Detailed information for compound 763679

Basic information

Technical information
  • TDR Targets ID: 763679
  • Name: methyl 2-[1-(3-chlorophenyl)-3,9-dioxo-1H-chr omeno[3,2-c]pyrrol-2-yl]-4-methyl-1,3-thiazol e-5-carboxylate
  • MW: 466.894 | Formula: C23H15ClN2O5S
  • H donors: 0 H acceptors: 4 LogP: 4.63 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1sc(nc1C)N1C(=O)c2c(C1c1cccc(c1)Cl)c(=O)c1c(o2)cccc1
  • InChi: 1S/C23H15ClN2O5S/c1-11-20(22(29)30-2)32-23(25-11)26-17(12-6-5-7-13(24)10-12)16-18(27)14-8-3-4-9-15(14)31-19(16)21(26)28/h3-10,17H,1-2H3
  • InChiKey: BDSMNGNRFWAUDV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • methyl 2-[1-(3-chlorophenyl)-3,9-dioxo-1H-chromeno[3,2-c]pyrrol-2-yl]-4-methyl-thiazole-5-carboxylate
  • 2-[1-(3-chlorophenyl)-3,9-dioxo-1H-chromeno[3,2-c]pyrrol-2-yl]-4-methyl-5-thiazolecarboxylic acid methyl ester
  • 2-[1-(3-chlorophenyl)-3,9-diketo-1H-chromeno[3,2-c]pyrrol-2-yl]-4-methyl-thiazole-5-carboxylic acid methyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis solute carrier family 22 0.0032 0.0217 0.0414
Loa Loa (eye worm) hypothetical protein 0.0032 0.0217 0.0899
Leishmania major threonyl-tRNA synthetase, putative 0.0013 0.0016 0.0218
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0075 0.0329
Mycobacterium tuberculosis Conserved protein 0.0037 0.027 0.1142
Mycobacterium tuberculosis Conserved protein 0.0037 0.027 0.1142
Loa Loa (eye worm) hypothetical protein 0.0032 0.0217 0.0899
Echinococcus multilocularis neuropeptide receptor A26 0.048 0.4874 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0217 0.0899
Trypanosoma cruzi hexose transporter, putative 0.0039 0.0286 0.3994
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.027 0.1142
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0028 0.0175 0.0714
Chlamydia trachomatis proline--tRNA ligase 0.0024 0.0134 0.2978
Plasmodium vivax calcium-dependent protein kinase, putative 0.007 0.0612 0.0597
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.007 0.0611 0.1227
Plasmodium falciparum calcium-dependent protein kinase 5 0.007 0.0612 0.0597
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0013 0.0016 0.0218
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0621 0.274
Echinococcus granulosus solute carrier family 22 0.0032 0.0217 0.0414
Loa Loa (eye worm) hypothetical protein 0.0037 0.027 0.1137
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0075 0.0059
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0229 0.2266 0.4631
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0075 0.0121
Toxoplasma gondii sugar transporter ST3 0.0032 0.0217 0.0327
Giardia lamblia Sugar-proton symporter 0.0032 0.0217 0.346
Loa Loa (eye worm) hypothetical protein 0.0032 0.0217 0.0899
Brugia malayi major facilitator superfamily protein 0.0032 0.0217 0.0899
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0229 0.2266 0.4631
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Loa Loa (eye worm) sugar transporter 0.0229 0.2266 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0217 0.0899
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.027 0.6532
Plasmodium vivax CDK-related protein kinase 6, putative 0.0973 1 1
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Trichomonas vaginalis glucose transporter, putative 0.0071 0.0621 0.274
Schistosoma mansoni hypothetical protein 0.0229 0.2266 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0006
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0239 0.2365 1
Echinococcus granulosus synaptic vesicle 2 protein 0.0032 0.0217 0.0414
Brugia malayi Major Facilitator Superfamily protein 0.0032 0.0217 0.0899
Schistosoma mansoni sugar transporter 0.0032 0.0217 0.0894
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Echinococcus granulosus Sugar transporter ERD6 protein 0.0032 0.0217 0.0414
Echinococcus multilocularis lysyl tRNA synthetase 0.0051 0.0414 0.0819
Loa Loa (eye worm) hypothetical protein 0.0069 0.0597 0.2587
Trypanosoma brucei glucose transporter, putative 0.0071 0.0621 0.868
Loa Loa (eye worm) hypothetical protein 0.0037 0.027 0.1137
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Trypanosoma brucei glucose transporter, putative 0.0071 0.0621 0.868
Loa Loa (eye worm) hypothetical protein 0.0037 0.027 0.1137
Leishmania major hypothetical protein, conserved 0.0037 0.027 0.3777
Trypanosoma brucei THT1 - hexose transporter, putative 0.0071 0.0621 0.868
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0075 0.1042
Loa Loa (eye worm) hypothetical protein 0.0032 0.0217 0.0899
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0069 0.0597 0.2587
Brugia malayi glycyl-tRNA synthetase 0.0013 0.0016 0.0006
Loa Loa (eye worm) hypothetical protein 0.0032 0.0217 0.0899
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0045 0.0348 0.1536
Trypanosoma brucei cytochrome P450, putative 0.0013 0.0014 0.02
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0032 0.0217 0.303
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.007 0.0611 0.2653
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0069 0.0597 0.2634
Schistosoma mansoni lysyl-tRNA synthetase 0.0051 0.0414 0.1769
Leishmania major glucose transporter, lmgt1 0.0071 0.0621 0.868
Echinococcus multilocularis solute carrier family 22 0.0032 0.0217 0.0414
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.027 0.1137
Mycobacterium ulcerans integral membrane transport protein 0.0032 0.0217 0.5239
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.007 0.0611 0.1227
Loa Loa (eye worm) hypothetical protein 0.0032 0.0217 0.0899
Giardia lamblia Prolyl-tRNA synthetase 0.0069 0.0597 1
Entamoeba histolytica protein kinase, putative 0.007 0.0611 1
Schistosoma mansoni protein kinase 0.007 0.0611 0.2648
Brugia malayi beta-lactamase family protein 0.0037 0.027 0.1137
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Loa Loa (eye worm) beta-lactamase 0.0037 0.027 0.1137
Mycobacterium ulcerans lipase LipD 0.0037 0.027 0.6532
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.007 0.0612 0.0597
Echinococcus granulosus solute carrier family 22 0.0032 0.0217 0.0414
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Brugia malayi Sugar transporter family protein 0.0229 0.2266 1
Mycobacterium ulcerans sugar transporter 0.0032 0.0217 0.5239
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0217 0.0956
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.007 0.0611 0.1227
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Trichomonas vaginalis conserved hypothetical protein 0.0229 0.2266 1
Plasmodium falciparum lysine--tRNA ligase 0.0051 0.0414 0.0399
Trypanosoma cruzi glucose transporter, putative 0.0032 0.0217 0.303
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.027 0.1142
Brugia malayi beta-lactamase family protein 0.0037 0.027 0.1137
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.008 0.0715 1
Trypanosoma cruzi cytochrome P450, putative 0.0013 0.0014 0.02
Plasmodium falciparum protein kinase 7 0.0648 0.6617 0.6612
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0013 0.0016 0.0006
Plasmodium falciparum calcium-dependent protein kinase 3 0.007 0.0612 0.0597
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0013 0.0016 0.0377
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0075 0.0989
Schistosoma mansoni serine/threonine protein kinase 0.007 0.0611 0.2648
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0013 0.0014 0.0345
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Mycobacterium ulcerans beta-lactamase 0.0037 0.027 0.6532
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0051 0.0414 1
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Brugia malayi lysyl-tRNA synthetase 0.0051 0.0414 0.1774
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.027 0.3777
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Loa Loa (eye worm) hypothetical protein 0.0032 0.0217 0.0899
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.027 0.0524
Schistosoma mansoni glucose transport protein 0.0229 0.2266 1
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.027 0.0524
Giardia lamblia Hexose transporter 0.0032 0.0217 0.346
Schistosoma mansoni protein kinase 0.007 0.0611 0.2648
Echinococcus granulosus neuropeptide receptor A26 0.048 0.4874 1
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Echinococcus granulosus General substrate transporter 0.0197 0.193 0.3941
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.007 0.0611 0.1227
Plasmodium falciparum mitogen-activated protein kinase 2 0.037 0.3734 0.3724
Mycobacterium leprae Probable lipase LipE 0.0037 0.027 0.4528
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.027 0.3777
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0075 0.0329
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.027 0.3777
Plasmodium vivax hexose transporter 0.0229 0.2266 0.2253
Leishmania major cytochrome p450-like protein 0.0013 0.0014 0.02
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0051 0.0414 0.5783
Leishmania major lysyl-tRNA synthetase, putative 0.0051 0.0414 0.5783
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Schistosoma mansoni lysyl-tRNA synthetase 0.0051 0.0414 0.1769
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.008 0.0715 0.1081
Plasmodium falciparum proline--tRNA ligase 0.008 0.0715 0.0701
Trypanosoma brucei THT1 - hexose transporter, putative 0.0071 0.0621 0.868
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.027 0.1142
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.027 0.1142
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Schistosoma mansoni sugar transporter 0.0032 0.0217 0.0894
Schistosoma mansoni hypothetical protein 0.0175 0.1701 0.7489
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Leishmania major protein kinase, putative 0.007 0.0611 0.855
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.007 0.0611 0.2653
Loa Loa (eye worm) hypothetical protein 0.0037 0.027 0.1137
Plasmodium vivax lysine--tRNA ligase, putative 0.0051 0.0414 0.0399
Brugia malayi Major Facilitator Superfamily protein 0.0032 0.0217 0.0899
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.007 0.0612 0.0925
Trypanosoma brucei THT1 - hexose transporter, putative 0.0071 0.0621 0.868
Plasmodium vivax proline--tRNA ligase, putative 0.008 0.0715 0.0701
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0013 0.0016 0.0069
Echinococcus granulosus neuropeptide s receptor 0.048 0.4874 1
Trypanosoma cruzi cytochrome P450, putative 0.0013 0.0014 0.02
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.027 0.1193
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0217 0.0956
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0229 0.2266 0.4631
Echinococcus multilocularis solute carrier family 22 0.0032 0.0217 0.0414
Brugia malayi Cam kinase protein 1 0.007 0.0611 0.2653
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0013 0.0016 0.0066
Trypanosoma brucei glucose transporter, putative 0.0071 0.0621 0.868
Schistosoma mansoni glucose transporter 0.0032 0.0217 0.0894
Brugia malayi Major Facilitator Superfamily protein 0.0032 0.0217 0.0899
Leishmania major hypothetical protein, conserved 0.0032 0.0217 0.303
Giardia lamblia Lysyl-tRNA synthetase 0.0051 0.0414 0.6849
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.027 0.1131
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Loa Loa (eye worm) hypothetical protein 0.0032 0.0217 0.0899
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0032 0.0217 0.0916
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.027 0.1137
Leishmania major glucose transporter/membrane transporter D2, putative 0.0071 0.0621 0.868
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0032 0.0217 0.5239
Toxoplasma gondii ABC1 family protein 0.0037 0.027 0.0408
Trypanosoma brucei glucose transporter, putative 0.0071 0.0621 0.868
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0069 0.0597 0.9752
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0024 0.0134 0.3243
Trypanosoma cruzi hexose transporter, putative 0.0071 0.0621 0.868
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.008 0.0715 1
Schistosoma mansoni glucose transport protein 0.0229 0.2266 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.027 0.1142
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.027 0.1193
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0013 0.0016 0.0006
Toxoplasma gondii sugar transporter ST1 0.0032 0.0217 0.0327
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.027 0.1193
Toxoplasma gondii lysine-tRNA ligase 0.0051 0.0414 0.0625
Plasmodium falciparum calcium-dependent protein kinase 1 0.007 0.0612 0.0597
Trypanosoma brucei sugar transporter, putative 0.0032 0.0217 0.303
Loa Loa (eye worm) major facilitator superfamily transporter 0.0032 0.0217 0.0899
Trypanosoma brucei glucose transporter, putative 0.0071 0.0621 0.868
Trypanosoma cruzi hexose transporter, putative 0.0071 0.0621 0.868
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0217 0.0956
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0069 0.0597 1
Brugia malayi hypothetical protein 0.0032 0.0217 0.0899
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0075 0.0059
Echinococcus granulosus solute carrier family 22 0.0032 0.0217 0.0414
Loa Loa (eye worm) hypothetical protein 0.0056 0.0463 0.1991
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.008 0.0715 1
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Loa Loa (eye worm) hypothetical protein 0.0037 0.027 0.1137
Plasmodium vivax sugar transporter, putative 0.0032 0.0217 0.0201
Echinococcus multilocularis geminin 0.0175 0.1701 0.3468
Echinococcus multilocularis solute carrier family 22 0.0032 0.0217 0.0414
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0032 0.0217 0.0894
Loa Loa (eye worm) hypothetical protein 0.0051 0.0414 0.1774
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0013 0.0016 0.0218
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0075 0.0121
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0051 0.0414 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.007 0.0611 0.1227
Brugia malayi Sugar transporter family protein 0.0032 0.0217 0.0899
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0032 0.0217 0.0414
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Schistosoma mansoni sugar transporter 0.0032 0.0217 0.0894
Trypanosoma brucei glucose transporter 1E 0.0071 0.0621 0.868
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.027 0.1193
Toxoplasma gondii transporter, major facilitator family protein 0.0032 0.0217 0.0327
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0621 0.274
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0075 0.1042
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0075 0.0268
Onchocerca volvulus 0.0037 0.027 1
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0217 0.0956
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0032 0.0217 0.5239
Mycobacterium tuberculosis Conserved protein 0.0037 0.027 0.1142
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.007 0.0612 0.0597
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.007 0.0612 0.0925
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0229 0.2266 0.4631
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.027 0.1131
Onchocerca volvulus 0.0037 0.027 1
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.027 0.1142
Trichomonas vaginalis sugar transport protein, putative 0.0032 0.0217 0.0956
Plasmodium falciparum calcium-dependent protein kinase 2 0.007 0.0612 0.0597
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0032 0.0217 0.0916
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0217 0.0956
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0069 0.0597 0.2587
Mycobacterium leprae conserved hypothetical protein 0.0037 0.027 0.4528
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.007 0.0611 0.1227
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0043 0.0333 0.5587
Loa Loa (eye worm) hypothetical protein 0.0069 0.0597 0.2587
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0217 0.303
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.007 0.0611 0.2653
Echinococcus multilocularis synaptic vesicle 2 protein 0.0032 0.0217 0.0414
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0051 0.0414 0.6932
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0075 0.497
Treponema pallidum prolyl-tRNA synthetase 0.0024 0.0134 1
Chlamydia trachomatis lysine--tRNA ligase 0.0051 0.0414 1
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0051 0.0414 0.5783
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0075 0.1042
Onchocerca volvulus 0.0037 0.027 1
Loa Loa (eye worm) major facilitator superfamily transporter 0.0032 0.0217 0.0899
Brugia malayi major facilitator superfamily protein 0.0032 0.0217 0.0899
Echinococcus granulosus calcium dependent protein kinase 0.0066 0.0566 0.1134
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.007 0.0612 0.0925
Loa Loa (eye worm) hypothetical protein 0.0032 0.0217 0.0899
Trichomonas vaginalis esterase, putative 0.0037 0.027 0.1193
Toxoplasma gondii exonuclease III APE 0.0019 0.0075 0.0113
Trichomonas vaginalis sugar transporter, putative 0.0071 0.0621 0.274
Schistosoma mansoni protein kinase 0.007 0.0611 0.2648
Plasmodium falciparum hexose transporter 0.0229 0.2266 0.2253
Schistosoma mansoni sugar transporter 0.0032 0.0217 0.0894
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.027 0.1193
Trichomonas vaginalis sugar transporter, putative 0.0071 0.0621 0.274
Entamoeba histolytica protein kinase, putative 0.007 0.0611 1
Echinococcus granulosus lysyl tRNA synthetase 0.0051 0.0414 0.0819
Brugia malayi beta-lactamase 0.0037 0.027 0.1137
Trypanosoma cruzi hexose transporter, putative 0.0071 0.0621 0.868
Loa Loa (eye worm) hypothetical protein 0.0032 0.0217 0.0899
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0229 0.2266 0.4631
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0043 0.0333 0.141
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0051 0.0414 0.1826
Schistosoma mansoni hypothetical protein 0.0175 0.1701 0.7489
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0032 0.0217 0.0201
Brugia malayi hypothetical protein 0.0032 0.0217 0.0899
Schistosoma mansoni ap endonuclease 0.0019 0.0075 0.0262
Mycobacterium ulcerans hypothetical protein 0.0037 0.027 0.6532
Leishmania major glucose transporter, lmgt2 0.0071 0.0621 0.868
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0013 0.0016 0.0377
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0069 0.0597 0.2583
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0229 0.2266 0.4631
Trypanosoma cruzi sugar transporter, putative 0.0032 0.0217 0.303
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.037 0.3734 0.5643
Toxoplasma gondii protein kinase, putative 0.0648 0.6617 1
Trypanosoma brucei glucose transporter 2A 0.0071 0.0621 0.868
Leishmania major glucose transporter, lmgt3 0.0071 0.0621 0.868
Trypanosoma cruzi hexose transporter 0.0071 0.0621 0.868
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0013 0.0016 0.0218
Loa Loa (eye worm) sugar transporter 0.0032 0.0217 0.0899
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0013 0.0016 0.0262
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0075 0.0268
Trypanosoma brucei glucose transporter, putative 0.0071 0.0621 0.868
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.008 0.0715 1
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.037 0.3734 0.3724
Toxoplasma gondii facilitative glucose transporter GT1 0.0229 0.2266 0.3424
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0075 0.1042
Loa Loa (eye worm) hypothetical protein 0.0032 0.0217 0.0899
Toxoplasma gondii sugar transporter ST2 0.0032 0.0217 0.0327
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.008 0.0715 1
Toxoplasma gondii glycyl-tRNA synthetase 0.0013 0.0016 0.0024
Brugia malayi Sugar transporter family protein 0.0032 0.0217 0.0899
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0013 0.0016 0.0006
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0075 0.0315
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0069 0.0597 0.1196
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.007 0.0612 0.0597
Loa Loa (eye worm) hypothetical protein 0.007 0.0611 0.2653
Trichomonas vaginalis sugar transporter, putative 0.0071 0.0621 0.274
Echinococcus multilocularis General substrate transporter 0.0197 0.193 0.3941
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.007 0.0611 0.1227
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0069 0.0597 0.1196
Plasmodium falciparum calcium-dependent protein kinase 4 0.007 0.0612 0.0597
Trichomonas vaginalis CAMK family protein kinase 0.007 0.0611 0.2699
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.007 0.0611 0.1227
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0013 0.0016 0.0006
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0075 0.1802
Trichomonas vaginalis glucose transporter, putative 0.0071 0.0621 0.274
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0229 0.2266 0.4631
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0043 0.0333 0.141
Loa Loa (eye worm) hypothetical protein 0.0032 0.0217 0.0899
Plasmodium vivax hypothetical protein, conserved 0.0037 0.027 0.0255
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Loa Loa (eye worm) hypothetical protein 0.0032 0.0217 0.0899
Echinococcus granulosus geminin 0.0175 0.1701 0.3468
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0013 0.0016 0.0218
Leishmania major myo-inositol/proton symporter (MIT) 0.0032 0.0217 0.303
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.027 0.6532
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0013 0.0016 0.0024
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0032 0.0217 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0069 0.0597 0.2583
Entamoeba histolytica hypothetical protein 0.0051 0.0414 0.6679
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0075 0.1014
Trypanosoma brucei glucose transporter, putative 0.0071 0.0621 0.868
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.027 0.1142
Echinococcus multilocularis calcium dependent protein kinase 0.0066 0.0566 0.1134
Schistosoma mansoni ap endonuclease 0.0019 0.0075 0.0262
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0229 0.2266 0.4631
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0075 0.2929
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0217 0.0956
Schistosoma mansoni glucose transport protein 0.0229 0.2266 1
Trichomonas vaginalis myo-inositol transporter, putative 0.0032 0.0217 0.0956
Brugia malayi hypothetical protein 0.0032 0.0217 0.0899
Echinococcus multilocularis neuropeptide s receptor 0.048 0.4874 1
Trypanosoma brucei glucose transporter, putative 0.0071 0.0621 0.868
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.007 0.0611 0.855
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0217 0.0956
Echinococcus granulosus solute carrier family 22 0.0032 0.0217 0.0414
Loa Loa (eye worm) hypothetical protein 0.0037 0.027 0.1137

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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