TDR Targets

Basic information

Technical information

TDR Targets ID: 784646
Name: N-[2-[4-(3-fluorobenzoyl)piperazin-1-yl]ethyl ]-N'-(4-methoxyphenyl)oxamide
MW: 428.457 | Formula: C22H25FN4O4
H donors: 2 H acceptors: 3 LogP: 1.85 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)NC(=O)C(=O)NCCN1CCN(CC1)C(=O)c1cccc(c1)F
InChi: 1S/C22H25FN4O4/c1-31-19-7-5-18(6-8-19)25-21(29)20(28)24-9-10-26-11-13-27(14-12-26)22(30)16-3-2-4-17(23)15-16/h2-8,15H,9-14H2,1H3,(H,24,28)(H,25,29)
InChiKey: RFQWUOLBYYXRAD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[2-[4-[(3-fluorophenyl)-oxomethyl]-1-piperazinyl]ethyl]-N'-(4-methoxyphenyl)oxamide
N-[2-[4-(3-fluorophenyl)carbonylpiperazin-1-yl]ethyl]-N'-(4-methoxyphenyl)ethanediamide
A0709/0033094

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0149	0.2007	0.4254
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0118	0.0249
Schistosoma mansoni	hypothetical protein	0.0335	0.4792	0.4792
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0042	0.0396	0.0838
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0706	0.0706
Echinococcus multilocularis	muscleblind protein 1	0.0295	0.4197	0.4197
Leishmania major	heat shock protein 83-1	0.0032	0.0248	0.0525
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.0118	0.019
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0029	0.0061
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0444	0.0444
Loa Loa (eye worm)	TAR-binding protein	0.0063	0.0706	0.1495
Brugia malayi	RNA recognition motif domain containing protein	0.0063	0.0706	0.1495
Echinococcus multilocularis	smad	0.0016	0.0007	0.0007
Loa Loa (eye worm)	helix-loop-helix DNA-binding domain-containing protein	0.0212	0.2952	0.6257
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.0157	0.2122	0.4497
Trichomonas vaginalis	heat shock protein, putative	0.0026	0.015	0.0428
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0118	0.019
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0118	0.0249
Echinococcus granulosus	tar DNA binding protein	0.0063	0.0706	0.0706
Echinococcus multilocularis	heat shock protein	0.0032	0.0248	0.0248
Loa Loa (eye worm)	Smad1	0.0016	0.0007	0.0016
Trypanosoma cruzi	heat shock protein 85, putative	0.0032	0.0248	0.0525
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0271	0.0575
Entamoeba histolytica	hypothetical protein	0.0071	0.0833	1
Plasmodium falciparum	endoplasmin, putative	0.002	0.0062	0.013
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.033	0.4718	0.4718
Brugia malayi	heat shock protein 90	0.0032	0.0248	0.0526
Echinococcus multilocularis	transcription factor eb	0.0213	0.2968	0.2968
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.014	0.0296
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0016	0.0007	0.0007
Toxoplasma gondii	heat shock protein 90, putative	0.0032	0.0248	0.0525
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0141	0.1886	0.3997
Loa Loa (eye worm)	MH1 domain-containing protein	0.0016	0.0007	0.0016
Brugia malayi	MH2 domain containing protein	0.0016	0.0007	0.0016
Leishmania major	hypothetical protein, conserved	0.0025	0.014	0.0296
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.033	0.4718	1
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.0118	0.0249
Mycobacterium ulcerans	heat shock protein 90	0.0026	0.015	0.0258
Echinococcus granulosus	smad	0.0016	0.0007	0.0007
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0042	0.0396	0.0838
Echinococcus granulosus	geminin	0.0335	0.4792	0.4792
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0444	0.0444
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.033	0.4718	1
Leishmania major	heat shock protein 83-1	0.0032	0.0248	0.0525
Leishmania major	heat shock protein 83-1	0.0032	0.0248	0.0525
Leishmania major	heat shock protein 83-1	0.0032	0.0248	0.0525
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0141	0.1886	0.3997
Plasmodium vivax	heat shock protein 86, putative	0.0032	0.0248	0.0525
Treponema pallidum	heat shock protein 90	0.0026	0.015	0.5
Schistosoma mansoni	hypothetical protein	0.0335	0.4792	0.4792
Schistosoma mansoni	smad1 5 8 and	0.0016	0.0007	0.0007
Schistosoma mansoni	smad1 5 8 and	0.0016	0.0007	0.0007
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0032	0.0248	1
Entamoeba histolytica	hypothetical protein	0.0071	0.0833	1
Trypanosoma cruzi	heat shock protein 90, putative	0.0032	0.0248	0.0525
Brugia malayi	MH2 domain containing protein	0.0016	0.0007	0.0016
Mycobacterium ulcerans	thymidylate synthase	0.033	0.4718	1
Onchocerca volvulus		0.0238	0.3335	0.6995
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0505	0.1071
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0505	0.1071
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0157	0.2125	0.4504
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0444	0.0942
Brugia malayi	hypothetical protein	0.0071	0.0833	0.1766
Leishmania major	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	0.0026	0.015	0.0317
Loa Loa (eye worm)	MH2 domain-containing protein	0.0016	0.0007	0.0016
Trypanosoma cruzi	heat shock protein 90, putative	0.0019	0.0051	0.0106
Entamoeba histolytica	hypothetical protein	0.0071	0.0833	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0118	0.0249
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0042	0.0396	0.0838
Brugia malayi	Pax transcription factor protein 2	0.0238	0.3335	0.707
Loa Loa (eye worm)	MH2 domain-containing protein	0.0236	0.3307	0.701
Leishmania major	heat shock protein 83-1	0.0032	0.0248	0.0525
Echinococcus multilocularis	thymidylate synthase	0.033	0.4718	0.4718
Leishmania major	heat shock protein 83-1	0.0032	0.0248	0.0525
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0299	0.4245	0.8998
Plasmodium vivax	endoplasmin, putative	0.0032	0.0248	0.0525
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.033	0.4718	1
Trypanosoma cruzi	heat shock protein 85, putative	0.0032	0.0248	0.0525
Entamoeba histolytica	hypothetical protein	0.0071	0.0833	1
Schistosoma mansoni	heat shock protein	0.0032	0.0248	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0029	0.0061
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.0029	0.006
Onchocerca volvulus		0.033	0.4718	1
Toxoplasma gondii	hypothetical protein	0.0048	0.0488	0.1035
Trypanosoma brucei	heat shock protein, putative	0.0032	0.0248	0.0525
Echinococcus granulosus	mothers against decapentaplegic 5	0.0016	0.0007	0.0007
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0299	0.4245	0.8998
Trypanosoma brucei	heat shock protein, putative	0.0032	0.0248	0.0525
Loa Loa (eye worm)	hypothetical protein	0.0234	0.3273	0.6938
Plasmodium falciparum	heat shock protein 90	0.0032	0.0248	0.0525
Schistosoma mansoni	endoplasmin	0.0032	0.0248	0.0248
Brugia malayi	hypothetical protein	0.0157	0.2122	0.4497
Brugia malayi	Endoplasmin precursor	0.0032	0.0248	0.0526
Trypanosoma brucei	heat shock protein, putative	0.0032	0.0248	0.0525
Leishmania major	heat shock protein 83-1	0.0032	0.0248	0.0525
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.033	0.4718	1
Entamoeba histolytica	heat shock protein 90, putative	0.0032	0.0248	0.1823
Brugia malayi	RNA binding protein	0.0063	0.0706	0.1495
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0029	0.0061
Echinococcus multilocularis	tar DNA binding protein	0.0063	0.0706	0.0706
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0016	0.0007	0.0007
Leishmania major	heat shock protein 83-1	0.0032	0.0248	0.0525
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0016	0.0007	0.0007
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0706	0.0706
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0016	0	0.0001
Trypanosoma brucei	heat shock protein 90, putative	0.0032	0.0248	0.0525
Echinococcus multilocularis	endoplasmin	0.0026	0.015	0.015
Wolbachia endosymbiont of Brugia malayi	heat shock protein 90	0.0026	0.015	0.5
Brugia malayi	hypothetical protein	0.0016	0.0007	0.0016
Mycobacterium leprae	PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G)	0.0026	0.015	0.007
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.014	0.0296
Loa Loa (eye worm)	thymidylate synthase	0.033	0.4718	1
Onchocerca volvulus		0.0048	0.0481	0.0791
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0051	0.0534	0.113
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0029	0.0061
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.033	0.4718	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.014	0.0296
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.0118	0.019
Mycobacterium tuberculosis	Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G)	0.0026	0.015	0.0317
Leishmania major	heat shock protein 83-1	0.0032	0.0248	0.0525
Echinococcus granulosus	endoplasmin	0.0026	0.015	0.015
Trichomonas vaginalis	conserved hypothetical protein	0.0157	0.2122	1
Trichomonas vaginalis	heat shock protein, putative	0.0032	0.0248	0.0905
Trichomonas vaginalis	heat shock protein, putative	0.0026	0.015	0.0428
Leishmania major	heat shock protein 83-1	0.0032	0.0248	0.0525
Echinococcus multilocularis	muscleblind protein	0.0295	0.4197	0.4197
Trichomonas vaginalis	heat shock protein, putative	0.0026	0.015	0.0428
Loa Loa (eye worm)	transcription factor SMAD2	0.0236	0.3307	0.701
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.0118	0.0249
Trypanosoma cruzi	heat shock protein 85, putative	0.0026	0.015	0.0317
Loa Loa (eye worm)	RNA binding protein	0.0063	0.0706	0.1495
Echinococcus multilocularis	heat shock protein 90	0.0032	0.0248	0.0248
Onchocerca volvulus		0.0149	0.2007	0.4107
Schistosoma mansoni	Smad4	0.0016	0.0007	0.0007
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0505	0.1071
Leishmania major	heat shock protein 83-1	0.0032	0.0248	0.0525
Schistosoma mansoni	hypothetical protein	0.0048	0.0481	0.0481
Leishmania major	heat shock protein 83-1	0.0032	0.0248	0.0525
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0118	0.0249
Schistosoma mansoni	heat shock protein	0.0032	0.0248	0.0248
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.033	0.4718	1
Trypanosoma brucei	heat shock protein, putative	0.0032	0.0248	0.0525
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0444	0.0444
Loa Loa (eye worm)	hypothetical protein	0.0212	0.2952	0.6257
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.014	0.0296
Schistosoma mansoni	transcription factor LCR-F1	0.0071	0.0833	0.0833
Brugia malayi	hypothetical protein	0.0025	0.014	0.0297
Entamoeba histolytica	heat shock protein 90, putative	0.0032	0.0248	0.1823
Leishmania major	mitochondrial DNA polymerase beta	0.0299	0.4245	0.8998
Trypanosoma cruzi	Heat shock protein 83, putative	0.0032	0.0248	0.0525
Echinococcus granulosus	transcription factor eb	0.0213	0.2968	0.2968
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0444	0.0444
Trypanosoma brucei	Heat shock protein 83, putative	0.0032	0.0248	0.0525
Brugia malayi	MH2 domain containing protein	0.0236	0.3307	0.701
Echinococcus granulosus	heat shock protein 90	0.0032	0.0248	0.0248
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.014	0.0296
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.033	0.4718	1
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0016	0.0007	0.0007
Schistosoma mansoni	hypothetical protein	0.0034	0.0271	0.0271
Trypanosoma cruzi	heat shock protein 90, putative	0.0026	0.015	0.0317
Leishmania major	heat shock protein 83-1	0.0032	0.0248	0.0525
Echinococcus granulosus	FTZ F1 alpha	0.039	0.5619	0.5619
Leishmania major	heat shock protein 83-1	0.0032	0.0248	0.0525
Trypanosoma cruzi	heat shock protein 85, putative	0.0032	0.0248	0.0525
Echinococcus multilocularis	geminin	0.0335	0.4792	0.4792
Brugia malayi	Isocitrate dehydrogenase	0.0016	0	0.0001
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0014	0.003
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0706	0.0706
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0118	0.019
Leishmania major	heat shock protein 83-1	0.0032	0.0248	0.0525
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0505	0.1071
Echinococcus multilocularis	microtubule associated protein 2	0.0682	1	1
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0299	0.4245	0.8998
Schistosoma mansoni	microtubule-associated protein tau	0.0682	1	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0118	0.0249
Echinococcus multilocularis	Smad4	0.0016	0.0007	0.0007
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.033	0.4718	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0029	0.0061
Trypanosoma brucei	heat shock protein, putative	0.0032	0.0248	0.0525
Echinococcus granulosus	heat shock protein heat shock protein 90 alpha	0.0026	0.015	0.015
Loa Loa (eye worm)	hypothetical protein	0.0025	0.014	0.0297
Schistosoma mansoni	smad	0.0016	0.0007	0.0007
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.0118	0.019
Echinococcus granulosus	heat shock protein 90	0.0026	0.015	0.015
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0141	0.1886	0.3997
Echinococcus granulosus	heat shock protein	0.0032	0.0248	0.0248
Echinococcus multilocularis	survival motor neuron protein 1	0.0234	0.3273	0.3273
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.014	0.0296
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0018	0.0029	0.5
Leishmania major	heat shock protein 83-1	0.0032	0.0248	0.0525
Loa Loa (eye worm)	endoplasmin	0.0032	0.0248	0.0526
Brugia malayi	hypothetical protein	0.0149	0.2007	0.4254
Loa Loa (eye worm)	pax transcription factor protein 2	0.0238	0.3335	0.707
Echinococcus granulosus	thymidylate synthase	0.033	0.4718	0.4718
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0048	0.0481	0.102
Echinococcus granulosus	muscleblind protein	0.0295	0.4197	0.4197
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0071	0.0833	0.0833
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0271	0.0575
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0706	0.0706
Schistosoma mansoni	endoplasmin	0.0032	0.0248	0.0248
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0444	0.0444
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.0118	0.019
Echinococcus multilocularis	heat shock protein 90	0.0026	0.015	0.015
Leishmania major	heat shock protein 83-1	0.0032	0.0248	0.0525
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0118	0.019
Brugia malayi	MH1 domain containing protein	0.0016	0.0007	0.0016
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0014	0.003
Trypanosoma brucei	heat shock protein, putative	0.0032	0.0248	0.0525
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0014	0.003
Mycobacterium ulcerans	hypothetical protein	0.0157	0.2125	0.4471
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0118	0.0249
Brugia malayi	thymidylate synthase	0.033	0.4718	1
Brugia malayi	hypothetical protein	0.0234	0.3273	0.6938
Mycobacterium tuberculosis	Hypothetical protein	0.0157	0.2122	0.4497
Echinococcus granulosus	survival motor neuron protein 1	0.0234	0.3273	0.3273
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0118	0.0249
Schistosoma mansoni	survival motor neuron protein	0.0048	0.0481	0.0481
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0118	0.0249
Schistosoma mansoni	hypothetical protein	0.0071	0.0833	0.0833
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0118	0.0249
Plasmodium falciparum	acyl-CoA synthetase	0.0018	0.0029	0.006
Trypanosoma brucei	heat shock protein 90, putative	0.0032	0.0248	0.0525
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0042	0.0396	0.0838
Brugia malayi	TAR-binding protein	0.0063	0.0706	0.1495
Toxoplasma gondii	heat shock protein HSP90	0.0032	0.0248	0.0525
Brugia malayi	Helix-loop-helix DNA-binding domain containing protein	0.0213	0.2968	0.629
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0706	0.0706
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0444	0.0444
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0444	0.0942
Loa Loa (eye worm)	hypothetical protein	0.0295	0.4197	0.8896
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0444	0.0444
Brugia malayi	MH1 domain containing protein	0.0016	0.0007	0.0016
Brugia malayi	isocitrate dehydrogenase	0.0016	0	0.0001
Echinococcus granulosus	Smad4	0.0016	0.0007	0.0007
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0063	0.0706	0.1495
Loa Loa (eye worm)	heat shock protein 90	0.0032	0.0248	0.0526
Trypanosoma brucei	heat shock protein, putative	0.0032	0.0248	0.0525
Brugia malayi	Smad1	0.0016	0.0007	0.0016
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0014	0.003
Plasmodium vivax	acyl-CoA synthetase, putative	0.0018	0.0029	0.006
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0118	0.019
Loa Loa (eye worm)	hypothetical protein	0.0295	0.4197	0.8896
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.014	0.0296
Schistosoma mansoni	smad1 5 8 and	0.0016	0.0007	0.0007
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0071	0.0833	0.0833
Trypanosoma brucei	heat shock protein, putative	0.0032	0.0248	0.0525
Brugia malayi	Muscleblind-like protein	0.0295	0.4197	0.8896

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 784646