Detailed information for compound 763538

Basic information

Technical information
  • TDR Targets ID: 763538
  • Name: 3-[2-(4-tert-butylphenoxy)-4-oxopyrido[1,2-a] pyrimidin-3-yl]-2-phenylsulfonylprop-2-enenit rile
  • MW: 485.554 | Formula: C27H23N3O4S
  • H donors: 0 H acceptors: 4 LogP: 4.69 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC(=Cc1c(Oc2ccc(cc2)C(C)(C)C)nc2n(c1=O)cccc2)S(=O)(=O)c1ccccc1
  • InChi: 1S/C27H23N3O4S/c1-27(2,3)19-12-14-20(15-13-19)34-25-23(26(31)30-16-8-7-11-24(30)29-25)17-22(18-28)35(32,33)21-9-5-4-6-10-21/h4-17H,1-3H3/b22-17+
  • InChiKey: BORJKGZCUROCTF-OQKWZONESA-N  


Substructure search Similarity search

Network

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Synonyms

  • (E)-3-[2-(4-tert-butylphenoxy)-4-oxopyrido[1,2-a]pyrimidin-3-yl]-2-phenylsulfonylprop-2-enenitrile
  • 3-[2-(4-tert-butylphenoxy)-4-oxo-pyrido[1,2-a]pyrimidin-3-yl]-2-phenylsulfonyl-prop-2-enenitrile
  • (E)-3-[2-(4-tert-butylphenoxy)-4-oxo-pyrido[1,2-a]pyrimidin-3-yl]-2-phenylsulfonyl-prop-2-enenitrile
  • 3-[2-(4-tert-butylphenoxy)-4-oxo-3-pyrido[1,2-a]pyrimidinyl]-2-phenylsulfonylprop-2-enenitrile
  • (E)-3-[2-(4-tert-butylphenoxy)-4-oxo-3-pyrido[1,2-a]pyrimidinyl]-2-phenylsulfonylprop-2-enenitrile
  • (E)-3-[2-(4-tert-butylphenoxy)-4-keto-pyrido[1,2-a]pyrimidin-3-yl]-2-phenylsulfonyl-acrylonitrile
  • 3-[2-(4-tert-butylphenoxy)-4-keto-pyrido[1,2-a]pyrimidin-3-yl]-2-phenylsulfonyl-acrylonitrile
  • ZINC02398686

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax CDK-related protein kinase 6, putative 0.0902 1 1
Toxoplasma gondii ABC1 family protein 0.0035 0.0272 0.041
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.003 0.0217 0.5239
Loa Loa (eye worm) hypothetical protein 0.003 0.0217 0.0897
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0213 0.2266 0.4614
Toxoplasma gondii facilitative glucose transporter GT1 0.0213 0.2266 0.3424
Echinococcus granulosus Sugar transporter ERD6 protein 0.003 0.0217 0.0412
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.003 0.0217 0.0894
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Trypanosoma cruzi hexose transporter, putative 0.0066 0.0621 0.868
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0213 0.2266 0.4614
Loa Loa (eye worm) hypothetical protein 0.003 0.0217 0.0897
Loa Loa (eye worm) hypothetical protein 0.003 0.0217 0.0897
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0217 0.0897
Brugia malayi Sugar transporter family protein 0.003 0.0217 0.0897
Giardia lamblia Hexose transporter 0.003 0.0217 0.346
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0222 0.2374 1
Brugia malayi lysyl-tRNA synthetase 0.0047 0.0414 0.1772
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0064 0.0597 0.9752
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0217 0.0956
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0272 0.1141
Onchocerca volvulus 0.0035 0.0272 1
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0012 0.0016 0.0024
Echinococcus multilocularis solute carrier family 22 0.003 0.0217 0.0412
Toxoplasma gondii sugar transporter ST1 0.003 0.0217 0.0327
Loa Loa (eye worm) hypothetical protein 0.0035 0.0272 0.1141
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Echinococcus granulosus neuropeptide s receptor 0.0447 0.4892 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0066 0.0621 0.868
Toxoplasma gondii sugar transporter ST3 0.003 0.0217 0.0327
Plasmodium vivax calcium-dependent protein kinase, putative 0.0065 0.0612 0.0597
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0065 0.0611 0.1222
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Leishmania major cytochrome p450-like protein 0.0012 0.0015 0.0206
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0065 0.0611 0.2651
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0012 0.0016 0.0066
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0272 0.3797
Echinococcus granulosus solute carrier family 22 0.003 0.0217 0.0412
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0012 0.0016 0.0377
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0213 0.2266 0.4614
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0272 0.1144
Brugia malayi glycyl-tRNA synthetase 0.0012 0.0016 0.0004
Echinococcus multilocularis solute carrier family 22 0.003 0.0217 0.0412
Plasmodium falciparum calcium-dependent protein kinase 3 0.0065 0.0612 0.0597
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Mycobacterium tuberculosis Conserved protein 0.0035 0.0272 0.1144
Entamoeba histolytica protein kinase, putative 0.0065 0.0611 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0065 0.0611 0.1222
Loa Loa (eye worm) hypothetical protein 0.0064 0.0597 0.2586
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0065 0.0611 0.1222
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Trichomonas vaginalis conserved hypothetical protein 0.0213 0.2266 1
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0217 0.0897
Echinococcus granulosus solute carrier family 22 0.003 0.0217 0.0412
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0272 0.4551
Schistosoma mansoni protein kinase 0.0065 0.0611 0.2648
Mycobacterium tuberculosis Conserved protein 0.0035 0.0272 0.1144
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.004 0.0333 0.5587
Brugia malayi Sugar transporter family protein 0.0213 0.2266 1
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0217 0.0956
Echinococcus multilocularis solute carrier family 22 0.003 0.0217 0.0412
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0272 0.1144
Trypanosoma brucei glucose transporter, putative 0.0066 0.0621 0.868
Echinococcus multilocularis solute carrier family 22 0.003 0.0217 0.0412
Trypanosoma brucei THT1 - hexose transporter, putative 0.0066 0.0621 0.868
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0217 0.0956
Trypanosoma brucei glucose transporter, putative 0.0066 0.0621 0.868
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0272 0.6566
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0286 0.3994
Schistosoma mansoni sugar transporter 0.003 0.0217 0.0894
Echinococcus multilocularis synaptic vesicle 2 protein 0.003 0.0217 0.0412
Echinococcus multilocularis calcium dependent protein kinase 0.0061 0.0566 0.1129
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0012 0.0016 0.0004
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0064 0.0597 0.2634
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0611 0.1222
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0272 0.0525
Loa Loa (eye worm) hypothetical protein 0.003 0.0217 0.0897
Schistosoma mansoni protein kinase 0.0065 0.0611 0.2648
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0047 0.0414 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0272 0.1144
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0047 0.0414 0.5783
Loa Loa (eye worm) hypothetical protein 0.003 0.0217 0.0897
Plasmodium falciparum lysine--tRNA ligase 0.0047 0.0414 0.0399
Treponema pallidum prolyl-tRNA synthetase 0.0023 0.0134 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0213 0.2266 0.4614
Mycobacterium ulcerans integral membrane transport protein 0.003 0.0217 0.5239
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0272 0.1199
Loa Loa (eye worm) hypothetical protein 0.003 0.0217 0.0897
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Plasmodium falciparum calcium-dependent protein kinase 4 0.0065 0.0612 0.0597
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0065 0.0611 0.2651
Echinococcus multilocularis General substrate transporter 0.0183 0.193 0.3927
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0217 0.0956
Echinococcus granulosus neuropeptide receptor A26 0.0447 0.4892 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Leishmania major hypothetical protein, conserved 0.0035 0.0272 0.3797
Plasmodium falciparum hexose transporter 0.0213 0.2266 0.2253
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0272 0.6566
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0012 0.0016 0.0004
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0272 0.1199
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0272 0.1141
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0344 0.3734 0.3724
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0074 0.0715 1
Trypanosoma brucei sugar transporter, putative 0.003 0.0217 0.303
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.003 0.0217 0.0913
Trichomonas vaginalis esterase, putative 0.0035 0.0272 0.1199
Loa Loa (eye worm) hypothetical protein 0.0065 0.0611 0.2651
Plasmodium falciparum protein kinase 7 0.0601 0.6617 0.6612
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0012 0.0016 0.0262
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Brugia malayi beta-lactamase family protein 0.0035 0.0272 0.1141
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0065 0.0612 0.0925
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.003 0.0217 1
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.004 0.0333 0.1405
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0272 0.0256
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0065 0.0612 0.0597
Echinococcus multilocularis neuropeptide s receptor 0.0447 0.4892 1
Loa Loa (eye worm) sugar transporter 0.003 0.0217 0.0897
Trypanosoma brucei glucose transporter 1E 0.0066 0.0621 0.868
Trypanosoma brucei glucose transporter, putative 0.0066 0.0621 0.868
Plasmodium falciparum calcium-dependent protein kinase 1 0.0065 0.0612 0.0597
Schistosoma mansoni glucose transport protein 0.0213 0.2266 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Onchocerca volvulus 0.0035 0.0272 1
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0217 0.0956
Trichomonas vaginalis sugar transport protein, putative 0.003 0.0217 0.0956
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0065 0.0612 0.0597
Loa Loa (eye worm) hypothetical protein 0.003 0.0217 0.0897
Chlamydia trachomatis lysine--tRNA ligase 0.0047 0.0414 1
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0047 0.0414 0.1826
Trypanosoma brucei glucose transporter, putative 0.0066 0.0621 0.868
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0074 0.0715 1
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0074 0.0715 1
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0047 0.0414 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0272 0.3797
Loa Loa (eye worm) hypothetical protein 0.003 0.0217 0.0897
Brugia malayi beta-lactamase 0.0035 0.0272 0.1141
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0065 0.0611 0.1222
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0074 0.0715 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Giardia lamblia Lysyl-tRNA synthetase 0.0047 0.0414 0.6849
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0065 0.0612 0.0925
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Trypanosoma brucei THT1 - hexose transporter, putative 0.0066 0.0621 0.868
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0217 0.0897
Trypanosoma brucei glucose transporter, putative 0.0066 0.0621 0.868
Entamoeba histolytica hypothetical protein 0.0047 0.0414 0.6679
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.003 0.0217 0.0913
Echinococcus granulosus solute carrier family 22 0.003 0.0217 0.0412
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0074 0.0715 0.1081
Loa Loa (eye worm) hypothetical protein 0.003 0.0217 0.0897
Giardia lamblia Sugar-proton symporter 0.003 0.0217 0.346
Schistosoma mansoni lysyl-tRNA synthetase 0.0047 0.0414 0.1769
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0012 0.0016 0.0218
Echinococcus multilocularis lysyl tRNA synthetase 0.0047 0.0414 0.0816
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0272 0.1144
Plasmodium vivax lysine--tRNA ligase, putative 0.0047 0.0414 0.0399
Leishmania major hypothetical protein, conserved 0.003 0.0217 0.303
Brugia malayi major facilitator superfamily protein 0.003 0.0217 0.0897
Trypanosoma brucei glucose transporter 2A 0.0066 0.0621 0.868
Trypanosoma cruzi glucose transporter, putative 0.003 0.0217 0.303
Schistosoma mansoni sugar transporter 0.003 0.0217 0.0894
Leishmania major glucose transporter, lmgt1 0.0066 0.0621 0.868
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0272 0.1138
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Chlamydia trachomatis proline--tRNA ligase 0.0023 0.0134 0.2978
Loa Loa (eye worm) hypothetical protein 0.003 0.0217 0.0897
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0213 0.2266 0.4614
Trypanosoma brucei glucose transporter, putative 0.0066 0.0621 0.868
Trichomonas vaginalis sugar transporter, putative 0.0066 0.0621 0.274
Echinococcus granulosus calcium dependent protein kinase 0.0061 0.0566 0.1129
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0012 0.0016 0.0004
Trichomonas vaginalis glucose transporter, putative 0.0066 0.0621 0.274
Brugia malayi beta-lactamase family protein 0.0035 0.0272 0.1141
Loa Loa (eye worm) hypothetical protein 0.003 0.0217 0.0897
Toxoplasma gondii sugar transporter ST2 0.003 0.0217 0.0327
Schistosoma mansoni protein kinase 0.0065 0.0611 0.2648
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0047 0.0414 0.6932
Loa Loa (eye worm) hypothetical protein 0.0035 0.0272 0.1141
Brugia malayi hypothetical protein 0.003 0.0217 0.0897
Mycobacterium ulcerans lipase LipD 0.0035 0.0272 0.6566
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0272 0.1144
Loa Loa (eye worm) hypothetical protein 0.0035 0.0272 0.1141
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0065 0.0611 0.2651
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0064 0.0597 0.2583
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0064 0.0597 0.2586
Mycobacterium tuberculosis Conserved protein 0.0035 0.0272 0.1144
Leishmania major threonyl-tRNA synthetase, putative 0.0012 0.0016 0.0218
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0042 0.0348 0.1536
Toxoplasma gondii glycyl-tRNA synthetase 0.0012 0.0016 0.0024
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.003 0.0217 0.5239
Giardia lamblia Prolyl-tRNA synthetase 0.0064 0.0597 1
Leishmania major myo-inositol/proton symporter (MIT) 0.003 0.0217 0.303
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0015 0.0206
Echinococcus granulosus lysyl tRNA synthetase 0.0047 0.0414 0.0816
Leishmania major lysyl-tRNA synthetase, putative 0.0047 0.0414 0.5783
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Mycobacterium ulcerans sugar transporter 0.003 0.0217 0.5239
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Loa Loa (eye worm) hypothetical protein 0.0064 0.0597 0.2586
Loa Loa (eye worm) hypothetical protein 0.0035 0.0272 0.1141
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0012 0.0016 0.0004
Leishmania major glucose transporter, lmgt2 0.0066 0.0621 0.868
Brugia malayi hypothetical protein 0.003 0.0217 0.0897
Trypanosoma brucei glucose transporter, putative 0.0066 0.0621 0.868
Mycobacterium ulcerans beta-lactamase 0.0035 0.0272 0.6566
Trypanosoma cruzi sugar transporter, putative 0.003 0.0217 0.303
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0065 0.0611 0.855
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0065 0.0612 0.0925
Schistosoma mansoni hypothetical protein 0.0213 0.2266 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0272 0.1138
Schistosoma mansoni glucose transporter 0.003 0.0217 0.0894
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0023 0.0134 0.3243
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0026 0.0175 0.0712
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0064 0.0597 0.1192
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Loa Loa (eye worm) beta-lactamase 0.0035 0.0272 0.1141
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0272 0.1144
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.003 0.0217 0.0201
Mycobacterium ulcerans hypothetical protein 0.0035 0.0272 0.6566
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0272 0.3797
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0004
Brugia malayi hypothetical protein 0.003 0.0217 0.0897
Trichomonas vaginalis myo-inositol transporter, putative 0.003 0.0217 0.0956
Toxoplasma gondii transporter, major facilitator family protein 0.003 0.0217 0.0327
Plasmodium falciparum proline--tRNA ligase 0.0074 0.0715 0.0701
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.004 0.0333 0.1405
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.003 0.0217 0.303
Plasmodium vivax hexose transporter 0.0213 0.2266 0.2253
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0064 0.0597 0.2586
Leishmania major glucose transporter/membrane transporter D2, putative 0.0066 0.0621 0.868
Loa Loa (eye worm) hypothetical protein 0.003 0.0217 0.0897
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0066 0.0621 0.274
Trypanosoma brucei glucose transporter, putative 0.0066 0.0621 0.868
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0621 0.274
Plasmodium falciparum mitogen-activated protein kinase 2 0.0344 0.3734 0.3724
Toxoplasma gondii protein kinase, putative 0.0601 0.6617 1
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0217 0.0897
Loa Loa (eye worm) hypothetical protein 0.003 0.0217 0.0897
Brugia malayi Sugar transporter family protein 0.003 0.0217 0.0897
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0074 0.0715 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0012 0.0015 0.0357
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0213 0.2266 0.4614
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0344 0.3734 0.5643
Leishmania major glucose transporter, lmgt3 0.0066 0.0621 0.868
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0012 0.0016 0.0218
Trichomonas vaginalis sugar transporter, putative 0.0066 0.0621 0.274
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0272 0.1199
Loa Loa (eye worm) hypothetical protein 0.003 0.0217 0.0897
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0065 0.0612 0.0597
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0047 0.0414 0.5783
Plasmodium vivax sugar transporter, putative 0.003 0.0217 0.0201
Echinococcus granulosus synaptic vesicle 2 protein 0.003 0.0217 0.0412
Onchocerca volvulus 0.0035 0.0272 1
Schistosoma mansoni glucose transport protein 0.0213 0.2266 1
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0611 0.2648
Trypanosoma cruzi hexose transporter, putative 0.0066 0.0621 0.868
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0012 0.0016 0.0218
Brugia malayi Cam kinase protein 1 0.0065 0.0611 0.2651
Trypanosoma cruzi hexose transporter, putative 0.0066 0.0621 0.868
Loa Loa (eye worm) hypothetical protein 0.0035 0.0272 0.1141
Trypanosoma cruzi hexose transporter, putative 0.003 0.0217 0.303
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0272 0.1199
Schistosoma mansoni glucose transport protein 0.0213 0.2266 1
Echinococcus multilocularis Sugar transporter ERD6 protein 0.003 0.0217 0.0412
Plasmodium falciparum calcium-dependent protein kinase 2 0.0065 0.0612 0.0597
Schistosoma mansoni sugar transporter 0.003 0.0217 0.0894
Toxoplasma gondii lysine-tRNA ligase 0.0047 0.0414 0.0625
Loa Loa (eye worm) hypothetical protein 0.0047 0.0414 0.1772
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0064 0.0597 1
Echinococcus granulosus solute carrier family 22 0.003 0.0217 0.0412
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0272 0.1144
Trichomonas vaginalis glucose transporter, putative 0.003 0.0217 0.0956
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0213 0.2266 0.4614
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Trypanosoma brucei cytochrome P450, putative 0.0012 0.0015 0.0206
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0213 0.2266 0.4614
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0012 0.0016 0.0069
Schistosoma mansoni lysyl-tRNA synthetase 0.0047 0.0414 0.1769
Trichomonas vaginalis glucose transporter, putative 0.0066 0.0621 0.274
Loa Loa (eye worm) hypothetical protein 0.0035 0.0272 0.1141
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0012 0.0016 0.0377
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0064 0.0597 0.2583
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0621 0.274
Echinococcus multilocularis neuropeptide receptor A26 0.0447 0.4892 1
Brugia malayi major facilitator superfamily protein 0.003 0.0217 0.0897
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0217 0.0897
Mycobacterium leprae Probable lipase LipE 0.0035 0.0272 0.4551
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Echinococcus granulosus General substrate transporter 0.0183 0.193 0.3927
Trypanosoma cruzi hexose transporter 0.0066 0.0621 0.868
Trichomonas vaginalis CAMK family protein kinase 0.0065 0.0611 0.2699
Entamoeba histolytica protein kinase, putative 0.0065 0.0611 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0463 0.199
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0015 0.0206
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0611 0.1222
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0064 0.0597 0.1192
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0611 0.1222
Loa Loa (eye worm) sugar transporter 0.0213 0.2266 1
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0012 0.0016 0.0218
Leishmania major protein kinase, putative 0.0065 0.0611 0.855
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0611 0.1222
Plasmodium falciparum calcium-dependent protein kinase 5 0.0065 0.0612 0.0597
Plasmodium vivax proline--tRNA ligase, putative 0.0074 0.0715 0.0701
Loa Loa (eye worm) hypothetical protein 0.003 0.0217 0.0897
Trichomonas vaginalis sugar transporter, putative 0.003 0.0217 0.0956
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0272 0.0525
Schistosoma mansoni sugar transporter 0.003 0.0217 0.0894
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0272 0.1199

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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