Detailed information for compound 763796

Basic information

Technical information
  • TDR Targets ID: 763796
  • Name: 3-(3-fluoro-4-phenylbenzoyl)-N,N-dimethylpipe ridine-1-sulfonamide
  • MW: 390.472 | Formula: C20H23FN2O3S
  • H donors: 0 H acceptors: 3 LogP: 2.99 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc(c(c1)F)c1ccccc1)C1CCCN(C1)S(=O)(=O)N(C)C
  • InChi: 1S/C20H23FN2O3S/c1-22(2)27(25,26)23-12-6-9-17(14-23)20(24)16-10-11-18(19(21)13-16)15-7-4-3-5-8-15/h3-5,7-8,10-11,13,17H,6,9,12,14H2,1-2H3
  • InChiKey: XJDQHVLIKZOCPF-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 3-(3-fluoro-4-phenyl-benzoyl)-N,N-dimethyl-piperidine-1-sulfonamide
  • 3-[(3-fluoro-4-phenylphenyl)-oxomethyl]-N,N-dimethyl-1-piperidinesulfonamide
  • 3-(3-fluoro-4-phenyl-phenyl)carbonyl-N,N-dimethyl-piperidine-1-sulfonamide
  • 3-[(2-fluorobiphenyl-4-yl)carbonyl]-N,N-dimethylpiperidine-1-sulfonamide
  • MLS000693765
  • SMR000319678

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens tyrosyl-DNA phosphodiesterase 1 Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Trypanosoma brucei gambiense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania infantum tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K01113 phosphodiesterase/alkaline phosphatase D [EC3.1.4.1], putative Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein Get druggable targets OG5_129037 All targets in OG5_129037
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis tyrosyl-DNA phosphodiesterase, putative;with=GeneDB:LinJ33_V3.3210 Get druggable targets OG5_129037 All targets in OG5_129037
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania donovani tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania mexicana tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Cryptosporidium parvum tyrosyl-DNA phodphodiesterase 1 (tdp1) Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0516
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.003 0.0113 0.0516
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0516
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.004 0.0231 0.1615
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0685 1
Trypanosoma cruzi hexose transporter, putative 0.003 0.0113 0.1646
Brugia malayi lysyl-tRNA synthetase 0.0047 0.0312 0.1428
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.003 0.0113 0.1646
Mycobacterium ulcerans sugar transporter 0.003 0.0113 0.3616
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.008 0.0685 0.3136
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0063 0.0497 0.2275
Brugia malayi hypothetical protein 0.003 0.0113 0.0516
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0516
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0047 0.0312 0.1428
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0113 0.0516
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0405 0.1855
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0405 0.1855
Trichomonas vaginalis glucose transporter, putative 0.0065 0.0521 0.2387
Loa Loa (eye worm) hypothetical protein 0.003 0.0113 0.0199
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0063 0.0497 0.2275
Leishmania major trypanothione reductase 0.0057 0.0426 0.6226
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.004 0.0231 0.1615
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.008 0.0685 0.3136
Schistosoma mansoni lysyl-tRNA synthetase 0.0047 0.0312 0.1428
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.008 0.0685 0.2906
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0113 0.0199
Plasmodium falciparum calcium-dependent protein kinase 4 0.0065 0.0512 0.0512
Mycobacterium tuberculosis Probable reductase 0.013 0.1262 0.8837
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0211 0.2183 1
Echinococcus multilocularis synaptic vesicle 2 protein 0.003 0.0113 0.0516
Echinococcus granulosus solute carrier family 22 0.003 0.0113 0.0516
Loa Loa (eye worm) hypothetical protein 0.003 0.0113 0.0199
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0273 0.1249
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.0273 0.3983
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.1262 0.8837
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0521 0.2387
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0074 0.0617 0.9005
Trypanosoma brucei glucosidase, putative 0.0044 0.0273 0.3983
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0512 0.2344
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0065 0.0512 0.2088
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0516
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0516
Brugia malayi Cam kinase protein 1 0.0065 0.0512 0.2344
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0516
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0065 0.0512 0.0778
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0113 0.0516
Loa Loa (eye worm) hypothetical protein 0.003 0.0113 0.0199
Echinococcus multilocularis General substrate transporter 0.0181 0.1845 0.8448
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.003 0.0113 0.3616
Leishmania major lysyl-tRNA synthetase, putative 0.0047 0.0312 0.4553
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.1262 0.8837
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0074 0.0617 0.9005
Loa Loa (eye worm) hypothetical protein 0.003 0.0113 0.0199
Brugia malayi Thioredoxin reductase 0.0057 0.0426 0.1953
Trichomonas vaginalis sugar transport protein, putative 0.003 0.0113 0.0516
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0521 0.7612
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0516
Brugia malayi hypothetical protein 0.003 0.0113 0.0516
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0.0273 0.1249
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.0301 0.1379
Schistosoma mansoni alpha glucosidase 0.0044 0.0273 0.1249
Plasmodium vivax glutathione reductase, putative 0.0057 0.0426 0.0426
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.0426 0.2985
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0113 0.0199
Trypanosoma brucei glucose transporter 1E 0.0065 0.0521 0.7612
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0516
Toxoplasma gondii sugar transporter ST2 0.003 0.0113 0.0171
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0405 0.1855
Trypanosoma cruzi glucose transporter, putative 0.003 0.0113 0.1646
Trypanosoma brucei glucose transporter, putative 0.0065 0.0521 0.7612
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0065 0.0512 0.0512
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0211 0.2183 1
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0063 0.0497 0.2275
Loa Loa (eye worm) hypothetical protein 0.0065 0.0512 0.2088
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0065 0.0512 0.0778
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0516
Loa Loa (eye worm) hypothetical protein 0.0047 0.0312 0.1141
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0521 0.7612
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0521 0.2387
Giardia lamblia Prolyl-tRNA synthetase 0.0063 0.0497 1
Chlamydia trachomatis proline--tRNA ligase 0.0022 0.0029 0.0939
Loa Loa (eye worm) hypothetical protein 0.003 0.0113 0.0199
Brugia malayi Sugar transporter family protein 0.003 0.0113 0.0516
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0065 0.0512 0.2344
Toxoplasma gondii sugar transporter ST1 0.003 0.0113 0.0171
Loa Loa (eye worm) hypothetical protein 0.0063 0.0497 0.2017
Trypanosoma brucei sugar transporter, putative 0.003 0.0113 0.1646
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0022 0.0029 0.0939
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0074 0.0617 0.9005
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0211 0.2183 1
Trypanosoma brucei glucose transporter, putative 0.0065 0.0521 0.7612
Trypanosoma cruzi sugar transporter, putative 0.003 0.0113 0.1646
Brugia malayi Sugar transporter family protein 0.003 0.0113 0.0516
Brugia malayi glutathione reductase 0.0057 0.0426 0.1953
Leishmania major glucose transporter, lmgt3 0.0065 0.0521 0.7612
Leishmania major protein kinase, putative 0.0065 0.0512 0.7474
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0113 0.0516
Echinococcus multilocularis Sugar transporter ERD6 protein 0.003 0.0113 0.0516
Toxoplasma gondii thioredoxin reductase 0.0057 0.0426 0.0648
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0521 0.2387
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.003 0.0113 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.0273 0.0956
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0063 0.0497 0.2275
Toxoplasma gondii facilitative glucose transporter GT1 0.0211 0.2183 0.3317
Echinococcus multilocularis calcium dependent protein kinase 0.0061 0.0466 0.2135
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.003 0.0113 0.3616
Trypanosoma brucei trypanothione reductase 0.0057 0.0426 0.6226
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0074 0.0617 0.0937
Schistosoma mansoni protein kinase 0.0065 0.0512 0.2344
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0074 0.0617 0.9005
Trypanosoma brucei glucose transporter 2A 0.0065 0.0521 0.7612
Trichomonas vaginalis conserved hypothetical protein 0.0211 0.2183 1
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.003 0.0113 0.0113
Echinococcus granulosus General substrate transporter 0.0181 0.1845 0.8448
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0063 0.0497 0.2275
Echinococcus granulosus synaptic vesicle 2 protein 0.003 0.0113 0.0516
Loa Loa (eye worm) hypothetical protein 0.003 0.0113 0.0199
Echinococcus granulosus lysyl tRNA synthetase 0.0047 0.0312 0.1428
Schistosoma mansoni sugar transporter 0.003 0.0113 0.0516
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0516
Schistosoma mansoni glucose transport protein 0.0211 0.2183 1
Brugia malayi Sugar transporter family protein 0.0211 0.2183 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0516
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.1428 1
Plasmodium vivax proline--tRNA ligase, putative 0.0074 0.0617 0.0617
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.0273 0.1249
Schistosoma mansoni alpha-glucosidase 0.0169 0.1709 0.7826
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0516
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0516
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0516
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.013 0.1262 0.8613
Plasmodium falciparum protein kinase 7 0.0596 0.6581 0.6581
Schistosoma mansoni glucose transport protein 0.0211 0.2183 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.1262 0.8837
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.008 0.0685 0.3136
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.0273 0.1249
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0273 0.1249
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0065 0.0512 0.7474
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0521 0.7612
Schistosoma mansoni protein kinase 0.0065 0.0512 0.2344
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0516
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0512 0.2344
Entamoeba histolytica protein kinase, putative 0.0065 0.0512 0.5801
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0521 0.7612
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.2022 0.926
Plasmodium falciparum proline--tRNA ligase 0.0074 0.0617 0.0617
Echinococcus granulosus calcium dependent protein kinase 0.0061 0.0466 0.2135
Giardia lamblia Lysyl-tRNA synthetase 0.0047 0.0312 0.6275
Echinococcus multilocularis solute carrier family 22 0.003 0.0113 0.0516
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.2022 0.9235
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0113 0.0516
Giardia lamblia Sugar-proton symporter 0.003 0.0113 0.2269
Trypanosoma brucei glucose transporter, putative 0.0065 0.0521 0.7612
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0065 0.0512 0.2344
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0211 0.2183 1
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0512 0.2344
Treponema pallidum prolyl-tRNA synthetase 0.0022 0.0029 1
Toxoplasma gondii transporter, major facilitator family protein 0.003 0.0113 0.0171
Leishmania major glucose transporter, lmgt1 0.0065 0.0521 0.7612
Onchocerca volvulus 0.0114 0.1074 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0405 0.1855
Plasmodium falciparum hexose transporter 0.0211 0.2183 0.2183
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0516
Giardia lamblia Hexose transporter 0.003 0.0113 0.2269
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0516
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0211 0.2183 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0516
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0047 0.0312 0.4553
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0516
Leishmania major myo-inositol/proton symporter (MIT) 0.003 0.0113 0.1646
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0512 0.2344
Trypanosoma cruzi hexose transporter 0.0065 0.0521 0.7612
Schistosoma mansoni sugar transporter 0.003 0.0113 0.0516
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0047 0.0312 1
Brugia malayi major facilitator superfamily protein 0.003 0.0113 0.0516
Echinococcus granulosus solute carrier family 22 0.003 0.0113 0.0516
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.1262 0.8837
Plasmodium vivax hexose transporter 0.0211 0.2183 0.2183
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0065 0.0512 0.2344
Brugia malayi hypothetical protein 0.003 0.0113 0.0516
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0341 0.3667 0.5572
Plasmodium falciparum thioredoxin reductase 0.0057 0.0426 0.0426
Loa Loa (eye worm) hypothetical protein 0.003 0.0113 0.0199
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0113 0.0516
Loa Loa (eye worm) glutathione reductase 0.0057 0.0426 0.1683
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0405 0.1855
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0113 0.0516
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0273 0.1249
Chlamydia trachomatis lysine--tRNA ligase 0.0047 0.0312 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0516
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0516
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0211 0.2183 1
Mycobacterium ulcerans integral membrane transport protein 0.003 0.0113 0.3616
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0405 0.1855
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0516
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0065 0.0512 0.0512
Loa Loa (eye worm) hypothetical protein 0.003 0.0113 0.0199
Leishmania major glucose transporter/membrane transporter D2, putative 0.0065 0.0521 0.7612
Echinococcus granulosus solute carrier family 22 0.003 0.0113 0.0516
Trypanosoma brucei glucose transporter, putative 0.0065 0.0521 0.7612
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.008 0.0685 0.3136
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.003 0.0113 0.0789
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.008 0.0685 1
Schistosoma mansoni hypothetical protein 0.0205 0.2112 0.9672
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0.0273 0.1249
Schistosoma mansoni sugar transporter 0.003 0.0113 0.0516
Leishmania major hypothetical protein, conserved 0.003 0.0113 0.1646
Schistosoma mansoni glucose transport protein 0.0211 0.2183 1
Echinococcus multilocularis solute carrier family 22 0.003 0.0113 0.0516
Loa Loa (eye worm) hypothetical protein 0.003 0.0113 0.0199
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.2022 0.926
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0273 0.3983
Plasmodium vivax CDK-related protein kinase 6, putative 0.0895 1 1
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0047 0.0312 1
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0065 0.0512 0.0512
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0521 0.2387
Schistosoma mansoni hypothetical protein 0.0211 0.2183 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0516
Echinococcus multilocularis solute carrier family 22 0.003 0.0113 0.0516
Plasmodium vivax sugar transporter, putative 0.003 0.0113 0.0113
Loa Loa (eye worm) hypothetical protein 0.003 0.0113 0.0199
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0041 0.0245 0.1124
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0516
Echinococcus multilocularis solute carrier family 22 0.003 0.0113 0.0516
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0065 0.0512 0.2344
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.0273 0.0414
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0063 0.0497 0.2222
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0516
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.1262 0.8837
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0047 0.0312 0.4553
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.008 0.0685 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0426 0.1953
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0685 1
Echinococcus granulosus transcription factor Dp 1 0.0046 0.0301 0.1379
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0273 0.1249
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0516
Leishmania major glucose transporter, lmgt2 0.0065 0.0521 0.7612
Trypanosoma brucei glucose transporter, putative 0.0065 0.0521 0.7612
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0273 0.1249
Plasmodium vivax lysine--tRNA ligase, putative 0.0047 0.0312 0.0312
Loa Loa (eye worm) hypothetical protein 0.003 0.0113 0.0199
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0113 0.0516
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0521 0.7612
Plasmodium falciparum calcium-dependent protein kinase 3 0.0065 0.0512 0.0512
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0065 0.0512 0.2088
Trypanosoma brucei glucose transporter, putative 0.0065 0.0521 0.7612
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0065 0.0512 0.2344
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0516
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0047 0.0312 0.0677
Trypanosoma brucei glucose transporter, putative 0.0065 0.0521 0.7612
Loa Loa (eye worm) hypothetical protein 0.003 0.0113 0.0199
Schistosoma mansoni hypothetical protein 0.0205 0.2112 0.9672
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0063 0.0497 0.5439
Schistosoma mansoni protein kinase 0.0065 0.0512 0.2344
Schistosoma mansoni lysyl-tRNA synthetase 0.0047 0.0312 0.1428
Loa Loa (eye worm) hypothetical protein 0.0051 0.0361 0.1375
Brugia malayi major facilitator superfamily protein 0.003 0.0113 0.0516
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0516
Schistosoma mansoni glucose transporter 0.003 0.0113 0.0516
Loa Loa (eye worm) hypothetical protein 0.003 0.0113 0.0199
Echinococcus granulosus geminin 0.0205 0.2112 0.9672
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.0273 0.1249
Plasmodium falciparum calcium-dependent protein kinase 1 0.0065 0.0512 0.0512
Toxoplasma gondii protein kinase, putative 0.0596 0.6581 1
Entamoeba histolytica protein kinase, putative 0.0065 0.0512 0.5801
Loa Loa (eye worm) sugar transporter 0.003 0.0113 0.0199
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0426 0.1953
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0273 0.1249
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.1428 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0521 0.7612
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0516
Echinococcus multilocularis lysyl tRNA synthetase 0.0047 0.0312 0.1428
Trichomonas vaginalis myo-inositol transporter, putative 0.003 0.0113 0.0516
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0516
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0516
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0426 0.0426
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0273 0.3983
Loa Loa (eye worm) sugar transporter 0.0211 0.2183 1
Toxoplasma gondii sugar transporter ST3 0.003 0.0113 0.0171
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0065 0.0512 0.0778
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0273 0.1249
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0063 0.0497 0.2275
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0426 0.6226
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0211 0.2183 1
Entamoeba histolytica hypothetical protein 0.0047 0.0312 0.0947
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0405 0.1855
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0426 0.1683
Loa Loa (eye worm) hypothetical protein 0.003 0.0113 0.0199
Echinococcus multilocularis geminin 0.0205 0.2112 0.9672
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0516
Plasmodium falciparum lysine--tRNA ligase 0.0047 0.0312 0.0312
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0516
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.2022 0.926
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0341 0.3667 0.3667
Trichomonas vaginalis CAMK family protein kinase 0.0065 0.0512 0.2344
Trypanosoma brucei glucose transporter, putative 0.0065 0.0521 0.7612
Trichomonas vaginalis glucose transporter, putative 0.003 0.0113 0.0516
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.1428 1
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0063 0.0497 0.2275
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0074 0.0617 0.9005
Schistosoma mansoni alpha-glucosidase 0.0169 0.1709 0.7826
Plasmodium vivax calcium-dependent protein kinase, putative 0.0065 0.0512 0.0512
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0521 0.2387
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0516
Schistosoma mansoni sugar transporter 0.003 0.0113 0.0516
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.2022 0.926
Plasmodium falciparum calcium-dependent protein kinase 5 0.0065 0.0512 0.0512
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0405 0.1583
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0405 0.1855
Loa Loa (eye worm) hypothetical protein 0.003 0.0113 0.0199
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0182 0.2664
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0512 0.2344
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0685 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.1428 1
Plasmodium falciparum mitogen-activated protein kinase 2 0.0341 0.3667 0.3667
Plasmodium falciparum calcium-dependent protein kinase 2 0.0065 0.0512 0.0512
Toxoplasma gondii lysine-tRNA ligase 0.0047 0.0312 0.0474
Loa Loa (eye worm) hypothetical protein 0.0063 0.0497 0.2017
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.003 0.0113 0.0789
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0113 0.0516
Trichomonas vaginalis glucose transporter, putative 0.0065 0.0521 0.2387
Trichomonas vaginalis sugar transporter, putative 0.003 0.0113 0.0516
Echinococcus granulosus solute carrier family 22 0.003 0.0113 0.0516
Plasmodium falciparum glutathione reductase 0.0057 0.0426 0.0426
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0211 0.2183 1
Echinococcus granulosus Sugar transporter ERD6 protein 0.003 0.0113 0.0516

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0731 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 0.7079 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.3096 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 16.3601 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5878 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 21.3313 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 23.1093 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.081 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (binding) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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