Detailed information for compound 738100

Basic information

Technical information
  • TDR Targets ID: 738100
  • Name: 2-(6-bromo-2-methoxynaphthalen-1-yl)-N-(2,4-d imethoxyphenyl)acetamide
  • MW: 430.292 | Formula: C21H20BrNO4
  • H donors: 1 H acceptors: 1 LogP: 4.55 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(c(c1)OC)NC(=O)Cc1c(OC)ccc2c1ccc(c2)Br
  • InChi: 1S/C21H20BrNO4/c1-25-15-6-8-18(20(11-15)27-3)23-21(24)12-17-16-7-5-14(22)10-13(16)4-9-19(17)26-2/h4-11H,12H2,1-3H3,(H,23,24)
  • InChiKey: AMGZNOHHTZWUQW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(6-bromo-2-methoxy-1-naphthyl)-N-(2,4-dimethoxyphenyl)acetamide
  • 2-(6-bromo-2-methoxy-naphthalen-1-yl)-N-(2,4-dimethoxyphenyl)ethanamide
  • CBKinase1_019663
  • ZINC00703764
  • AF-399/42309610
  • CBKinase1_007263

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica hypothetical protein 0.0035 0.026 0.0256
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0034 0.0246 0.0295
Trichomonas vaginalis AGC family protein kinase 0.0024 0.0124 0.1174
Schistosoma mansoni cpg binding protein 0.006 0.0547 0.0668
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0146 0.3372
Echinococcus multilocularis p2X purinoceptor 4 0.0036 0.0268 0.0248
Mycobacterium tuberculosis Conserved protein 0.0035 0.0255 0.0906
Loa Loa (eye worm) hypothetical protein 0.0035 0.0255 0.0284
Trichomonas vaginalis CAMK family protein kinase 0.01 0.1026 1
Echinococcus multilocularis Glutaredoxin protein 5 0.0034 0.0246 0.0227
Entamoeba histolytica serine/threonine protein kinase, putative 0.01 0.1026 0.1965
Loa Loa (eye worm) hypothetical protein 0.0035 0.0255 0.0284
Trichomonas vaginalis AGC family protein kinase 0.0024 0.0124 0.1174
Brugia malayi Protein kinase domain containing protein 0.0034 0.0248 0.0275
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0439 0.4253
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0049 0.0139
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0551 0.0666
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0114 0.1185 0.4737
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0248 0.0277
Entamoeba histolytica PH domain containing protein kinase, putative 0.0036 0.0268 0.0273
Brugia malayi Hr1 repeat family protein 0.0034 0.0248 0.0275
Loa Loa (eye worm) hypothetical protein 0.0035 0.0255 0.0284
Loa Loa (eye worm) hypothetical protein 0.0086 0.0861 0.1066
Brugia malayi hypothetical protein 0.0154 0.1661 0.21
Schistosoma mansoni serine/threonine protein kinase 0.0218 0.2409 0.3098
Entamoeba histolytica protein kinase, putative 0.0068 0.0649 0.1123
Echinococcus granulosus jumonji domain containing protein 0.004 0.0321 0.0392
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0248 0.0277
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0049 0.1135
Entamoeba histolytica hypothetical protein 0.0406 0.4625 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0126 0.1335 0.5353
Brugia malayi protein kinase C II. 0.0034 0.0248 0.0275
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0126 0.1335 0.5353
Loa Loa (eye worm) AGC/AKT protein kinase 0.0068 0.0649 0.0792
Brugia malayi beta-lactamase 0.0035 0.0255 0.0284
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0114 0.1185 0.4737
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0035 0.0016
Brugia malayi jmjC domain containing protein 0.0038 0.0299 0.0341
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0255 0.0906
Trichomonas vaginalis AGC family protein kinase 0.0068 0.0649 0.6307
Trichomonas vaginalis CAMK family protein kinase 0.01 0.1026 1
Echinococcus granulosus protein kinase c epsilon type 0.0034 0.0248 0.0297
Trichomonas vaginalis AGC family protein kinase 0.0024 0.0124 0.1174
Schistosoma mansoni eyes absent homolog 0.0086 0.0861 0.1077
Echinococcus granulosus cGMP dependent protein kinase 1 0.0041 0.0334 0.0409
Toxoplasma gondii ABC1 family protein 0.0035 0.0255 0.1929
Loa Loa (eye worm) hypothetical protein 0.0034 0.0248 0.0275
Brugia malayi Protein kinase domain containing protein 0.0056 0.0505 0.0607
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0255 0.0284
Giardia lamblia Kinase, PLK 0.01 0.1026 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0433 0.0414
Trichomonas vaginalis AGC family protein kinase 0.0024 0.0124 0.1174
Echinococcus granulosus cGMP dependent protein kinase 1 0.0041 0.0334 0.0409
Echinococcus granulosus geminin 0.0177 0.193 0.2488
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0187 0.0196
Trichomonas vaginalis flap endonuclease-1, putative 0.0025 0.0146 0.1381
Echinococcus granulosus cGMP dependent protein kinase 0.0041 0.0334 0.0409
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0034 0.0246 0.0227
Trypanosoma brucei rac serine-threonine kinase, putative 0.0068 0.0649 0.6192
Plasmodium falciparum thioredoxin reductase 0.0017 0.0049 0.1135
Brugia malayi glutathione reductase 0.005 0.0433 0.0514
Schistosoma mansoni hypothetical protein 0.0417 0.476 0.6165
Schistosoma mansoni hypothetical protein 0.0029 0.0187 0.0198
Entamoeba histolytica hypothetical protein 0.0035 0.026 0.0256
Echinococcus granulosus p2X purinoceptor 4 0.0036 0.0268 0.0323
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0299 0.0344
Giardia lamblia Flap structure-specific endonuclease 0.0025 0.0146 0.0988
Trichomonas vaginalis AGC family protein kinase 0.0024 0.0124 0.1174
Loa Loa (eye worm) hypothetical protein 0.0035 0.0255 0.0284
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0222 0.2463 1
Echinococcus granulosus serine threonine protein kinase nrc 0.0036 0.0268 0.0323
Trypanosoma cruzi polo-like protein kinase, putative 0.01 0.1026 1
Schistosoma mansoni hypothetical protein 0.0035 0.026 0.0293
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0024 0.0132 0.0125
Loa Loa (eye worm) hypothetical protein 0.0154 0.1661 0.21
Brugia malayi serine/threonine-protein kinase plk-2 0.01 0.1026 0.1279
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0024 0.0124 0.1174
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.026 0.0293
Brugia malayi Latrophilin receptor protein 2 0.0047 0.04 0.0471
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0025 0.0146 0.1113
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0505 0.4901
Echinococcus multilocularis serine:threonine protein kinase N2 0.0034 0.0248 0.0228
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0255 0.2456
Echinococcus granulosus dnaJ subfamily B 0.0417 0.476 0.6173
Trypanosoma cruzi Protein kinase B 0.0036 0.0268 0.2348
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0255 0.0906
Echinococcus granulosus GPCR family 2 0.0047 0.04 0.0495
Plasmodium vivax thioredoxin reductase, putative 0.005 0.0433 1
Onchocerca volvulus Serine\/threonine kinase homolog 0.01 0.1026 0.3773
Trichomonas vaginalis AGC family protein kinase 0.0024 0.0124 0.1174
Trichomonas vaginalis AGC family protein kinase 0.0068 0.0649 0.6307
Brugia malayi hypothetical protein 0.0026 0.0146 0.0143
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0255 0.0906
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0049 0.0029
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0149 0.1598 0.2019
Schistosoma mansoni hypothetical protein 0.0047 0.04 0.0476
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0146 0.1117
Echinococcus multilocularis cpg binding protein 0.0063 0.0587 0.0569
Brugia malayi jmjC domain containing protein 0.0095 0.0964 0.12
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0049 0.0139
Trichomonas vaginalis serine/threonine-protein kinase, putative 0.0024 0.0124 0.1174
Echinococcus multilocularis dnaJ subfamily B 0.0417 0.476 0.4749
Echinococcus multilocularis nervana 2 0.0034 0.0246 0.0227
Schistosoma mansoni hypothetical protein 0.0102 0.1044 0.1316
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0146 0.3372
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0049 0.0018
Schistosoma mansoni serine/threonine-protein kinase 0.0036 0.0268 0.0303
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.026 0.0241
Brugia malayi hypothetical protein 0.0035 0.026 0.029
Schistosoma mansoni hypothetical protein 0.0177 0.193 0.2473
Echinococcus multilocularis peregrin 0.0029 0.0187 0.0168
Trichomonas vaginalis CAMK family protein kinase 0.01 0.1026 1
Entamoeba histolytica protein kinase, putative 0.0034 0.0248 0.0229
Onchocerca volvulus 0.0035 0.0255 0.0307
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.04 0.0381
Trichomonas vaginalis AGC family protein kinase 0.0024 0.0124 0.1174
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0114 0.1185 0.4737
Trichomonas vaginalis AGC family protein kinase 0.0024 0.0124 0.1174
Mycobacterium ulcerans hypothetical protein 0.004 0.0313 0.2257
Trichomonas vaginalis CAMK family protein kinase 0.01 0.1026 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0255 0.0287
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0049 0.0139
Loa Loa (eye worm) hypothetical protein 0.0086 0.0861 0.1066
Trichomonas vaginalis CAMK family protein kinase 0.01 0.1026 1
Brugia malayi Protein kinase domain containing protein 0.0068 0.0649 0.0792
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0116 0.1217 0.1199
Trypanosoma cruzi polo-like protein kinase, putative 0.01 0.1026 1
Trichomonas vaginalis AGC family protein kinase 0.0068 0.0649 0.6307
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0034 0.0248 0.0297
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.01 0.1026 0.1008
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0255 0.0284
Entamoeba histolytica protein kinase, putative 0.0068 0.0649 0.1123
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0255 0.2456
Toxoplasma gondii histone lysine methyltransferase SET1 0.0113 0.1175 1
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0036 0.0268 0.6189
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0248 0.0277
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0116 0.1217 0.1559
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0116 0.1217 0.1526
Trichomonas vaginalis CAMK family protein kinase 0.01 0.1026 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0255 0.1766
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0248 0.0277
Trichomonas vaginalis AGC family protein kinase 0.0024 0.0124 0.1174
Loa Loa (eye worm) AGC/NDR protein kinase 0.0034 0.0248 0.0275
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0187 0.1331
Entamoeba histolytica PH domain containing protein kinase, putative 0.0036 0.0268 0.0273
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0149 0.1598 0.2019
Trichomonas vaginalis AGC family protein kinase 0.0024 0.0124 0.1174
Echinococcus granulosus Glutaredoxin protein 5 0.0034 0.0246 0.0295
Mycobacterium tuberculosis Conserved protein 0.0035 0.0255 0.0906
Trichomonas vaginalis AGC family protein kinase 0.0024 0.0124 0.1174
Loa Loa (eye worm) hypothetical protein 0.0035 0.0255 0.0284
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0049 0.0057
Echinococcus multilocularis nervana 2 0.0034 0.0246 0.0227
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.0433 0.1637
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0433 0.4015
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0049 0.5
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0095 0.0964 0.123
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0255 0.0906
Brugia malayi beta-lactamase family protein 0.0035 0.0255 0.0284
Trichomonas vaginalis AGC family protein kinase 0.0024 0.0124 0.1174
Trichomonas vaginalis AGC family protein kinase 0.0068 0.0649 0.6307
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.01 0.1026 0.1279
Schistosoma mansoni cpg binding protein 0.0063 0.0587 0.072
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0126 0.1335 0.5353
Echinococcus multilocularis rho associated protein kinase 0.0218 0.2409 0.2394
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0109 0.1124 0.1407
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0034 0.0248 0.0228
Plasmodium vivax glutathione reductase, putative 0.005 0.0433 1
Trypanosoma brucei trypanothione reductase 0.005 0.0433 0.4015
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0036 0.0268 0.2348
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0255 0.0906
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0049 0.012
Trichomonas vaginalis AGC family protein kinase 0.0024 0.0124 0.1174
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0116 0.1217 0.1542
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0056 0.0505 0.0607
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0049 0.0139
Echinococcus granulosus nervana 2 0.0034 0.0246 0.0295
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0255 0.2221
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0034 0.0248 0.0297
Loa Loa (eye worm) beta-lactamase 0.0035 0.0255 0.0284
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0255 0.0906
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0041 0.0334 0.0315
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0299 0.0341
Trichomonas vaginalis AGC family protein kinase 0.0068 0.0649 0.6307
Plasmodium vivax flap endonuclease 1, putative 0.0025 0.0146 0.3363
Trichomonas vaginalis AGC family protein kinase 0.0024 0.0124 0.1174
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0248 0.0277
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.04 0.0381
Echinococcus multilocularis flap endonuclease 1 0.0025 0.0146 0.0126
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0321 0.0302
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.04 0.0471
Schistosoma mansoni flap endonuclease-1 0.0023 0.0117 0.0106
Echinococcus multilocularis serine:threonine protein kinase 38 0.0034 0.0248 0.0228
Mycobacterium ulcerans beta-lactamase 0.0035 0.0255 0.1766
Plasmodium falciparum glutathione reductase 0.0017 0.0049 0.1135
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0034 0.0248 0.0275
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0049 0.0139
Echinococcus multilocularis GPCR, family 2 0.0047 0.04 0.0381
Loa Loa (eye worm) thioredoxin reductase 0.005 0.0433 0.0514
Echinococcus granulosus serine/threonine protein kinase 0.0036 0.0268 0.0323
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0035 0.0818
Entamoeba histolytica protein kinase 2, putative 0.0036 0.0268 0.0273
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0255 0.5897
Echinococcus multilocularis serine threonine protein kinase 0.0034 0.0248 0.0228
Brugia malayi Protein kinase domain containing protein 0.0673 0.7776 1
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0025 0.0146 0.1113
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0049 0.0139
Trypanosoma brucei polo-like protein kinase 0.01 0.1026 1
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0673 0.7776 1
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0081 0.0797 0.1454
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0255 0.0906
Trichomonas vaginalis esterase, putative 0.0035 0.0255 0.2456
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0063 0.0035
Loa Loa (eye worm) hypothetical protein 0.0102 0.1044 0.1302
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0035 0.0016
Brugia malayi hypothetical protein 0.0086 0.0861 0.1066
Loa Loa (eye worm) flap endonuclease-1 0.0025 0.0146 0.0142
Loa Loa (eye worm) hypothetical protein 0.0035 0.0255 0.0284
Echinococcus granulosus muscleblind protein 0.0151 0.1626 0.2091
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0187 0.0218
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0439 0.4253
Treponema pallidum NADH oxidase 0.0017 0.0049 0.5
Echinococcus multilocularis geminin 0.0177 0.193 0.1914
Schistosoma mansoni P2X receptor subunit 0.0036 0.0268 0.0303
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.04 0.0471
Schistosoma mansoni hypothetical protein 0.0047 0.04 0.0476
Plasmodium falciparum phd finger protein, putative 0.0029 0.0187 0.4322
Schistosoma mansoni P2X receptor subunit 0.0036 0.0268 0.0303
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0063 0.0056
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0035 0.0818
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0049 0.0139
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0255 0.2456
Toxoplasma gondii thioredoxin reductase 0.005 0.0433 0.3488
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0505 0.4901
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0095 0.0964 0.0946
Trichomonas vaginalis serine/threonine-protein kinase ypk, putative 0.0024 0.0124 0.1174
Echinococcus granulosus rho-associated protein kinase 1 0.0218 0.2409 0.3112
Loa Loa (eye worm) hypothetical protein 0.0047 0.04 0.0471
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0054 0.0483 0.4689
Echinococcus multilocularis expressed conserved protein 0.0041 0.0334 0.0315
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0146 0.3372
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0299 0.0344
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0334 0.039
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0034 0.0248 0.0275
Echinococcus granulosus Protein kinase C brain isozyme 0.0034 0.0248 0.0297
Echinococcus granulosus p2X purinoceptor 4 0.0036 0.0268 0.0323
Schistosoma mansoni serine/threonine-protein kinase 0.0036 0.0268 0.0303
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0035 0.0016
Giardia lamblia Kinase, AGC PKA 0.0036 0.0268 0.2241
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0049 0.012
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0024 0.0124 0.1174
Schistosoma mansoni hypothetical protein 0.0047 0.04 0.0476
Trichomonas vaginalis AGC family protein kinase 0.0024 0.0124 0.1174
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.04 0.0495
Trichomonas vaginalis AGC family protein kinase 0.0024 0.0124 0.1174
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0063 0.0043
Trichomonas vaginalis CAMK family protein kinase 0.01 0.1026 1
Brugia malayi beta-lactamase family protein 0.0035 0.0255 0.0284
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0049 0.1135
Brugia malayi Flap endonuclease-1 0.0025 0.0146 0.0142
Trichomonas vaginalis AGC family protein kinase 0.0024 0.0124 0.1174
Trichomonas vaginalis AGC family protein kinase 0.0024 0.0124 0.1174
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0049 0.0018
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0081 0.0797 0.1454
Mycobacterium tuberculosis Probable dehydrogenase 0.0114 0.1185 0.4737
Brugia malayi CXXC zinc finger family protein 0.006 0.0547 0.0661
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0116 0.1217 1
Leishmania major trypanothione reductase 0.005 0.0433 0.3365
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0034 0.0248 0.0297
Loa Loa (eye worm) hypothetical protein 0.0151 0.1626 0.2055
Mycobacterium ulcerans lipase LipD 0.0035 0.0255 0.1766
Trichomonas vaginalis AGC family protein kinase 0.0024 0.0124 0.1174
Onchocerca volvulus 0.0218 0.2409 1
Entamoeba histolytica protein kinase, putative 0.0068 0.0649 0.1123
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0049 0.0139
Onchocerca volvulus 0.0035 0.0255 0.0307
Trichomonas vaginalis AGC family protein kinase 0.0024 0.0124 0.1174
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0248 0.0277
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.04 0.0495
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0049 0.0116
Echinococcus granulosus NDR protein kinase 0.0034 0.0248 0.0297
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0049 0.0116
Echinococcus multilocularis muscleblind protein 0.0151 0.1626 0.1609
Loa Loa (eye worm) hypothetical protein 0.0026 0.0146 0.0143
Trichomonas vaginalis AGC family protein kinase 0.0024 0.0124 0.1174
Trichomonas vaginalis AGC family protein kinase 0.0024 0.0124 0.1174
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0025 0.0146 0.0967
Trichomonas vaginalis AGC family protein kinase 0.0024 0.0124 0.1174
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0049 0.0139
Trichomonas vaginalis AGC family protein kinase 0.0024 0.0124 0.1174
Echinococcus granulosus microtubule associated protein 2 0.0667 0.7699 1
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0068 0.0649 0.0792
Echinococcus granulosus flap endonuclease 1 0.0025 0.0146 0.0164
Plasmodium falciparum flap endonuclease 1 0.0025 0.0146 0.3363
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0041 0.0334 0.0315
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0049 0.0116
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0035 0.002
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0126 0.1335 1
Entamoeba histolytica hypothetical protein 0.0035 0.026 0.0256
Brugia malayi F/Y-rich N-terminus family protein 0.0028 0.0172 0.0176
Trichomonas vaginalis AGC family protein kinase 0.0024 0.0124 0.1174
Brugia malayi Bromodomain containing protein 0.0029 0.0187 0.0196
Echinococcus granulosus protein kinase C gamma type 0.0034 0.0248 0.0297
Echinococcus granulosus protein kinase c iota type 0.0034 0.0248 0.0297
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0036 0.0268 0.0249
Trichomonas vaginalis AGC family protein kinase 0.0024 0.0124 0.1174
Entamoeba histolytica hypothetical protein 0.0035 0.026 0.0256
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0255 0.2456
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0049 0.0436
Brugia malayi Thioredoxin reductase 0.005 0.0433 0.0514
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0116 0.1217 0.4866
Leishmania major hypothetical protein, conserved 0.0026 0.0146 0.0936
Echinococcus granulosus cpg binding protein 0.0063 0.0587 0.0739
Trichomonas vaginalis AGC family protein kinase 0.0024 0.0124 0.1174
Loa Loa (eye worm) hypothetical protein 0.0029 0.0187 0.0196
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0255 0.2456
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0049 0.0038
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.01 0.1026 0.8382
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0049 0.0139
Loa Loa (eye worm) CXXC zinc finger family protein 0.006 0.0547 0.0661
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0036 0.0268 0.2348
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0034 0.0248 0.0228
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0248 0.2383
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0049 0.0116
Echinococcus granulosus nervana 2 0.0034 0.0246 0.0295
Mycobacterium tuberculosis Probable reductase 0.0114 0.1185 0.4737
Echinococcus multilocularis protein kinase c epsilon type 0.0034 0.0248 0.0228
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.026 0.0313
Brugia malayi p70 ribosomal S6 kinase beta 0.0068 0.0649 0.0792
Trichomonas vaginalis AGC family protein kinase 0.0024 0.0124 0.1174
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0041 0.0334 0.2623
Loa Loa (eye worm) hypothetical protein 0.005 0.0431 0.0511
Onchocerca volvulus 0.0035 0.0255 0.0307
Trichomonas vaginalis AGC family protein kinase 0.0024 0.0124 0.1174
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0049 0.1135
Brugia malayi PHD-finger family protein 0.0029 0.0187 0.0196
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0035 0.0016
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0433 0.0538
Loa Loa (eye worm) hypothetical protein 0.0151 0.1626 0.2055
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0187 0.0198
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0255 0.2221
Trichomonas vaginalis AGC family protein kinase 0.0024 0.0124 0.1174
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0255 0.1766
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0049 0.0139
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0049 0.1135
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0034 0.0248 0.0228
Trichomonas vaginalis AGC family protein kinase 0.0024 0.0124 0.1174
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0255 0.0287
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0049 0.0139
Loa Loa (eye worm) hypothetical protein 0.0149 0.1598 0.2019
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0025 0.0146 0.0933
Schistosoma mansoni serine/threonine protein kinase 0.01 0.1026 0.1292
Brugia malayi Calcitonin receptor-like protein seb-1 0.0149 0.1598 0.2019
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0035 0.0016
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0034 0.0248 0.0275
Trichomonas vaginalis AGC family protein kinase 0.0068 0.0649 0.6307
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0146 0.1117
Trichomonas vaginalis AGC family protein kinase 0.0024 0.0124 0.1174
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0049 0.0436
Brugia malayi latrophilin 2 splice variant baaae 0.0102 0.1044 0.1302
Leishmania major hypothetical protein, conserved 0.0035 0.0255 0.1862
Schistosoma mansoni serine/threonine kinase 0.0034 0.0248 0.0277
Echinococcus multilocularis p2X purinoceptor 4 0.0036 0.0268 0.0248
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0114 0.1185 0.4737
Schistosoma mansoni hypothetical protein 0.0177 0.193 0.2473
Echinococcus multilocularis rac serine:threonine kinase 0.0036 0.0268 0.0249
Schistosoma mansoni kinase 0.0052 0.0454 0.0546
Mycobacterium tuberculosis Conserved protein 0.0035 0.0255 0.0906
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0187 0.0168
Schistosoma mansoni P2X receptor subunit 0.0036 0.0268 0.0303
Echinococcus granulosus p2X purinoceptor 4 0.0036 0.0268 0.0323
Trichomonas vaginalis cAMP-dependent protein kinase catalytic subunit, putative 0.0024 0.0124 0.1174
Brugia malayi Egg laying defective protein 4 0.0041 0.0334 0.0386
Trichomonas vaginalis AGC family protein kinase 0.0024 0.0124 0.1174
Trichomonas vaginalis AGC family protein kinase 0.0024 0.0124 0.1174
Mycobacterium ulcerans hypothetical protein 0.0035 0.0255 0.1766
Echinococcus multilocularis microtubule associated protein 2 0.0667 0.7699 0.7694
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0049 0.5
Giardia lamblia PHD finger protein 15 0.0029 0.0187 0.1413
Schistosoma mansoni microtubule-associated protein tau 0.0667 0.7699 1
Loa Loa (eye worm) glutathione reductase 0.005 0.0433 0.0514
Schistosoma mansoni atypical protein kinase C 0.0034 0.0248 0.0277
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0049 0.0139
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0187 0.4322
Onchocerca volvulus 0.0154 0.1661 0.6633
Schistosoma mansoni cpg binding protein 0.0063 0.0587 0.072
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.0049 0.5
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0505 0.4901
Echinococcus multilocularis p2X purinoceptor 4 0.0036 0.0268 0.0248
Echinococcus multilocularis serine:threonine protein kinase N2 0.0034 0.0248 0.0228
Echinococcus granulosus serine:threonine protein kinase N2 0.0034 0.0248 0.0297
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0116 0.1217 1
Trichomonas vaginalis AGC family protein kinase 0.0068 0.0649 0.6307
Brugia malayi Muscleblind-like protein 0.0151 0.1626 0.2055
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0116 0.1217 1
Plasmodium falciparum thioredoxin reductase 0.005 0.0433 1
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0255 0.2221
Trichomonas vaginalis AGC family protein kinase 0.0024 0.0124 0.1174
Onchocerca volvulus 0.0216 0.2388 0.9902
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0259 0.024
Echinococcus multilocularis muscleblind protein 1 0.0151 0.1626 0.1609
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0036 0.0268 0.0323
Loa Loa (eye worm) AGC/PKN protein kinase 0.0034 0.0248 0.0275
Schistosoma mansoni hypothetical protein 0.0047 0.04 0.0476
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0255 0.0236
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0255 0.0307
Loa Loa (eye worm) hypothetical protein 0.0081 0.0797 0.0984
Echinococcus multilocularis protein kinase c iota type 0.0034 0.0248 0.0228
Onchocerca volvulus 0.006 0.0547 0.1621
Loa Loa (eye worm) AGC/PKG protein kinase 0.0041 0.0334 0.0386
Echinococcus granulosus peregrin 0.0029 0.0187 0.0218
Trichomonas vaginalis AGC family protein kinase 0.0024 0.0124 0.1174
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0126 0.1334 0.1695
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.0248 0.0277
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0299 0.0363
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0334 0.039
Brugia malayi hypothetical protein 0.0016 0.004 0.0005
Echinococcus granulosus serine:threonine protein kinase PLK1 0.01 0.1026 0.131
Schistosoma mansoni P2X receptor subunit 0.0036 0.0268 0.0303
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0036 0.0268 0.6189
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0114 0.1185 0.8615
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0146 0.097
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0034 0.0248 0.0228
Toxoplasma gondii AGC kinase 0.0068 0.0649 0.538
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0187 0.1331
Plasmodium falciparum glutathione reductase 0.005 0.0433 1
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0146 0.1117
Plasmodium falciparum cGMP-dependent protein kinase 0.0041 0.0334 0.7723
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0734 0.0912

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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