma mansoni inositol transporter 0.0041 0.0616 0.0807
Entamoeba histolytica hypothetical protein 0.0037 0.0536 0.1409
Echinococcus granulosus GPCR family 2 0.0049 0.0788 0.1031
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.1272 0.1238
Brugia malayi Sodium:solute symporter family protein 0.0041 0.0616 0.0704
Echinococcus granulosus sodium:glucose cotransporter 2 0.0041 0.0616 0.0807
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0277 0.5664 0.7415
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.1272 0.1272
Loa Loa (eye worm) hypothetical protein 0.0071 0.1272 0.1453
Plasmodium vivax importin-beta 2, putative 0.0031 0.0401 0.2362
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0154 0.304 0.3472
Loa Loa (eye worm) hypothetical protein 0.0071 0.1272 0.1453
Onchocerca volvulus 0.0024 0.0261 0.0261
Mycobacterium leprae conserved hypothetical protein 0.0071 0.1272 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0261 0.1143
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0166 0.0346
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0549 0.1053
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0536 0.0702
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0261 0.0299
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0166 0.0346
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0166 0.0217
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0166 0.0189
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0277 0.0305
Loa Loa (eye worm) hypothetical protein 0.0018 0.0131 0.015
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0788 0.09
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.1038 0.1359
Plasmodium falciparum protease, putative 0.0039 0.0584 0.8437
Toxoplasma gondii ABC1 family protein 0.0071 0.1272 1
Echinococcus granulosus sodium:glucose cotransporter 0.0041 0.0616 0.0807
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.1272 0.1272
Echinococcus granulosus dna polymerase eta 0.002 0.0166 0.0217
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0277 0.5664 0.7415
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0166 0.0217
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.0039 0.0584 0.0505
Loa Loa (eye worm) hypothetical protein 0.0024 0.0261 0.0299
Onchocerca volvulus 0.0071 0.1272 0.1272
Trypanosoma brucei CAAX amino terminal protease, putative 0.019 0.3808 1
Schistosoma mansoni hypothetical protein 0.017 0.3384 0.4429
Loa Loa (eye worm) hypothetical protein 0.037 0.764 0.8726
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0261 0.0161
Entamoeba histolytica CAAX prenyl protease family 0.019 0.3808 1
Mycobacterium ulcerans hypothetical protein 0.0039 0.0584 0.397
Echinococcus multilocularis geminin 0.017 0.3384 0.4429
Giardia lamblia Hypothetical protein 0.019 0.3808 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0277 0.5664 0.647
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0422 0.8755 1
Brugia malayi Pre-SET motif family protein 0.0422 0.8755 1
Mycobacterium ulcerans beta-lactamase 0.0071 0.1272 1
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0166 0.0304
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0456 0.9496 1
Schistosoma mansoni high-affinity choline transporter 0.037 0.764 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0166 0.0059
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0166 0.0346
Loa Loa (eye worm) hypothetical protein 0.0031 0.0401 0.0458
Brugia malayi beta-lactamase family protein 0.0071 0.1272 0.1453
Echinococcus multilocularis high affinity choline transporter 1 0.037 0.764 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0261 0.0263
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0261 0.1143
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0788 0.09
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0131 0.0022
Echinococcus multilocularis muscleblind protein 1 0.03 0.6156 0.8058
Mycobacterium ulcerans hypothetical protein 0.0039 0.0584 0.397
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0275 0.1266
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0261 0.0299
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0166 0.0346
Brugia malayi beta-lactamase 0.0071 0.1272 0.1453
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0166 0.0189
Echinococcus multilocularis CAAX prenyl protease 2 0.019 0.3808 0.4984
Leishmania major hypothetical protein, conserved 0.0025 0.0275 0.0301
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0549 0.0628
Leishmania major CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) 0.019 0.3808 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0549 0.1053
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.1272 0.3037
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.1272 0.1665
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0041 0.0616 0.0807
Brugia malayi Muscleblind-like protein 0.03 0.6156 0.7031
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0277 0.0277
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.0039 0.0584 0.0505
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.016 0.3166 0.4145
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0166 0.0346
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0166 0.0346
Brugia malayi RNA, U transporter 1 0.0087 0.1608 0.1836
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0277 0.5664 0.7415
Echinococcus granulosus geminin 0.017 0.3384 0.4429
Leishmania major importin beta-1 subunit, putative 0.0025 0.0277 0.0305
Plasmodium falciparum histone acetyltransferase GCN5 0.0043 0.0668 1
Mycobacterium tuberculosis Conserved protein 0.0071 0.1272 0.1238
Brugia malayi CAAX amino terminal protease family protein 0.019 0.3808 0.4349
Echinococcus granulosus high affinity choline transporter 1 0.037 0.764 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0261 0.0161
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0166 0.0217
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0047 0.0752 0.544
Loa Loa (eye worm) hypothetical protein 0.0024 0.0261 0.0299
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0788 0.1031
Brugia malayi latrophilin 2 splice variant baaae 0.0105 0.1997 0.2281
Mycobacterium ulcerans hypothetical protein 0.0071 0.1272 1
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.1272 0.1238

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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