Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0026 | 0.4383 | 0.5834 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0 | 0.5 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0028 | 0.4773 | 0.6357 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0011 | 0.0657 | 0.0657 |
Brugia malayi | AMP-binding enzyme family protein | 0.0008 | 0.0039 | 0.0039 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0021 | 0.3157 | 0.4188 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0028 | 0.4773 | 0.6376 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.8648 | 1 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0017 | 0.2258 | 0.2981 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0011 | 0.0657 | 0.0657 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0011 | 0.0657 | 0.5 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0026 | 0.4383 | 0.5856 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0011 | 0.0657 | 0.5 |
Mycobacterium ulcerans | polyketide synthase | 0.0028 | 0.4773 | 0.6357 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0011 | 0.0657 | 0.0657 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0011 | 0.0657 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0011 | 0.0657 | 0.0657 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.1625 | 0.1211 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0017 | 0.218 | 0.2574 |
Onchocerca volvulus | 0.0045 | 0.9028 | 0.9555 | |
Schistosoma mansoni | thyroid hormone receptor | 0.0011 | 0.0657 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0011 | 0.0657 | 0.5 |
Giardia lamblia | Methyltransferase like 2 | 0.0008 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0011 | 0.0657 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0011 | 0.0657 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0019 | 0.2616 | 0.3495 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0011 | 0.0657 | 0.0657 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0011 | 0.0657 | 0.0657 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0039 | 0.7486 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0011 | 0.0657 | 0.5 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0026 | 0.4383 | 0.5834 |
Echinococcus granulosus | FTZ F1 alpha | 0.0011 | 0.0657 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0011 | 0.0657 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0011 | 0.0657 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0011 | 0.0657 | 1 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0022 | 0.3337 | 0.4398 |
Onchocerca volvulus | 0.0024 | 0.3971 | 0.3783 | |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0011 | 0.0657 | 0.0657 |
Loa Loa (eye worm) | fatty acid synthase | 0.0026 | 0.43 | 0.4558 |
Schistosoma mansoni | coup transcription factor | 0.0011 | 0.0657 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0011 | 0.0657 | 0.0657 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0011 | 0.0657 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0011 | 0.0657 | 0.0657 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0011 | 0.0657 | 0.0657 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0011 | 0.0657 | 0.0657 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0011 | 0.0657 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0011 | 0.0657 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0011 | 0.0657 | 0.5 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0024 | 0.3971 | 0.4147 |
Mycobacterium ulcerans | polyketide synthase | 0.0026 | 0.4383 | 0.5834 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0009 | 0.0267 | 0.0356 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0021 | 0.3157 | 0.4188 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0017 | 0.2258 | 0.2941 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0011 | 0.0657 | 0.0657 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0019 | 0.2576 | 0.3708 |
Schistosoma mansoni | nuclear hormone receptor | 0.0011 | 0.0657 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0011 | 0.0657 | 0.0657 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0011 | 0.0657 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0011 | 0.0657 | 1 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0008 | 0.0081 | 0.0056 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0011 | 0.0657 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0011 | 0.0657 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0011 | 0.0657 | 1 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0026 | 0.4383 | 0.4383 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0028 | 0.4773 | 0.6337 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0026 | 0.4383 | 0.5856 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0039 | 0.7486 | 1 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0028 | 0.4773 | 1 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0022 | 0.3337 | 0.4459 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0011 | 0.0657 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0011 | 0.0657 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0021 | 0.324 | 0.4329 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0026 | 0.4383 | 0.5856 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0021 | 0.3157 | 0.4155 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0011 | 0.0657 | 0.0657 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0026 | 0.4383 | 0.581 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0028 | 0.4773 | 0.6357 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0011 | 0.0657 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0015 | 0.1676 | 0.224 |
Mycobacterium ulcerans | thioesterase | 0.0022 | 0.3337 | 0.443 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0026 | 0.4383 | 0.581 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0011 | 0.0657 | 0.5 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0047 | 0.9418 | 1 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0028 | 0.4773 | 0.6337 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0011 | 0.0657 | 0.5 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0017 | 0.2258 | 0.2981 |
Mycobacterium tuberculosis | Polyketide synthetase MbtD (polyketide synthase) | 0.0008 | 0.0039 | 0.0052 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0011 | 0.0657 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0011 | 0.0657 | 0.0657 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0039 | 0.7486 | 1 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0039 | 0.7486 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0011 | 0.0657 | 1 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0028 | 0.4773 | 0.6376 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0008 | 0.0081 | 0.0108 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0011 | 0.0647 | 0.0864 |
Mycobacterium ulcerans | thioesterase TesA | 0.0022 | 0.3337 | 0.443 |
Leishmania major | hypothetical protein, conserved | 0.0008 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0028 | 0.4773 | 0.6376 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0011 | 0.0657 | 0.0657 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0024 | 0.3971 | 0.5305 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0026 | 0.4383 | 0.5834 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0011 | 0.0657 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0011 | 0.0657 | 0.0657 |
Brugia malayi | ecdysteroid receptor | 0.0011 | 0.0657 | 0.0657 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0025 | 0.4191 | 0.5599 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0025 | 0.4191 | 0.5599 |
Loa Loa (eye worm) | acyl carrier protein | 0.0012 | 0.0995 | 0.0423 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0026 | 0.4383 | 0.5834 |
Brugia malayi | nuclear hormone receptor | 0.0011 | 0.0657 | 0.0657 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.3971 | 0.3971 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0011 | 0.0657 | 0.0657 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0028 | 0.4773 | 0.6337 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.