Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Glycerol-3-phosphate dehydrogenase | 0.0027 | 0 | 0.5 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0324 | 0.9947 | 1 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0046 | 0.064 | 0.0643 |
Mycobacterium leprae | PROBABLE D-AMINO ACID OXIDASE AAO | 0.0326 | 1 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0059 | 0.1078 | 0.1084 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.1078 | 0.1078 |
Chlamydia trachomatis | D-amino acid dehydrogenase | 0.0027 | 0 | 0.5 |
Echinococcus multilocularis | zinc finger protein | 0.004 | 0.0436 | 0.0438 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0035 | 0.0262 | 0.0262 |
Trypanosoma cruzi | ISWI complex protein | 0.0031 | 0.0142 | 0.0143 |
Onchocerca volvulus | Dimethylglycine dehydrogenase, mitochondrial homolog | 0.0027 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0031 | 0.0142 | 0.0143 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0324 | 0.9947 | 0.9947 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.1078 | 0.1078 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0324 | 0.9947 | 0.9947 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.1078 | 0.1078 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0142 | 0.0142 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0074 | 0.156 | 0.1568 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0035 | 0.0262 | 0.0264 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0074 | 0.156 | 0.1568 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0123 | 0.3193 | 0.321 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0035 | 0.0262 | 0.0262 |
Brugia malayi | PHD-finger family protein | 0.0051 | 0.0802 | 0.0807 |
Onchocerca volvulus | Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial homolog | 0.0027 | 0 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.1078 | 0.1078 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.189 | 0.189 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0123 | 0.3193 | 0.321 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0324 | 0.9947 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.1078 | 0.1078 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.2021 | 0.2021 |
Trypanosoma brucei | ISWI complex protein | 0.0031 | 0.0142 | 0.0143 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0059 | 0.1078 | 0.1084 |
Trypanosoma cruzi | ISWI complex protein | 0.0031 | 0.0142 | 0.0143 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0059 | 0.1078 | 0.1084 |
Schistosoma mansoni | d-amino acid oxidase | 0.0326 | 1 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0324 | 0.9947 | 1 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0324 | 0.9947 | 1 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0324 | 0.9947 | 1 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0035 | 0.0262 | 0.0262 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0035 | 0.0262 | 0.0262 |
Plasmodium vivax | FAD-dependent glycerol-3-phosphate dehydrogenase, putative | 0.0027 | 0 | 0.5 |
Schistosoma mansoni | zinc finger protein | 0.004 | 0.0436 | 0.0436 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0035 | 0.0262 | 0.0264 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0046 | 0.064 | 0.064 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0188 | 0.5375 | 0.5403 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0046 | 0.064 | 0.0643 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0036 | 0.0304 | 0.0304 |
Mycobacterium tuberculosis | Probable D-amino acid oxidase Aao | 0.0299 | 0.9091 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0262 | 0.0262 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0035 | 0.0262 | 0.0264 |
Schistosoma mansoni | bromodomain containing protein | 0.013 | 0.3439 | 0.3439 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0035 | 0.0262 | 0.0264 |
Echinococcus granulosus | zinc finger protein | 0.004 | 0.0436 | 0.0438 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0324 | 0.9947 | 1 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0188 | 0.5375 | 0.5403 |
Schistosoma mansoni | zinc finger protein | 0.0031 | 0.0142 | 0.0142 |
Plasmodium falciparum | FAD-dependent glycerol-3-phosphate dehydrogenase, putative | 0.0027 | 0 | 0.5 |
Onchocerca volvulus | Putative fad oxidoreductase | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0042 | 0.0508 | 0.0508 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0059 | 0.1078 | 0.1186 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0508 | 0.0508 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0324 | 0.9947 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0079 | 0.1722 | 0.1731 |
Brugia malayi | Bromodomain containing protein | 0.0154 | 0.4244 | 0.4266 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.395 | 0.395 |
Mycobacterium ulcerans | D-amino acid oxidase Aao | 0.0326 | 1 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0324 | 0.9947 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0059 | 0.1078 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.1727 | 0.1727 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.