TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 256.209 | Formula: C11H12O7
H donors: 2 H acceptors: 5 LogP: -1.55 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CC(=O)OCC1=CC2OC1C(C2C(=O)O)C(=O)O
InChi: 1S/C11H12O7/c1-4(12)17-3-5-2-6-7(10(13)14)8(11(15)16)9(5)18-6/h2,6-9H,3H2,1H3,(H,13,14)(H,15,16)
InChiKey: UHVPWJFPLCJVGL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0387	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0205	0.2227	0.32
Brugia malayi	hypothetical protein	0.0108	0.0986	0.1417
Echinococcus granulosus	acetylcholinesterase	0.0068	0.0475	0.127
Echinococcus granulosus	acetylcholinesterase	0.0068	0.0475	0.127
Leishmania major	cathepsin L-like protease	0.0062	0.0387	1
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0097	0.0837	0.1203
Brugia malayi	hypoxia-induced factor 1	0.0145	0.1463	0.2102
Brugia malayi	bZIP transcription factor family protein	0.0246	0.2749	0.3951
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0837	0.1203
Loa Loa (eye worm)	hypothetical protein	0.0205	0.2227	0.32
Loa Loa (eye worm)	hypothetical protein	0.0205	0.2227	0.32
Brugia malayi	hypothetical protein	0.0097	0.0837	0.1203
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0163	0.0284
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0214	0.0307
Loa Loa (eye worm)	carboxylesterase	0.0068	0.0475	0.0682
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0205	0.2227	0.32
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0205	0.2227	0.4333
Schistosoma mansoni	thyroid hormone receptor	0.0205	0.2227	0.4333
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0108	0.0986	0.1417
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.0163	0.0234
Brugia malayi	small heat shock protein	0.0574	0.6958	1
Echinococcus multilocularis	FTZ F1 alpha	0.0205	0.2227	0.8071
Brugia malayi	Nuclear hormone receptor-like 1	0.0108	0.0986	0.1417
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0387	1
Echinococcus multilocularis	carboxylesterase 5A	0.0068	0.0475	0.1599
Schistosoma mansoni	RAR-like nuclear receptor	0.0205	0.2227	0.4333
Echinococcus multilocularis	survival motor neuron protein 1	0.0228	0.2528	0.9185
Schistosoma mansoni	jun-related protein	0.02	0.2158	0.4198
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0387	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0205	0.2227	0.8071
Mycobacterium ulcerans	putative regulatory protein	0.0035	0.0042	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0837	0.1203
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0986	0.1417
Echinococcus multilocularis	jun protein	0.0246	0.2749	1
Brugia malayi	nuclear hormone receptor	0.0097	0.0837	0.1203
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0205	0.2227	0.32
Brugia malayi	Nuclear hormone receptor E75	0.0097	0.0837	0.1203
Echinococcus multilocularis	ecdysone induced protein 78C	0.0205	0.2227	0.8071
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0986	0.1417
Schistosoma mansoni	coup transcription factor	0.0205	0.2227	0.4333
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0837	0.1203
Brugia malayi	conserved hypotetical protein	0.0097	0.0837	0.1203
Brugia malayi	orphan nuclear receptor NR2E1	0.0097	0.0837	0.1203
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0097	0.0837	0.2936
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.03	0.3449	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0837	0.1203
Trypanosoma cruzi	cruzipain precursor, putative	0.0062	0.0387	1
Schistosoma mansoni	nuclear receptor	0.0097	0.0837	0.1606
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0246	0.2749	1
Schistosoma mansoni	thyroid hormone receptor	0.0205	0.2227	0.4333
Echinococcus multilocularis	Ankyrin	0.0042	0.014	0.0362
Brugia malayi	nuclear hormone receptor	0.0205	0.2227	0.32
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0205	0.2227	0.8071
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0042	0.0135	0.0345
Brugia malayi	ecdysone receptor	0.0097	0.0837	0.1203
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0387	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0163	0.0284
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0387	1
Brugia malayi	follicle stimulating hormone receptor	0.0249	0.2796	0.4018
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.0214	0.0307
Echinococcus multilocularis	nuclear receptor nhr 48	0.0097	0.0837	0.2936
Brugia malayi	Carboxylesterase family protein	0.0068	0.0475	0.0682
Schistosoma mansoni	nuclear receptor	0.0097	0.0837	0.1606
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0097	0.0837	0.1203
Loa Loa (eye worm)	hypothetical protein	0.0042	0.014	0.0201
Onchocerca volvulus		0.0205	0.2227	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0205	0.2227	0.6412
Loa Loa (eye worm)	nuclear hormone receptor	0.0097	0.0837	0.1203
Brugia malayi	nuclear receptor NHR-88	0.0097	0.0837	0.1203
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0205	0.2227	0.4333
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0205	0.2227	0.4333
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0475	0.0682
Schistosoma mansoni	zinc finger protein	0.0097	0.0837	0.1606
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0097	0.0837	0.2332
Loa Loa (eye worm)	hypothetical protein	0.0205	0.2227	0.32
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0018	0.0026
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0205	0.2227	0.32
Brugia malayi	Nuclear hormone receptor E75	0.0097	0.0837	0.1203
Loa Loa (eye worm)	hypothetical protein	0.0239	0.2662	0.3827
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0108	0.0986	0.1898
Echinococcus granulosus	nuclear receptor nhr 48	0.0097	0.0837	0.2332
Brugia malayi	bHLH-PAS transcription factor	0.0035	0.0042	0.006
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0837	0.1203
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0986	0.1417
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0192	0.2059	0.7453
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0205	0.2227	0.32
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0215	0.2361	0.8566
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0042	0.0135	0.0195
Brugia malayi	hypothetical protein	0.0158	0.162	0.2328
Loa Loa (eye worm)	hypothetical protein	0.0205	0.2227	0.32
Schistosoma mansoni	single-minded	0.0047	0.0199	0.0354
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0837	0.1203
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0205	0.2227	0.32
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0837	0.1203
Brugia malayi	PAS domain containing protein	0.0047	0.0199	0.0286
Brugia malayi	Steroid receptor seven-up type 2	0.0205	0.2227	0.32
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0097	0.0837	0.1203
Onchocerca volvulus		0.0097	0.0837	0.3637
Echinococcus multilocularis	acetylcholinesterase	0.0068	0.0475	0.1599
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0205	0.2227	0.6412
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0205	0.2227	0.32
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0163	0.0446
Loa Loa (eye worm)	DR-78	0.0097	0.0837	0.1203
Loa Loa (eye worm)	hypothetical protein	0.0205	0.2227	0.32
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0205	0.2227	0.32
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.0387	1
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0108	0.0986	0.3486
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0986	0.1417
Brugia malayi	photoreceptor-specific nuclear receptor	0.0205	0.2227	0.32
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0387	1
Echinococcus granulosus	Ankyrin	0.0042	0.014	0.0287
Brugia malayi	Nuclear hormone receptor-like 1	0.0108	0.0986	0.1417
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0018	0.0026
Schistosoma mansoni	hypothetical protein	0.0047	0.0194	0.0344
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0837	0.1203
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0205	0.2227	0.32
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0097	0.0837	0.2936
Onchocerca volvulus	Protein ultraspiracle homolog	0.0205	0.2227	1
Loa Loa (eye worm)	steroid hormone receptor	0.0205	0.2227	0.32
Brugia malayi	Nuclear hormone receptor-like 1	0.0205	0.2227	0.32
Echinococcus granulosus	carboxylesterase 5A	0.0068	0.0475	0.127
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0205	0.2227	0.32
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0387	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0163	0.0354
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0205	0.2227	0.6412
Echinococcus granulosus	thyroid hormone receptor alpha	0.0097	0.0837	0.2332
Brugia malayi	Carboxylesterase family protein	0.0068	0.0475	0.0682
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0097	0.0837	0.2332
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0042	0.0135	0.0274
Schistosoma mansoni	hypothetical protein	0.02	0.2158	0.4198
Brugia malayi	steroid hormone receptor	0.0205	0.2227	0.32
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0205	0.2227	0.32
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0163	0.0446
Trypanosoma cruzi	major cysteine proteinase, putative	0.0048	0.0217	0.5622
Loa Loa (eye worm)	acetylcholinesterase 1	0.0068	0.0475	0.0682
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0205	0.2227	0.32
Onchocerca volvulus		0.0193	0.2072	0.929
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0205	0.2227	0.32
Schistosoma mansoni	ankyrin 23/unc44	0.0042	0.0135	0.023
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0475	0.0682
Echinococcus granulosus	jun protein	0.0246	0.2749	0.7944
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0135	0.0195
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0205	0.2227	0.6412
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0205	0.2227	0.6412
Brugia malayi	Death domain containing protein	0.0042	0.0135	0.0195
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0205	0.2227	0.32
Leishmania major	cathepsin L-like protease	0.0062	0.0387	1
Mycobacterium tuberculosis	Proteasome alpha subunit PrcA; assembles with beta subunit PrcB.	0.081	1	0.5
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0249	0.2796	0.4018
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0837	0.1203
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0837	0.1203
Loa Loa (eye worm)	hypothetical protein	0.0228	0.2528	0.3634
Schistosoma mansoni	retinoic acid receptor RXR	0.03	0.3449	0.6731
Brugia malayi	ecdysteroid receptor	0.0205	0.2227	0.32
Schistosoma mansoni	hypothetical protein	0.0042	0.0135	0.023
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0205	0.2227	0.4333
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0097	0.0837	0.2936
Loa Loa (eye worm)	hypothetical protein	0.0205	0.2227	0.32
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0387	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0837	0.1203
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0387	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0205	0.2227	0.8071
Brugia malayi	nuclear receptor RXR	0.0108	0.0986	0.1417
Onchocerca volvulus		0.0047	0.0194	0.0694
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0205	0.2227	0.4333
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0042	0.0135	0.0195
Echinococcus granulosus	FTZ F1 alpha	0.0205	0.2227	0.6412
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0205	0.2227	0.32
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0205	0.2227	0.4333
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0205	0.2227	0.32
Brugia malayi	hypothetical protein	0.0228	0.2528	0.3634
Loa Loa (eye worm)	hypothetical protein	0.0574	0.6958	1
Onchocerca volvulus	Netrin receptor homolog	0.0042	0.0135	0.0427
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0837	0.1203
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0042	0.014	0.0239
Schistosoma mansoni	aryl hydrocarbon receptor	0.0047	0.0199	0.0354
Brugia malayi	tailless protein	0.0097	0.0837	0.1203
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0205	0.2227	0.6412
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0986	0.1417
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0135	0.0195
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0387	1
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0097	0.0837	0.3637
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0215	0.2361	0.6805
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0068	0.0475	0.0896
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0108	0.0986	0.1898
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0205	0.2227	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.0214	0.0307
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0145	0.1463	0.2102
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.043	0.5116	1
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0194	0.0344
Loa Loa (eye worm)	hypothetical protein	0.0205	0.2227	0.32
Echinococcus multilocularis	acetylcholinesterase	0.0068	0.0475	0.1599
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0163	0.0284
Leishmania major	cathepsin L-like protease	0.0062	0.0387	1
Brugia malayi	Cytochrome P450 family protein	0.01	0.0879	0.1264
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0097	0.0837	0.2332
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0205	0.2227	0.32
Schistosoma mansoni	nuclear hormone receptor	0.0097	0.0837	0.1606
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.0387	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0062	0.0387	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0205	0.2227	0.8071
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0205	0.2227	0.8071
Onchocerca volvulus	Bile acid receptor homolog	0.0205	0.2227	1
Loa Loa (eye worm)	hypothetical protein	0.0205	0.2227	0.32
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0108	0.0986	0.2769
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0097	0.0837	0.2936
Echinococcus granulosus	survival motor neuron protein 1	0.0228	0.2528	0.7297
Schistosoma mansoni	nuclear hormone receptor	0.0097	0.0837	0.1606
Mycobacterium ulcerans	proteasome PrcA	0.081	1	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.01	0.0879	0.1264
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0056	0.0318	0.8225
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0837	0.1203
Schistosoma mansoni	netrin receptor unc5	0.0042	0.0135	0.023
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0097	0.0837	0.3637
Brugia malayi	nuclear receptor RXR	0.0097	0.0837	0.1203
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0097	0.0837	0.1203
Brugia malayi	Uncoordinated protein 44	0.0042	0.0135	0.0195
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0194	0.0278
Brugia malayi	nuclear receptor NHR-67	0.0097	0.0837	0.1203
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0205	0.2227	0.32
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0205	0.2227	0.8071
Trypanosoma cruzi	cysteine peptidase, putative	0.0062	0.0387	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0205	0.2227	0.4333
Schistosoma mansoni	nuclear receptor nhr-48	0.0097	0.0837	0.1606
Echinococcus multilocularis	netrin receptor unc 5	0.0042	0.0135	0.0345
Brugia malayi	hypothetical protein	0.0108	0.0986	0.1417
Brugia malayi	hypothetical protein	0.0097	0.0837	0.1203
Onchocerca volvulus		0.0097	0.0837	0.3637
Brugia malayi	nuclear receptor NHR-88	0.0205	0.2227	0.32
Brugia malayi	nuclear hormone receptor family member odr-7	0.0097	0.0837	0.1203
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0097	0.0837	0.2332
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0163	0.0354
Loa Loa (eye worm)	hypothetical protein	0.0158	0.162	0.2328
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.0163	0.0234
Echinococcus granulosus	netrin receptor unc 5	0.0042	0.0135	0.0274
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0246	0.2749	0.7944
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0205	0.2227	0.32
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.0214	0.0307
Echinococcus granulosus	death domain containing protein	0.0042	0.0135	0.0274
Brugia malayi	hypothetical protein	0.0193	0.2072	0.2978
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0205	0.2227	0.32
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0205	0.2227	0.6412
Schistosoma mansoni	nuclear hormone receptor	0.0205	0.2227	0.4333
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0097	0.0837	0.1606
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0205	0.2227	0.8071

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (binding)	= 20 %	Inhibition of Protein phosphatase 2B (PP2B) at 0.1 mM	ChEMBL.	No reference
Inhibition (binding)	= 40 %	Inhibition of Protein phosphatase 2A1 (PP2A1) at 0.1 mM	ChEMBL.	No reference
Inhibition (binding)	= 50 %	Inhibition of Protein phosphatase 1 at 0.1 mM	ChEMBL.	No reference
Inhibition (binding)	= 80 %	Inhibition of Protein phosphatase 1 at 1 mM	ChEMBL.	No reference
Inhibition (binding)	= 89 %	Inhibition of Protein phosphatase 2B (PP2B) at 1 mM	ChEMBL.	No reference
Inhibition (binding)	= 90 %	Inhibition of Protein phosphatase 2A1 (PP2A1) at 1 mM	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

No literature references available for this target.

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Detailed information for compound 76773