TDR Targets

Basic information

Technical information

TDR Targets ID: 763633
Name: 2-(4,5-dimethyl-1,3-thiazol-2-yl)-1-(4-ethoxy -3-methoxyphenyl)-1H-chromeno[2,3-c]pyrrole-3 ,9-dione
MW: 462.518 | Formula: C25H22N2O5S
H donors: 0 H acceptors: 3 LogP: 4.52 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1ccc(cc1OC)C1N(c2sc(c(n2)C)C)C(=O)c2c1c(=O)c1c(o2)cccc1
InChi: 1S/C25H22N2O5S/c1-5-31-18-11-10-15(12-19(18)30-4)21-20-22(28)16-8-6-7-9-17(16)32-23(20)24(29)27(21)25-26-13(2)14(3)33-25/h6-12,21H,5H2,1-4H3
InChiKey: BHCAMGMZNAGQIR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-(4,5-dimethylthiazol-2-yl)-1-(4-ethoxy-3-methoxy-phenyl)-1H-chromeno[2,3-c]pyrrole-3,9-dione
2-(4,5-dimethyl-2-thiazolyl)-1-(4-ethoxy-3-methoxyphenyl)-1H-chromeno[2,3-c]pyrrole-3,9-dione
2-(4,5-dimethylthiazol-2-yl)-1-(4-ethoxy-3-methoxy-phenyl)-1H-chromeno[2,3-c]pyrrole-3,9-quinone
2-(4,5-dimethyl-1,3-thiazol-2-yl)-1-(4-ethoxy-3-methoxy-phenyl)-1H-chromeno[2,3-c]pyrrole-3,9-dione
STOCK3S-79700

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	hypothetical protein	0.0182	0.1185	0.5164
Mycobacterium tuberculosis	Probable esterase LipL	0.0039	0.019	0.0946
Brugia malayi	hypothetical protein	0.0048	0.0254	0.1058
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0038	0.0165
Echinococcus granulosus	Threonyl tRNA synthetase C	0.0019	0.0053	0.0157
Schistosoma mansoni	protein kinase	0.0105	0.0647	0.2819
Onchocerca volvulus		0.0048	0.0254	1
Loa Loa (eye worm)	threonyl-tRNA synthetase	0.0019	0.0053	0.0233
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0048	0.0254	0.5639
Leishmania major	lysyl-tRNA synthetase, putative	0.0076	0.045	0.5996
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.012	0.075	1
Brugia malayi	beta-lactamase family protein	0.0039	0.019	0.078
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.012	0.075	1
Trichomonas vaginalis	glucose transporter, putative	0.0106	0.0656	0.286
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0036	0.0171	0.3811
Loa Loa (eye worm)	hypothetical protein	0.0076	0.045	0.196
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0076	0.045	1
Wolbachia endosymbiont of Brugia malayi	prolyl-tRNA synthetase	0.0019	0.0053	0.2103
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0105	0.0647	0.1907
Onchocerca volvulus	Putative transporter	0.0048	0.0254	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0239	0.0705
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0019	0.0054	0.0718
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0239	0.0705
Mycobacterium leprae	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase)	0.0019	0.0053	0.0262
Trichomonas vaginalis	myo-inositol transporter, putative	0.0048	0.0254	0.1106
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0239	0.1043
Plasmodium falciparum	threonine--tRNA ligase	0.0019	0.0053	0.0053
Brugia malayi	Sugar transporter family protein	0.0342	0.2295	1
Trypanosoma brucei	glucose transporter, putative	0.0106	0.0656	0.8747
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0105	0.0647	0.0647
Plasmodium vivax	proline--tRNA ligase, putative	0.012	0.075	0.075
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0553	0.3758	0.5667
Leishmania major	threonyl-tRNA synthetase, putative	0.0019	0.0053	0.0711
Onchocerca volvulus		0.0048	0.0254	1
Schistosoma mansoni	glycyl-tRNA synthetase	0.0019	0.0053	0.0233
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0105	0.0647	0.0976
Brugia malayi	Major Facilitator Superfamily protein	0.0048	0.0254	0.1058
Plasmodium vivax	lysine--tRNA ligase, putative	0.0076	0.045	0.045
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0105	0.0647	0.2819
Brugia malayi	threonyl-tRNA synthetase, cytoplasmic	0.0019	0.0053	0.0181
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Brugia malayi	Sugar transporter family protein	0.0048	0.0254	0.1058
Treponema pallidum	threonyl-tRNA synthetase	0.0019	0.0053	0.3113
Toxoplasma gondii	threonyl-tRNA synthetase family protein	0.0019	0.0053	0.008
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.019	0.0829
Entamoeba histolytica	protein kinase, putative	0.0105	0.0647	1
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0054	0.0054
Plasmodium falciparum	protein kinase 7	0.0967	0.663	0.663
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0054	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0254	0.1106
Plasmodium vivax	sugar transporter, putative	0.0048	0.0254	0.0254
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.012	0.075	1
Echinococcus granulosus	neuropeptide s receptor	0.05	0.3393	1
Onchocerca volvulus		0.0048	0.0254	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0342	0.2295	0.6764
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.019	0.0829
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Echinococcus multilocularis	solute carrier family 22	0.0048	0.0254	0.0748
Brugia malayi	Major Facilitator Superfamily protein	0.0048	0.0254	0.1058
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0105	0.0647	0.1907
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0039	0.019	0.0946
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0553	0.3758	0.3758
Echinococcus multilocularis	General substrate transporter	0.0294	0.1961	0.578
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0105	0.0647	0.0976
Onchocerca volvulus		0.0048	0.0254	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0013	0.0012	0.0053
Plasmodium vivax	hypothetical protein, conserved	0.0039	0.019	0.019
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0019	0.0053	0.0711
Plasmodium falciparum	hexose transporter	0.0342	0.2295	0.2295
Schistosoma mansoni	ap endonuclease	0.0019	0.0054	0.0235
Echinococcus multilocularis	solute carrier family 22	0.0048	0.0254	0.0748
Onchocerca volvulus		0.0048	0.0254	1
Loa Loa (eye worm)	glycyl-tRNA synthetase	0.0019	0.0053	0.0233
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0053	0.0233
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0254	0.1106
Echinococcus granulosus	lysyl tRNA synthetase	0.0076	0.045	0.1326
Trypanosoma brucei	Aminoacyl-tRNA editing domain containing protein, putative	0.0017	0.0038	0.0504
Mycobacterium ulcerans	beta-lactamase	0.0039	0.019	0.4227
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0076	0.045	0.5996
Trypanosoma cruzi	hexose transporter, putative	0.0106	0.0656	0.8747
Echinococcus multilocularis	lysyl tRNA synthetase	0.0076	0.045	0.1326
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0254	0.1106
Mycobacterium ulcerans	integral membrane transport protein	0.0048	0.0254	0.5639
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Brugia malayi	beta-lactamase	0.0039	0.019	0.078
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0038	0.0165
Entamoeba histolytica	protein kinase, putative	0.0105	0.0647	1
Giardia lamblia	Prolyl-tRNA synthetase	0.0103	0.0632	1
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0103	0.0632	0.9772
Echinococcus multilocularis	solute carrier family 22	0.0048	0.0254	0.0748
Trypanosoma brucei	glycyl-tRNA synthetase, putative	0.0019	0.0053	0.0711
Brugia malayi	hypothetical protein	0.0048	0.0254	0.1058
Trichomonas vaginalis	esterase, putative	0.0039	0.019	0.0829
Mycobacterium tuberculosis	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase)	0.0019	0.0053	0.0097
Toxoplasma gondii	exonuclease III APE	0.0019	0.0054	0.0081
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0067	0.0385	0.1676
Trypanosoma brucei	cytochrome P450, putative	0.0013	0.0012	0.0162
Trypanosoma brucei	glucose transporter, putative	0.0106	0.0656	0.8747
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0106	0.0656	0.8747
Trichomonas vaginalis	conserved hypothetical protein	0.0048	0.0254	0.1106
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0039	0.019	0.0829
Onchocerca volvulus		0.0048	0.0254	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.019	0.0829
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.0054	0.2124
Trichomonas vaginalis	glucose transporter, putative	0.0106	0.0656	0.286
Trichomonas vaginalis	conserved hypothetical protein	0.0048	0.0254	0.1106
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0254	0.1106
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0076	0.045	0.6932
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0342	0.2295	0.6764
Trypanosoma cruzi	sugar transporter, putative	0.0048	0.0254	0.3381
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0239	0.1043
Onchocerca volvulus		0.0048	0.0254	1
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0105	0.0647	0.1907
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0054	0.0718
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0254	0.1106
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0105	0.0647	0.1907
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0342	0.2295	0.6764
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.019	0.0829
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0105	0.0647	0.0647
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0105	0.0647	0.0647
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0103	0.0632	0.2755
Onchocerca volvulus		0.0048	0.0254	1
Mycobacterium tuberculosis	Conserved protein	0.0039	0.019	0.0946
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Schistosoma mansoni	protein kinase	0.0105	0.0647	0.2819
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0342	0.2295	0.6764
Mycobacterium tuberculosis	Probable lipase LipE	0.0039	0.019	0.0946
Trichomonas vaginalis	glucose transporter, putative	0.0048	0.0254	0.1106
Trypanosoma brucei	hypothetical protein, conserved	0.0039	0.019	0.2534
Brugia malayi	Major Facilitator Superfamily protein	0.0048	0.0254	0.1058
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0105	0.0647	0.0647
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.019	0.0829
Toxoplasma gondii	ABC1 family protein	0.0039	0.019	0.0287
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Trypanosoma brucei	glucose transporter, putative	0.0106	0.0656	0.8747
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0054	0.0159
Trypanosoma cruzi	hexose transporter, putative	0.0048	0.0254	0.3381
Leishmania major	cytochrome p450-like protein	0.0013	0.0012	0.0162
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0239	0.0705
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0105	0.0647	0.1907
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0105	0.0647	0.0976
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0054	0.0718
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0553	0.3758	0.3758
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0254	0.1106
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0054	0.0054
Trypanosoma cruzi	hexose transporter, putative	0.0058	0.0322	0.4296
Toxoplasma gondii	glycyl-tRNA synthetase	0.0019	0.0053	0.008
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0254	0.1106
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0054	0.0235
Plasmodium vivax	glycine--tRNA ligase, putative	0.0019	0.0053	0.0053
Echinococcus granulosus	synaptic vesicle 2 protein	0.0048	0.0254	0.0748
Trypanosoma cruzi	cytochrome P450, putative	0.0013	0.0012	0.0162
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0048	0.0254	0.0748
Mycobacterium ulcerans	esterase/lipase LipP	0.0039	0.019	0.4227
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Leishmania major	hypothetical protein, conserved	0.0017	0.0038	0.0504
Schistosoma mansoni	lysyl-tRNA synthetase	0.0076	0.045	0.196
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0103	0.0632	0.2717
Plasmodium vivax	hexose transporter	0.0342	0.2295	0.2295
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0054	0.0235
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.0054	0.0718
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0254	0.1106
Onchocerca volvulus		0.0048	0.0254	1
Giardia lamblia	Hexose transporter	0.0048	0.0254	0.346
Trypanosoma brucei	threonyl-tRNA synthetase, putative	0.0019	0.0053	0.0711
Echinococcus granulosus	solute carrier family 22	0.0048	0.0254	0.0748
Schistosoma mansoni	sugar transporter	0.0048	0.0254	0.1106
Onchocerca volvulus		0.0048	0.0254	1
Toxoplasma gondii	YbaK/proline-tRNA ligase associated domain-containing protein	0.0017	0.0038	0.0057
Trichomonas vaginalis	sugar transporter, putative	0.0106	0.0656	0.286
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0342	0.2295	0.6764
Echinococcus granulosus	solute carrier family 22	0.0048	0.0254	0.0748
Schistosoma mansoni	glucose transport protein	0.0342	0.2295	1
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0048	0.0254	0.0748
Loa Loa (eye worm)	hypothetical protein	0.0039	0.019	0.0829
Onchocerca volvulus		0.0048	0.0254	1
Plasmodium vivax	CDK-related protein kinase 6, putative	0.1452	1	1
Trypanosoma cruzi	Aminoacyl-tRNA editing domain containing protein, putative	0.0017	0.0038	0.0504
Onchocerca volvulus		0.0048	0.0254	1
Echinococcus granulosus	General substrate transporter	0.0294	0.1961	0.578
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0254	0.1106
Trypanosoma cruzi	glucose transporter, putative	0.0048	0.0254	0.3381
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0065	0.037	0.2064
Brugia malayi	glycyl-tRNA synthetase	0.0019	0.0053	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0039	0.019	0.0829
Echinococcus granulosus	geminin	0.0182	0.1185	0.3493
Echinococcus granulosus	glycyl tRNA synthetase	0.0019	0.0053	0.0157
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Trichomonas vaginalis	CAMK family protein kinase	0.0105	0.0647	0.2819
Echinococcus multilocularis	glycyl tRNA synthetase	0.0019	0.0053	0.0157
Schistosoma mansoni	ap endonuclease	0.0019	0.0054	0.0235
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0105	0.0647	0.1907
Loa Loa (eye worm)	CYP4Cod1	0.0013	0.0012	0.0053
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.019	0.0829
Leishmania major	glucose transporter, lmgt2	0.0106	0.0656	0.8747
Mycobacterium ulcerans	glycyl-tRNA synthetase	0.0019	0.0053	0.1186
Toxoplasma gondii	facilitative glucose transporter GT1	0.0342	0.2295	0.3461
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0105	0.0647	0.8623
Schistosoma mansoni	protein kinase	0.0105	0.0647	0.2819
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.0054	0.01
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0632	0.2755
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0039	0.019	0.0946
Trichomonas vaginalis	sugar transporter, putative	0.0106	0.0656	0.286
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0249	0.1647	1
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0103	0.0632	0.2755
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0105	0.0647	0.0647
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0105	0.0647	0.0647
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0042	0.0212	0.0925
Brugia malayi	major facilitator superfamily protein	0.0048	0.0254	0.1058
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.0054	0.3143
Entamoeba histolytica	threonyl-tRNA synthetase, putative	0.0019	0.0053	0.0825
Leishmania major	protein kinase, putative	0.0105	0.0647	0.8623
Echinococcus multilocularis	neuropeptide receptor A26	0.05	0.3393	1
Leishmania major	glucose transporter, lmgt1	0.0106	0.0656	0.8747
Onchocerca volvulus		0.0048	0.0254	1
Trypanosoma brucei	glucose transporter, putative	0.0106	0.0656	0.8747
Echinococcus granulosus	calcium dependent protein kinase	0.0098	0.0602	0.1774
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.019	0.2534
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0039	0.019	0.4227
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0039	0.019	0.0946
Mycobacterium leprae	conserved hypothetical protein	0.0039	0.019	0.2563
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0342	0.2295	0.6764
Echinococcus granulosus	beta LACTamase domain containing family member	0.0039	0.019	0.056
Schistosoma mansoni	glucose transport protein	0.0342	0.2295	1
Echinococcus granulosus	solute carrier family 22	0.0048	0.0254	0.0748
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0054	0.0235
Toxoplasma gondii	sugar transporter ST3	0.0048	0.0254	0.0383
Onchocerca volvulus		0.0048	0.0254	1
Chlamydia trachomatis	threonine--tRNA ligase	0.0019	0.0053	0.1186
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0054	0.0159
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0076	0.045	0.5996
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0103	0.0632	0.1864
Schistosoma mansoni	lysyl-tRNA synthetase	0.0076	0.045	0.196
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0254	0.1106
Leishmania major	glucose transporter, lmgt3	0.0106	0.0656	0.8747
Brugia malayi	Sugar transporter family protein	0.0048	0.0254	0.1058
Leishmania major	hypothetical protein, conserved	0.0017	0.0038	0.0504
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0065	0.037	0.5587
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0342	0.2295	0.6764
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0013	0.0012	0.027
Trichomonas vaginalis	sugar transport protein, putative	0.0048	0.0254	0.1106
Leishmania major	hypothetical protein, conserved	0.0048	0.0254	0.3381
Trypanosoma cruzi	hypothetical protein, conserved	0.0017	0.0038	0.0504
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0105	0.0647	0.2781
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0106	0.0656	0.8747
Trichomonas vaginalis	threonyl-tRNA synthetase, putative	0.0019	0.0053	0.0233
Loa Loa (eye worm)	hypothetical protein	0.0039	0.019	0.0829
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0647	0.2819
Schistosoma mansoni	glucose transport protein	0.0342	0.2295	1
Trypanosoma cruzi	hexose transporter, putative	0.0106	0.0656	0.8747
Echinococcus multilocularis	calcium dependent protein kinase	0.0098	0.0602	0.1774
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Schistosoma mansoni	sugar transporter	0.0048	0.0254	0.1106
Brugia malayi	hypothetical protein	0.0048	0.0254	0.1058
Onchocerca volvulus		0.0048	0.0254	1
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Mycobacterium leprae	Probable lipase LipE	0.0039	0.019	0.2563
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0105	0.0647	0.2819
Loa Loa (eye worm)	beta-lactamase	0.0039	0.019	0.0829
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Echinococcus multilocularis	solute carrier family 22	0.0048	0.0254	0.0748
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.012	0.075	1
Trypanosoma brucei	glucose transporter 2A	0.0106	0.0656	0.8747
Mycobacterium tuberculosis	Probable hydrolase	0.0039	0.019	0.0946
Plasmodium falciparum	proline--tRNA ligase	0.012	0.075	0.075
Echinococcus multilocularis	neuropeptide s receptor	0.05	0.3393	1
Loa Loa (eye worm)	sugar transporter	0.0342	0.2295	1
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0019	0.0054	0.0833
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0019	0.0054	0.0009
Trichomonas vaginalis	sugar transporter, putative	0.0106	0.0656	0.286
Brugia malayi	probable proline-trna synthetase - fission yeast, putative	0.0019	0.0053	0.0181
Trypanosoma brucei	glucose transporter 1E	0.0106	0.0656	0.8747
Toxoplasma gondii	protein kinase, putative	0.0967	0.663	1
Echinococcus granulosus	neuropeptide receptor A26	0.05	0.3393	1
Trypanosoma cruzi	hexose transporter	0.0106	0.0656	0.8747
Mycobacterium ulcerans	sugar transporter	0.0048	0.0254	0.5639
Plasmodium vivax	threonine--tRNA ligase, putative	0.0019	0.0053	0.0053
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0048	0.0254	0.0254
Trichomonas vaginalis	conserved hypothetical protein	0.0342	0.2295	1
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0103	0.0632	0.2755
Trichomonas vaginalis	conserved hypothetical protein	0.0106	0.0656	0.286
Entamoeba histolytica	glycyl-tRNA synthetase, putative	0.0019	0.0053	0.0825
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0048	0.0254	0.1106
Loa Loa (eye worm)	cytochrome P450 family protein	0.0013	0.0012	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0254	0.1106
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0239	0.0705
Plasmodium falciparum	lysine--tRNA ligase	0.0076	0.045	0.045
Mycobacterium ulcerans	threonyl-tRNA synthetase	0.0019	0.0053	0.1186
Echinococcus multilocularis	geminin	0.0182	0.1185	0.3493
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.019	0.0829
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0048	0.0254	1
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Trichomonas vaginalis	conserved hypothetical protein	0.0048	0.0254	0.1106
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0254	0.1106
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0048	0.0254	0.1341
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0254	0.1106
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0105	0.0647	0.0647
Brugia malayi	beta-lactamase family protein	0.0039	0.019	0.078
Trypanosoma cruzi	cytochrome P450, putative	0.0013	0.0012	0.0162
Mycobacterium ulcerans	hypothetical protein	0.0039	0.019	0.4227
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0105	0.0647	0.1907
Schistosoma mansoni	hypothetical protein	0.0342	0.2295	1
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0105	0.0647	0.0647
Leishmania major	myo-inositol/proton symporter (MIT)	0.0048	0.0254	0.3381
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Trypanosoma cruzi	hexose transporter, putative	0.0106	0.0656	0.8747
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Leishmania major	hypothetical protein, conserved	0.0039	0.019	0.2534
Chlamydia trachomatis	proline--tRNA ligase	0.0036	0.0171	0.3811
Onchocerca volvulus		0.0048	0.0254	1
Trichomonas vaginalis	conserved hypothetical protein	0.0048	0.0254	0.1106
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0106	0.0656	0.8747
Toxoplasma gondii	transporter, major facilitator family protein	0.0048	0.0254	0.0383
Brugia malayi	Cam kinase protein 1	0.0105	0.0647	0.2781
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0038	0.0165
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0048	0.0254	0.5639
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0254	0.1106
Chlamydia trachomatis	lysine--tRNA ligase	0.0076	0.045	1
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0076	0.045	1
Wolbachia endosymbiont of Brugia malayi	threonyl-tRNA synthetase	0.0019	0.0053	0.2103
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.019	0.0829
Trypanosoma cruzi	Aminoacyl-tRNA editing domain containing protein, putative	0.0017	0.0038	0.0504
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0105	0.0647	0.0647
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0048	0.0254	0.1106
Toxoplasma gondii	sugar transporter ST1	0.0048	0.0254	0.0383
Mycobacterium tuberculosis	Probable lipase LipD	0.0039	0.019	0.0946
Toxoplasma gondii	lysine-tRNA ligase	0.0076	0.045	0.0679
Mycobacterium tuberculosis	Conserved protein	0.0039	0.019	0.0946
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0103	0.0632	0.1864
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0065	0.037	0.2064
Trypanosoma cruzi	hypothetical protein, conserved	0.0017	0.0038	0.0504
Mycobacterium tuberculosis	Conserved protein	0.0039	0.019	0.0946
Loa Loa (eye worm)	hypothetical protein	0.0103	0.0632	0.2755
Schistosoma mansoni	serine/threonine protein kinase	0.0105	0.0647	0.2819
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0076	0.045	0.196
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0105	0.0647	0.1907
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Echinococcus multilocularis	Threonyl tRNA synthetase, C	0.0019	0.0053	0.0157
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0048	0.0254	0.1106
Mycobacterium ulcerans	lipase LipD	0.0039	0.019	0.4227
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0103	0.0632	0.2717
Trypanosoma brucei	glucose transporter, putative	0.0106	0.0656	0.8747
Trichomonas vaginalis	conserved hypothetical protein	0.0048	0.0254	0.1106
Trypanosoma brucei	glucose transporter, putative	0.0106	0.0656	0.8747
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0019	0.0054	0.1198
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0342	0.2295	0.6764
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.012	0.075	0.1132
Trypanosoma brucei	sugar transporter, putative	0.0048	0.0254	0.3381
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0039	0.019	0.056
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0039	0.019	0.078
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0239	0.1043
Trypanosoma brucei	glucose transporter, putative	0.0106	0.0656	0.8747
Brugia malayi	major facilitator superfamily protein	0.0048	0.0254	0.1058
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Schistosoma mansoni	sugar transporter	0.0048	0.0254	0.1106
Trypanosoma brucei	glucose transporter, putative	0.0106	0.0656	0.8747
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0048	0.0254	0.3381
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0239	0.1043
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Schistosoma mansoni	glucose transporter	0.0048	0.0254	0.1106
Entamoeba histolytica	hypothetical protein	0.0076	0.045	0.6953
Loa Loa (eye worm)	hypothetical protein	0.0039	0.019	0.0829
Treponema pallidum	prolyl-tRNA synthetase	0.0036	0.0171	1
Brugia malayi	lysyl-tRNA synthetase	0.0076	0.045	0.1918
Giardia lamblia	Sugar-proton symporter	0.0048	0.0254	0.346
Giardia lamblia	Lysyl-tRNA synthetase	0.0076	0.045	0.6849
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0019	0.0053	0.0711
Loa Loa (eye worm)	hypothetical protein	0.0039	0.019	0.0829
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0254	0.1106
Schistosoma mansoni	hypothetical protein	0.0182	0.1185	0.5164
Toxoplasma gondii	sugar transporter ST2	0.0048	0.0254	0.0383
Mycobacterium ulcerans	hypothetical protein	0.0017	0.0038	0.0841
Echinococcus granulosus	solute carrier family 22	0.0048	0.0254	0.0748
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0239	0.0995
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.012	0.075	1
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0499	0.2173
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0048	0.0254	0.1341
Loa Loa (eye worm)	sugar transporter	0.0048	0.0254	0.1106
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.019	0.2534
Schistosoma mansoni	sugar transporter	0.0048	0.0254	0.1106
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0048	0.0254	0.0748
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0106	0.0656	0.8747
Trichomonas vaginalis	conserved hypothetical protein	0.0106	0.0656	0.286
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0103	0.0632	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 763633