Detailed information for compound 734786

Basic information

Technical information
  • TDR Targets ID: 734786
  • Name: 6-[(2-ethoxyphenyl)carbamoyl]spiro[bicyclo[2. 2.1]hept-2-ene-7,1'-cyclopropane]-5-carboxyli c acid
  • MW: 327.374 | Formula: C19H21NO4
  • H donors: 2 H acceptors: 3 LogP: 2.42 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccccc1NC(=O)C1C(C(=O)O)C2C3(C1C=C2)CC3
  • InChi: 1S/C19H21NO4/c1-2-24-14-6-4-3-5-13(14)20-17(21)15-11-7-8-12(16(15)18(22)23)19(11)9-10-19/h3-8,11-12,15-16H,2,9-10H2,1H3,(H,20,21)(H,22,23)
  • InChiKey: IYYKIRSUZICUEO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-[[(2-ethoxyphenyl)amino]-oxomethyl]-5-spiro[bicyclo[2.2.1]hept-2-ene-7,1'-cyclopropane]carboxylic acid
  • Oprea1_566139
  • CBKinase1_013008
  • Oprea1_440974
  • CBKinase1_000608
  • AG-205/36408054

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.1264 0.1417
Mycobacterium ulcerans hypothetical protein 0.0024 0.033 0.3106
Echinococcus multilocularis muscleblind protein 1 0.0303 0.6183 0.8763
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0596 0.0572
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0596 0.1366
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0235 0.0299
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0157 0.3122 0.4408
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0235 0.0824
Entamoeba histolytica hypothetical protein 0.0072 0.1334 0.3569
Schistosoma mansoni hypothetical protein 0.0069 0.1264 0.1763
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0184 0.3692 0.5219
Trichomonas vaginalis Clan U, family U48, CaaX prenyl peptidase 2-like 0.0184 0.3692 0.3677
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.033 0.0894
Onchocerca volvulus 0.0037 0.0596 0.0572
Loa Loa (eye worm) hypothetical protein 0.0303 0.6183 0.7047
Loa Loa (eye worm) hypothetical protein 0.0018 0.0201 0.0201
Brugia malayi GH02984p 0.0344 0.7052 0.8041
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0305 0.028
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0235 0.0361
Chlamydia trachomatis hypothetical protein 0.0038 0.0617 1
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0038 0.0616 0.0841
Entamoeba histolytica hypothetical protein 0.0072 0.1334 0.3569
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.1334 0.1863
Entamoeba histolytica hypothetical protein 0.0072 0.1334 0.3569
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.033 0.3106
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0235 0.0361
Schistosoma mansoni inositol transporter 0.0038 0.0616 0.0841
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0235 0.0636
Leishmania major CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) 0.0184 0.3692 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0235 0.024
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.033 0.0894
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0229 0.4636 0.6561
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0596 0.4387
Treponema pallidum hypothetical protein 0.0038 0.0617 1
Brugia malayi beta-lactamase 0.0037 0.0596 0.0653
Trypanosoma cruzi CAAX prenyl protease 2, putative 0.0184 0.3692 1
Giardia lamblia Hypothetical protein 0.0184 0.3692 1
Schistosoma mansoni high-affinity choline transporter 0.0344 0.7052 1
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.0709 0.137
Brugia malayi AMP-binding enzyme family protein 0.0024 0.033 0.0349
Loa Loa (eye worm) hypothetical protein 0.0037 0.0596 0.0653
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0229 0.4636 0.6561
Loa Loa (eye worm) hypothetical protein 0.0184 0.3692 0.4197
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0229 0.4636 0.6561
Brugia malayi Pre-SET motif family protein 0.0425 0.8764 1
Echinococcus multilocularis CAAX prenyl protease 2 0.0184 0.3692 0.5219
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0425 0.8764 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0235 0.0361
Echinococcus multilocularis high affinity choline transporter 1 0.0344 0.7052 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0235 0.0299
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.1334 0.1863
Echinococcus granulosus high affinity choline transporter 1 0.0344 0.7052 1
Echinococcus granulosus importin subunit beta 1 0.0029 0.0418 0.0559
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0235 0.0636
Onchocerca volvulus 0.0038 0.0616 0.0592
Echinococcus granulosus geminin 0.0339 0.6947 0.9851
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0235 0.0361
Echinococcus granulosus solute carrier family 5 0.0038 0.0616 0.0841
Echinococcus multilocularis dna polymerase eta 0.002 0.0235 0.0299
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0596 0.9477
Schistosoma mansoni hypothetical protein 0.0305 0.6224 0.8822
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0235 0.012
Onchocerca volvulus 0.0024 0.033 0.0306
Schistosoma mansoni hypothetical protein 0.0032 0.0487 0.0658
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0235 0.0361
Schistosoma mansoni hypothetical protein 0.0032 0.0487 0.0658
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0235 0.0211
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0235 0.024
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0201 0.0045
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0038 0.0616 0.0841
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0616 0.0947
Mycobacterium leprae Probable lipase LipE 0.0037 0.0596 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.033 0.0832
Echinococcus granulosus sodium:glucose cotransporter 2 0.0038 0.0616 0.0841
Loa Loa (eye worm) hypothetical protein 0.0037 0.0596 0.0653
Echinococcus multilocularis dna polymerase kappa 0.002 0.0235 0.0299
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.1101 0.1532
Schistosoma mansoni DNA polymerase eta 0.002 0.0235 0.0299
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0229 0.4636 0.5276
Mycobacterium ulcerans beta-lactamase 0.0037 0.0596 0.9477
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0305 0.028
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0487 0.0529
Schistosoma mansoni inositol transporter 0.0038 0.0616 0.0841
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0616 0.0841
Loa Loa (eye worm) beta-lactamase 0.0037 0.0596 0.0653
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0596 0.0812
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.079 0.6541
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.1933 0.2183
Schistosoma mansoni importin beta-1 0.0029 0.0418 0.0559
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0229 0.4636 0.5276
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.1101 0.1532
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.079 0.0767
Loa Loa (eye worm) hypothetical protein 0.0024 0.033 0.0349
Entamoeba histolytica CAAX amino terminal protease family 0.0038 0.0617 0.1616
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0418 0.0559
Mycobacterium tuberculosis Conserved hypothetical protein 0.0038 0.0617 0.095
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.079 0.544
Plasmodium vivax protease, putative 0.0038 0.0617 0.4629
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0235 0.012
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.0709 0.1864
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0596 0.0903
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0418 0.0871
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0596 1
Leishmania major importin beta-1 subunit, putative 0.0023 0.0305 0.0825
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0235 0.0299
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.1101 0.1532
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0596 0.0903
Schistosoma mansoni ap endonuclease 0.0038 0.0616 0.0841
Brugia malayi CAAX amino terminal protease family protein 0.0184 0.3692 0.4197
Plasmodium vivax SET domain protein, putative 0.0061 0.1101 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0616 0.4614
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0235 0.0361
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0616 0.0676
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0596 0.1613
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0596 0.0903
Leishmania major DNA polymerase eta, putative 0.002 0.0235 0.0636
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0305 0.6224 0.7094
Toxoplasma gondii hypothetical protein 0.0038 0.0617 0.2919
Loa Loa (eye worm) hypothetical protein 0.0032 0.0487 0.0529
Echinococcus granulosus GPCR family 2 0.0032 0.0487 0.0658
Echinococcus granulosus muscleblind protein 0.0303 0.6183 0.8763
Loa Loa (eye worm) hypothetical protein 0.0344 0.7052 0.8041
Brugia malayi Importin beta-1 subunit 0.0029 0.0418 0.045
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.033 0.3106
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.033 0.3106
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0596 0.0903
Loa Loa (eye worm) hypothetical protein 0.0101 0.1933 0.2183
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0305 0.0825
Trypanosoma brucei CAAX amino terminal protease, putative 0.0184 0.3692 1
Echinococcus granulosus sodium:glucose cotransporter 0.0038 0.0616 0.0841
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.0038 0.0617 0.095
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0235 0.0361
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.1933 0.2183
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.1101 1
Entamoeba histolytica hypothetical protein 0.0023 0.0305 0.0763
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0235 0.0361
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0184 0.3692 0.5219
Loa Loa (eye worm) hypothetical protein 0.0018 0.0201 0.0201
Schistosoma mansoni sodium/solute symporter 0.0038 0.0616 0.0841
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.1054 0.1464
Mycobacterium ulcerans hypothetical protein 0.0037 0.0596 0.9477
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0616 0.1612
Brugia malayi AMP-binding enzyme family protein 0.0024 0.033 0.0349
Loa Loa (eye worm) hypothetical protein 0.002 0.0235 0.024
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0236 0.4786 1
Loa Loa (eye worm) acetyltransferase 0.0157 0.3122 0.3544
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.1101 0.1532
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0235 0.0361
Trichomonas vaginalis set domain proteins, putative 0.0484 1 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0596 0.0653
Echinococcus granulosus dna polymerase kappa 0.002 0.0235 0.0299
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.033 0.3106
Brugia malayi Muscleblind-like protein 0.0303 0.6183 0.7047
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0616 0.0676
Toxoplasma gondii CAAX amino terminal protease family protein 0.0038 0.0617 0.2919
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0596 0.0572
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0235 0.024
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0235 0.0636
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0596 0.0903
Loa Loa (eye worm) hypothetical protein 0.0069 0.1264 0.1417
Plasmodium vivax importin-beta 2, putative 0.0029 0.0418 0.2415
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0305 0.028
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.033 0.0326
Loa Loa (eye worm) hypothetical protein 0.0061 0.1101 0.1231
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.1101 0.1532
Loa Loa (eye worm) hypothetical protein 0.0037 0.0596 0.0653
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0616 0.1668
Toxoplasma gondii exonuclease III APE 0.0038 0.0616 0.2899
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0487 0.0658
Brugia malayi AMP-binding enzyme family protein 0.0024 0.033 0.0349
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0235 0.0636
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0038 0.0616 0.0841
Mycobacterium ulcerans hypothetical protein 0.0038 0.0617 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.033 0.0349
Loa Loa (eye worm) hypothetical protein 0.0038 0.0616 0.0676
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.079 0.0767
Entamoeba histolytica CAAX prenyl protease family 0.0184 0.3692 1
Echinococcus multilocularis GPCR, family 2 0.0032 0.0487 0.0658
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.1101 0.1532
Onchocerca volvulus 0.0037 0.0596 0.0572
Brugia malayi hypothetical protein 0.0072 0.1334 0.1498
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0616 0.0593
Entamoeba histolytica hypothetical protein 0.0072 0.1334 0.3569
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.079 0.1088
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0596 0.0812
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.0709 1
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0235 0.0361
Loa Loa (eye worm) hypothetical protein 0.0037 0.0596 0.0653
Plasmodium falciparum importin beta, putative 0.0029 0.0418 0.428
Loa Loa (eye worm) hypothetical protein 0.0018 0.0201 0.0201
Loa Loa (eye worm) hypothetical protein 0.0037 0.0596 0.0653
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0616 0.9967
Mycobacterium ulcerans integral membrane protein 0.0038 0.0617 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0235 0.0636
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.033 0.0894
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0235 0.0824
Loa Loa (eye worm) hypothetical protein 0.0018 0.0201 0.0201
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0596 0.0572
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0596 0.0572
Loa Loa (eye worm) hypothetical protein 0.0024 0.033 0.0349
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.1933 0.2183
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0229 0.4636 0.6561
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0487 0.0658
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0616 0.0841
Leishmania major DNA polymerase kappa, putative 0.002 0.0235 0.0636
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.033 0.3106
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0487 0.0658
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0596 0.0812
Loa Loa (eye worm) hypothetical protein 0.0303 0.6183 0.7047
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0235 0.0573
Schistosoma mansoni ap endonuclease 0.0038 0.0616 0.0841
Brugia malayi acetyltransferase, GNAT family protein 0.0157 0.3122 0.3544
Schistosoma mansoni hypothetical protein 0.0032 0.0487 0.0658
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0038 0.0616 0.2895
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.033 0.0326
Echinococcus multilocularis geminin 0.0339 0.6947 0.9851
Echinococcus multilocularis muscleblind protein 0.0303 0.6183 0.8763
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0616 0.1668
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0596 0.1613
Trypanosoma brucei unspecified product 0.002 0.0235 0.0361
Schistosoma mansoni hypothetical protein 0.0339 0.6947 0.9851
Toxoplasma gondii hypothetical protein 0.0038 0.0617 0.2919
Trichomonas vaginalis esterase, putative 0.0037 0.0596 0.0572
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0235 0.0361
Trypanosoma cruzi peptidase with unknown catalytic mechanism (family U48) 0.0184 0.3692 1
Brugia malayi Sodium:solute symporter family protein 0.0038 0.0616 0.0676
Mycobacterium ulcerans hypothetical protein 0.0038 0.0617 1
Mycobacterium tuberculosis Conserved protein 0.0037 0.0596 0.0903
Mycobacterium ulcerans lipase LipD 0.0037 0.0596 0.9477
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0616 0.1668
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0235 0.0636
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0596 0.0903
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0596 0.0812
Echinococcus multilocularis snurportin 1 0.0305 0.6224 0.8822
Echinococcus multilocularis solute carrier family 5 0.0038 0.0616 0.0841
Leishmania major hypothetical protein, conserved 0.0037 0.0596 0.1613
Echinococcus granulosus CAAX prenyl protease 2 0.0184 0.3692 0.5219
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0229 0.4636 0.6561
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0616 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0229 0.4636 0.6561
Entamoeba histolytica CAAX amino terminal protease family 0.0038 0.0617 0.1616
Echinococcus granulosus snurportin 1 0.0305 0.6224 0.8822
Echinococcus granulosus sodium:myo inositol cotransporter 0.0038 0.0616 0.0841
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0487 0.0529
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0596 0.0903
Schistosoma mansoni hypothetical protein 0.0339 0.6947 0.9851
Schistosoma mansoni hypothetical protein 0.0072 0.1334 0.1863
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0235 0.0299
Mycobacterium tuberculosis Probable integral membrane protein 0.0038 0.0617 0.095
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0596 0.0653
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0235 0.0361
Brugia malayi beta-lactamase family protein 0.0037 0.0596 0.0653
Mycobacterium tuberculosis Conserved protein 0.0037 0.0596 0.0903
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0418 0.0871
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.1334 0.1863
Loa Loa (eye worm) hypothetical protein 0.0018 0.0201 0.0201
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0235 0.0211
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0596 0.0653
Brugia malayi beta-lactamase family protein 0.0037 0.0596 0.0653
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0616 0.8177
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.033 0.0832
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0616 0.1423
Onchocerca volvulus 0.0061 0.1101 0.1079
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0235 0.0361
Brugia malayi RNA, U transporter 1 0.0081 0.1524 0.1716
Toxoplasma gondii ABC1 family protein 0.0037 0.0596 0.26
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0235 0.0361
Brugia malayi Pre-SET motif family protein 0.0061 0.1101 0.1231
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.0038 0.0617 0.095
Echinococcus granulosus histone acetyltransferase KAT2B 0.0153 0.303 0.4276
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0616 0.0593
Schistosoma mansoni hypothetical protein 0.0032 0.0487 0.0658
Mycobacterium tuberculosis Conserved protein 0.0037 0.0596 0.0903
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0229 0.4636 0.6561
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.033 0.0832
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0616 0.1102
Echinococcus granulosus dna polymerase eta 0.002 0.0235 0.0299
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0038 0.0616 0.0841
Onchocerca volvulus 0.0037 0.0596 0.0572
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.033 0.3106
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.079 0.544
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.033 0.3106
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0596 0.0572
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0157 0.3122 0.4408
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0487 0.0529
Loa Loa (eye worm) hypothetical protein 0.0029 0.0418 0.045
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0487 0.0658
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.1101 0.1532
Plasmodium falciparum protease, putative 0.0038 0.0617 0.8204
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0596 0.9477

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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