TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 350.496 | Formula: C20H34N2O3
H donors: 3 H acceptors: 2 LogP: 2.16 Rotable bonds: 11
Rule of 5 violations (Lipinski): 1
SMILES: OCCCNCc1ccccc1OCC(CN(C1CCCCC1)C)O
InChi: 1S/C20H34N2O3/c1-22(18-9-3-2-4-10-18)15-19(24)16-25-20-11-6-5-8-17(20)14-21-12-7-13-23/h5-6,8,11,18-19,21,23-24H,2-4,7,9-10,12-16H2,1H3
InChiKey: WKRXUGIGFMVSDU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0217	0.0956
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0037	0.0265	0.0521
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0069	0.0611	0.1242
Mycobacterium leprae	conserved hypothetical protein	0.0037	0.0265	0.4449
Echinococcus granulosus	synaptic vesicle 2 protein	0.0032	0.0217	0.0419
Toxoplasma gondii	exonuclease III APE	0.0018	0.0072	0.0109
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0217	0.0956
Toxoplasma gondii	protein kinase, putative	0.0641	0.6617	1
Trichomonas vaginalis	sugar transporter, putative	0.007	0.0621	0.274
Trypanosoma brucei	THT1 - hexose transporter, putative	0.007	0.0621	0.868
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0072	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0597	0.2592
Trichomonas vaginalis	glucose transporter, putative	0.007	0.0621	0.274
Echinococcus granulosus	solute carrier family 22	0.0032	0.0217	0.0419
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0018	0.0072	0.1749
Trypanosoma brucei	glucose transporter, putative	0.007	0.0621	0.868
Leishmania major	lysyl-tRNA synthetase, putative	0.0051	0.0414	0.5783
Echinococcus multilocularis	neuropeptide receptor A26	0.0469	0.4813	1
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0217	0.0956
Echinococcus multilocularis	lysyl tRNA synthetase	0.0051	0.0414	0.083
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0217	0.0906
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0069	0.0611	0.855
Schistosoma mansoni	glucose transport protein	0.0227	0.2266	1
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0072	0.0319
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0069	0.0611	0.2658
Plasmodium falciparum	lysine--tRNA ligase	0.0051	0.0414	0.0399
Echinococcus multilocularis	solute carrier family 22	0.0032	0.0217	0.0419
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0069	0.0611	0.1242
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0227	0.2266	0.469
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0069	0.0611	0.1242
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0068	0.0597	0.1211
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0032	0.0217	0.0419
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0051	0.0414	0.1826
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0217	0.0906
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0018	0.0072	0.1012
Giardia lamblia	Hexose transporter	0.0032	0.0217	0.346
Onchocerca volvulus		0.0037	0.0265	1
Plasmodium falciparum	calcium-dependent protein kinase 2	0.007	0.0612	0.0597
Toxoplasma gondii	sugar transporter ST1	0.0032	0.0217	0.0327
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0217	0.0906
Trypanosoma brucei	THT1 - hexose transporter, putative	0.007	0.0621	0.868
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0227	0.2266	0.469
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0051	0.0414	0.5783
Entamoeba histolytica	hypothetical protein	0.0051	0.0414	0.6679
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0265	0.3711
Giardia lamblia	Lysyl-tRNA synthetase	0.0051	0.0414	0.6849
Trypanosoma brucei	THT1 - hexose transporter, putative	0.007	0.0621	0.868
Schistosoma mansoni	hypothetical protein	0.0171	0.1679	0.7392
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0018	0.0072	0.1012
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0217	0.0956
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0963	1	1
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.007	0.0612	0.0597
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0265	0.1137
Trichomonas vaginalis	CAMK family protein kinase	0.0069	0.0611	0.2699
Plasmodium falciparum	calcium-dependent protein kinase 5	0.007	0.0612	0.0597
Schistosoma mansoni	sugar transporter	0.0032	0.0217	0.0894
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0037	0.0265	0.6418
Brugia malayi	Major Facilitator Superfamily protein	0.0032	0.0217	0.0906
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0069	0.0611	0.1242
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0227	0.2266	0.469
Schistosoma mansoni	protein kinase	0.0069	0.0611	0.2648
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0032	0.0217	0.0201
Plasmodium vivax	lysine--tRNA ligase, putative	0.0051	0.0414	0.0399
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0265	0.1137
Mycobacterium leprae	Probable lipase LipE	0.0037	0.0265	0.4449
Echinococcus multilocularis	solute carrier family 22	0.0032	0.0217	0.0419
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0217	0.0956
Toxoplasma gondii	sugar transporter ST3	0.0032	0.0217	0.0327
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0265	0.1172
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0217	0.0906
Schistosoma mansoni	hypothetical protein	0.0171	0.1679	0.7392
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0227	0.2266	0.469
Giardia lamblia	Prolyl-tRNA synthetase	0.0068	0.0597	1
Loa Loa (eye worm)	beta-lactamase	0.0037	0.0265	0.1122
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0217	0.0956
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0032	0.0217	0.0419
Echinococcus multilocularis	solute carrier family 22	0.0032	0.0217	0.0419
Brugia malayi	hypothetical protein	0.0032	0.0217	0.0906
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0227	0.2266	0.469
Brugia malayi	Major Facilitator Superfamily protein	0.0032	0.0217	0.0906
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0217	0.0956
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0234	0.2335	1
Schistosoma mansoni	ap endonuclease	0.0018	0.0072	0.0252
Giardia lamblia	Sugar-proton symporter	0.0032	0.0217	0.346
Leishmania major	glucose transporter, lmgt2	0.007	0.0621	0.868
Echinococcus granulosus	solute carrier family 22	0.0032	0.0217	0.0419
Schistosoma mansoni	glucose transporter	0.0032	0.0217	0.0894
Trichomonas vaginalis	esterase, putative	0.0037	0.0265	0.1172
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0068	0.0597	0.2592
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0217	0.0956
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0032	0.0217	0.5239
Brugia malayi	threonyl-tRNA synthetase, cytoplasmic	0.0013	0.0016	0.0013
Brugia malayi	major facilitator superfamily protein	0.0032	0.0217	0.0906
Schistosoma mansoni	sugar transporter	0.0032	0.0217	0.0894
Trypanosoma brucei	hypothetical protein, conserved	0.0037	0.0265	0.3711
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0069	0.0611	0.1242
Brugia malayi	beta-lactamase family protein	0.0037	0.0265	0.1122
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0217	0.0956
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0037	0.0265	0.1137
Trypanosoma cruzi	hexose transporter, putative	0.007	0.0621	0.868
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0079	0.0715	1
Echinococcus multilocularis	neuropeptide s receptor	0.0469	0.4813	1
Brugia malayi	glycyl-tRNA synthetase	0.0013	0.0016	0.0013
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0028	0.0175	0.0721
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0217	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0217	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0265	0.1122
Schistosoma mansoni	glucose transport protein	0.0227	0.2266	1
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0037	0.0265	0.1122
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0217	0.0906
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0072	0.1012
Trypanosoma brucei	cytochrome P450, putative	0.0012	0.0013	0.0177
Brugia malayi	hypothetical protein	0.0032	0.0217	0.0906
Trypanosoma brucei	sugar transporter, putative	0.0032	0.0217	0.303
Trypanosoma cruzi	hexose transporter, putative	0.0038	0.0286	0.3994
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0217	0.0956
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0217	0.303
Trypanosoma cruzi	cytochrome P450, putative	0.0012	0.0013	0.0177
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0079	0.0715	1
Plasmodium falciparum	calcium-dependent protein kinase 3	0.007	0.0612	0.0597
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0051	0.0414	1
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0367	0.3734	0.5643
Trypanosoma brucei	glucose transporter 1E	0.007	0.0621	0.868
Schistosoma mansoni	glucose transport protein	0.0227	0.2266	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0217	0.0906
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0217	0.0956
Brugia malayi	Sugar transporter family protein	0.0032	0.0217	0.0906
Plasmodium falciparum	calcium-dependent protein kinase 1	0.007	0.0612	0.0597
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0068	0.0597	0.9752
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0227	0.2266	0.469
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0068	0.0597	0.1211
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0367	0.3734	0.3724
Loa Loa (eye worm)	glycyl-tRNA synthetase	0.0013	0.0016	0.0013
Mycobacterium tuberculosis	Probable esterase LipL	0.0037	0.0265	0.1137
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0265	0.111
Mycobacterium leprae	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase)	0.0013	0.0016	0.0262
Entamoeba histolytica	protein kinase, putative	0.0069	0.0611	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0265	0.1172
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0079	0.0715	1
Trichomonas vaginalis	myo-inositol transporter, putative	0.0032	0.0217	0.0956
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0024	0.0134	0.3243
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0217	0.0956
Trypanosoma cruzi	cytochrome P450, putative	0.0012	0.0013	0.0177
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0217	0.0956
Echinococcus granulosus	neuropeptide receptor A26	0.0469	0.4813	1
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0217	0.0956
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0018	0.0072	0.0265
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0597	0.2592
Brugia malayi	beta-lactamase	0.0037	0.0265	0.1122
Trypanosoma cruzi	hexose transporter, putative	0.007	0.0621	0.868
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.007	0.0612	0.0925
Mycobacterium ulcerans	glycyl-tRNA synthetase	0.0013	0.0016	0.0377
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0068	0.0597	0.2583
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0068	0.0597	0.2592
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0265	0.1122
Plasmodium vivax	hexose transporter	0.0227	0.2266	0.2253
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.007	0.0612	0.0597
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0032	0.0217	0.0928
Echinococcus multilocularis	General substrate transporter	0.0195	0.193	0.3991
Plasmodium falciparum	protein kinase 7	0.0641	0.6617	0.6612
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0217	0.0956
Toxoplasma gondii	ABC1 family protein	0.0037	0.0265	0.0401
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0217	0.0956
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.007	0.0612	0.0925
Trichomonas vaginalis	sugar transport protein, putative	0.0032	0.0217	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0217	0.0956
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0265	0.1172
Schistosoma mansoni	lysyl-tRNA synthetase	0.0051	0.0414	0.1769
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0013	0.0016	0.0218
Entamoeba histolytica	protein kinase, putative	0.0069	0.0611	1
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0044	0.0348	0.1536
Leishmania major	hypothetical protein, conserved	0.0032	0.0217	0.303
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0217	0.0906
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0227	0.2266	0.469
Mycobacterium ulcerans	hypothetical protein	0.0037	0.0265	0.6418
Trypanosoma cruzi	hexose transporter	0.007	0.0621	0.868
Trypanosoma cruzi	sugar transporter, putative	0.0032	0.0217	0.303
Echinococcus multilocularis	calcium dependent protein kinase	0.0065	0.0566	0.1148
Schistosoma mansoni	protein kinase	0.0069	0.0611	0.2648
Brugia malayi	beta-lactamase family protein	0.0037	0.0265	0.1122
Trypanosoma brucei	glucose transporter, putative	0.007	0.0621	0.868
Trypanosoma brucei	threonyl-tRNA synthetase, putative	0.0013	0.0016	0.0218
Echinococcus granulosus	solute carrier family 22	0.0032	0.0217	0.0419
Leishmania major	hypothetical protein, conserved	0.0037	0.0265	0.3711
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0069	0.0611	0.2658
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0217	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0217	0.0906
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0013	0.0016	0.0218
Echinococcus granulosus	neuropeptide s receptor	0.0469	0.4813	1
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0018	0.0072	0.2822
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0043	0.0333	0.1428
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0217	0.0956
Mycobacterium tuberculosis	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase)	0.0013	0.0016	0.0067
Echinococcus granulosus	geminin	0.0171	0.1679	0.3467
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0032	0.0217	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0414	0.178
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0217	0.0906
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0611	0.2658
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0032	0.0217	0.5239
Mycobacterium tuberculosis	Probable hydrolase	0.0037	0.0265	0.1137
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0072	0.0319
Loa Loa (eye worm)	sugar transporter	0.0227	0.2266	1
Toxoplasma gondii	transporter, major facilitator family protein	0.0032	0.0217	0.0327
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0265	0.1172
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.007	0.0612	0.0925
Toxoplasma gondii	lysine-tRNA ligase	0.0051	0.0414	0.0625
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0265	0.1137
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0217	0.0956
Brugia malayi	Sugar transporter family protein	0.0227	0.2266	1
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0217	0.0956
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0018	0.0072	0.0952
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0032	0.0217	0.303
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0265	0.111
Leishmania major	glucose transporter/membrane transporter D2, putative	0.007	0.0621	0.868
Trypanosoma cruzi	glucose transporter, putative	0.0032	0.0217	0.303
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0217	0.0956
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0051	0.0414	1
Leishmania major	myo-inositol/proton symporter (MIT)	0.0032	0.0217	0.303
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0217	0.0906
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0217	0.0956
Trypanosoma cruzi	hexose transporter, putative	0.007	0.0621	0.868
Plasmodium falciparum	proline--tRNA ligase	0.0079	0.0715	0.0701
Echinococcus multilocularis	geminin	0.0171	0.1679	0.3467
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0051	0.0414	0.6932
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0217	0.0906
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0217	0.0956
Leishmania major	cytochrome p450-like protein	0.0012	0.0013	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0217	0.0906
Loa Loa (eye worm)	threonyl-tRNA synthetase	0.0013	0.0016	0.0013
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0079	0.0715	0.1081
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0051	0.0414	0.5783
Leishmania major	glucose transporter, lmgt1	0.007	0.0621	0.868
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0072	0.0057
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0037	0.0265	0.1137
Trypanosoma brucei	glucose transporter, putative	0.007	0.0621	0.868
Trypanosoma brucei	glucose transporter, putative	0.007	0.0621	0.868
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0043	0.0333	0.5587
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0016	0.0013
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0217	0.0956
Trichomonas vaginalis	sugar transporter, putative	0.007	0.0621	0.274
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0037	0.0265	0.1137
Brugia malayi	Sugar transporter family protein	0.0032	0.0217	0.0906
Schistosoma mansoni	lysyl-tRNA synthetase	0.0051	0.0414	0.1769
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0032	0.0217	0.0928
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0217	0.0956
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0069	0.0611	0.2658
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0217	0.0956
Trichomonas vaginalis	conserved hypothetical protein	0.007	0.0621	0.274
Toxoplasma gondii	threonyl-tRNA synthetase family protein	0.0013	0.0016	0.0024
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0068	0.0597	0.2634
Schistosoma mansoni	hypothetical protein	0.0227	0.2266	1
Leishmania major	glucose transporter, lmgt3	0.007	0.0621	0.868
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0217	0.0956
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0069	0.0611	0.1242
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0227	0.2266	0.469
Trypanosoma brucei	glucose transporter, putative	0.007	0.0621	0.868
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0069	0.0611	0.1242
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0217	0.0956
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0032	0.0217	0.0906
Mycobacterium tuberculosis	Probable lipase LipD	0.0037	0.0265	0.1137
Schistosoma mansoni	sugar transporter	0.0032	0.0217	0.0894
Toxoplasma gondii	facilitative glucose transporter GT1	0.0227	0.2266	0.3424
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0265	0.3711
Brugia malayi	exodeoxyribonuclease III family protein	0.0018	0.0072	0.0265
Schistosoma mansoni	serine/threonine protein kinase	0.0069	0.0611	0.2648
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0217	0.0956
Echinococcus granulosus	beta LACTamase domain containing family member	0.0037	0.0265	0.0521
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0069	0.0611	0.1242
Trichomonas vaginalis	glucose transporter, putative	0.007	0.0621	0.274
Trypanosoma brucei	glycyl-tRNA synthetase, putative	0.0013	0.0016	0.0218
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0079	0.0715	1
Echinococcus multilocularis	solute carrier family 22	0.0032	0.0217	0.0419
Trypanosoma brucei	glucose transporter, putative	0.007	0.0621	0.868
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0217	0.0956
Plasmodium vivax	calcium-dependent protein kinase, putative	0.007	0.0612	0.0597
Brugia malayi	Cam kinase protein 1	0.0069	0.0611	0.2658
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0217	0.0956
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0072	0.1012
Mycobacterium tuberculosis	Probable lipase LipE	0.0037	0.0265	0.1137
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0265	0.1172
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0265	0.1122
Trypanosoma brucei	glucose transporter, putative	0.007	0.0621	0.868
Leishmania major	threonyl-tRNA synthetase, putative	0.0013	0.0016	0.0218
Trichomonas vaginalis	threonyl-tRNA synthetase, putative	0.0013	0.0016	0.0069
Trichomonas vaginalis	sugar transporter, putative	0.007	0.0621	0.274
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0068	0.0597	1
Onchocerca volvulus		0.0037	0.0265	1
Plasmodium vivax	hypothetical protein, conserved	0.0037	0.0265	0.025
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0217	0.0956
Leishmania major	protein kinase, putative	0.0069	0.0611	0.855
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0032	0.0217	0.0906
Trypanosoma brucei	glucose transporter, putative	0.007	0.0621	0.868
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0217	0.0956
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0043	0.0333	0.1428
Brugia malayi	lysyl-tRNA synthetase	0.0051	0.0414	0.178
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0079	0.0715	1
Mycobacterium ulcerans	esterase/lipase LipP	0.0037	0.0265	0.6418
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0265	0.1122
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0217	0.0906
Echinococcus granulosus	solute carrier family 22	0.0032	0.0217	0.0419
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0217	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0265	0.1122
Mycobacterium ulcerans	sugar transporter	0.0032	0.0217	0.5239
Toxoplasma gondii	sugar transporter ST2	0.0032	0.0217	0.0327
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0012	0.0013	0.0306
Brugia malayi	Major Facilitator Superfamily protein	0.0032	0.0217	0.0906
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0032	0.0217	0.0894
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.007	0.0612	0.0597
Onchocerca volvulus		0.0037	0.0265	1
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0032	0.0217	0.0419
Plasmodium falciparum	calcium-dependent protein kinase 4	0.007	0.0612	0.0597
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0217	0.0956
Schistosoma mansoni	protein kinase	0.0069	0.0611	0.2648
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0217	0.0956
Brugia malayi	major facilitator superfamily protein	0.0032	0.0217	0.0906
Plasmodium falciparum	hexose transporter	0.0227	0.2266	0.2253
Plasmodium vivax	sugar transporter, putative	0.0032	0.0217	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0217	0.0906
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0217	0.0906
Toxoplasma gondii	glycyl-tRNA synthetase	0.0013	0.0016	0.0024
Schistosoma mansoni	ap endonuclease	0.0018	0.0072	0.0252
Trypanosoma brucei	glucose transporter 2A	0.007	0.0621	0.868
Plasmodium vivax	proline--tRNA ligase, putative	0.0079	0.0715	0.0701
Mycobacterium ulcerans	integral membrane transport protein	0.0032	0.0217	0.5239
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0068	0.0597	0.2583
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0018	0.0072	0.031
Schistosoma mansoni	sugar transporter	0.0032	0.0217	0.0894
Mycobacterium ulcerans	lipase LipD	0.0037	0.0265	0.6418
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0367	0.3734	0.3724
Mycobacterium ulcerans	beta-lactamase	0.0037	0.0265	0.6418
Brugia malayi	hypothetical protein	0.0032	0.0217	0.0906
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0217	0.0956
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0265	0.1122
Mycobacterium ulcerans	threonyl-tRNA synthetase	0.0013	0.0016	0.0377
Loa Loa (eye worm)	sugar transporter	0.0032	0.0217	0.0906
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0463	0.1997
Chlamydia trachomatis	lysine--tRNA ligase	0.0051	0.0414	1
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0217	0.0956
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0018	0.0072	0.4788
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0037	0.0265	0.1122
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0018	0.0072	0.0118
Brugia malayi	probable proline-trna synthetase - fission yeast, putative	0.0013	0.0016	0.0013
Chlamydia trachomatis	proline--tRNA ligase	0.0024	0.0134	0.2978
Echinococcus granulosus	calcium dependent protein kinase	0.0065	0.0566	0.1148
Trichomonas vaginalis	conserved hypothetical protein	0.007	0.0621	0.274
Echinococcus granulosus	General substrate transporter	0.0195	0.193	0.3991
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0018	0.0072	0.0976
Echinococcus granulosus	lysyl tRNA synthetase	0.0051	0.0414	0.083
Treponema pallidum	prolyl-tRNA synthetase	0.0024	0.0134	1
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0018	0.0072	0.0118
Trichomonas vaginalis	conserved hypothetical protein	0.0227	0.2266	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 763747