Detailed information for compound 764484

Basic information

Technical information
  • TDR Targets ID: 764484
  • Name: 3-[5-[(E)-(carbamothioylhydrazinylidene)methy l]furan-2-yl]benzoic acid
  • MW: 289.31 | Formula: C13H11N3O3S
  • H donors: 3 H acceptors: 2 LogP: 1.79 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=S)N/N=C/c1ccc(o1)c1cccc(c1)C(=O)O
  • InChi: 1S/C13H11N3O3S/c14-13(20)16-15-7-10-4-5-11(19-10)8-2-1-3-9(6-8)12(17)18/h1-7H,(H,17,18)(H3,14,16,20)/b15-7+
  • InChiKey: YAAQQGFFRHANNZ-VIZOYTHASA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[5-[(carbamothioylhydrazinylidene)methyl]furan-2-yl]benzoic acid
  • 3-[5-[(carbamothioylhydrazono)methyl]-2-furyl]benzoic acid
  • 3-[5-[(E)-(carbamothioylhydrazono)methyl]-2-furyl]benzoic acid
  • 3-[5-[(thiocarbamoylhydrazono)methyl]-2-furyl]benzoic acid
  • 3-[5-[(E)-(thiocarbamoylhydrazono)methyl]-2-furyl]benzoic acid
  • ST057051

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.003 0.0008 0.0008
Brugia malayi Smad1 0.0044 0.0018 0.0018
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0044 0.0018 0.0018
Loa Loa (eye worm) Smad1 0.0044 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0052 0.0024 0.0024
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0039 1
Loa Loa (eye worm) hypothetical protein 1.3341 1 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0099 0.0059 0.0059
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.0062 0.0062
Echinococcus granulosus GPCR family 2 0.0032 0.001 0.001
Mycobacterium leprae Probable lipase LipE 0.0072 0.0039 0.5
Toxoplasma gondii ABC1 family protein 0.0072 0.0039 1
Onchocerca volvulus 1.3341 1 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.0039 0.0039
Schistosoma mansoni sodium-bile acid cotransporter related 1.3341 1 1
Echinococcus granulosus Smad4 0.0044 0.0018 0.0018
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0039 0.5
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0008 0.0008
Echinococcus granulosus sodium bile acid cotransporter 1.3341 1 1
Echinococcus granulosus microtubule associated protein 2 0.2296 0.1709 0.1709
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.001 0.001
Brugia malayi jmjC domain containing protein 0.0037 0.0013 0.0013
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0044 0.0018 0.0018
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.0039 0.5
Schistosoma mansoni hypothetical protein 0.003 0.0008 0.0008
Echinococcus granulosus TGF beta signal transducer SmadC 0.0044 0.0018 0.0018
Brugia malayi MH1 domain containing protein 0.0044 0.0018 0.0018
Schistosoma mansoni jumonji domain containing protein 0.0079 0.0044 0.0044
Echinococcus granulosus tar DNA binding protein 0.0127 0.0081 0.0081
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.0062 0.0062
Schistosoma mansoni hypothetical protein 0.007 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0162 0.0107 0.0107
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0081 0.0081
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0039 0.5
Echinococcus multilocularis microtubule associated protein 2 0.2296 0.1709 0.1709
Loa Loa (eye worm) hypothetical protein 0.0072 0.0039 0.0039
Brugia malayi PHD-finger family protein 0.003 0.0008 0.0008
Echinococcus multilocularis tar DNA binding protein 0.0127 0.0081 0.0081
Echinococcus multilocularis peregrin 0.003 0.0008 0.0008
Echinococcus multilocularis sodium bile acid cotransporter 1.3341 1 1
Entamoeba histolytica hypothetical protein 0.0035 0.0011 0.5
Loa Loa (eye worm) hypothetical protein 0.0072 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0024 0.0003 0.0003
Loa Loa (eye worm) nuclear factor I 0.0024 0.0003 0.0003
Entamoeba histolytica hypothetical protein 0.0035 0.0011 0.5
Plasmodium falciparum phd finger protein, putative 0.003 0.0008 0.5
Brugia malayi Latrophilin receptor protein 2 0.0032 0.001 0.001
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0081 0.0081
Brugia malayi MH1 domain containing protein 0.0044 0.0018 0.0018
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0039 0.0039
Leishmania major hypothetical protein, conserved 0.0072 0.0039 0.5
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0013 0.0013
Schistosoma mansoni sodium-bile acid cotransporter related 0.541 0.4046 0.4046
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0461 0.0332 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0044 0.0018 0.0018
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0081 0.0081
Echinococcus multilocularis sodium bile acid cotransporter 1.3341 1 1
Echinococcus granulosus sodium bile acid cotransporter 1.3341 1 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.0039 0.0039
Echinococcus multilocularis smad 0.0044 0.0018 0.0018
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0032 0.001 0.001
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0072 0.0039 0.0039
Echinococcus multilocularis sodium bile acid cotransporter 1.3341 1 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.0039 0.0039
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0013 0.0013
Onchocerca volvulus 0.0072 0.0039 0.0039
Brugia malayi beta-lactamase 0.0072 0.0039 0.0039
Brugia malayi MH1 domain containing protein 0.0024 0.0003 0.0003
Loa Loa (eye worm) beta-lactamase 0.0072 0.0039 0.0039
Brugia malayi RNA binding protein 0.0127 0.0081 0.0081
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0081 0.0081
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0072 0.0039 0.0039
Brugia malayi TAR-binding protein 0.0127 0.0081 0.0081
Brugia malayi beta-lactamase family protein 0.0072 0.0039 0.0039
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0032 0.0032
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0039 0.5
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0127 0.0081 0.0081
Entamoeba histolytica hypothetical protein 0.0035 0.0011 0.5
Schistosoma mansoni hypothetical protein 0.0032 0.001 0.001
Brugia malayi MH2 domain containing protein 0.0645 0.0469 0.0469
Mycobacterium ulcerans beta-lactamase 0.0072 0.0039 0.5
Loa Loa (eye worm) hypothetical protein 0.0103 0.0062 0.0062
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0039 0.5
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0013 0.0013
Mycobacterium ulcerans lipase LipD 0.0072 0.0039 0.5
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0039 0.5
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0008 0.0008
Trichomonas vaginalis esterase, putative 0.0072 0.0039 0.5
Loa Loa (eye worm) RNA binding protein 0.0127 0.0081 0.0081
Brugia malayi MH1 domain containing protein 0.0024 0.0003 0.0003
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.0039 0.0039
Schistosoma mansoni hypothetical protein 0.0032 0.001 0.001
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.001 0.001
Entamoeba histolytica hypothetical protein 0.0035 0.0011 0.5
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0011 0.0011
Giardia lamblia PHD finger protein 15 0.003 0.0008 0.5
Onchocerca volvulus 0.0162 0.0107 0.0107
Brugia malayi jmjC domain containing protein 0.0099 0.0059 0.0059
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0011 0.0011
Mycobacterium leprae conserved hypothetical protein 0.0072 0.0039 0.5
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.0039 0.5
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.0062 0.0062
Schistosoma mansoni smad1 5 8 and 0.0044 0.0018 0.0018
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0072 0.0039 0.0039
Schistosoma mansoni sodium-bile acid cotransporter 0.7932 0.5939 0.5939
Schistosoma mansoni smad 0.0044 0.0018 0.0018
Echinococcus multilocularis GPCR, family 2 0.0032 0.001 0.001
Echinococcus granulosus sodium bile acid cotransporter 1.3341 1 1
Brugia malayi Bromodomain containing protein 0.003 0.0008 0.0008
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0039 0.5
Echinococcus multilocularis tumor protein p63 0.1107 0.0816 0.0816
Echinococcus granulosus mothers against decapentaplegic 5 0.0044 0.0018 0.0018
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0008 0.0008
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0017 0.0017
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0011 0.0011
Echinococcus multilocularis Smad4 0.0044 0.0018 0.0018
Schistosoma mansoni microtubule-associated protein tau 0.2296 0.1709 0.1709
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0013 0.0013
Brugia malayi MH2 domain containing protein 0.0044 0.0018 0.0018
Onchocerca volvulus Alhambra homolog 0.003 0.0008 0.0008
Schistosoma mansoni hypothetical protein 0.0032 0.001 0.001
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0038 0.0038
Brugia malayi Cytochrome P450 family protein 0.0025 0.0004 0.0004
Loa Loa (eye worm) TAR-binding protein 0.0127 0.0081 0.0081
Schistosoma mansoni smad1 5 8 and 0.0044 0.0018 0.0018
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0039 0.5
Onchocerca volvulus 0.0072 0.0039 0.0039
Echinococcus multilocularis mothers against decapentaplegic 5 0.0044 0.0018 0.0018
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.001 0.001
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0017 0.0017
Schistosoma mansoni hypothetical protein 0.0035 0.0011 0.0011
Brugia malayi beta-lactamase family protein 0.0072 0.0039 0.0039
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0099 0.0059 0.0059
Mycobacterium ulcerans hypothetical protein 0.0072 0.0039 0.5
Brugia malayi RNA recognition motif domain containing protein 0.0127 0.0081 0.0081
Echinococcus granulosus tumor protein p63 0.1107 0.0816 0.0816
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0032 0.001 0.001
Onchocerca volvulus 0.0072 0.0039 0.0039
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.001 0.001
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0039 0.5
Loa Loa (eye worm) MH2 domain-containing protein 0.0645 0.0469 0.0469
Brugia malayi hypothetical protein 0.0035 0.0011 0.0011
Loa Loa (eye worm) MH2 domain-containing protein 0.0044 0.0018 0.0018
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0081 0.0081
Brugia malayi MH2 domain containing protein 0.0044 0.0018 0.0018
Echinococcus granulosus peregrin 0.003 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0072 0.0039 0.0039
Schistosoma mansoni Smad4 0.0044 0.0018 0.0018
Schistosoma mansoni smad1 5 8 and 0.0044 0.0018 0.0018
Schistosoma mansoni cellular tumor antigen P53 0.0162 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.007 0.0038 0.0038
Echinococcus granulosus smad 0.0044 0.0018 0.0018
Loa Loa (eye worm) transcription factor SMAD2 0.0645 0.0469 0.0469

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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