TDR Targets

Basic information

Technical information

TDR Targets ID: 763677
Name: methyl 4-methyl-2-[1-(4-nitrophenyl)-3,9-diox o-1H-chromeno[3,2-c]pyrrol-2-yl]-1,3-thiazole -5-carboxylate
MW: 477.446 | Formula: C23H15N3O7S
H donors: 0 H acceptors: 6 LogP: 3.83 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COC(=O)c1sc(nc1C)N1C(=O)c2c(C1c1ccc(cc1)[N+](=O)[O-])c(=O)c1c(o2)cccc1
InChi: 1S/C23H15N3O7S/c1-11-20(22(29)32-2)34-23(24-11)25-17(12-7-9-13(10-8-12)26(30)31)16-18(27)14-5-3-4-6-15(14)33-19(16)21(25)28/h3-10,17H,1-2H3
InChiKey: ZYWXJYZJQQDSCT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

methyl 4-methyl-2-[1-(4-nitrophenyl)-3,9-dioxo-1H-chromeno[3,2-c]pyrrol-2-yl]thiazole-5-carboxylate
4-methyl-2-[1-(4-nitrophenyl)-3,9-dioxo-1H-chromeno[3,2-c]pyrrol-2-yl]-5-thiazolecarboxylic acid methyl ester
2-[3,9-diketo-1-(4-nitrophenyl)-1H-chromeno[2,3-c]pyrrol-2-yl]-4-methyl-thiazole-5-carboxylic acid methyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	Threonyl tRNA synthetase C	0.0018	0.0053	0.0158
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0055	0.0739
Trypanosoma cruzi	cytochrome P450, putative	0.0013	0.0012	0.0158
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0063	0.0385	0.1676
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0097	0.0632	0.2718
Echinococcus multilocularis	solute carrier family 22	0.0046	0.0254	0.075
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0254	0.1106
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0055	0.0191
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0189	0.0826
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0037	0.0189	0.0778
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0046	0.0254	0.1345
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0018	0.0053	0.0711
Onchocerca volvulus		0.0046	0.0254	1
Trichomonas vaginalis	glucose transporter, putative	0.0101	0.0656	0.286
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0275	0.0811
Trypanosoma brucei	glucose transporter, putative	0.0101	0.0656	0.8747
Trichomonas vaginalis	myo-inositol transporter, putative	0.0046	0.0254	0.1106
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0101	0.0656	0.8747
Mycobacterium tuberculosis	Probable esterase LipL	0.0037	0.0189	0.0945
Mycobacterium ulcerans	sugar transporter	0.0046	0.0254	0.5639
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0254	0.1106
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0046	0.0254	0.075
Trypanosoma cruzi	hexose transporter, putative	0.0101	0.0656	0.8747
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0072	0.045	1
Entamoeba histolytica	protein kinase, putative	0.0099	0.0647	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0632	0.2755
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0037	0.0189	0.4211
Leishmania major	hypothetical protein, conserved	0.0016	0.0038	0.0504
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0189	0.0945
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0099	0.0647	0.0647
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0099	0.0647	0.0647
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0632	0.2755
Schistosoma mansoni	protein kinase	0.0099	0.0647	0.2819
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0254	0.1106
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0072	0.045	0.6932
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0324	0.2295	0.6782
Brugia malayi	probable proline-trna synthetase - fission yeast, putative	0.0018	0.0053	0.0182
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0046	0.0254	0.0254
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0099	0.0647	0.1912
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0324	0.2295	0.6782
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0254	0.1106
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0189	0.0826
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Leishmania major	myo-inositol/proton symporter (MIT)	0.0046	0.0254	0.3381
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0099	0.0647	0.1912
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Trypanosoma cruzi	hexose transporter, putative	0.0055	0.0322	0.4296
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0524	0.3758	0.3758
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0046	0.0254	0.5639
Echinococcus multilocularis	glycyl tRNA synthetase	0.0018	0.0053	0.0158
Onchocerca volvulus		0.0046	0.0254	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0189	0.0826
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0254	0.1106
Mycobacterium leprae	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase)	0.0018	0.0053	0.0262
Trypanosoma brucei	threonyl-tRNA synthetase, putative	0.0018	0.0053	0.0711
Schistosoma mansoni	ap endonuclease	0.0019	0.0055	0.0242
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0254	0.1106
Trypanosoma cruzi	cytochrome P450, putative	0.0013	0.0012	0.0158
Onchocerca volvulus		0.0046	0.0254	1
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0324	0.2295	0.6782
Echinococcus granulosus	beta LACTamase domain containing family member	0.0037	0.0189	0.056
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0189	0.2525
Brugia malayi	hypothetical protein	0.0046	0.0254	0.1059
Trypanosoma brucei	glucose transporter, putative	0.0101	0.0656	0.8747
Chlamydia trachomatis	threonine--tRNA ligase	0.0018	0.0053	0.1186
Loa Loa (eye worm)	CYP4Cod1	0.0013	0.0012	0.0052
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0099	0.0647	0.1912
Toxoplasma gondii	sugar transporter ST2	0.0046	0.0254	0.0383
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0055	0.0055
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0099	0.0647	0.0976
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0099	0.0647	0.0647
Mycobacterium leprae	conserved hypothetical protein	0.0037	0.0189	0.2551
Brugia malayi	beta-lactamase family protein	0.0037	0.0189	0.0778
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Trypanosoma cruzi	Aminoacyl-tRNA editing domain containing protein, putative	0.0016	0.0038	0.0504
Onchocerca volvulus		0.0046	0.0254	1
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0324	0.2295	0.6782
Trichomonas vaginalis	sugar transporter, putative	0.0101	0.0656	0.286
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Plasmodium vivax	CDK-related protein kinase 6, putative	0.1376	1	1
Echinococcus granulosus	General substrate transporter	0.0279	0.1961	0.5795
Onchocerca volvulus		0.0046	0.0254	1
Mycobacterium ulcerans	hypothetical protein	0.0016	0.0038	0.0841
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0254	0.1106
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0046	0.0254	0.1106
Schistosoma mansoni	glucose transport protein	0.0324	0.2295	1
Trypanosoma cruzi	glucose transporter, putative	0.0046	0.0254	0.3381
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0037	0.0189	0.0826
Giardia lamblia	Prolyl-tRNA synthetase	0.0097	0.0632	1
Schistosoma mansoni	lysyl-tRNA synthetase	0.0072	0.045	0.196
Trypanosoma cruzi	Aminoacyl-tRNA editing domain containing protein, putative	0.0016	0.0038	0.0504
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Onchocerca volvulus		0.0046	0.0254	1
Brugia malayi	Major Facilitator Superfamily protein	0.0046	0.0254	0.1059
Trypanosoma brucei	glycyl-tRNA synthetase, putative	0.0018	0.0053	0.0711
Brugia malayi	Sugar transporter family protein	0.0046	0.0254	0.1059
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0254	0.1106
Plasmodium vivax	hexose transporter	0.0324	0.2295	0.2295
Mycobacterium ulcerans	glycyl-tRNA synthetase	0.0018	0.0053	0.1186
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0055	0.0242
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0113	0.075	1
Trichomonas vaginalis	glucose transporter, putative	0.0101	0.0656	0.286
Echinococcus granulosus	lysyl tRNA synthetase	0.0072	0.045	0.1329
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0113	0.075	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0189	0.0826
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0072	0.045	0.5996
Brugia malayi	lysyl-tRNA synthetase	0.0072	0.045	0.1919
Entamoeba histolytica	glycyl-tRNA synthetase, putative	0.0018	0.0053	0.0825
Chlamydia trachomatis	proline--tRNA ligase	0.0034	0.0171	0.3811
Toxoplasma gondii	YbaK/proline-tRNA ligase associated domain-containing protein	0.0016	0.0038	0.0057
Echinococcus multilocularis	Threonyl tRNA synthetase, C	0.0018	0.0053	0.0158
Schistosoma mansoni	protein kinase	0.0099	0.0647	0.2819
Schistosoma mansoni	hypothetical protein	0.0172	0.1182	0.5152
Mycobacterium ulcerans	esterase/lipase LipP	0.0037	0.0189	0.4211
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0254	0.1106
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Mycobacterium ulcerans	threonyl-tRNA synthetase	0.0018	0.0053	0.1186
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0524	0.3758	0.5667
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0055	0.0164
Plasmodium vivax	proline--tRNA ligase, putative	0.0113	0.075	0.075
Trypanosoma brucei	glucose transporter, putative	0.0101	0.0656	0.8747
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0099	0.0647	0.0647
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0046	0.0254	0.075
Echinococcus granulosus	synaptic vesicle 2 protein	0.0046	0.0254	0.075
Toxoplasma gondii	lysine-tRNA ligase	0.0072	0.045	0.0679
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0099	0.0647	0.0976
Plasmodium vivax	threonine--tRNA ligase, putative	0.0018	0.0053	0.0053
Brugia malayi	hypothetical protein	0.0046	0.0254	0.1059
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0019	0.0055	0.0857
Giardia lamblia	Hexose transporter	0.0046	0.0254	0.346
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0099	0.0647	0.1912
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0254	0.1106
Toxoplasma gondii	transporter, major facilitator family protein	0.0046	0.0254	0.0383
Toxoplasma gondii	threonyl-tRNA synthetase family protein	0.0018	0.0053	0.008
Brugia malayi	Sugar transporter family protein	0.0324	0.2295	1
Schistosoma mansoni	ap endonuclease	0.0019	0.0055	0.0242
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0048	0.0275	0.1196
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.0055	0.2185
Entamoeba histolytica	protein kinase, putative	0.0099	0.0647	1
Plasmodium falciparum	protein kinase 7	0.0916	0.663	0.663
Toxoplasma gondii	exonuclease III APE	0.0019	0.0055	0.0084
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0113	0.075	1
Onchocerca volvulus		0.0046	0.0254	1
Schistosoma mansoni	sugar transporter	0.0046	0.0254	0.1106
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0275	0.0811
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Brugia malayi	Major Facilitator Superfamily protein	0.0046	0.0254	0.1059
Schistosoma mansoni	glycyl-tRNA synthetase	0.0018	0.0053	0.0233
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0099	0.0647	0.2819
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.0055	0.011
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0189	0.0826
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0055	0.0739
Plasmodium falciparum	hexose transporter	0.0324	0.2295	0.2295
Plasmodium falciparum	threonine--tRNA ligase	0.0018	0.0053	0.0053
Onchocerca volvulus		0.0046	0.0254	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0048	0.0275	0.0811
Treponema pallidum	threonyl-tRNA synthetase	0.0018	0.0053	0.3113
Loa Loa (eye worm)	glycyl-tRNA synthetase	0.0018	0.0053	0.0233
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0254	0.1106
Leishmania major	cytochrome p450-like protein	0.0013	0.0012	0.0158
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0189	0.0945
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0053	0.0233
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Schistosoma mansoni	lysyl-tRNA synthetase	0.0072	0.045	0.196
Onchocerca volvulus		0.0046	0.0254	1
Echinococcus multilocularis	lysyl tRNA synthetase	0.0072	0.045	0.1329
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0038	0.0165
Mycobacterium leprae	Probable lipase LipE	0.0037	0.0189	0.2551
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0324	0.2295	0.6782
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0189	0.2525
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0254	0.1106
Echinococcus granulosus	neuropeptide s receptor	0.0473	0.3384	1
Trichomonas vaginalis	glucose transporter, putative	0.0046	0.0254	0.1106
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0099	0.0647	0.1912
Echinococcus multilocularis	General substrate transporter	0.0279	0.1961	0.5795
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0099	0.0647	0.0976
Mycobacterium tuberculosis	Probable lipase LipE	0.0037	0.0189	0.0945
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0524	0.3758	0.3758
Trypanosoma brucei	sugar transporter, putative	0.0046	0.0254	0.3381
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0034	0.0171	0.3811
Trypanosoma brucei	hypothetical protein, conserved	0.0037	0.0189	0.2525
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0048	0.0275	0.0811
Brugia malayi	hypothetical protein	0.0046	0.0254	0.1059
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0101	0.0656	0.8747
Trypanosoma cruzi	hexose transporter, putative	0.0101	0.0656	0.8747
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Trypanosoma cruzi	sugar transporter, putative	0.0046	0.0254	0.3381
Onchocerca volvulus	Putative transporter	0.0046	0.0254	1
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0038	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0254	0.1106
Toxoplasma gondii	sugar transporter ST3	0.0046	0.0254	0.0383
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0099	0.0647	0.8623
Leishmania major	protein kinase, putative	0.0099	0.0647	0.8623
Brugia malayi	beta-lactamase	0.0037	0.0189	0.0778
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0046	0.0254	0.5639
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0275	0.1196
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0275	0.1196
Onchocerca volvulus		0.0046	0.0254	1
Onchocerca volvulus		0.0046	0.0254	1
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0099	0.0647	0.0647
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0099	0.0647	0.1912
Schistosoma mansoni	hypothetical protein	0.0324	0.2295	1
Schistosoma mansoni	sugar transporter	0.0046	0.0254	0.1106
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Toxoplasma gondii	ABC1 family protein	0.0037	0.0189	0.0286
Trypanosoma brucei	cytochrome P450, putative	0.0013	0.0012	0.0158
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0061	0.037	0.2069
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0097	0.0632	0.2755
Schistosoma mansoni	serine/threonine protein kinase	0.0099	0.0647	0.2819
Trichomonas vaginalis	sugar transport protein, putative	0.0046	0.0254	0.1106
Trypanosoma cruzi	hypothetical protein, conserved	0.0016	0.0038	0.0504
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0189	0.0826
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0097	0.0632	0.1869
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0189	0.0826
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0038	0.0165
Entamoeba histolytica	hypothetical protein	0.0072	0.045	0.6953
Chlamydia trachomatis	lysine--tRNA ligase	0.0072	0.045	1
Wolbachia endosymbiont of Brugia malayi	threonyl-tRNA synthetase	0.0018	0.0053	0.2103
Mycobacterium ulcerans	hypothetical protein	0.0037	0.0189	0.4211
Giardia lamblia	Lysyl-tRNA synthetase	0.0072	0.045	0.6849
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0189	0.0945
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0099	0.0647	0.0647
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0254	0.1106
Schistosoma mansoni	glucose transporter	0.0046	0.0254	0.1106
Trypanosoma brucei	glucose transporter, putative	0.0101	0.0656	0.8747
Leishmania major	hypothetical protein, conserved	0.0046	0.0254	0.3381
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Brugia malayi	beta-lactamase family protein	0.0037	0.0189	0.0778
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0046	0.0254	0.1345
Mycobacterium tuberculosis	Probable lipase LipD	0.0037	0.0189	0.0945
Giardia lamblia	Sugar-proton symporter	0.0046	0.0254	0.346
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0046	0.0254	0.1106
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0072	0.045	0.5996
Trypanosoma brucei	glucose transporter, putative	0.0101	0.0656	0.8747
Brugia malayi	major facilitator superfamily protein	0.0046	0.0254	0.1059
Echinococcus granulosus	solute carrier family 22	0.0046	0.0254	0.075
Echinococcus multilocularis	solute carrier family 22	0.0046	0.0254	0.075
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0048	0.0275	0.1151
Plasmodium vivax	lysine--tRNA ligase, putative	0.0072	0.045	0.045
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0099	0.0647	0.1912
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0254	0.1106
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0019	0.0055	0.0739
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0254	0.1106
Entamoeba histolytica	threonyl-tRNA synthetase, putative	0.0018	0.0053	0.0825
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0324	0.2295	0.6782
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0113	0.075	0.1132
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0189	0.0826
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0097	0.0632	0.1869
Trypanosoma brucei	glucose transporter, putative	0.0101	0.0656	0.8747
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Trypanosoma brucei	glucose transporter, putative	0.0101	0.0656	0.8747
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0499	0.2173
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0113	0.075	1
Onchocerca volvulus		0.0046	0.0254	1
Onchocerca volvulus		0.0046	0.0254	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0189	0.0826
Schistosoma mansoni	sugar transporter	0.0046	0.0254	0.1106
Leishmania major	hypothetical protein, conserved	0.0016	0.0038	0.0504
Brugia malayi	Sugar transporter family protein	0.0046	0.0254	0.1059
Echinococcus granulosus	solute carrier family 22	0.0046	0.0254	0.075
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0097	0.0632	1
Onchocerca volvulus		0.0046	0.0254	1
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0101	0.0656	0.8747
Trichomonas vaginalis	conserved hypothetical protein	0.0101	0.0656	0.286
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0072	0.045	0.196
Mycobacterium ulcerans	lipase LipD	0.0037	0.0189	0.4211
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0018	0.0053	0.0711
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0072	0.045	1
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0189	0.0826
Treponema pallidum	prolyl-tRNA synthetase	0.0034	0.0171	1
Brugia malayi	Major Facilitator Superfamily protein	0.0046	0.0254	0.1059
Schistosoma mansoni	hypothetical protein	0.0172	0.1182	0.5152
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0254	0.1106
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Schistosoma mansoni	protein kinase	0.0099	0.0647	0.2819
Loa Loa (eye worm)	threonyl-tRNA synthetase	0.0018	0.0053	0.0233
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0097	0.0632	0.9772
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0099	0.0647	0.0647
Trichomonas vaginalis	sugar transporter, putative	0.0101	0.0656	0.286
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0235	0.1643	1
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0097	0.0632	0.2718
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0099	0.0647	0.0647
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0099	0.0647	0.0647
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0189	0.0826
Plasmodium vivax	hypothetical protein, conserved	0.0037	0.0189	0.0189
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.0055	0.0739
Echinococcus granulosus	geminin	0.0172	0.1182	0.3494
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0046	0.0254	0.1106
Brugia malayi	major facilitator superfamily protein	0.0046	0.0254	0.1059
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0061	0.037	0.2069
Wolbachia endosymbiont of Brugia malayi	prolyl-tRNA synthetase	0.0018	0.0053	0.2103
Loa Loa (eye worm)	cytochrome P450 family protein	0.0013	0.0012	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0189	0.0826
Leishmania major	glucose transporter, lmgt2	0.0101	0.0656	0.8747
Toxoplasma gondii	glycyl-tRNA synthetase	0.0018	0.0053	0.008
Toxoplasma gondii	facilitative glucose transporter GT1	0.0324	0.2295	0.3461
Trichomonas vaginalis	CAMK family protein kinase	0.0099	0.0647	0.2819
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0055	0.0242
Trichomonas vaginalis	threonyl-tRNA synthetase, putative	0.0018	0.0053	0.0233
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0099	0.0647	0.1912
Mycobacterium ulcerans	beta-lactamase	0.0037	0.0189	0.4211
Mycobacterium tuberculosis	Probable hydrolase	0.0037	0.0189	0.0945
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0037	0.0189	0.0945
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0324	0.2295	0.6782
Trichomonas vaginalis	esterase, putative	0.0037	0.0189	0.0826
Schistosoma mansoni	glucose transport protein	0.0324	0.2295	1
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Trypanosoma brucei	glucose transporter, putative	0.0101	0.0656	0.8747
Echinococcus granulosus	calcium dependent protein kinase	0.0093	0.0602	0.1779
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0037	0.0189	0.0945
Leishmania major	lysyl-tRNA synthetase, putative	0.0072	0.045	0.5996
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0097	0.0632	0.2755
Echinococcus granulosus	solute carrier family 22	0.0046	0.0254	0.075
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.0254	0.1106
Echinococcus granulosus	glycyl tRNA synthetase	0.0018	0.0053	0.0158
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0055	0.0055
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Mycobacterium tuberculosis	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase)	0.0018	0.0053	0.0097
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Plasmodium vivax	sugar transporter, putative	0.0046	0.0254	0.0254
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.004	0.0212	0.0925
Plasmodium vivax	glycine--tRNA ligase, putative	0.0018	0.0053	0.0053
Brugia malayi	threonyl-tRNA synthetase, cytoplasmic	0.0018	0.0053	0.0182
Brugia malayi	Cam kinase protein 1	0.0099	0.0647	0.2782
Echinococcus multilocularis	neuropeptide receptor A26	0.0473	0.3384	1
Leishmania major	glucose transporter, lmgt1	0.0101	0.0656	0.8747
Schistosoma mansoni	sugar transporter	0.0046	0.0254	0.1106
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0647	0.2819
Schistosoma mansoni	glucose transport protein	0.0324	0.2295	1
Trypanosoma cruzi	hexose transporter, putative	0.0101	0.0656	0.8747
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0189	0.0826
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0048	0.0275	0.1196
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0254	0.1106
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0037	0.0189	0.0945
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0099	0.0647	0.2819
Echinococcus multilocularis	calcium dependent protein kinase	0.0093	0.0602	0.1779
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Loa Loa (eye worm)	sugar transporter	0.0046	0.0254	0.1106
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0046	0.0254	0.075
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0061	0.037	0.5587
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0324	0.2295	0.6782
Loa Loa (eye worm)	hypothetical protein	0.0072	0.045	0.196
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0254	0.1106
Leishmania major	glucose transporter, lmgt3	0.0101	0.0656	0.8747
Echinococcus multilocularis	solute carrier family 22	0.0046	0.0254	0.075
Trypanosoma brucei	Aminoacyl-tRNA editing domain containing protein, putative	0.0016	0.0038	0.0504
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0099	0.0647	0.2782
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0101	0.0656	0.8747
Leishmania major	threonyl-tRNA synthetase, putative	0.0018	0.0053	0.0711
Loa Loa (eye worm)	cytochrome P450 family protein	0.0013	0.0012	0.0052
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Trypanosoma cruzi	hypothetical protein, conserved	0.0016	0.0038	0.0504
Echinococcus granulosus	solute carrier family 22	0.0046	0.0254	0.075
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0046	0.0254	1
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0013	0.0012	0.0264
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0097	0.0632	0.2755
Trichomonas vaginalis	conserved hypothetical protein	0.0324	0.2295	1
Trichomonas vaginalis	conserved hypothetical protein	0.0101	0.0656	0.286
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0055	0.0164
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Leishmania major	hypothetical protein, conserved	0.0037	0.0189	0.2525
Trichomonas vaginalis	sugar transporter, putative	0.0046	0.0254	0.1106
Mycobacterium ulcerans	integral membrane transport protein	0.0046	0.0254	0.5639
Toxoplasma gondii	sugar transporter ST1	0.0046	0.0254	0.0383
Plasmodium falciparum	lysine--tRNA ligase	0.0072	0.045	0.045
Brugia malayi	glycyl-tRNA synthetase	0.0018	0.0053	0.0182
Echinococcus multilocularis	geminin	0.0172	0.1182	0.3494
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0019	0.0055	0.0036
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0046	0.0254	0.3381
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0019	0.0055	0.1232
Loa Loa (eye worm)	beta-lactamase	0.0037	0.0189	0.0826
Trypanosoma cruzi	hexose transporter, putative	0.0046	0.0254	0.3381
Echinococcus multilocularis	solute carrier family 22	0.0046	0.0254	0.075
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0113	0.075	1
Trypanosoma brucei	glucose transporter 2A	0.0101	0.0656	0.8747
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0037	0.0189	0.056
Plasmodium falciparum	proline--tRNA ligase	0.0113	0.075	0.075
Echinococcus multilocularis	neuropeptide s receptor	0.0473	0.3384	1
Loa Loa (eye worm)	sugar transporter	0.0324	0.2295	1
Onchocerca volvulus		0.0046	0.0254	1
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0055	0.0242
Onchocerca volvulus		0.0046	0.0254	1
Trichomonas vaginalis	sugar transporter, putative	0.0101	0.0656	0.286
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.0055	0.3234
Trypanosoma brucei	glucose transporter 1E	0.0101	0.0656	0.8747
Echinococcus granulosus	neuropeptide receptor A26	0.0473	0.3384	1
Toxoplasma gondii	protein kinase, putative	0.0916	0.663	1
Trypanosoma cruzi	hexose transporter	0.0101	0.0656	0.8747

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 763677