Detailed information for compound 739139

Basic information

Technical information
  • TDR Targets ID: 739139
  • Name: (4-propan-2-yloxyphenyl)-pyrrolidin-1-ylmetha none
  • MW: 233.306 | Formula: C14H19NO2
  • H donors: 0 H acceptors: 1 LogP: 2.64 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(Oc1ccc(cc1)C(=O)N1CCCC1)C
  • InChi: 1S/C14H19NO2/c1-11(2)17-13-7-5-12(6-8-13)14(16)15-9-3-4-10-15/h5-8,11H,3-4,9-10H2,1-2H3
  • InChiKey: QYFZAUFNDSHHQU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (4-isopropoxyphenyl)-pyrrolidin-1-yl-methanone
  • (4-isopropoxyphenyl)-1-pyrrolidinylmethanone
  • (4-propan-2-yloxyphenyl)-pyrrolidin-1-yl-methanone
  • isopropyl 4-(1-pyrrolidinylcarbonyl)phenyl ether
  • ZINC06746392
  • ARONIS012108
  • ALD-N013128
  • AN-329/43385790

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi mbt repeat family protein 0.0058 0.0109 0.0569
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0093 0.0433
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0093 0.0722
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0169 0.0879 0.4585
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0104 0.0434 0.0668
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0093 0.0433
Schistosoma mansoni amine oxidase 0.0104 0.0434 0.2031
Schistosoma mansoni hypothetical protein 0.035 0.2138 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.6501 1
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0227 0.1284 1
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0169 0.0879 0.4585
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0112 0.0106
Loa Loa (eye worm) hypothetical protein 0.0104 0.0434 0.1873
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0093 0.0484
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.0169 0.0879 0.5
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0989 0.6567 0.6411
Echinococcus multilocularis protoporphyrinogen oxidase 0.0104 0.0434 0.0668
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0989 0.6567 0.6411
Loa Loa (eye worm) hypothetical protein 0.0104 0.0434 0.1873
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0112 0.0584
Schistosoma mansoni amine oxidase 0.0104 0.0434 0.2031
Trichomonas vaginalis glutaminase, putative 0.0318 0.1916 1
Schistosoma mansoni dihydroorotate dehydrogenase 0.0169 0.0879 0.4109
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.0164 0.0253
Onchocerca volvulus 0.0104 0.0434 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0112 0.0584
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.1484 1 1
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.0164 0.0253
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.0164 0.0858
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0227 0.1284 0.1975
Entamoeba histolytica fatty acid elongase, putative 0.0128 0.06 1
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0066 0.0166 0.0255
Echinococcus multilocularis 0.0104 0.0434 0.0668
Loa Loa (eye worm) hypothetical protein 0.0104 0.0434 0.1873
Trypanosoma cruzi UDP-galactopyranose mutase 0.0104 0.0434 0.3764
Leishmania major dihydroorotate dehydrogenase 0.0169 0.0879 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0093 0.0433
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.0169 0.0879 0.0503
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.0169 0.0879 0.0464
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0093 0.0722
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0093 0.0143
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0066 0.0166 0.1294
Loa Loa (eye worm) hypothetical protein 0.0104 0.0434 0.1873
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.0169 0.0879 1
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.0109 0.0168
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.0109 0.009
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.0109 0.0849
Schistosoma mansoni glutaminase 0.0318 0.1916 0.8963
Plasmodium falciparum dihydroorotate dehydrogenase 0.0169 0.0879 0.0725
Echinococcus granulosus lysine specific histone demethylase 1A 0.0104 0.0434 0.3383
Entamoeba histolytica fatty acid elongase, putative 0.0128 0.06 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.0164 0.0393
Mycobacterium ulcerans glutaminase 0.0318 0.1916 0.1549
Brugia malayi Zinc finger, C2H2 type family protein 0.0066 0.0166 0.0867
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.1379 0.9275 1
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.0164 0.128
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.0109 0.0849
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0093 0.0143
Brugia malayi amine oxidase, flavin-containing family protein 0.0104 0.0434 0.2266
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.0164 0.128
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.0109 0.0168
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0066 0.0166 0.0255
Entamoeba histolytica fatty acid elongase, putative 0.0128 0.06 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.0434 0.1873
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.0989 0.6567 0.6937
Loa Loa (eye worm) MBCTL1 0.0066 0.0164 0.0393
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0989 0.6567 1
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.0989 0.6567 1
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0169 0.0879 0.0725
Loa Loa (eye worm) hypothetical protein 0.0058 0.0112 0.0106
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0104 0.0434 0.2031
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0066 0.0166 0.1294
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0058 0.0109 0.051
Trypanosoma cruzi UDP-galactopyranose mutase 0.0104 0.0434 0.3764
Brugia malayi glutaminase DH11.1 0.0318 0.1916 1
Brugia malayi SWIRM domain containing protein 0.0104 0.0434 0.2266
Entamoeba histolytica fatty acid elongase, putative 0.0128 0.06 1
Entamoeba histolytica fatty acid elongase, putative 0.0128 0.06 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.0434 0.1873
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.0169 0.0879 1
Echinococcus granulosus lysine specific histone demethylase 1A 0.0104 0.0434 0.3383
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.0164 0.0769
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0109 0.051
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.0989 0.6567 1
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0066 0.0166 0.2767
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0109 0.051
Loa Loa (eye worm) hypothetical protein 0.0058 0.0109 0.009
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0169 0.0879 1
Brugia malayi hypothetical protein 0.0104 0.0434 0.2266
Loa Loa (eye worm) glutaminase 2 0.0318 0.1916 1
Brugia malayi mbt repeat family protein 0.0058 0.0109 0.0569
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.0169 0.0879 1
Chlamydia trachomatis oxoacyl-ACP synthase III 0.0989 0.6567 1
Loa Loa (eye worm) glutaminase 0.0318 0.1916 1
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.0989 0.6567 0.6411
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0104 0.0434 0.2031
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0169 0.0879 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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