Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.082 | 0.1392 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.008 | 0.5 |
Trichomonas vaginalis | helicase, putative | 0.0007 | 0.008 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0212 | 0.0185 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0047 | 0.002 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0011 | 0.0212 | 0.0185 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0011 | 0.0212 | 0.0185 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0295 | 0.0269 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0011 | 0.0212 | 0.0185 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0011 | 0.0212 | 0.0185 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0016 | 0.0362 | 0.0335 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0015 | 0.0312 | 0.0286 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.008 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0011 | 0.0212 | 0.0185 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.003 | 0.0794 | 0.0769 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.008 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0054 | 0.1529 | 0.2596 |
Schistosoma mansoni | thyroid hormone receptor | 0.0011 | 0.0212 | 0.036 |
Schistosoma mansoni | nuclear receptor | 0.0005 | 0.0027 | 0.0047 |
Echinococcus multilocularis | FAD linked sulfhydryl oxidase ALR | 0.0113 | 0.335 | 0.3332 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0011 | 0.0212 | 0.0185 |
Echinococcus multilocularis | lamin | 0.003 | 0.0794 | 0.0769 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0011 | 0.0212 | 0.0185 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0011 | 0.0212 | 0.0185 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0006 | 0.0047 | 0.008 |
Onchocerca volvulus | 0.003 | 0.0794 | 0.5108 | |
Loa Loa (eye worm) | hypothetical protein | 0.0265 | 0.803 | 0.8025 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0011 | 0.0212 | 0.0185 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0011 | 0.0212 | 0.1228 |
Leishmania major | hypothetical protein, conserved | 0.0113 | 0.335 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.003 | 0.0794 | 0.0769 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0005 | 0.0027 | 0.0047 |
Onchocerca volvulus | 0.003 | 0.0794 | 0.5108 | |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0016 | 0.0362 | 0.0335 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0011 | 0.0212 | 0.036 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0011 | 0.0212 | 0.0185 |
Schistosoma mansoni | nuclear hormone receptor | 0.0011 | 0.0212 | 0.036 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.0874 | 0.1485 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.001 | 0.0159 | 0.0132 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0011 | 0.0212 | 0.0185 |
Brugia malayi | CXXC zinc finger family protein | 0.0031 | 0.082 | 0.0795 |
Schistosoma mansoni | nuclear hormone receptor | 0.0005 | 0.0027 | 0.0047 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0312 | 0.0286 |
Loa Loa (eye worm) | histone methyltransferase | 0.001 | 0.0159 | 0.0132 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0212 | 0.0185 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.008 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0011 | 0.0212 | 0.0185 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0011 | 0.0212 | 0.1228 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0008 | 0.01 | 0.0073 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0011 | 0.0212 | 0.036 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0011 | 0.0212 | 0.0185 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0011 | 0.0212 | 0.0185 |
Echinococcus granulosus | geminin | 0.0195 | 0.5889 | 0.5878 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0005 | 0.0027 | 0.0047 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0006 | 0.0047 | 0.002 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0011 | 0.0212 | 0.0185 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.008 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0011 | 0.0212 | 0.0185 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0066 | 0.1893 | 0.3214 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0011 | 0.0212 | 0.0185 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0011 | 0.0212 | 0.0185 |
Brugia malayi | intermediate filament protein | 0.003 | 0.0794 | 0.0769 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0011 | 0.0212 | 0.0185 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0031 | 0.082 | 0.0795 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0011 | 0.0212 | 0.0185 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0011 | 0.0212 | 0.036 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0009 | 0.0155 | 0.0128 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0011 | 0.0212 | 0.0185 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0011 | 0.0212 | 0.0185 |
Echinococcus granulosus | intermediate filament protein | 0.003 | 0.0794 | 0.0769 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0011 | 0.0212 | 0.0185 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.008 | 0.5 |
Brugia malayi | hypothetical protein | 0.0006 | 0.0047 | 0.002 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0011 | 0.0212 | 0.0185 |
Echinococcus multilocularis | geminin | 0.0195 | 0.5889 | 0.5878 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0006 | 0.0047 | 0.008 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0011 | 0.0212 | 0.0185 |
Schistosoma mansoni | thyroid hormone receptor | 0.0011 | 0.0212 | 0.036 |
Plasmodium vivax | FAD-linked sulfhydryl oxidase ERV1, putative | 0.0113 | 0.335 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0212 | 0.0185 |
Trypanosoma cruzi | Present in the outer mitochondrial membrane proteome 4 | 0.0113 | 0.335 | 1 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0054 | 0.1529 | 0.1505 |
Echinococcus granulosus | FTZ F1 alpha | 0.0011 | 0.0212 | 0.0185 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0417 | 0.0391 |
Schistosoma mansoni | hypothetical protein | 0.0195 | 0.5889 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0212 | 0.0185 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0212 | 0.0185 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0212 | 0.0185 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0005 | 0.0027 | 0.0047 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0047 | 0.002 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0047 | 0.002 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0006 | 0.0047 | 0.002 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0011 | 0.0212 | 0.0185 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0011 | 0.0212 | 0.0185 |
Schistosoma mansoni | intermediate filament proteins | 0.003 | 0.0794 | 0.1349 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.001 | 0.0159 | 0.0132 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0006 | 0.0047 | 0.002 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0047 | 0.002 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0015 | 0.0312 | 0.0286 |
Echinococcus granulosus | sulfhydryl oxidase 1 | 0.0018 | 0.0417 | 0.0391 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0011 | 0.0212 | 0.0185 |
Brugia malayi | nuclear receptor RXR | 0.0006 | 0.0047 | 0.002 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0011 | 0.0212 | 0.0185 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0329 | 1 | 1 |
Echinococcus multilocularis | cpg binding protein | 0.0033 | 0.0874 | 0.0849 |
Loa Loa (eye worm) | intermediate filament protein | 0.003 | 0.0794 | 0.0769 |
Echinococcus granulosus | lamin dm0 | 0.003 | 0.0794 | 0.0769 |
Schistosoma mansoni | cpg binding protein | 0.0033 | 0.0874 | 0.1485 |
Echinococcus granulosus | FAD linked sulfhydryl oxidase ALR | 0.0113 | 0.335 | 0.3332 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0011 | 0.0212 | 0.0185 |
Loa Loa (eye worm) | hypothetical protein | 0.0329 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0011 | 0.0212 | 0.1228 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.008 | 0.5 |
Onchocerca volvulus | 0.0054 | 0.1529 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0417 | 0.0391 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.008 | 0.5 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0008 | 0.01 | 0.0171 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0011 | 0.0212 | 0.0185 |
Schistosoma mansoni | quiescin q6-related sulfhydryl oxidase | 0.0018 | 0.0417 | 0.0708 |
Echinococcus multilocularis | muscleblind protein | 0.0329 | 1 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.008 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0329 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0265 | 0.803 | 0.8025 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.008 | 0.5 |
Loa Loa (eye worm) | hepatopoietin HPO2 | 0.0113 | 0.335 | 0.3332 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0265 | 0.803 | 0.8025 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0011 | 0.0212 | 0.0185 |
Brugia malayi | nuclear hormone receptor | 0.0011 | 0.0212 | 0.0185 |
Schistosoma mansoni | coup transcription factor | 0.0011 | 0.0212 | 0.036 |
Schistosoma mansoni | zinc finger protein | 0.0005 | 0.0027 | 0.0047 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0011 | 0.0212 | 0.0185 |
Schistosoma mansoni | nuclear receptor | 0.0005 | 0.0027 | 0.0047 |
Toxoplasma gondii | Erv1 / Alr family protein | 0.0113 | 0.335 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.008 | 0.5 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.008 | 0.5 |
Echinococcus multilocularis | musashi | 0.003 | 0.0794 | 0.0769 |
Brugia malayi | hypothetical protein | 0.0006 | 0.0047 | 0.002 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0011 | 0.0212 | 0.036 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0011 | 0.0212 | 0.0185 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.008 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0011 | 0.0212 | 0.0185 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0212 | 0.0185 |
Schistosoma mansoni | lamin | 0.003 | 0.0794 | 0.1349 |
Brugia malayi | Augmenter of liver regeneration | 0.0113 | 0.335 | 0.3332 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.008 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0011 | 0.0212 | 0.0185 |
Trypanosoma brucei | ERV/ALR sulfhydryl oxidase domain-containing protein | 0.0113 | 0.335 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.008 | 0.5 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0059 | 0.1676 | 0.4292 |
Schistosoma mansoni | hypothetical protein | 0.0195 | 0.5889 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0011 | 0.0212 | 0.0185 |
Trypanosoma cruzi | ERV/ALR sulfhydryl oxidase domain-containing protein | 0.0113 | 0.335 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0008 | 0.01 | 0.0073 |
Schistosoma mansoni | lamin | 0.003 | 0.0794 | 0.1349 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.008 | 0.5 |
Trypanosoma cruzi | Present in the outer mitochondrial membrane proteome 4 | 0.0113 | 0.335 | 1 |
Loa Loa (eye worm) | Erv1/Alr family protein | 0.0018 | 0.0417 | 0.0391 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0777 | 0.0752 |
Brugia malayi | quiescin Q6 | 0.0018 | 0.0417 | 0.0391 |
Plasmodium falciparum | FAD-linked sulfhydryl oxidase ERV1, putative | 0.0113 | 0.335 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0794 | 0.0769 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0011 | 0.0212 | 0.036 |
Toxoplasma gondii | Erv1 / Alr family protein | 0.0113 | 0.335 | 1 |
Echinococcus multilocularis | sulfhydryl oxidase 1 | 0.0018 | 0.0417 | 0.0391 |
Onchocerca volvulus | 0.0031 | 0.082 | 0.5278 | |
Echinococcus granulosus | muscleblind protein | 0.0329 | 1 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0008 | 0.01 | 0.0073 |
Onchocerca volvulus | Sulfhydryl oxidase homolog | 0.0018 | 0.0417 | 0.2596 |
Brugia malayi | ecdysteroid receptor | 0.0011 | 0.0212 | 0.0185 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0006 | 0.0047 | 0.002 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0008 | 0.01 | 0.0073 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0265 | 0.803 | 0.8025 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0011 | 0.0212 | 0.036 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0011 | 0.0212 | 0.0185 |
Echinococcus multilocularis | lamin dm0 | 0.003 | 0.0794 | 0.0769 |
Loa Loa (eye worm) | quiescin Q6 | 0.0018 | 0.0417 | 0.0391 |
Onchocerca volvulus | Sulfhydryl oxidase homolog | 0.0018 | 0.0417 | 0.2596 |
Onchocerca volvulus | Sulfhydryl oxidase homolog | 0.0018 | 0.0417 | 0.2596 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0011 | 0.0212 | 0.036 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0011 | 0.0212 | 0.0185 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.008 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0011 | 0.0212 | 0.036 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0011 | 0.0212 | 0.0185 |
Brugia malayi | Erv1 / Alr family protein | 0.0018 | 0.0417 | 0.0391 |
Echinococcus granulosus | cpg binding protein | 0.0033 | 0.0874 | 0.0849 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0011 | 0.0212 | 0.036 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0011 | 0.0212 | 0.0185 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0212 | 0.0185 |
Schistosoma mansoni | survival motor neuron protein | 0.0054 | 0.1529 | 0.2596 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0011 | 0.0212 | 0.0185 |
Loa Loa (eye worm) | hypothetical protein | 0.0006 | 0.0047 | 0.002 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0011 | 0.0212 | 0.0185 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0006 | 0.0047 | 0.002 |
Schistosoma mansoni | nuclear hormone receptor | 0.0005 | 0.0027 | 0.0047 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0295 | 0.0269 |
Onchocerca volvulus | 0.0011 | 0.0212 | 0.1228 | |
Echinococcus granulosus | lamin | 0.003 | 0.0794 | 0.0769 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.