Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | hypothetical protein, conserved | 0.0077 | 0.0147 | 0.7281 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0094 | 0.0193 | 0.4919 |
Trichomonas vaginalis | esterase, putative | 0.0077 | 0.0147 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0037 | 0.5 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0054 | 0.0084 | 0.1735 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0077 | 0.0147 | 0.0224 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0039 | 0.0015 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0077 | 0.0147 | 0.0224 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0238 | 0.0591 | 0.1032 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0033 | 0.0024 | 0.5 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0077 | 0.0147 | 0.2412 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0128 | 0.0288 | 0.4368 |
Toxoplasma gondii | ABC1 family protein | 0.0077 | 0.0147 | 0.3582 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0077 | 0.0147 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0238 | 0.0591 | 0.1032 |
Trypanosoma brucei | trypanothione reductase | 0.0094 | 0.0193 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0095 | 0.0195 | 0.0171 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0055 | 0.0087 | 0.0847 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0103 | 0.0218 | 0.0195 |
Brugia malayi | beta-lactamase family protein | 0.0077 | 0.0147 | 0.2412 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0245 | 0.0609 | 0.0587 |
Brugia malayi | beta-lactamase | 0.0077 | 0.0147 | 0.2412 |
Mycobacterium tuberculosis | Transcriptional regulatory repressor protein (TetR-family) EthR | 0.2027 | 0.5518 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0077 | 0.0147 | 0.19 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.0363 | 0.5685 |
Mycobacterium leprae | conserved hypothetical protein | 0.0077 | 0.0147 | 0.0117 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0054 | 0.0084 | 0.1735 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0157 | 0.0368 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0147 | 0.19 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0077 | 0.0147 | 0.0123 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0147 | 0.19 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0055 | 0.0087 | 0.1426 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0103 | 0.0218 | 0.0354 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.3653 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0077 | 0.0147 | 0.7281 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0214 | 0.0525 | 0.0912 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.0039 | 0.0633 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0095 | 0.0195 | 0.0171 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0157 | 0.0368 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0245 | 0.0609 | 1 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.0072 | 0.0048 |
Mycobacterium tuberculosis | Conserved protein | 0.0077 | 0.0147 | 0.0224 |
Mycobacterium ulcerans | beta-lactamase | 0.0077 | 0.0147 | 0.0224 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0147 | 0.19 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0157 | 0.0368 | 0.0522 |
Brugia malayi | glutathione reductase | 0.0094 | 0.0193 | 0.3167 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.005 | 0.0072 | 0.1179 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0077 | 0.0147 | 0.0224 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0077 | 0.0147 | 0.0224 |
Plasmodium vivax | glutathione reductase, putative | 0.0094 | 0.0193 | 0.4919 |
Leishmania major | trypanothione reductase | 0.0094 | 0.0193 | 1 |
Onchocerca volvulus | 0.0077 | 0.0147 | 0.2581 | |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0157 | 0.0368 | 1 |
Brugia malayi | hypothetical protein | 0.0245 | 0.0609 | 1 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0094 | 0.0193 | 0.0308 |
Onchocerca volvulus | 0.0156 | 0.0363 | 1 | |
Trypanosoma brucei | hypothetical protein, conserved | 0.0077 | 0.0147 | 0.7281 |
Mycobacterium tuberculosis | Conserved protein | 0.0077 | 0.0147 | 0.0224 |
Brugia malayi | beta-lactamase family protein | 0.0077 | 0.0147 | 0.2412 |
Schistosoma mansoni | survival motor neuron protein | 0.005 | 0.0072 | 0.0048 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0157 | 0.0368 | 0.0345 |
Mycobacterium ulcerans | AcrR family transcriptional regulator | 0.203 | 0.5529 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0094 | 0.0193 | 0.3167 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0245 | 0.0609 | 0.0587 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0103 | 0.0218 | 0.0354 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.0368 | 0.5767 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0077 | 0.0147 | 0.0224 |
Mycobacterium ulcerans | transcriptional regulator | 0.203 | 0.5529 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0087 | 0.0847 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0077 | 0.0147 | 0.0224 |
Mycobacterium tuberculosis | Conserved protein | 0.0077 | 0.0147 | 0.0224 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0157 | 0.0368 | 1 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0157 | 0.0368 | 0.0625 |
Brugia malayi | hypothetical protein | 0.0037 | 0.0037 | 0.0604 |
Brugia malayi | Probable ClpP-like protease | 0.0157 | 0.0368 | 0.6035 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0156 | 0.0363 | 0.034 |
Echinococcus granulosus | tumor protein p63 | 0.1064 | 0.2865 | 0.2848 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0077 | 0.0147 | 0.0224 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0214 | 0.0525 | 0.0912 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0077 | 0.0147 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0094 | 0.0193 | 0.4919 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0077 | 0.0147 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0077 | 0.0147 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0214 | 0.0525 | 0.0912 |
Mycobacterium tuberculosis | Probable reductase | 0.0214 | 0.0525 | 0.0912 |
Onchocerca volvulus | 0.0077 | 0.0147 | 0.2581 | |
Plasmodium falciparum | thioredoxin reductase | 0.0094 | 0.0193 | 0.4919 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.0037 | 0.0013 |
Loa Loa (eye worm) | glutathione reductase | 0.0094 | 0.0193 | 0.2706 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.0037 | 0.0013 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0055 | 0.0087 | 0.1426 |
Plasmodium vivax | hypothetical protein, conserved | 0.0077 | 0.0147 | 0.3582 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0037 | 0.5 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0214 | 0.0525 | 0.0912 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0157 | 0.0368 | 1 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0077 | 0.0147 | 0.0224 |
Mycobacterium ulcerans | TetR family transcriptional regulator | 0.203 | 0.5529 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0128 | 0.0288 | 0.4724 |
Mycobacterium leprae | Probable transcriptional regulatory repressor protein (TetR-family) EthR | 0.203 | 0.5529 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0037 | 0.0013 |
Mycobacterium ulcerans | hypothetical protein | 0.0077 | 0.0147 | 0.0224 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0054 | 0.0084 | 0.1735 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0494 | 0.1294 | 0.2313 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0037 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.0037 | 0.0013 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0103 | 0.0218 | 0.0248 |
Schistosoma mansoni | microtubule-associated protein tau | 0.3653 | 1 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0077 | 0.0147 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0214 | 0.0525 | 0.0912 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0157 | 0.0368 | 0.0345 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0037 | 0.5 |
Loa Loa (eye worm) | beta-lactamase | 0.0077 | 0.0147 | 0.19 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0157 | 0.0368 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0054 | 0.0084 | 0.1735 |
Mycobacterium ulcerans | lipase LipD | 0.0077 | 0.0147 | 0.0224 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0147 | 0.19 |
Mycobacterium leprae | Probable lipase LipE | 0.0077 | 0.0147 | 0.0117 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0103 | 0.0218 | 0.0195 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0238 | 0.0591 | 0.1032 |
Echinococcus multilocularis | tumor protein p63 | 0.1064 | 0.2865 | 0.2848 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0094 | 0.0193 | 0.2706 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0077 | 0.0147 | 0.7281 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0128 | 0.0288 | 0.4368 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0077 | 0.0147 | 0.0123 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0157 | 0.0368 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0094 | 0.0193 | 0.4919 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0214 | 0.0525 | 0.081 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0033 | 0.0024 | 0.0391 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0094 | 0.0193 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0077 | 0.0147 | 0.0123 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0157 | 0.0368 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0077 | 0.0147 | 0.0123 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0147 | 0.19 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0147 | 0.19 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0157 | 0.0368 | 0.0345 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0157 | 0.0368 | 0.0625 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0238 | 0.0591 | 0.0931 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0077 | 0.0147 | 0.0224 |
Onchocerca volvulus | 0.0077 | 0.0147 | 0.2581 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.