Detailed information for compound 76264

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 346.424 | Formula: C18H26N4O3
  • H donors: 2 H acceptors: 5 LogP: 4.13 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1cc(C(=O)C)c(cc1OCCCCC(c1nnn[nH]1)(C)C)O
  • InChi: 1S/C18H26N4O3/c1-5-13-10-14(12(2)23)15(24)11-16(13)25-9-7-6-8-18(3,4)17-19-21-22-20-17/h10-11,24H,5-9H2,1-4H3,(H,19,20,21,22)
  • InChiKey: RHHDWFGUSMVSMD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0123 1
Echinococcus multilocularis protein kinase c epsilon type 0.0048 0.0354 0.0354
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0354 0.1057
Schistosoma mansoni protein kinase C 0.0022 0.0039 0.0118
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0026 0.0085 0.0085
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0348 0.1091
Plasmodium vivax SET domain protein, putative 0.0029 0.0129 1
Schistosoma mansoni hypothetical protein 0.0109 0.1104 0.3298
Echinococcus granulosus 6 phosphofructokinase 0.0106 0.1074 0.3366
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0115 0.0362
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0085 0.0027
Entamoeba histolytica hypothetical protein 0.0035 0.0202 0.1181
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0123 0.8655
Brugia malayi 6-phosphofructokinase 0.0106 0.1074 0.4739
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0026 0.0085 0.0377
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0348 0.0348
Brugia malayi jmjC domain containing protein 0.0093 0.0915 0.404
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0422 0.0422
Loa Loa (eye worm) MBCTL1 0.0053 0.0422 0.1861
Echinococcus multilocularis 6 phosphofructokinase 0.0106 0.1074 0.1074
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0026 0.0085 0.0377
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0007 0.0022
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1074 0.3931
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.1074 1
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0123 0.9521
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0123 1
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0123 0.9521
Loa Loa (eye worm) hypothetical protein 0.0019 0.0007 0.0032
Loa Loa (eye worm) hypothetical protein 0.0019 0.0007 0.0032
Schistosoma mansoni hypothetical protein 0.0035 0.0202 0.0603
Loa Loa (eye worm) matrixin family protein 0.017 0.1856 0.8195
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.012 0.8068
Loa Loa (eye worm) hypothetical protein 0.0029 0.012 0.0531
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0123 0.0175
Loa Loa (eye worm) AGC/NDR protein kinase 0.0026 0.0085 0.0377
Brugia malayi Pre-SET motif family protein 0.0029 0.0129 0.0568
Trichomonas vaginalis set domain proteins, putative 0.0232 0.261 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0129 0.0384
Entamoeba histolytica hypothetical protein 0.0035 0.0202 0.1181
Schistosoma mansoni jumonji domain containing protein 0.0074 0.068 0.2031
Brugia malayi phosphofructokinase 0.0106 0.1074 0.4739
Echinococcus multilocularis peregrin 0.0029 0.012 0.012
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0343 0.1074
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.012 0.0531
Onchocerca volvulus Alhambra homolog 0.0029 0.012 0.0435
Echinococcus granulosus jumonji domain containing protein 0.004 0.0257 0.0806
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0007 0.0007
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0123 0.0175
Brugia malayi Matrixin family protein 0.0186 0.2044 0.9025
Loa Loa (eye worm) hypothetical protein 0.0137 0.1444 0.6374
Brugia malayi Matrixin family protein 0.0077 0.0711 0.3139
Schistosoma mansoni hypothetical protein 0.0029 0.012 0.0359
Echinococcus multilocularis serine threonine protein kinase 0.0148 0.1582 0.1582
Echinococcus granulosus Protein kinase C brain isozyme 0.0166 0.1805 0.5658
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0123 0.8655
Echinococcus granulosus unc 13 munc13 0.0022 0.0039 0.0124
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.012 0.0377
Brugia malayi Protein kinase domain containing protein 0.0026 0.0085 0.0377
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.012 0.0359
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0422 0.1259
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0184 0.2024 0.2024
Loa Loa (eye worm) hypothetical protein 0.0029 0.0129 0.0568
Loa Loa (eye worm) AGC/PKN protein kinase 0.0026 0.0085 0.0377
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0123 0.0379
Echinococcus multilocularis dnaJ subfamily C 6 0.006 0.0505 0.0505
Loa Loa (eye worm) phosphofructokinase 0.0106 0.1074 0.4739
Echinococcus multilocularis conserved hypothetical protein 0.029 0.3325 0.3325
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0123 1
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0026 0.0085 0.0268
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0184 0.2024 0.6345
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0085 0.0027
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0106 0.1074 1
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1074 0.3931
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0129 0.0384
Loa Loa (eye worm) hypothetical protein 0.0077 0.0711 0.3139
Echinococcus granulosus serine:threonine protein kinase N2 0.0026 0.0085 0.0268
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0123 0.0175
Echinococcus multilocularis RUN 0.0019 0.0007 0.0007
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.1074 0.3207
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0202 0.0633
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0343 0.1512
Onchocerca volvulus 0.0077 0.0711 0.2705
Brugia malayi mbt repeat family protein 0.0047 0.0343 0.1512
Plasmodium falciparum phd finger protein, putative 0.0029 0.012 0.978
Brugia malayi Matrixin family protein 0.0077 0.0711 0.3139
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0007 0.0022
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0458 0.0458
Echinococcus granulosus protein kinase c epsilon type 0.0048 0.0354 0.111
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0348 0.1039
Schistosoma mansoni glucose-6-phosphatase 0.0292 0.3348 1
Schistosoma mansoni serine/threonine protein kinase 0.0026 0.0085 0.0255
Brugia malayi Doublecortin family protein 0.0019 0.0007 0.0032
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0348 0.1039
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0085 0.0027
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0343 0.0343
Entamoeba histolytica hypothetical protein 0.0035 0.0202 0.1181
Brugia malayi jmjC domain containing protein 0.0035 0.0194 0.0855
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0348 0.1091
Schistosoma mansoni serine/threonine protein kinase 0.0166 0.1805 0.539
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0422 0.0422
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1074 0.3931
Echinococcus granulosus peregrin 0.0029 0.012 0.0377
Brugia malayi Matrixin family protein 0.0077 0.0711 0.3139
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0007 0.0032
Onchocerca volvulus 0.0029 0.0129 0.0467
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0412 0.1819
Echinococcus multilocularis RNA directed DNA polymerase 0.0118 0.1222 0.1222
Leishmania major ATP-dependent phosphofructokinase 0.0106 0.1074 1
Onchocerca volvulus 0.0047 0.0343 0.1289
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0123 0.0175
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0085 0.0027
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.0915 0.0915
Echinococcus multilocularis conserved hypothetical protein 0.029 0.3325 0.3325
Echinococcus multilocularis serine:threonine protein kinase N2 0.0026 0.0085 0.0085
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.2265 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0348 0.1536
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0348 0.0348
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0093 0.0916 0.4044
Echinococcus multilocularis unc 13 (munc13) 0.0022 0.0039 0.0039
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.1074 0.4739
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.012 0.8068
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0123 0.8655
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.0432 0.1356
Mycobacterium ulcerans 6-phosphofructokinase 0.0106 0.1074 1
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0026 0.0085 0.0268
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0129 0.0384
Echinococcus granulosus NDR protein kinase 0.0026 0.0085 0.0268
Brugia malayi 6-phosphofructokinase 0.0106 0.1074 0.4739
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0129 0.0384
Loa Loa (eye worm) matrixin family protein 0.0186 0.2044 0.9025
Schistosoma mansoni loxhd1 0.0019 0.0007 0.0021
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0085 0.0027
Brugia malayi DnaJ domain containing protein 0.006 0.0505 0.2229
Brugia malayi PHD-finger family protein 0.0029 0.012 0.0531
Schistosoma mansoni unc-13 (munc13) 0.0022 0.0039 0.0118
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0422 0.1322
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0194 0.0608
Loa Loa (eye worm) hypothetical protein 0.0077 0.0711 0.3139
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0106 0.1074 1
Loa Loa (eye worm) DnaJ domain-containing protein 0.006 0.0505 0.2229
Echinococcus granulosus RUN 0.0019 0.0007 0.0022
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1074 0.3931
Brugia malayi hypothetical protein 0.0035 0.0202 0.0892
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0085 0.0027
Onchocerca volvulus 0.0109 0.1104 0.4214
Brugia malayi mbt repeat family protein 0.0047 0.0343 0.1512
Loa Loa (eye worm) hypothetical protein 0.0077 0.0711 0.3139
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0007 0.0007
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0343 0.1074
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.1074 1
Echinococcus granulosus dnaJ subfamily C 6 0.006 0.0505 0.1583
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0022 0.0039 0.0039
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0343 0.1023
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0166 0.1805 0.1805
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0026 0.0085 0.0377
Echinococcus multilocularis protein kinase c iota type 0.0044 0.0308 0.0308
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0129 0.0129
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0348 0.1536
Echinococcus granulosus protein kinase C gamma type 0.0148 0.1582 0.4961
Brugia malayi Protein kinase c protein 2 0.0141 0.1497 0.6608
Loa Loa (eye worm) matrix metalloproteinase 0.0077 0.0711 0.3139
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0422 0.1322
Schistosoma mansoni hypothetical protein 0.0019 0.0007 0.0021
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0022 0.0039 0.0124
Brugia malayi Protein kinase domain containing protein 0.0026 0.0085 0.0377
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0194 0.0855
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0085 0.0027
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.012 0.012
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0129 0.0129
Brugia malayi Pre-SET motif family protein 0.0204 0.2265 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0007 0.0007
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.1074 0.4739
Onchocerca volvulus Matrilysin homolog 0.0077 0.0711 0.2705
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0202 0.0603
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0257 0.0257
Onchocerca volvulus 0.0232 0.261 1
Entamoeba histolytica hypothetical protein 0.0035 0.0202 0.1181
Schistosoma mansoni rab6-interacting 0.0019 0.0007 0.0021
Onchocerca volvulus 0.0022 0.0039 0.0124
Brugia malayi Matrixin family protein 0.0077 0.0711 0.3139
Schistosoma mansoni lipoxygenase 0.0054 0.0432 0.1292
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0458 0.2024
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0048 0.0354 0.1562
Loa Loa (eye worm) hypothetical protein 0.0093 0.0916 0.4044
Loa Loa (eye worm) hypothetical protein 0.0049 0.037 0.1633
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0129 1
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0026 0.0085 0.0085
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0194 0.0579
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0343 0.1023
Loa Loa (eye worm) hypothetical protein 0.0118 0.1222 0.5393
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.1074 0.5
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0077 0.0711 0.2124
Brugia malayi p70 ribosomal S6 kinase beta 0.0026 0.0085 0.0377
Schistosoma mansoni serine/threonine protein kinase 0.0026 0.0085 0.0255
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0348 0.1039
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0343 0.1023
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0458 0.1437
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0422 0.1861
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0085 0.0027
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0118 0.1222 0.1222
Schistosoma mansoni serine/threonine protein kinase 0.0026 0.0085 0.0255
Loa Loa (eye worm) hypothetical protein 0.0053 0.0422 0.1861
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.1074 0.3207
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0026 0.0085 0.0085
Schistosoma mansoni hypothetical protein 0.006 0.0505 0.1508
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0093 0.0916 0.7439
Brugia malayi Bromodomain containing protein 0.0029 0.012 0.0531
Schistosoma mansoni unc-13 (munc13) 0.0022 0.0039 0.0118
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0123 0.5
Echinococcus granulosus protein kinase c iota type 0.0044 0.0308 0.0965
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0202 0.0202
Plasmodium vivax hypothetical protein, conserved 0.0029 0.012 0.9312
Loa Loa (eye worm) AGC/AKT protein kinase 0.0026 0.0085 0.0377
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0026 0.0085 0.0268
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0123 0.0175
Brugia malayi Hemopexin family protein 0.0109 0.1104 0.4874
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0123 0.5
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0343 0.1289
Brugia malayi Protein kinase domain containing protein 0.0026 0.0085 0.0377
Brugia malayi hypothetical protein 0.0019 0.0007 0.0032
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0492 0.2173
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0056 0.0458 0.1369
Schistosoma mansoni atypical protein kinase C 0.0044 0.0308 0.0919
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0194 0.0194
Schistosoma mansoni serine/threonine protein kinase 0.0166 0.1805 0.539
Schistosoma mansoni serine/threonine kinase 0.0026 0.0085 0.0255
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0007 0.0022
Brugia malayi protein kinase C II. 0.0048 0.0354 0.1562
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0123 0.0175
Trichomonas vaginalis protein kinase inhibitor, putative 0.006 0.0505 0.1685
Brugia malayi Hr1 repeat family protein 0.0026 0.0085 0.0377
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0279 0.3189 1
Echinococcus multilocularis serine:threonine protein kinase N2 0.0026 0.0085 0.0085
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0085 0.0027
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0106 0.1074 1
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.1074 1
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0081 0.0763 0.228
Onchocerca volvulus Matrilysin homolog 0.017 0.1856 0.7105
Schistosoma mansoni hypothetical protein 0.0284 0.3246 0.9696
Loa Loa (eye worm) hypothetical protein 0.0026 0.0085 0.0377
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0194 0.0579
Loa Loa (eye worm) hypothetical protein 0.0022 0.0039 0.0174
Echinococcus multilocularis serine:threonine protein kinase 38 0.0026 0.0085 0.0085
Schistosoma mansoni hypothetical protein 0.0101 0.1011 0.3021
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0085 0.0027
Schistosoma mansoni rab6-interacting 0.0019 0.0007 0.0021
Schistosoma mansoni lipoxygenase 0.0019 0.0007 0.0021
Brugia malayi hypothetical protein 0.0019 0.0007 0.0032
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0343 0.0343
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0123 0.0175
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.0915 0.287
Loa Loa (eye worm) hypothetical protein 0.0047 0.0343 0.1512
Echinococcus granulosus RNA directed DNA polymerase 0.0118 0.1222 0.383
Onchocerca volvulus Matrix metalloproteinase homolog 0.017 0.1856 0.7105
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0279 0.3189 0.3189
Schistosoma mansoni polycystin 1-related 0.0019 0.0007 0.0021
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0129 0.0403
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0123 0.1275 0.5626
Schistosoma mansoni serine/threonine protein kinase 0.0026 0.0085 0.0255
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.0432 0.0432
Mycobacterium ulcerans hydrolase 0.0093 0.0916 0.7439
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0085 0.0027
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0026 0.0085 0.0377
Trypanosoma brucei RNA helicase, putative 0.0101 0.1011 0.9371
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.1074 1

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 17 % Inhibition of [3H]-LTB4 binding to leukotriene B4 receptor of human peripheral neutrophils(PMN) at a concentration of 0.1 uM. ChEMBL. 1316967
Inhibition (binding) = 17 % Inhibition of [3H]-LTB4 binding to leukotriene B4 receptor of human peripheral neutrophils(PMN) at a concentration of 0.1 uM. ChEMBL. 1316967
Inhibition (binding) = 66 % Inhibition of [3H]-LTB4 binding to leukotriene B4 receptor from human peripheral neutrophils (PMN), at a concentration of 1 microM ChEMBL. 1316967
Inhibition (binding) = 66 % Inhibition of [3H]-LTB4 binding to leukotriene B4 receptor from human peripheral neutrophils (PMN), at a concentration of 1 microM ChEMBL. 1316967

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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