TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 355.355 | Formula: C17H20F3N3O2
H donors: 0 H acceptors: 2 LogP: 3.16 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COCC1CCCN(C1)Cc1onc(n1)c1ccc(cc1)C(F)(F)F
InChi: 1S/C17H20F3N3O2/c1-24-11-12-3-2-8-23(9-12)10-15-21-16(22-25-15)13-4-6-14(7-5-13)17(18,19)20/h4-7,12H,2-3,8-11H2,1H3
InChiKey: SHKRXCXGNHKOBY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	cytochrome P450 family protein	0.0014	0.0015	0.0066
Brugia malayi	lysyl-tRNA synthetase	0.0076	0.045	0.1907
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0104	0.0647	0.119
Brugia malayi	threonyl-tRNA synthetase, cytoplasmic	0.0019	0.0053	0.0167
Loa Loa (eye worm)	hypothetical protein	0.004	0.0199	0.0868
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0104	0.0647	0.8623
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0014	0.0015	0.0085
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0104	0.0647	0.1844
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.0557	0.2428
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0102	0.0632	0.9772
Brugia malayi	probable proline-trna synthetase - fission yeast, putative	0.0019	0.0053	0.0167
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.004	0.0199	0.0868
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0038	0.0165
Leishmania major	protein kinase, putative	0.0104	0.0647	0.8623
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Schistosoma mansoni	sugar transporter	0.0048	0.0254	0.1106
Trichomonas vaginalis	penicillin-binding protein, putative	0.004	0.0199	0.0868
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0499	0.2173
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0199	0.2654
Onchocerca volvulus		0.0048	0.0254	1
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0119	0.075	0.1132
Brugia malayi	Sugar transporter family protein	0.0048	0.0254	0.1046
Loa Loa (eye worm)	beta-lactamase	0.004	0.0199	0.0868
Mycobacterium tuberculosis	Conserved protein	0.004	0.0199	0.0968
Echinococcus multilocularis	lysyl tRNA synthetase	0.0076	0.045	0.0828
Leishmania major	myo-inositol/proton symporter (MIT)	0.0048	0.0254	0.3381
Leishmania major	cytochrome p450-like protein	0.0014	0.0015	0.0203
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0105	0.0656	0.8747
Brugia malayi	hypothetical protein	0.0048	0.0254	0.1046
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0104	0.0647	0.119
Mycobacterium ulcerans	integral membrane transport protein	0.0048	0.0254	0.1426
Loa Loa (eye worm)	glycyl-tRNA synthetase	0.0019	0.0053	0.0233
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Onchocerca volvulus		0.0048	0.0254	1
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0076	0.045	0.6932
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0076	0.045	0.2528
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0254	0.1106
Onchocerca volvulus		0.0048	0.0254	1
Trichomonas vaginalis	D-aminoacylase, putative	0.004	0.0199	0.0868
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0104	0.0647	0.119
Echinococcus multilocularis	beta LACTamase domain containing family member	0.004	0.0199	0.0366
Toxoplasma gondii	YbaK/proline-tRNA ligase associated domain-containing protein	0.0017	0.0038	0.0057
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0339	0.2295	0.654
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0104	0.0647	0.0976
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0104	0.0647	0.2819
Echinococcus multilocularis	solute carrier family 22	0.0048	0.0254	0.0467
Trichomonas vaginalis	myo-inositol transporter, putative	0.0048	0.0254	0.1106
Trypanosoma cruzi	Aminoacyl-tRNA editing domain containing protein, putative	0.0017	0.0038	0.0504
Brugia malayi	hypothetical protein	0.0048	0.0254	0.1046
Trichomonas vaginalis	conserved hypothetical protein	0.0048	0.0254	0.1106
Echinococcus granulosus	geminin	0.0187	0.1227	0.3498
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0102	0.0632	0.1802
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0254	0.1106
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0254	0.1106
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.004	0.0199	0.0968
Schistosoma mansoni	sugar transporter	0.0048	0.0254	0.1106
Leishmania major	glucose transporter, lmgt3	0.0105	0.0656	0.8747
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0048	0.0254	0.0467
Trypanosoma brucei	glucose transporter, putative	0.0105	0.0656	0.8747
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0102	0.0632	0.1163
Mycobacterium tuberculosis	Probable hydrolase	0.004	0.0199	0.0968
Loa Loa (eye worm)	hypothetical protein	0.004	0.0199	0.0868
Echinococcus granulosus	calcium dependent protein kinase	0.0098	0.0602	0.1716
Brugia malayi	hypothetical protein	0.0048	0.0254	0.1046
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0091	0.0557	0.1025
Brugia malayi	beta-lactamase family protein	0.004	0.0199	0.0807
Wolbachia endosymbiont of Brugia malayi	threonyl-tRNA synthetase	0.0019	0.0053	0.2103
Trichomonas vaginalis	glutaminase, putative	0.0266	0.1779	0.7753
Onchocerca volvulus		0.0048	0.0254	1
Brugia malayi	major facilitator superfamily protein	0.0048	0.0254	0.1046
Trichomonas vaginalis	D-aminoacylase, putative	0.004	0.0199	0.0868
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0048	0.0254	0.1426
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Loa Loa (eye worm)	cytochrome P450 family protein	0.0014	0.0015	0.0066
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Trichomonas vaginalis	glucose transporter, putative	0.0048	0.0254	0.1106
Trypanosoma cruzi	hexose transporter, putative	0.0105	0.0656	0.8747
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0254	0.1106
Brugia malayi	Major Facilitator Superfamily protein	0.0048	0.0254	0.1046
Trypanosoma cruzi	hexose transporter, putative	0.0105	0.0656	0.8747
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0048	0.0254	0.1295
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Echinococcus granulosus	solute carrier family 22	0.0048	0.0254	0.0723
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.0557	0.2428
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0091	0.0557	0.1588
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0076	0.045	0.2528
Trichomonas vaginalis	conserved hypothetical protein	0.0048	0.0254	0.1106
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0104	0.0647	0.0647
Onchocerca volvulus		0.0048	0.0254	1
Trypanosoma brucei	hypothetical protein, conserved	0.004	0.0199	0.2654
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Trypanosoma cruzi	sugar transporter, putative	0.0048	0.0254	0.3381
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0254	0.1106
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0632	0.2755
Mycobacterium ulcerans	lipase LipD	0.004	0.0199	0.1119
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0105	0.0656	0.8747
Onchocerca volvulus		0.0048	0.0254	1
Trichomonas vaginalis	sugar transporter, putative	0.0105	0.0656	0.286
Trypanosoma brucei	glycyl-tRNA synthetase, putative	0.0019	0.0053	0.0711
Plasmodium falciparum	hexose transporter	0.0339	0.2295	0.2295
Plasmodium vivax	proline--tRNA ligase, putative	0.0119	0.075	0.075
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0064	0.037	0.1992
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0119	0.075	1
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0102	0.0632	0.2707
Toxoplasma gondii	ABC1 family protein	0.004	0.0199	0.03
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0199	0.2654
Loa Loa (eye worm)	sugar transporter	0.0339	0.2295	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.004	0.0199	0.0807
Trichomonas vaginalis	conserved hypothetical protein	0.0048	0.0254	0.1106
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.004	0.0199	0.0868
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0339	0.2295	0.4222
Brugia malayi	Major Facilitator Superfamily protein	0.0048	0.0254	0.1046
Treponema pallidum	threonyl-tRNA synthetase	0.0019	0.0053	0.3113
Echinococcus granulosus	solute carrier family 22	0.0048	0.0254	0.0723
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Toxoplasma gondii	threonyl-tRNA synthetase family protein	0.0019	0.0053	0.008
Treponema pallidum	prolyl-tRNA synthetase	0.0036	0.0171	1
Giardia lamblia	Prolyl-tRNA synthetase	0.0102	0.0632	1
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0104	0.0647	0.0647
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Trichomonas vaginalis	conserved hypothetical protein	0.0048	0.0254	0.1106
Plasmodium vivax	sugar transporter, putative	0.0048	0.0254	0.0254
Trypanosoma cruzi	cytochrome P450, putative	0.0014	0.0015	0.0203
Leishmania major	hypothetical protein, conserved	0.0048	0.0254	0.3381
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0058	0.0058
Brugia malayi	Cam kinase protein 1	0.0104	0.0647	0.2772
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.002	0.0058	0.0254
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0549	0.3758	0.3758
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0119	0.075	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0104	0.0647	0.1844
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0104	0.0647	0.0647
Plasmodium vivax	glycine--tRNA ligase, putative	0.0019	0.0053	0.0053
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0104	0.0647	0.119
Leishmania major	hypothetical protein, conserved	0.004	0.0199	0.2654
Trichomonas vaginalis	conserved hypothetical protein	0.0105	0.0656	0.286
Echinococcus granulosus	General substrate transporter	0.0292	0.1961	0.5589
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0102	0.0632	0.2755
Entamoeba histolytica	protein kinase, putative	0.0104	0.0647	1
Schistosoma mansoni	protein kinase	0.0104	0.0647	0.2819
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.002	0.0058	0.0328
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0076	0.045	0.5996
Echinococcus granulosus	solute carrier family 22	0.0048	0.0254	0.0723
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0254	0.1106
Loa Loa (eye worm)	glutaminase 2	0.0266	0.1779	0.7753
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.0058	0.0254
Schistosoma mansoni	protein kinase	0.0104	0.0647	0.2819
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0058	0.0058
Schistosoma mansoni	glycyl-tRNA synthetase	0.0019	0.0053	0.0233
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0104	0.0647	0.0976
Leishmania major	hypothetical protein, conserved	0.0017	0.0038	0.0504
Trichomonas vaginalis	D-aminoacylase, putative	0.004	0.0199	0.0868
Leishmania major	glucose transporter, lmgt1	0.0105	0.0656	0.8747
Toxoplasma gondii	facilitative glucose transporter GT1	0.0339	0.2295	0.3461
Echinococcus multilocularis	glycyl tRNA synthetase	0.0019	0.0053	0.0098
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0104	0.0647	0.0647
Schistosoma mansoni	hypothetical protein	0.0339	0.2295	1
Trichomonas vaginalis	sugar transporter, putative	0.0105	0.0656	0.286
Toxoplasma gondii	exonuclease III APE	0.002	0.0058	0.0088
Schistosoma mansoni	glucose transporter	0.0048	0.0254	0.1106
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0038	0.0165
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Schistosoma mansoni	lysyl-tRNA synthetase	0.0076	0.045	0.196
Trypanosoma brucei	threonyl-tRNA synthetase, putative	0.0019	0.0053	0.0711
Loa Loa (eye worm)	glutaminase	0.0266	0.1779	0.7753
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0048	0.0254	1
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.004	0.0199	0.0968
Onchocerca volvulus		0.0048	0.0254	1
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.004	0.0199	0.0868
Schistosoma mansoni	glutaminase	0.0266	0.1779	0.7753
Echinococcus multilocularis	solute carrier family 22	0.0048	0.0254	0.0467
Trypanosoma cruzi	hexose transporter, putative	0.0048	0.0254	0.3381
Mycobacterium ulcerans	esterase/lipase LipP	0.004	0.0199	0.1119
Trichomonas vaginalis	sugar transporter, putative	0.0105	0.0656	0.286
Echinococcus multilocularis	geminin	0.0187	0.1227	0.2258
Schistosoma mansoni	glucose transport protein	0.0339	0.2295	1
Echinococcus granulosus	neuropeptide s receptor	0.0513	0.3509	1
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.002	0.0058	0.0166
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0048	0.0254	0.3381
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.002	0.0058	0.0123
Trypanosoma brucei	glucose transporter 1E	0.0105	0.0656	0.8747
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0119	0.075	1
Mycobacterium leprae	conserved hypothetical protein	0.004	0.0199	0.2714
Echinococcus granulosus	neuropeptide receptor A26	0.0513	0.3509	1
Plasmodium falciparum	protein kinase 7	0.0959	0.663	0.663
Plasmodium falciparum	proline--tRNA ligase	0.0119	0.075	0.075
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Trichomonas vaginalis	penicillin-binding protein, putative	0.004	0.0199	0.0868
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0254	0.1106
Trichomonas vaginalis	esterase, putative	0.004	0.0199	0.0868
Trypanosoma brucei	glucose transporter, putative	0.0105	0.0656	0.8747
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0339	0.2295	0.4222
Trypanosoma brucei	glucose transporter, putative	0.0105	0.0656	0.8747
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0102	0.0632	0.2707
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0066	0.0385	0.1676
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0254	0.1106
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0048	0.0254	0.0254
Leishmania major	lysyl-tRNA synthetase, putative	0.0076	0.045	0.5996
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0254	0.1106
Trypanosoma cruzi	cytochrome P450, putative	0.0014	0.0015	0.0203
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0105	0.0656	0.8747
Loa Loa (eye worm)	hypothetical protein	0.004	0.0199	0.0868
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.0557	0.2428
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0254	0.1106
Trichomonas vaginalis	conserved hypothetical protein	0.0105	0.0656	0.286
Trypanosoma cruzi	hypothetical protein, conserved	0.0017	0.0038	0.0504
Giardia lamblia	Lysyl-tRNA synthetase	0.0076	0.045	0.6849
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0339	0.2295	0.654
Leishmania major	hypothetical protein, conserved	0.0017	0.0038	0.0504
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0064	0.037	0.5587
Mycobacterium ulcerans	threonyl-tRNA synthetase	0.0019	0.0053	0.03
Echinococcus granulosus	synaptic vesicle 2 protein	0.0048	0.0254	0.0723
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0104	0.0647	0.0647
Chlamydia trachomatis	threonine--tRNA ligase	0.0019	0.0053	0.1186
Trypanosoma brucei	glucose transporter 2A	0.0105	0.0656	0.8747
Schistosoma mansoni	protein kinase	0.0104	0.0647	0.2819
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0647	0.2819
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0104	0.0647	0.0647
Loa Loa (eye worm)	CYP4Cod1	0.0014	0.0015	0.0066
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0254	0.1106
Loa Loa (eye worm)	hypothetical protein	0.004	0.0199	0.0868
Schistosoma mansoni	serine/threonine protein kinase	0.0104	0.0647	0.2819
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0048	0.0254	0.1106
Schistosoma mansoni	lysyl-tRNA synthetase	0.0076	0.045	0.196
Trichomonas vaginalis	conserved hypothetical protein	0.0339	0.2295	1
Toxoplasma gondii	sugar transporter ST3	0.0048	0.0254	0.0383
Trichomonas vaginalis	conserved hypothetical protein	0.0048	0.0254	0.1106
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0104	0.0647	0.0647
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Onchocerca volvulus		0.0048	0.0254	1
Mycobacterium tuberculosis	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase)	0.0019	0.0053	0.0093
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0104	0.0647	0.0647
Onchocerca volvulus		0.0048	0.0254	1
Schistosoma mansoni	glucose transport protein	0.0339	0.2295	1
Loa Loa (eye worm)	sugar transporter	0.0048	0.0254	0.1106
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Onchocerca volvulus		0.0048	0.0254	1
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0102	0.0632	0.2755
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0254	0.1106
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.002	0.0058	0.0777
Plasmodium vivax	hypothetical protein, conserved	0.004	0.0199	0.0199
Echinococcus granulosus	Threonyl tRNA synthetase C	0.0019	0.0053	0.0152
Brugia malayi	exodeoxyribonuclease III family protein	0.002	0.0058	0.0189
Entamoeba histolytica	hypothetical protein	0.0076	0.045	0.6953
Mycobacterium ulcerans	hypothetical protein	0.0017	0.0038	0.0213
Trypanosoma cruzi	hexose transporter	0.0105	0.0656	0.8747
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0119	0.075	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0254	0.1106
Mycobacterium tuberculosis	Conserved protein	0.004	0.0199	0.0968
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0048	0.0254	0.1106
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Echinococcus granulosus	glycyl tRNA synthetase	0.0019	0.0053	0.0152
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0105	0.0656	0.8747
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0254	0.1106
Plasmodium falciparum	lysine--tRNA ligase	0.0076	0.045	0.045
Trichomonas vaginalis	glucose transporter, putative	0.0105	0.0656	0.286
Echinococcus multilocularis	calcium dependent protein kinase	0.0098	0.0602	0.1108
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Loa Loa (eye worm)	hypothetical protein	0.004	0.0199	0.0868
Wolbachia endosymbiont of Brugia malayi	prolyl-tRNA synthetase	0.0019	0.0053	0.2103
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0104	0.0647	0.1844
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0632	0.2755
Onchocerca volvulus		0.0048	0.0254	1
Mycobacterium ulcerans	glycyl-tRNA synthetase	0.0019	0.0053	0.03
Trypanosoma brucei	glucose transporter, putative	0.0105	0.0656	0.8747
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0339	0.2295	0.654
Echinococcus multilocularis	solute carrier family 22	0.0048	0.0254	0.0467
Brugia malayi	Major Facilitator Superfamily protein	0.0048	0.0254	0.1046
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0339	0.2295	0.4222
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0042	0.0212	0.0925
Onchocerca volvulus		0.0048	0.0254	1
Plasmodium vivax	CDK-related protein kinase 6, putative	0.1441	1	1
Trypanosoma brucei	sugar transporter, putative	0.0048	0.0254	0.3381
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0339	0.2295	0.4222
Trypanosoma cruzi	hypothetical protein, conserved	0.0017	0.0038	0.0504
Onchocerca volvulus		0.0048	0.0254	1
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0019	0.0053	0.0711
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0091	0.0557	0.1025
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0104	0.0647	0.2772
Echinococcus multilocularis	neuropeptide s receptor	0.0513	0.3509	0.6455
Mycobacterium leprae	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase)	0.0019	0.0053	0.0262
Schistosoma mansoni	ap endonuclease	0.002	0.0058	0.0254
Brugia malayi	Sugar transporter family protein	0.0048	0.0254	0.1046
Toxoplasma gondii	sugar transporter ST1	0.0048	0.0254	0.0383
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0048	0.0254	0.1426
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.002	0.0058	0.0777
Toxoplasma gondii	transporter, major facilitator family protein	0.0048	0.0254	0.0383
Trypanosoma cruzi	glucose transporter, putative	0.0048	0.0254	0.3381
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0549	0.3758	0.3758
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0019	0.0053	0.0711
Echinococcus granulosus	lysyl tRNA synthetase	0.0076	0.045	0.1282
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.002	0.0058	0.0902
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0048	0.0254	0.0467
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0036	0.0171	0.0964
Plasmodium falciparum	threonine--tRNA ligase	0.0019	0.0053	0.0053
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Trypanosoma brucei	Aminoacyl-tRNA editing domain containing protein, putative	0.0017	0.0038	0.0504
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Brugia malayi	beta-lactamase family protein	0.004	0.0199	0.0807
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0064	0.037	0.1992
Trypanosoma cruzi	hexose transporter, putative	0.0058	0.0322	0.4296
Schistosoma mansoni	glucose transport protein	0.0339	0.2295	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.004	0.0199	0.0568
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.004	0.0199	0.0968
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Onchocerca volvulus	Putative transporter	0.0048	0.0254	1
Trypanosoma cruzi	hexose transporter, putative	0.0105	0.0656	0.8747
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.004	0.0199	0.1119
Brugia malayi	beta-lactamase	0.004	0.0199	0.0807
Trichomonas vaginalis	sugar transport protein, putative	0.0048	0.0254	0.1106
Toxoplasma gondii	sugar transporter ST2	0.0048	0.0254	0.0383
Trypanosoma brucei	glucose transporter, putative	0.0105	0.0656	0.8747
Trichomonas vaginalis	conserved hypothetical protein	0.0017	0.0038	0.0165
Entamoeba histolytica	threonyl-tRNA synthetase, putative	0.0019	0.0053	0.0825
Giardia lamblia	Sugar-proton symporter	0.0048	0.0254	0.346
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0104	0.0647	0.0647
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0104	0.0647	0.2819
Treponema pallidum	exodeoxyribonuclease (exoA)	0.002	0.0058	0.3403
Trichomonas vaginalis	CAMK family protein kinase	0.0104	0.0647	0.2819
Schistosoma mansoni	hypothetical protein	0.0187	0.1227	0.5348
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0119	0.075	1
Mycobacterium ulcerans	sugar transporter	0.0048	0.0254	0.1426
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0788	0.5436	1
Chlamydia trachomatis	proline--tRNA ligase	0.0036	0.0171	0.3811
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Plasmodium vivax	threonine--tRNA ligase, putative	0.0019	0.0053	0.0053
Trichomonas vaginalis	glucose transporter, putative	0.0105	0.0656	0.286
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0048	0.0254	0.1295
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0076	0.045	0.196
Trypanosoma brucei	glucose transporter, putative	0.0105	0.0656	0.8747
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Schistosoma mansoni	sugar transporter	0.0048	0.0254	0.1106
Mycobacterium leprae	Probable lipase LipE	0.004	0.0199	0.2714
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.002	0.0058	0.0777
Toxoplasma gondii	lysine-tRNA ligase	0.0076	0.045	0.0679
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.002	0.0058	0.0086
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Plasmodium vivax	hexose transporter	0.0339	0.2295	0.2295
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0091	0.0557	0.2377
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0255	0.1705	1
Mycobacterium ulcerans	hypothetical protein	0.004	0.0199	0.1119
Brugia malayi	glutaminase DH11.1	0.0266	0.1779	0.7738
Trypanosoma brucei	glucose transporter, putative	0.0105	0.0656	0.8747
Mycobacterium tuberculosis	Probable lipase LipE	0.004	0.0199	0.0968
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0091	0.0557	0.1588
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0102	0.0632	1
Echinococcus multilocularis	Threonyl tRNA synthetase, C	0.0019	0.0053	0.0098
Mycobacterium ulcerans	glutaminase	0.0266	0.1779	1
Echinococcus granulosus	solute carrier family 22	0.0048	0.0254	0.0723
Brugia malayi	major facilitator superfamily protein	0.0048	0.0254	0.1046
Trichomonas vaginalis	threonyl-tRNA synthetase, putative	0.0019	0.0053	0.0233
Schistosoma mansoni	ap endonuclease	0.002	0.0058	0.0254
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0104	0.0647	0.1844
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0254	0.1106
Onchocerca volvulus		0.0048	0.0254	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0053	0.0233
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Trypanosoma brucei	cytochrome P450, putative	0.0014	0.0015	0.0203
Mycobacterium tuberculosis	Probable lipase LipD	0.004	0.0199	0.0968
Toxoplasma gondii	glycyl-tRNA synthetase	0.0019	0.0053	0.008
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0339	0.2295	0.654
Echinococcus multilocularis	solute carrier family 22	0.0048	0.0254	0.0467
Brugia malayi	glycyl-tRNA synthetase	0.0019	0.0053	0.0167
Leishmania major	threonyl-tRNA synthetase, putative	0.0019	0.0053	0.0711
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0076	0.045	0.5996
Loa Loa (eye worm)	threonyl-tRNA synthetase	0.0019	0.0053	0.0233
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0102	0.0632	0.2755
Trypanosoma cruzi	Aminoacyl-tRNA editing domain containing protein, putative	0.0017	0.0038	0.0504
Mycobacterium ulcerans	beta-lactamase	0.004	0.0199	0.1119
Chlamydia trachomatis	lysine--tRNA ligase	0.0076	0.045	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0091	0.0557	0.2428
Echinococcus multilocularis	neuropeptide receptor A26	0.0513	0.3509	0.6455
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Brugia malayi	Sugar transporter family protein	0.0339	0.2295	1
Mycobacterium tuberculosis	Conserved protein	0.004	0.0199	0.0968
Plasmodium vivax	lysine--tRNA ligase, putative	0.0076	0.045	0.045
Onchocerca volvulus		0.0048	0.0254	1
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0048	0.0254	0.0723
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0048	0.0254	0.1106
Entamoeba histolytica	protein kinase, putative	0.0104	0.0647	1
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0549	0.3758	0.5667
Mycobacterium tuberculosis	Probable esterase LipL	0.004	0.0199	0.0968
Trypanosoma brucei	glucose transporter, putative	0.0105	0.0656	0.8747
Echinococcus multilocularis	General substrate transporter	0.0292	0.1961	0.3607
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0104	0.0647	0.0976
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.002	0.0058	0.0777
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.002	0.0058	0.23
Toxoplasma gondii	protein kinase, putative	0.0959	0.663	1
Trichomonas vaginalis	sugar transporter, putative	0.0048	0.0254	0.1106
Loa Loa (eye worm)	hypothetical protein	0.0076	0.045	0.196
Schistosoma mansoni	sugar transporter	0.0048	0.0254	0.1106
Schistosoma mansoni	hypothetical protein	0.0187	0.1227	0.5348
Leishmania major	glucose transporter, lmgt2	0.0105	0.0656	0.8747
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.002	0.0058	0.0107
Giardia lamblia	Hexose transporter	0.0048	0.0254	0.346
Onchocerca volvulus		0.0048	0.0254	1
Entamoeba histolytica	glycyl-tRNA synthetase, putative	0.0019	0.0053	0.0825
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.0058	0.0254
Loa Loa (eye worm)	hypothetical protein	0.004	0.0199	0.0868

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 763749