Detailed information for compound 763577

Basic information

Technical information
  • TDR Targets ID: 763577
  • Name: (E)-2-cyano-3-[2-(4-ethylphenoxy)-4-oxopyrido [1,2-a]pyrimidin-3-yl]-N-(3-propan-2-yloxypro pyl)prop-2-enamide
  • MW: 460.525 | Formula: C26H28N4O4
  • H donors: 1 H acceptors: 3 LogP: 3.31 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC(=Cc1c(Oc2ccc(cc2)CC)nc2n(c1=O)cccc2)C(=O)NCCCOC(C)C
  • InChi: 1S/C26H28N4O4/c1-4-19-9-11-21(12-10-19)34-25-22(26(32)30-14-6-5-8-23(30)29-25)16-20(17-27)24(31)28-13-7-15-33-18(2)3/h5-6,8-12,14,16,18H,4,7,13,15H2,1-3H3,(H,28,31)/b20-16+
  • InChiKey: QRYQLVOLJDMMMT-CAPFRKAQSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-cyano-3-[2-(4-ethylphenoxy)-4-oxopyrido[1,2-a]pyrimidin-3-yl]-N-(3-propan-2-yloxypropyl)prop-2-enamide
  • 2-cyano-3-[2-(4-ethylphenoxy)-4-oxo-pyrido[1,2-a]pyrimidin-3-yl]-N-(3-isopropoxypropyl)prop-2-enamide
  • (E)-2-cyano-3-[2-(4-ethylphenoxy)-4-oxo-pyrido[1,2-a]pyrimidin-3-yl]-N-(3-isopropoxypropyl)prop-2-enamide
  • 2-cyano-3-[2-(4-ethylphenoxy)-4-oxo-3-pyrido[1,2-a]pyrimidinyl]-N-(3-isopropoxypropyl)prop-2-enamide
  • (E)-2-cyano-3-[2-(4-ethylphenoxy)-4-oxo-3-pyrido[1,2-a]pyrimidinyl]-N-(3-isopropoxypropyl)prop-2-enamide
  • 2-cyano-3-[2-(4-ethylphenoxy)-4-keto-pyrido[1,2-a]pyrimidin-3-yl]-N-(3-isopropoxypropyl)acrylamide
  • (E)-2-cyano-3-[2-(4-ethylphenoxy)-4-keto-pyrido[1,2-a]pyrimidin-3-yl]-N-(3-isopropoxypropyl)acrylamide
  • (E)-2-cyano-3-[2-(4-ethylphenoxy)-4-oxo-pyrido[1,2-a]pyrimidin-3-yl]-N-(3-propan-2-yloxypropyl)prop-2-enamide
  • 2-cyano-3-[2-(4-ethylphenoxy)-4-oxo-pyrido[1,2-a]pyrimidin-3-yl]-N-(3-propan-2-yloxypropyl)prop-2-enamide
  • STOCK4S-48312

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0356 0.057
Trichomonas vaginalis interferon-induced, double-stranded RNA-activated protein kinase, putative 0.0007 0.0001 0.0006
Schistosoma mansoni hypothetical protein 0.0047 0.0356 0.0355
Echinococcus multilocularis neuropeptides capa receptor 0.0047 0.0356 0.057
Echinococcus granulosus hypothetical protein 0.0047 0.0356 0.057
Trichomonas vaginalis glucose transporter, putative 0.0064 0.0498 0.1989
Loa Loa (eye worm) hypothetical protein 0.0047 0.0356 0.1417
Trypanosoma cruzi glucose transporter, putative 0.0029 0.0193 0.3384
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0046 0.0342 0.1365
Loa Loa (eye worm) melatonin receptor type 1A 0.0047 0.0356 0.1417
Loa Loa (eye worm) hypothetical protein 0.0047 0.0356 0.1417
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0356 0.0355
Echinococcus multilocularis neuropeptide Y receptor 0.0047 0.0356 0.057
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0193 0.0772
Loa Loa (eye worm) hypothetical protein 0.0047 0.0356 0.1417
Trypanosoma brucei glucose transporter, putative 0.0064 0.0498 0.8747
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0006 0.0007
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0063 0.0491 0.0648
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0356 0.057
Echinococcus multilocularis serotonin receptor 0.0047 0.0356 0.057
Toxoplasma gondii glycyl-tRNA synthetase 0.0012 0.0042 0.0081
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0047 0.0356 0.0355
Trichomonas vaginalis conserved hypothetical protein 0.001 0.003 0.012
Loa Loa (eye worm) hypothetical protein 0.0063 0.0491 0.1957
Schistosoma mansoni amine GPCR 0.0047 0.0356 0.0355
Echinococcus multilocularis neuropeptide FF receptor 2 0.0047 0.0356 0.057
Loa Loa (eye worm) hypothetical protein 0.0047 0.0356 0.1417
Echinococcus multilocularis sex peptide receptor 0.0047 0.0356 0.057
Echinococcus granulosus orexin receptor type 2 0.0047 0.0356 0.057
Loa Loa (eye worm) hypothetical protein 0.0029 0.0193 0.0768
Brugia malayi hypothetical protein 0.0029 0.0193 0.0768
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.001 0.003 0.0508
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0202 0.0803
Echinococcus multilocularis synaptic vesicle 2 protein 0.0029 0.0193 0.0309
Brugia malayi putative neuropeptide receptor NPR1 0.0047 0.0356 0.1417
Loa Loa (eye worm) hypothetical protein 0.0047 0.0356 0.1417
Echinococcus multilocularis neuropeptide receptor 0.0047 0.0356 0.057
Echinococcus granulosus neuropeptide receptor 0.0047 0.0356 0.057
Loa Loa (eye worm) hypothetical protein 0.0047 0.0356 0.1417
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0029 0.0193 0.6499
Loa Loa (eye worm) hypothetical protein 0.0047 0.0356 0.1417
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0193 0.0772
Brugia malayi sulfakinin receptor protein 0.0047 0.0356 0.1417
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0047 0.0356 0.057
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0063 0.0491 0.1957
Trichomonas vaginalis sugar transport protein, putative 0.0029 0.0193 0.0772
Loa Loa (eye worm) hypothetical protein 0.0047 0.0356 0.1417
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0193 0.0772
Chlamydia trachomatis histidine--tRNA ligase 0.0007 0.0001 0.0008
Trichomonas vaginalis glutaminase, putative 0.0292 0.2505 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0047 0.0356 0.0355
Echinococcus multilocularis neuropeptides capa receptor 0.0047 0.0356 0.057
Loa Loa (eye worm) hypothetical protein 0.0047 0.0356 0.1417
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0193 0.0772
Plasmodium falciparum protein kinase 6 0.087 0.7569 1
Plasmodium vivax lysine--tRNA ligase, putative 0.0046 0.0342 0.045
Echinococcus multilocularis cpg binding protein 0.0032 0.0217 0.0347
Loa Loa (eye worm) hypothetical protein 0.0047 0.0356 0.1417
Plasmodium falciparum mitogen-activated protein kinase 2 0.0331 0.2845 0.3758
Brugia malayi Tachykinin-like peptides receptor 99D 0.0047 0.0356 0.1417
Onchocerca volvulus 0.0047 0.0356 1
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.003 0.0508
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0205 0.1738 0.2791
Loa Loa (eye worm) hypothetical protein 0.0047 0.0356 0.1417
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0356 0.057
Loa Loa (eye worm) hypothetical protein 0.0047 0.0356 0.1417
Loa Loa (eye worm) neuropeptide F receptor 0.0047 0.0356 0.1417
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0029 0.0193 0.0309
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0047 0.0356 0.1417
Echinococcus multilocularis dro:myosuppressin receptor 0.0047 0.0356 0.057
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0029 0.0193 0.6499
Toxoplasma gondii histidyl-tRNA synthetase (HisRS), putative 0.0007 0.0001 0.0001
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0061 0.048 0.1912
Brugia malayi CXXC zinc finger family protein 0.003 0.0202 0.0803
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0193 0.0772
Trypanosoma brucei glucose transporter 1E 0.0064 0.0498 0.8747
Leishmania major hypothetical protein, conserved 0.001 0.003 0.0508
Echinococcus granulosus General substrate transporter 0.0176 0.1485 0.2385
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0356 0.0355
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0047 0.0356 0.1417
Echinococcus multilocularis solute carrier family 22 0.0029 0.0193 0.0309
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0047 0.0356 0.1417
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0012 0.0042 0.0081
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0356 0.057
Schistosoma mansoni glucose transport protein 0.0205 0.1738 0.1737
Loa Loa (eye worm) hypothetical protein 0.0047 0.0356 0.1417
Entamoeba histolytica glycyl-tRNA synthetase, putative 0.0012 0.0042 0.083
Echinococcus multilocularis serotonin receptor 0.0047 0.0356 0.057
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0047 0.0356 0.1417
Loa Loa (eye worm) hypothetical protein 0.0047 0.0356 0.1417
Trichomonas vaginalis glucose transporter, putative 0.0029 0.0193 0.0772
Trypanosoma cruzi hexose transporter, putative 0.0064 0.0498 0.8747
Echinococcus granulosus fmrfamide receptor 0.0047 0.0356 0.057
Schistosoma mansoni microtubule-associated protein tau 0.0716 0.6223 0.6223
Trypanosoma brucei glucose transporter, putative 0.0064 0.0498 0.8747
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0022 0.0131 0.0519
Onchocerca volvulus 0.0047 0.0356 1
Wolbachia endosymbiont of Brugia malayi histidyl-tRNA synthetase 0.0007 0.0001 0.0014
Echinococcus granulosus 7TM GPCR rhodopsin 0.0047 0.0356 0.057
Echinococcus multilocularis glycyl tRNA synthetase 0.0012 0.0042 0.0065
Schistosoma mansoni adenoreceptor 0.0047 0.0356 0.0355
Giardia lamblia Sugar-proton symporter 0.0029 0.0193 0.4016
Schistosoma mansoni biogenic amine receptor 0.0047 0.0356 0.0355
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0029 0.0193 1
Echinococcus granulosus tm gpcr rhodopsin 0.0047 0.0356 0.057
Leishmania major protein kinase, putative 0.0063 0.0491 0.8623
Echinococcus multilocularis solute carrier family 22 0.0029 0.0193 0.0309
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0193 0.0772
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0012 0.0042 0.0167
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0193 0.0772
Echinococcus granulosus serotonin receptor 0.0047 0.0356 0.057
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0063 0.0491 0.0787
Schistosoma mansoni biogenic amine receptor 0.0047 0.0356 0.0355
Schistosoma mansoni amine GPCR 0.0047 0.0356 0.0355
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0193 0.0772
Mycobacterium ulcerans hypothetical protein 0.001 0.003 0.0115
Trypanosoma brucei sugar transporter, putative 0.0029 0.0193 0.3384
Trypanosoma cruzi glycyl-tRNA synthetase, putative 0.0007 0.0001 0.0005
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0046 0.0342 0.5997
Trypanosoma brucei glucose transporter 2A 0.0064 0.0498 0.8747
Brugia malayi Sugar transporter family protein 0.0029 0.0193 0.0768
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0047 0.0356 0.0355
Loa Loa (eye worm) hypothetical protein 0.0047 0.0356 0.1417
Onchocerca volvulus 0.0047 0.0356 1
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0046 0.0342 0.6932
Brugia malayi hypothetical protein 0.0047 0.0356 0.1417
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0012 0.0042 0.0162
Brugia malayi hypothetical protein 0.0047 0.0356 0.1417
Onchocerca volvulus 0.0047 0.0356 1
Brugia malayi G-protein coupled receptor 0.0047 0.0356 0.1417
Schistosoma mansoni sugar transporter 0.0029 0.0193 0.0192
Echinococcus granulosus neuropeptides capa receptor 0.0047 0.0356 0.057
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0332 0.1323
Brugia malayi hypothetical protein 0.0047 0.0356 0.1417
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0025 0.0162 0.0642
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0063 0.0491 0.0648
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0356 0.0355
Echinococcus granulosus microtubule associated protein 2 0.0716 0.6223 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0047 0.0356 0.057
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0022 0.0082
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0047 0.0356 0.057
Echinococcus granulosus dnaJ subfamily B 0.0424 0.3665 0.5888
Trypanosoma brucei histidyl-tRNA synthetase 0.0007 0.0001 0.0005
Leishmania major lysyl-tRNA synthetase, putative 0.0046 0.0342 0.5997
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0022 0.0033
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0193 0.0772
Loa Loa (eye worm) hypothetical protein 0.0029 0.0193 0.0768
Loa Loa (eye worm) hypothetical protein 0.0029 0.0193 0.0768
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0193 0.0772
Echinococcus granulosus cpg binding protein 0.0032 0.0217 0.0347
Brugia malayi hypothetical protein 0.0047 0.0356 0.1417
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.004 0.0292 0.1168
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0072 0.0569 0.1132
Plasmodium falciparum calcium-dependent protein kinase 5 0.0063 0.0491 0.0648
Loa Loa (eye worm) hypothetical protein 0.0047 0.0356 0.1417
Echinococcus granulosus solute carrier family 22 0.0029 0.0193 0.0309
Echinococcus granulosus Threonyl tRNA synthetase C 0.0012 0.0042 0.0065
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0012 0.0042 0.0715
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0012 0.0042 0.0162
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0063 0.0491 0.0787
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0047 0.0356 0.1417
Loa Loa (eye worm) hypothetical protein 0.0047 0.0356 0.1417
Echinococcus granulosus neuropeptide Y receptor 0.0047 0.0356 0.057
Loa Loa (eye worm) hypothetical protein 0.0047 0.0356 0.1417
Mycobacterium ulcerans integral membrane transport protein 0.0029 0.0193 0.0768
Schistosoma mansoni cpg binding protein 0.0032 0.0217 0.0216
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0047 0.0356 0.057
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0332 0.0532
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0063 0.0491 0.0977
Treponema pallidum glycyl-tRNA synthetase 0.0007 0.0001 0.002
Schistosoma mansoni lysyl-tRNA synthetase 0.0046 0.0342 0.0341
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0012 0.0042 0.0162
Loa Loa (eye worm) hypothetical protein 0.0047 0.0356 0.1417
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0061 0.048 0.1912
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0193 0.0772
Loa Loa (eye worm) hypothetical protein 0.0047 0.0356 0.1417
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0495 0.0494
Plasmodium vivax glycine--tRNA ligase, putative 0.0012 0.0042 0.0054
Loa Loa (eye worm) sugar transporter 0.0029 0.0193 0.0768
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0356 0.0355
Schistosoma mansoni lysyl-tRNA synthetase 0.0046 0.0342 0.0341
Echinococcus granulosus calcium dependent protein kinase 0.0059 0.0457 0.0733
Loa Loa (eye worm) hypothetical protein 0.0047 0.0356 0.1417
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0193 0.0768
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0193 0.0772
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0356 0.057
Echinococcus granulosus g protein coupled receptor 0.0047 0.0356 0.057
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0047 0.0356 0.057
Trichomonas vaginalis glycyl-tRNA synthetase, putative 0.0007 0.0001 0.0006
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0006 0.0004
Schistosoma mansoni sugar transporter 0.0029 0.0193 0.0192
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0047 0.0356 0.0355
Onchocerca volvulus 0.0047 0.0356 1
Brugia malayi Dopamine receptor protein 2 0.0047 0.0356 0.1417
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0029 0.0193 0.3384
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0039 0.0281 1
Treponema pallidum threonyl-tRNA synthetase 0.0012 0.0042 0.3127
Plasmodium vivax proline--tRNA ligase, putative 0.0072 0.0569 0.0751
Schistosoma mansoni biogenic amine (5HT) receptor 0.0047 0.0356 0.0355
Giardia lamblia Prolyl-tRNA synthetase 0.0061 0.048 1
Trypanosoma brucei glucose transporter, putative 0.0064 0.0498 0.8747
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0047 0.0356 0.057
Onchocerca volvulus 0.0047 0.0356 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0356 0.1417
Echinococcus granulosus biogenic amine 5HT receptor 0.0047 0.0356 0.057
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0193 0.0772
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0047 0.0356 0.057
Trypanosoma brucei glucose transporter, putative 0.0064 0.0498 0.8747
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0061 0.048 0.1916
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0047 0.0356 1
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0012 0.0042 0.0715
Trichomonas vaginalis conserved hypothetical protein 0.001 0.003 0.012
Toxoplasma gondii lysine-tRNA ligase 0.0046 0.0342 0.0679
Toxoplasma gondii sugar transporter ST1 0.0029 0.0193 0.0383
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0193 0.0772
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0047 0.0356 0.0355
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0012 0.0042 0.0262
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0193 0.0772
Onchocerca volvulus 0.0047 0.0356 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0356 0.1417
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0356 0.0355
Brugia malayi G protein-coupled receptor F59B2.13 0.0047 0.0356 0.1417
Loa Loa (eye worm) hypothetical protein 0.0047 0.0356 0.1417
Echinococcus granulosus solute carrier family 22 0.0029 0.0193 0.0309
Plasmodium falciparum calcium-dependent protein kinase 4 0.0063 0.0491 0.0648
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0063 0.0491 0.0787
Loa Loa (eye worm) hypothetical protein 0.0029 0.0193 0.0768
Entamoeba histolytica protein kinase, putative 0.0063 0.0491 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0332 0.0331
Schistosoma mansoni opsin-like receptor 0.0047 0.0356 0.0355
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0063 0.0491 0.0977
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0039 0.0281 1
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.0193 0.0768
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0046 0.0342 0.1361
Brugia malayi neuropeptide F receptor 0.0047 0.0356 0.1417
Echinococcus multilocularis orexin receptor type 2 0.0047 0.0356 0.057
Schistosoma mansoni myosin xvIII 0.0047 0.0356 0.0355
Echinococcus multilocularis g-protein coupled receptor 0.0047 0.0356 0.057
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0193 0.0772
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0061 0.048 0.9773
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0063 0.0491 0.0787
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0012 0.0042 0.0715
Echinococcus multilocularis lysyl tRNA synthetase 0.0046 0.0342 0.0548
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0047 0.0356 0.057
Schistosoma mansoni neuropeptide F-like receptor 0.0047 0.0356 0.0355
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0205 0.1738 0.2791
Brugia malayi larval opioid receptor 0.0047 0.0356 0.1417
Schistosoma mansoni glutaminase 0.0292 0.2505 0.2504
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0012 0.0042 0.0715
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0063 0.0491 0.0787
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0047 0.0356 0.057
Echinococcus multilocularis neuropeptide receptor 0.0047 0.0356 0.057
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0039 0.0281 0.5587
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0047 0.0356 0.1417
Trichomonas vaginalis aspartyl/lysyl-tRNA synthetase, putative 0.0007 0.0001 0.0005
Chlamydia trachomatis threonine--tRNA ligase 0.0012 0.0042 0.1193
Echinococcus granulosus neuropeptide FF receptor 2 0.0047 0.0356 0.057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0332 0.0331
Schistosoma mansoni neuropeptide receptor 0.0047 0.0356 0.0355
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0061 0.048 1
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0021 0.0077
Loa Loa (eye worm) hypothetical protein 0.0047 0.0356 0.1417
Loa Loa (eye worm) glutaminase 0.0292 0.2505 1
Trypanosoma brucei glucose transporter, putative 0.0064 0.0498 0.8747
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0356 0.0355
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0012 0.0042 0.0065
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0063 0.0491 0.0977
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0193 0.0772
Echinococcus granulosus lysyl tRNA synthetase 0.0046 0.0342 0.0548
Plasmodium falciparum threonine--tRNA ligase 0.0012 0.0042 0.0054
Trypanosoma cruzi hexose transporter 0.0064 0.0498 0.8747
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0332 0.1323
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0047 0.0356 0.057
Plasmodium falciparum lysine--tRNA ligase 0.0046 0.0342 0.045
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0356 0.057
Mycobacterium ulcerans glutaminase 0.0292 0.2505 1
Entamoeba histolytica hypothetical protein 0.0046 0.0342 0.6955
Loa Loa (eye worm) hypothetical protein 0.0047 0.0356 0.1417
Brugia malayi major facilitator superfamily protein 0.0029 0.0193 0.0768
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0356 0.057
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0193 0.0772
Loa Loa (eye worm) neuropeptide F receptor 0.0047 0.0356 0.1417
Brugia malayi ORL1-like opioid receptor 0.0047 0.0356 0.1417
Trypanosoma cruzi hexose transporter, putative 0.0029 0.0193 0.3384
Loa Loa (eye worm) hypothetical protein 0.0012 0.0042 0.0162
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0047 0.0356 0.0355
Trichomonas vaginalis conserved hypothetical protein 0.0205 0.1738 0.6938
Loa Loa (eye worm) hypothetical protein 0.0047 0.0356 0.1417
Loa Loa (eye worm) hypothetical protein 0.0046 0.0342 0.1361
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0331 0.2845 0.3758
Giardia lamblia Glycyl-tRNA synthetase 0.0012 0.0042 0.0849
Schistosoma mansoni opsin-like receptor 0.0047 0.0356 0.0355
Onchocerca volvulus 0.0047 0.0356 1
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0029 0.0193 0.0254
Brugia malayi G protein-coupled receptor 0.0047 0.0356 0.1417
Brugia malayi Sugar transporter family protein 0.0029 0.0193 0.0768
Brugia malayi Melatonin receptor type 1A 0.0047 0.0356 0.1417
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0193 0.0772
Schistosoma mansoni hypothetical protein 0.0047 0.0356 0.0355
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0072 0.0569 1
Trypanosoma cruzi hexose transporter, putative 0.0064 0.0498 0.8747
Brugia malayi hypothetical protein 0.0047 0.0356 0.1417
Schistosoma mansoni hypothetical protein 0.0424 0.3665 0.3664
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0205 0.1738 0.2791
Brugia malayi hypothetical protein 0.0047 0.0356 0.1417
Treponema pallidum prolyl-tRNA synthetase 0.0022 0.0131 1
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0498 0.1989
Trypanosoma brucei glucose transporter, putative 0.0064 0.0498 0.8747
Brugia malayi G-protein coupled receptor 0.0047 0.0356 0.1417
Leishmania major myo-inositol/proton symporter (MIT) 0.0029 0.0193 0.3384
Schistosoma mansoni biogenic amine (5HT) receptor 0.0047 0.0356 0.0355
Echinococcus granulosus sex peptide receptor 0.0047 0.0356 0.057
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0356 0.057
Loa Loa (eye worm) hypothetical protein 0.0061 0.048 0.1912
Schistosoma mansoni neuropeptide f receptor 76f 0.0047 0.0356 0.0355
Plasmodium vivax calcium-dependent protein kinase, putative 0.0063 0.0491 0.0648
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0061 0.048 0.0769
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0047 0.0356 0.1417
Giardia lamblia Lysyl-tRNA synthetase 0.0046 0.0342 0.7117
Chlamydia trachomatis proline--tRNA ligase 0.0022 0.0131 0.3815
Echinococcus multilocularis G protein coupled receptor 139 0.0047 0.0356 0.057
Trypanosoma cruzi hexose transporter, putative 0.0035 0.0245 0.4299
Schistosoma mansoni sugar transporter 0.0029 0.0193 0.0192
Toxoplasma gondii sugar transporter ST2 0.0029 0.0193 0.0383
Loa Loa (eye worm) hypothetical protein 0.005 0.0379 0.1508
Loa Loa (eye worm) hypothetical protein 0.0029 0.0193 0.0768
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0006 0.0007
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0193 0.0772
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0332 0.0532
Trypanosoma brucei Aminoacyl-tRNA editing domain containing protein, putative 0.001 0.003 0.0508
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0063 0.0491 0.1957
Loa Loa (eye worm) hypothetical protein 0.0061 0.048 0.1912
Echinococcus multilocularis g protein coupled receptor 0.0047 0.0356 0.057
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0063 0.0491 0.8623
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.001 0.003 0.0508
Brugia malayi Sugar transporter family protein 0.0205 0.1738 0.6937
Brugia malayi hypothetical protein 0.0047 0.0356 0.1417
Loa Loa (eye worm) hypothetical protein 0.0047 0.0356 0.1417
Plasmodium falciparum calcium-dependent protein kinase 2 0.0063 0.0491 0.0648
Mycobacterium ulcerans sugar transporter 0.0029 0.0193 0.0768
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0047 0.0356 0.057
Schistosoma mansoni hypothetical protein 0.0205 0.1738 0.1737
Onchocerca volvulus 0.0047 0.0356 1
Echinococcus granulosus allatostatin A receptor 0.0047 0.0356 0.057
Brugia malayi AKH receptor 0.0047 0.0356 0.1417
Echinococcus granulosus 7tm_1 domain containing protein 0.0047 0.0356 0.057
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0332 0.0532
Echinococcus granulosus solute carrier family 22 0.0029 0.0193 0.0309
Toxoplasma gondii protein kinase, putative 0.0579 0.5019 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0356 0.1417
Leishmania major hypothetical protein, conserved 0.0029 0.0193 0.3384
Echinococcus granulosus neuropeptide s receptor 0.0047 0.0356 0.057
Brugia malayi glycyl-tRNA synthetase 0.0012 0.0042 0.0162
Schistosoma mansoni histamine h1 receptor 0.0047 0.0356 0.0355
Loa Loa (eye worm) hypothetical protein 0.0047 0.0356 0.1417
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0332 0.0331
Trichomonas vaginalis glucose transporter, putative 0.0064 0.0498 0.1989
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0063 0.0491 0.1957
Schistosoma mansoni serine/threonine protein kinase 0.0063 0.0491 0.049
Mycobacterium ulcerans histidyl-tRNA synthetase 0.0007 0.0001 0.0001
Brugia malayi neuropeptide F receptor 0.0047 0.0356 0.1417
Brugia malayi RE15519p 0.0047 0.0356 0.1417
Loa Loa (eye worm) hypothetical protein 0.0047 0.0356 0.1417
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0029 0.0193 0.0192
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0356 0.0355
Onchocerca volvulus 0.0047 0.0356 1
Loa Loa (eye worm) sugar transporter 0.0205 0.1738 0.6937
Onchocerca volvulus 0.0047 0.0356 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0356 0.1417
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0193 0.0772
Brugia malayi lysyl-tRNA synthetase 0.0046 0.0342 0.1361
Trichomonas vaginalis sugar transporter, putative 0.0064 0.0498 0.1989
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0193 0.0772
Onchocerca volvulus 0.0047 0.0356 1
Loa Loa (eye worm) G-protein coupled receptor 0.0047 0.0356 0.1417
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0331 0.2845 0.5668
Echinococcus granulosus tachykinin peptides receptor 99D 0.0047 0.0356 0.057
Wolbachia endosymbiont of Brugia malayi threonyl-tRNA synthetase 0.0012 0.0042 0.2114
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0063 0.0491 0.0787
Giardia lamblia Hexose transporter 0.0029 0.0193 0.4016
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0193 0.0772
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0046 0.0342 0.1361
Plasmodium vivax threonine--tRNA ligase, putative 0.0012 0.0042 0.0054
Loa Loa (eye worm) hypothetical protein 0.0047 0.0356 0.1417
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0047 0.0356 0.0355
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0047 0.0356 0.0355
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0193 0.0772
Schistosoma mansoni glucose transport protein 0.0205 0.1738 0.1737
Onchocerca volvulus 0.0047 0.0356 1
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0193 0.0772
Brugia malayi Dopamine receptor 0.0047 0.0356 0.1417
Onchocerca volvulus 0.0047 0.0356 1
Echinococcus granulosus synaptic vesicle 2 protein 0.0029 0.0193 0.0309
Trypanosoma cruzi glycyl-tRNA synthetase, putative 0.0007 0.0001 0.0005
Chlamydia trachomatis lysine--tRNA ligase 0.0046 0.0342 1
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0063 0.0491 0.0648
Brugia malayi hypothetical protein 0.0047 0.0356 0.1417
Loa Loa (eye worm) hypothetical protein 0.0029 0.0193 0.0768
Schistosoma mansoni glycyl-tRNA synthetase 0.0012 0.0042 0.0041
Leishmania major glycyl tRNA synthetase, putative 0.0007 0.0001 0.0005
Schistosoma mansoni biogenic amine receptor 0.0047 0.0356 0.0355
Entamoeba histolytica protein kinase, putative 0.0063 0.0491 1
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0072 0.0569 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0047 0.0356 0.1417
Loa Loa (eye worm) glutaminase 2 0.0292 0.2505 1
Echinococcus granulosus dro:myosuppressin receptor 0.0047 0.0356 0.057
Schistosoma mansoni hypothetical protein 0.0047 0.0356 0.0355
Echinococcus multilocularis solute carrier family 22 0.0029 0.0193 0.0309
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0193 0.0772
Onchocerca volvulus 0.0047 0.0356 1
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0029 0.0193 0.0768
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0012 0.0042 0.0162
Loa Loa (eye worm) hypothetical protein 0.0029 0.0193 0.0768
Echinococcus multilocularis General substrate transporter 0.0176 0.1485 0.2385
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0047 0.0356 0.057
Loa Loa (eye worm) hypothetical protein 0.0029 0.0193 0.0768
Loa Loa (eye worm) G-protein coupled receptor 0.0047 0.0356 0.1417
Echinococcus multilocularis microtubule associated protein 2 0.0716 0.6223 1
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0193 0.0772
Loa Loa (eye worm) hypothetical protein 0.0029 0.0193 0.0768
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0047 0.0356 0.0355
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0356 0.0355
Echinococcus granulosus somatostatin receptor 0.0047 0.0356 0.057
Loa Loa (eye worm) hypothetical protein 0.0047 0.0356 0.1417
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0193 0.0772
Giardia lamblia Threonyl-tRNA synthetase 0.0012 0.0042 0.0849
Echinococcus granulosus neuropeptide Y receptor 0.0047 0.0356 0.057
Loa Loa (eye worm) hypothetical protein 0.0029 0.0193 0.0768
Echinococcus multilocularis calcium dependent protein kinase 0.0059 0.0457 0.0733
Schistosoma mansoni cpg binding protein 0.003 0.0202 0.0201
Leishmania major hypothetical protein, conserved 0.001 0.003 0.0508
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0205 0.1738 0.2791
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0356 0.057
Onchocerca volvulus 0.0047 0.0356 1
Echinococcus granulosus g protein coupled receptor 0.0047 0.0356 0.057
Plasmodium vivax hexose transporter 0.0205 0.1738 0.2295
Leishmania major glucose transporter, lmgt2 0.0064 0.0498 0.8747
Loa Loa (eye worm) hypothetical protein 0.0047 0.0356 0.1417
Toxoplasma gondii YbaK/proline-tRNA ligase associated domain-containing protein 0.001 0.003 0.0058
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0205 0.1738 0.2791
Echinococcus granulosus alpha 1A adrenergic receptor 0.0047 0.0356 0.057
Loa Loa (eye worm) hypothetical protein 0.0029 0.0193 0.0768
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0047 0.0356 0.0355
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.0012 0.0042 0.083
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0356 0.057
Echinococcus multilocularis neuropeptide s receptor 0.0047 0.0356 0.057
Trypanosoma cruzi histidyl-tRNA synthetase 0.0007 0.0001 0.0005
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0193 0.0772
Echinococcus multilocularis neuropeptide receptor A26 0.0047 0.0356 0.057
Plasmodium vivax sugar transporter, putative 0.0029 0.0193 0.0254
Loa Loa (eye worm) hypothetical protein 0.0047 0.0356 0.1417
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0063 0.0491 0.0787
Brugia malayi Serotonin receptor 0.0047 0.0356 0.1417
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0356 0.057
Echinococcus multilocularis fmrfamide receptor 0.0047 0.0356 0.057
Trypanosoma cruzi hexose transporter, putative 0.0064 0.0498 0.8747
Echinococcus granulosus neuropeptide receptor A26 0.0047 0.0356 0.057
Echinococcus multilocularis allatostatin A receptor 0.0047 0.0356 0.057
Brugia malayi glutaminase DH11.1 0.0292 0.2505 1
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0193 0.0772
Brugia malayi Cam kinase protein 1 0.0063 0.0491 0.1957
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.003 0.0508
Echinococcus granulosus neuropeptide receptor 0.0047 0.0356 0.057
Brugia malayi hypothetical protein 0.0047 0.0356 0.1417
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0046 0.0342 0.5997
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0193 0.0772
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0193 0.0772
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0047 0.0356 0.057
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0356 0.057
Echinococcus granulosus solute carrier family 22 0.0029 0.0193 0.0309
Schistosoma mansoni neuropeptide receptor 0.0047 0.0356 0.0355
Echinococcus multilocularis solute carrier family 22 0.0029 0.0193 0.0309
Schistosoma mansoni protein kinase 0.0063 0.0491 0.049
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0332 0.0532
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0193 0.0772
Brugia malayi major facilitator superfamily protein 0.0029 0.0193 0.0768
Brugia malayi putative neuropeptide receptor 0.0047 0.0356 0.1417
Schistosoma mansoni amine GPCR 0.0047 0.0356 0.0355
Leishmania major histidyl-tRNA synthetase, putative 0.0007 0.0001 0.0005
Onchocerca volvulus Neuropeptide F receptor homolog 0.0047 0.0356 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0356 0.1417
Loa Loa (eye worm) hypothetical protein 0.0029 0.0193 0.0768
Schistosoma mansoni hypothetical protein 0.0047 0.0356 0.0355
Loa Loa (eye worm) histidyl-tRNA synthetase 0.0007 0.0001 0.0001
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0047 0.0356 0.1417
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0047 0.0356 0.057
Trichomonas vaginalis myo-inositol transporter, putative 0.0029 0.0193 0.0772
Leishmania major threonyl-tRNA synthetase, putative 0.0012 0.0042 0.0715
Schistosoma mansoni sugar transporter 0.0029 0.0193 0.0192
Trichomonas vaginalis sugar transporter, putative 0.0064 0.0498 0.1989
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0047 0.0356 0.057
Loa Loa (eye worm) TYRA-2 protein 0.0047 0.0356 0.1417
Trichomonas vaginalis sugar transporter, putative 0.0064 0.0498 0.1989
Echinococcus multilocularis g protein coupled receptor 0.0047 0.0356 0.057
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0029 0.0193 0.0768
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0193 0.0772
Echinococcus multilocularis somatostatin receptor 0.0047 0.0356 0.057
Echinococcus granulosus g protein coupled receptor 0.0047 0.0356 0.057
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0205 0.1738 0.2791
Trypanosoma brucei THT1 - hexose transporter, putative 0.0064 0.0498 0.8747
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0193 0.0768
Trichomonas vaginalis CAMK family protein kinase 0.0063 0.0491 0.1961
Loa Loa (eye worm) hypothetical protein 0.0047 0.0356 0.1417
Echinococcus granulosus tm gpcr rhodopsin 0.0047 0.0356 0.057
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0356 0.057
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0047 0.0356 0.0355
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0047 0.0356 0.057
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0061 0.048 0.0479
Leishmania major glucose transporter/membrane transporter D2, putative 0.0064 0.0498 0.8747
Plasmodium falciparum proline--tRNA ligase 0.0072 0.0569 0.0751
Echinococcus multilocularis g protein coupled receptor 0.0047 0.0356 0.057
Schistosoma mansoni alpha-1 adrenergic receptor 0.0047 0.0356 0.0355
Loa Loa (eye worm) hypothetical protein 0.0047 0.0356 0.1417
Loa Loa (eye worm) hypothetical protein 0.0047 0.0356 0.1417
Plasmodium falciparum hexose transporter 0.0205 0.1738 0.2295
Entamoeba histolytica histidyl-tRNA synthetase, putative 0.0007 0.0001 0.0005
Loa Loa (eye worm) hypothetical protein 0.0029 0.0193 0.0768
Echinococcus granulosus peptide allatostatin:somatostatin 0.0047 0.0356 0.057
Brugia malayi GnHR receptor homolog 0.0047 0.0356 0.1417
Echinococcus granulosus Sugar transporter ERD6 protein 0.0029 0.0193 0.0309
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0436 0.0867
Brugia malayi Dopamine receptor protein 1 0.0047 0.0356 0.1417
Trypanosoma brucei THT1 - hexose transporter, putative 0.0064 0.0498 0.8747
Schistosoma mansoni glucose transport protein 0.0205 0.1738 0.1737
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0193 0.0768
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0061 0.048 0.0479
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0022 0.0033
Brugia malayi hypothetical protein 0.0029 0.0193 0.0768
Schistosoma mansoni neuropeptide receptor 0.0047 0.0356 0.0355
Echinococcus granulosus g-protein coupled receptor 0.0047 0.0356 0.057
Plasmodium falciparum calcium-dependent protein kinase 3 0.0063 0.0491 0.0648
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0012 0.0042 0.0162
Schistosoma mansoni protein kinase 0.0063 0.0491 0.049
Schistosoma mansoni opsin-like receptor 0.0047 0.0356 0.0355
Trypanosoma brucei THT1 - hexose transporter, putative 0.0064 0.0498 0.8747
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0205 0.1738 0.2791
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0047 0.0356 0.0355
Trichomonas vaginalis conserved hypothetical protein 0.001 0.003 0.012
Plasmodium falciparum calcium-dependent protein kinase 1 0.0063 0.0491 0.0648
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0205 0.1738 0.2791
Loa Loa (eye worm) hypothetical protein 0.0047 0.0356 0.1417
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0193 0.0772
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0047 0.0356 0.057
Echinococcus granulosus neuropeptides capa receptor 0.0047 0.0356 0.057
Onchocerca volvulus 0.003 0.0202 0.0539
Loa Loa (eye worm) hypothetical protein 0.0047 0.0356 0.1417
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0047 0.0356 0.1417
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0047 0.0356 0.057
Brugia malayi follicle stimulating hormone receptor 0.0047 0.0356 0.1417
Toxoplasma gondii anticodon binding domain-containing protein 0.0007 0.0001 0.0001
Echinococcus granulosus glycyl tRNA synthetase 0.0012 0.0042 0.0065
Schistosoma mansoni amine GPCR 0.0047 0.0356 0.0355
Schistosoma mansoni neuropeptide F-like receptor 0.0047 0.0356 0.0355
Echinococcus granulosus rhodopsin orphan GPCR 0.0047 0.0356 0.057
Trypanosoma brucei glucose transporter, putative 0.0064 0.0498 0.8747
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0061 0.048 0.0769
Brugia malayi Serotonin receptor 0.0047 0.0356 0.1417
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0047 0.0356 0.0355
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0193 0.0772
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0047 0.0356 0.0355
Plasmodium falciparum protein kinase 7 0.0579 0.5019 0.663
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0072 0.0569 1
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0193 0.0772
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0047 0.0356 0.1417
Echinococcus multilocularis neuropeptide Y receptor 0.0047 0.0356 0.057
Loa Loa (eye worm) hypothetical protein 0.0029 0.0193 0.0768
Schistosoma mansoni protein kinase 0.0063 0.0491 0.049
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.0193 0.0768
Echinococcus granulosus biogenic amine 5HT receptor 0.0047 0.0356 0.057
Loa Loa (eye worm) hypothetical protein 0.0047 0.0356 0.1417
Trypanosoma brucei glucose transporter, putative 0.0064 0.0498 0.8747
Schistosoma mansoni cpg binding protein 0.0032 0.0217 0.0216
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0012 0.0042 0.0162
Brugia malayi hypothetical protein 0.0029 0.0193 0.0768
Toxoplasma gondii sugar transporter ST3 0.0029 0.0193 0.0383
Echinococcus granulosus G protein coupled receptor 139 0.0047 0.0356 0.057
Loa Loa (eye worm) hypothetical protein 0.0029 0.0193 0.0768
Toxoplasma gondii transporter, major facilitator family protein 0.0029 0.0193 0.0383
Schistosoma mansoni glucose transporter 0.0029 0.0193 0.0192
Wolbachia endosymbiont of Brugia malayi prolyl-tRNA synthetase 0.0012 0.0042 0.2114
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0193 0.0772
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0047 0.0356 0.057
Leishmania major glucose transporter, lmgt1 0.0064 0.0498 0.8747
Loa Loa (eye worm) hypothetical protein 0.0047 0.0356 0.1417
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0047 0.0356 0.057
Schistosoma mansoni growth hormone secretagogue receptor 0.0047 0.0356 0.0355
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0193 0.0772
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0012 0.0042 0.0468
Echinococcus granulosus tm gpcr rhodopsin 0.0047 0.0356 0.057
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0006 0.0007
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0063 0.0491 0.0787
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0193 0.0772
Leishmania major glucose transporter, lmgt3 0.0064 0.0498 0.8747
Onchocerca volvulus 0.0047 0.0356 1
Brugia malayi hypothetical protein 0.0047 0.0356 0.1417
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0498 0.1989
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0072 0.0569 1
Trypanosoma cruzi sugar transporter, putative 0.0029 0.0193 0.3384
Plasmodium vivax CDK-related protein kinase 6, putative 0.087 0.7569 1
Echinococcus multilocularis dnaJ subfamily B 0.0424 0.3665 0.5888
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0072 0.0569 1
Echinococcus multilocularis fmrfamide receptor 0.0047 0.0356 0.057
Schistosoma mansoni neuropeptide receptor 0.0047 0.0356 0.0355
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0047 0.0356 0.057
Echinococcus multilocularis rhodopsin orphan GPCR 0.0047 0.0356 0.057
Toxoplasma gondii facilitative glucose transporter GT1 0.0205 0.1738 0.3462

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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