TDR Targets

Basic information

Technical information

TDR Targets ID: 755925
Name: N-(4-methoxyphenyl)sulfonyl-2-methyl-N-(2-oxo benzo[g][1,3]benzoxathiol-5-yl)propanamide
MW: 457.519 | Formula: C22H19NO6S2
H donors: 0 H acceptors: 4 LogP: 5 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)S(=O)(=O)N(c1cc2sc(=O)oc2c2c1cccc2)C(=O)C(C)C
InChi: 1S/C22H19NO6S2/c1-13(2)21(24)23(31(26,27)15-10-8-14(28-3)9-11-15)18-12-19-20(29-22(25)30-19)17-7-5-4-6-16(17)18/h4-13H,1-3H3
InChiKey: JHGPBDUIIHFKQV-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

N-(4-methoxyphenyl)sulfonyl-2-methyl-N-(2-oxo-5-benzo[g][1,3]benzoxathiolyl)propanamide
N-(2-ketobenzo[g][1,3]benzoxathiol-5-yl)-N-(4-methoxyphenyl)sulfonyl-2-methyl-propionamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	lysyl-tRNA synthetase, putative	0.0023	0.0283	0.0871
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0031	0.0468	0.168
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0031	0.0468	0.168
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0493	0.1787
Chlamydia trachomatis	lysine--tRNA ligase	0.0023	0.0283	0.6225
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0174
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0113	0.2374	1
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.0565	0.0982
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0588	0.2204
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0493	0.1787
Echinococcus granulosus	6 phosphofructokinase	0.0113	0.2374	1
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0032	0.0494	0.1793
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0441	1	1
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0493	0.1787
Trypanosoma brucei	metacaspase MCA2	0.0018	0.0161	0.0337
Trichomonas vaginalis	phosphofructokinase, putative	0.0113	0.2374	1
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0031	0.0468	0.0887
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0031	0.0468	0.1615
Onchocerca volvulus	Cell death protein 3 homolog	0.006	0.113	1
Loa Loa (eye worm)	6-phosphofructokinase	0.0113	0.2374	0.9618
Leishmania major	protein kinase, putative	0.0032	0.0494	0.1793
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0054	0.099	0.3956
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0714	0.2773
Trypanosoma brucei	metacaspase	0.0018	0.0161	0.0337
Plasmodium vivax	6-phosphofructokinase, putative	0.0031	0.0455	0.0374
Schistosoma mansoni	caspase-7 (C14 family)	0.006	0.113	0.4571
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0494	0.1793
Schistosoma mansoni	subfamily C14A unassigned peptidase (C14 family)	0.0018	0.0161	0.0337
Echinococcus multilocularis	mitogen activated protein kinase	0.0054	0.099	0.3956
Schistosoma mansoni	caspase-3 (C14 family)	0.0018	0.0161	0.0337
Toxoplasma gondii	phosphofructokinase PFKII	0.0031	0.0455	0.0572
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0018	0.0161	0.0337
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0493	0.1787
Trypanosoma cruzi	metacaspase, putative	0.0018	0.0161	0.0337
Leishmania major	ATP-dependent phosphofructokinase	0.0113	0.2374	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0565	0.2103
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.0565	0.2381
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0018	0.0161	0.0119
Brugia malayi	Cam kinase protein 1	0.0032	0.0494	0.1723
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0468	0.1761
Mycobacterium ulcerans	sugar transporter	0.0015	0.0084	0.0352
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0493	0.1787
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0565	0.216
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0168	0.3656	0.3602
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0455	0.162
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0161	0.0337
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0113	0.2374	1
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0493	0.1787
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0032	0.0495	0.0633
Echinococcus multilocularis	apoptotic protease activating factor 1	0.0042	0.0714	0.2752
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0032	0.0494	0.1867
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0863	0.3405
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0493	0.1787
Plasmodium falciparum	lysine--tRNA ligase	0.0023	0.0283	0.0201
Entamoeba histolytica	pyrophosphate-dependent phosphofructokinase	0.0031	0.0455	0.0821
Brugia malayi	6-phosphofructokinase	0.0113	0.2374	0.9612
Brugia malayi	beta-lactamase	0.0035	0.0565	0.2021
Onchocerca volvulus		0.0042	0.0714	0.6021
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0493	0.1787
Trypanosoma brucei	metacaspase 5, putative	0.0018	0.0161	0.0337
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0032	0.0494	0.1867
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0036	0.0588	0.2204
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0863	0.3405
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0863	0.3405
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0588	0.2204
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0048	0.0863	0.339
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0161	0.0337
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0493	0.1787
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0032	0.0495	0.0633
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0455	0.162
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.0565	0.0982
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0054	0.099	0.3956
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0565	0.216
Leishmania major	glucose transporter, lmgt2	0.0032	0.0493	0.1787
Brugia malayi	Cell death protein 3 precursor	0.006	0.113	0.4393
Trypanosoma brucei	metacaspase MCA3	0.0018	0.0161	0.0337
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0032	0.0495	0.0414
Echinococcus granulosus	caspase 3 apoptosis cysteine peptidase	0.0018	0.0161	0.0337
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0494	0.1793
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0104	0.2158	0.9058
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0104	0.2158	0.9058
Toxoplasma gondii	ABC1 family protein	0.0035	0.0565	0.0742
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0161	0.0337
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0468	0.1761
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0174
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0565	0.2103
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0032	0.0495	0.0414
Echinococcus multilocularis	caspase	0.0018	0.0161	0.0337
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0054	0.099	0.3956
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0168	0.3656	0.3602
Brugia malayi	phosphofructokinase	0.0113	0.2374	0.9612
Echinococcus granulosus	apoptotic protease activating factor 1	0.0042	0.0714	0.2752
Leishmania major	glucose transporter, lmgt1	0.0032	0.0493	0.1787
Echinococcus granulosus	lysyl tRNA synthetase	0.0023	0.0283	0.0871
Mycobacterium ulcerans	beta-lactamase	0.0035	0.0565	0.2381
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0493	0.1787
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0018	0.0161	0.0337
Brugia malayi	6-phosphofructokinase	0.0113	0.2374	0.9612
Loa Loa (eye worm)	MH2 domain-containing protein	0.0117	0.2466	1
Schistosoma mansoni	protein kinase	0.0032	0.0494	0.1793
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0565	0.0982
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.0565	0.2381
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0161	0.0337
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0493	0.1787
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0565	0.0982
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0565	0.216
Schistosoma mansoni	6-phosphofructokinase	0.0113	0.2374	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0032	0.0494	0.1793
Trypanosoma cruzi	metacaspase 5, putative	0.0018	0.0161	0.0337
Schistosoma mansoni	protein kinase	0.0032	0.0494	0.1793
Trypanosoma cruzi	hexose transporter, putative	0.0018	0.0153	0.0305
Mycobacterium ulcerans	integral membrane transport protein	0.0015	0.0084	0.0352
Entamoeba histolytica	protein kinase, putative	0.0032	0.0494	0.101
Plasmodium vivax	lysine--tRNA ligase, putative	0.0023	0.0283	0.0201
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0015	0.0084	0.5
Trypanosoma brucei	protein kinase, putative	0.0054	0.099	0.3956
Toxoplasma gondii	facilitative glucose transporter GT1	0.0104	0.2158	0.3196
Giardia lamblia	Prolyl-tRNA synthetase	0.0031	0.0468	0.4247
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0565	0.216
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0032	0.0493	0.1787
Plasmodium falciparum	protein kinase 7	0.0294	0.6575	0.6546
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0084	0.0174
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0863	0.3405
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0174
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0113	0.2374	1
Trypanosoma cruzi	metacaspase, putative	0.0018	0.0161	0.0337
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0565	0.216
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0174
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0015	0.0084	0.0352
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.002	0.0202	0.0241
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0018	0.0161	0.0337
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0493	0.1787
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0054	0.099	0.3956
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0565	0.216
Echinococcus multilocularis	calcium dependent protein kinase	0.003	0.0438	0.1546
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0054	0.099	0.3956
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0493	0.1787
Loa Loa (eye worm)	sugar transporter	0.0015	0.0084	0.0174
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0226	0.4989	1
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0032	0.0495	0.0414
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0048	0.0863	0.3273
Plasmodium falciparum	hexose transporter	0.0104	0.2158	0.2092
Schistosoma mansoni	glucose transport protein	0.0104	0.2158	0.9058
Schistosoma mansoni	serine/threonine protein kinase	0.0032	0.0494	0.1793
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0032	0.0495	0.0414
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0565	0.2103
Brugia malayi	hypothetical protein	0.0042	0.0714	0.2645
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0283	0.0871
Trypanosoma cruzi	metacaspase, putative	0.0018	0.0161	0.0337
Entamoeba histolytica	phosphofructokinase, putative	0.0113	0.2374	1
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.0565	0.0982
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.0565	0.0982
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0015	0.0084	0.0352
Echinococcus granulosus	caspase 2	0.006	0.113	0.4571
Loa Loa (eye worm)	sugar transporter	0.0104	0.2158	0.8729
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0018	0.0161	0.0337
Schistosoma mansoni	glucose transport protein	0.0104	0.2158	0.9058
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0565	0.2103
Brugia malayi	lysyl-tRNA synthetase	0.0023	0.0283	0.0837
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0493	0.1787
Schistosoma mansoni	glucose transport protein	0.0104	0.2158	0.9058
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0161	0.0492
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0565	0.2103
Toxoplasma gondii	lysine-tRNA ligase	0.0023	0.0283	0.0307
Trypanosoma brucei	Metacaspase-4	0.0018	0.0161	0.0337
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0174
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.0565	0.0982
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0565	0.2103
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0054	0.099	0.3956
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0032	0.0495	0.0633
Schistosoma mansoni	serine/threonine protein kinase	0.0054	0.099	0.3956
Giardia lamblia	Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit	0.0031	0.0455	0.4095
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0174
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0032	0.0494	0.1723
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0493	0.1787
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0565	0.2103
Plasmodium vivax	hexose transporter	0.0104	0.2158	0.2092
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.002	0.0217	0.0581
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0031	0.0468	0.168
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0104	0.2158	0.9058
Loa Loa (eye worm)	6-phosphofructokinase	0.0113	0.2374	0.9618
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0104	0.2158	0.9058
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0493	0.1787
Echinococcus multilocularis	General substrate transporter	0.0089	0.1819	0.7576
Echinococcus granulosus	caspase	0.0018	0.0161	0.0337
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0565	0.2103
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0032	0.0495	0.0414
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0023	0.0283	0.0871
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0494	0.1867
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0494	0.1793
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0174
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0031	0.0455	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0863	0.3405
Mycobacterium leprae	Probable lipase LipE	0.0035	0.0565	0.1673
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.0565	0.1673
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0565	0.0982
Trichomonas vaginalis	6-phosphofructokinase, putative	0.0031	0.0455	0.162
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0023	0.0283	0.0871
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0493	0.1787
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0333	0.1201
Echinococcus granulosus	calcium dependent protein kinase	0.003	0.0438	0.1546
Echinococcus granulosus	General substrate transporter	0.0089	0.1819	0.7576
Loa Loa (eye worm)	hypothetical protein	0.006	0.113	0.4491
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.0031	0.0455	0.0572
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0494	0.1793
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0023	0.0283	0.0871
Plasmodium falciparum	metacaspase-like protein	0.0018	0.0161	0.0078
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0161	0.0337
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0032	0.0495	0.0414
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0565	0.216
Brugia malayi	mucosa associated lymphoid tissue lymphoma translocation protein 1	0.0018	0.0161	0.0323
Plasmodium vivax	hypothetical protein, conserved	0.0018	0.0161	0.0078
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0031	0.0468	0.168
Toxoplasma gondii	6-phosphofructokinase	0.0031	0.0455	0.0572
Entamoeba histolytica	hypothetical protein	0.0037	0.0615	0.1586
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0174
Brugia malayi	beta-lactamase family protein	0.0035	0.0565	0.2021
Onchocerca volvulus		0.0035	0.0565	0.46
Entamoeba histolytica	protein kinase, putative	0.0032	0.0494	0.101
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.0615	0.2318
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0036	0.0588	0.2204
Leishmania major	metacaspase, putative	0.0018	0.0161	0.0337
Trichomonas vaginalis	esterase, putative	0.0035	0.0565	0.2103
Plasmodium falciparum	proline--tRNA ligase	0.0036	0.0588	0.0509
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0494	0.1793
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0031	0.0468	0.1227
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0054	0.099	0.3956
Trichomonas vaginalis	phosphofructokinase, putative	0.0113	0.2374	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0863	0.3405
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0161	0.0337
Entamoeba histolytica	hypothetical protein	0.0037	0.0615	0.1586
Trypanosoma cruzi	metacaspase 5, putative	0.0018	0.0161	0.0337
Leishmania major	glucose transporter, lmgt3	0.0032	0.0493	0.1787
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0032	0.0495	0.0414
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0565	0.216
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0565	0.2021
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0031	0.0455	0.0374
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0493	0.1787
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0032	0.0495	0.0414
Entamoeba histolytica	hypothetical protein	0.0037	0.0615	0.1586
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0283	0.1192
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0054	0.099	0.391
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0283	0.0996
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0565	0.2103
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0018	0.0161	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0174
Plasmodium vivax	6-phosphofructokinase, putative	0.0031	0.0455	0.0374
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0104	0.2158	0.9058
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0493	0.1787
Trypanosoma brucei	glucose transporter 1E	0.0032	0.0493	0.1787
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0494	0.1793
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0174
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0104	0.2158	0.9058
Brugia malayi	MH2 domain containing protein	0.0117	0.2466	1
Toxoplasma gondii	protein kinase, putative	0.0294	0.6575	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0104	0.2158	0.9058
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0174
Echinococcus multilocularis	caspase 2	0.006	0.113	0.4571
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0023	0.0283	0.0374
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0174
Loa Loa (eye worm)	transcription factor SMAD2	0.0117	0.2466	1
Mycobacterium ulcerans	6-phosphofructokinase	0.0113	0.2374	1
Trichomonas vaginalis	conserved hypothetical protein	0.0104	0.2158	0.9058
Echinococcus granulosus	mitogen activated protein kinase 3	0.0054	0.099	0.3956
Schistosoma mansoni	caspase-7 (C14 family)	0.0018	0.0161	0.0337
Trypanosoma cruzi	hexose transporter	0.0032	0.0493	0.1787
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0104	0.2158	0.9058
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0283	0.0871
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0018	0.0161	0.0337
Schistosoma mansoni	protein kinase	0.0032	0.0494	0.1793
Echinococcus multilocularis	lysyl tRNA synthetase	0.0023	0.0283	0.0871
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0018	0.0161	0.0337
Entamoeba histolytica	phosphofructokinase, putative	0.0113	0.2374	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0565	0.2103
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.002	0.0202	0.0241
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0031	0.0455	1
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0031	0.0455	0.1915
Trichomonas vaginalis	CMGC family protein kinase	0.0054	0.099	0.3956
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0588	0.2204
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0113	0.2374	0.4669
Giardia lamblia	Kinase, CMGC MAPK	0.0054	0.099	1
Brugia malayi	hypothetical protein	0.0037	0.0615	0.2228
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0455	0.162
Mycobacterium ulcerans	lipase LipD	0.0035	0.0565	0.2381
Echinococcus multilocularis	6 phosphofructokinase	0.0113	0.2374	1
Onchocerca volvulus		0.0035	0.0565	0.46
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0031	0.0455	0.0374
Echinococcus granulosus	mitogen activated protein kinase	0.0054	0.099	0.3956
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0493	0.1787
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.0565	0.0982
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0054	0.099	0.3956
Echinococcus multilocularis	caspase 8	0.0018	0.0161	0.0337
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0493	0.1787
Mycobacterium ulcerans	hypothetical protein	0.0035	0.0565	0.2381
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0031	0.0468	0.168
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0455	0.162
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0565	0.2103
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.0565	0.0982
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0054	0.099	0.1396
Trichomonas vaginalis	phosphofructokinase, putative	0.0113	0.2374	1
Trichomonas vaginalis	CMGC family protein kinase	0.0054	0.099	0.3956
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0084	0.0174
Schistosoma mansoni	hypothetical protein	0.0104	0.2158	0.9058
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0168	0.3656	0.5503
Entamoeba histolytica	hypothetical protein	0.0037	0.0615	0.1586
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0283	0.1192
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0455	0.162
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0494	0.1793
Echinococcus granulosus	caspase 8	0.0018	0.0161	0.0337
Plasmodium vivax	proline--tRNA ligase, putative	0.0036	0.0588	0.0509
Onchocerca volvulus		0.0035	0.0565	0.46
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0174
Trichomonas vaginalis	CAMK family protein kinase	0.0032	0.0494	0.1793
Giardia lamblia	Lysyl-tRNA synthetase	0.0023	0.0283	0.2201
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0455	0.162
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0113	0.2374	1
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0018	0.0161	0.0337
Trypanosoma cruzi	metacaspase, putative	0.0018	0.0161	0.0337
Schistosoma mansoni	6-phosphofructokinase	0.0113	0.2374	1
Plasmodium falciparum	metacaspase 1	0.0018	0.0161	0.0078
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0018	0.0161	0.0337
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0018	0.0161	0.0337
Leishmania major	hypothetical protein, conserved	0.0035	0.0565	0.2103
Brugia malayi	Sugar transporter family protein	0.0104	0.2158	0.8706
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0565	0.0486
Loa Loa (eye worm)	phosphofructokinase	0.0113	0.2374	0.9618
Plasmodium vivax	metacaspase 1, putative	0.0018	0.0161	0.0078
Trichomonas vaginalis	CMGC family protein kinase	0.0054	0.099	0.3956
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0863	0.3405
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0174
Schistosoma mansoni	hypothetical protein	0.0042	0.0714	0.2752
Trypanosoma brucei	glucose transporter 2A	0.0032	0.0493	0.1787
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0174
Trichomonas vaginalis	phosphofructokinase, putative	0.0113	0.2374	1
Echinococcus multilocularis	caspase 3, apoptosis cysteine peptidase	0.0018	0.0161	0.0337
Brugia malayi	beta-lactamase family protein	0.0035	0.0565	0.2021
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0032	0.0495	0.0414
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0031	0.0468	0.1615
Schistosoma mansoni	hypothetical protein	0.0037	0.0615	0.2318
Trichomonas vaginalis	CMGC family protein kinase	0.0054	0.099	0.3956
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0565	0.2103
Entamoeba histolytica	phosphofructokinase, putative	0.0113	0.2374	1
Brugia malayi	MAP kinase sur-1	0.0054	0.099	0.3803
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0018	0.0161	0.0119
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0036	0.0588	0.0778
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.0615	0.2318
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.0615	0.2318

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 755925