Detailed information for compound 790518

Basic information

Technical information
  • TDR Targets ID: 790518
  • Name: N-[[5-[2-[(4-methoxyphenyl)amino]-2-oxoethyl] sulfanyl-1,3,4-oxadiazol-2-yl]methyl]thiophen e-2-carboxamide
  • MW: 404.463 | Formula: C17H16N4O4S2
  • H donors: 2 H acceptors: 4 LogP: 2.29 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)NC(=O)CSc1nnc(o1)CNC(=O)c1cccs1
  • InChi: 1S/C17H16N4O4S2/c1-24-12-6-4-11(5-7-12)19-14(22)10-27-17-21-20-15(25-17)9-18-16(23)13-3-2-8-26-13/h2-8H,9-10H2,1H3,(H,18,23)(H,19,22)
  • InChiKey: MVFLLVKRDOEDIP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[[5-[2-[(4-methoxyphenyl)amino]-2-oxo-ethyl]sulfanyl-1,3,4-oxadiazol-2-yl]methyl]thiophene-2-carboxamide
  • N-[[5-[[2-[(4-methoxyphenyl)amino]-2-oxoethyl]thio]-1,3,4-oxadiazol-2-yl]methyl]-2-thiophenecarboxamide
  • N-[[5-[[2-keto-2-[(4-methoxyphenyl)amino]ethyl]thio]-1,3,4-oxadiazol-2-yl]methyl]thiophene-2-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0099 0.0564 0.3346
Loa Loa (eye worm) jmjC domain-containing protein 0.0031 0.0043 0.006
Schistosoma mansoni jumonji domain containing protein 0.0115 0.068 0.064
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0099 0.0564 0.5503
Plasmodium vivax acyl-CoA synthetase, putative 0.0054 0.0219 0.1914
Onchocerca volvulus 0.0035 0.008 0.0179
Onchocerca volvulus 0.0111 0.0649 0.1451
Brugia malayi CXXC zinc finger family protein 0.0084 0.0448 0.0973
Echinococcus multilocularis GPCR, family 2 0.0031 0.0045 0.0029
Loa Loa (eye worm) beta-lactamase 0.0035 0.008 0.0142
Schistosoma mansoni hypothetical protein 0.0031 0.0045 0.0002
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0356 0.1534
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0072 0.0356 0.191
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0262 0.1071
Schistosoma mansoni alpha glucosidase 0.0035 0.0078 0.0035
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0054 0.0219 0.0958
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0131 0.043
Plasmodium vivax hypothetical protein, conserved 0.0035 0.008 0.0401
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.008 0.018
Loa Loa (eye worm) hypothetical protein 0.0097 0.0549 0.1195
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0045 0.0002
Plasmodium falciparum kinesin-5 0.0058 0.0247 0.2227
Plasmodium vivax kinesin-5 0.0058 0.0247 0.2227
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0078 0.0168
Brugia malayi jmjC domain containing protein 0.0119 0.0716 0.1575
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.008 0.0063
Mycobacterium ulcerans hypothetical protein 0.0158 0.1008 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.1526 1
Brugia malayi beta-lactamase 0.0035 0.008 0.0148
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0288 0.0614
Echinococcus granulosus kinesin family 1 0.0443 0.3164 0.3152
Brugia malayi Augmenter of liver regeneration 0.0034 0.007 0.0125
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0288 0.0609
Schistosoma mansoni alpha-glucosidase 0.0136 0.0843 0.0803
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.1356 0.3006
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0045 0.0029
Schistosoma mansoni hypothetical protein 0.0031 0.0045 0.0002
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.008 0.0016
Toxoplasma gondii histone lysine methyltransferase SET1 0.016 0.1025 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0031 0.0043 0.006
Echinococcus multilocularis microtubule associated protein 2 0.1345 1 1
Loa Loa (eye worm) kinesin-like protein KLP2 0.0058 0.0247 0.0517
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.101 0.0995
Trichomonas vaginalis cdc25b, putative 0.0111 0.0649 0.3835
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.0886 0.4135
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.007 0.0288
Brugia malayi jmjC domain containing protein 0.0031 0.0043 0.0065
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.008 0.0037
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0111 0.0649 0.3835
Schistosoma mansoni kinesin eg-5 0.0058 0.0247 0.0205
Schistosoma mansoni hypothetical protein 0.0031 0.0045 0.0002
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0045 0.0002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0196 0.0805
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0072 0.0356 0.3142
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0288 0.0609
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0045 0.0019
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0072 0.0356 0.2976
Loa Loa (eye worm) hypothetical protein 0.0067 0.0316 0.0672
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0035 0.008 0.0063
Loa Loa (eye worm) hypothetical protein 0.0035 0.008 0.0142
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.007 0.0129
Brugia malayi Rhodanese-like domain containing protein 0.0111 0.0649 0.1424
Schistosoma mansoni m-phase inducer phosphatase(cdc25) 0.0111 0.0649 0.0608
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.007 0.0129
Entamoeba histolytica kinesin, putative 0.0058 0.0247 0.2967
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0356 0.1534
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0035 0.008 0.0063
Entamoeba histolytica rodhanase-like domain containing protein 0.0111 0.0649 1
Loa Loa (eye worm) hypothetical protein 0.0152 0.0959 0.2115
Loa Loa (eye worm) hypothetical protein 0.0072 0.0356 0.0762
Mycobacterium ulcerans hypothetical protein 0.011 0.0645 0.6092
Mycobacterium ulcerans hypothetical protein 0.0072 0.0356 0.2976
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.008 0.0016
Leishmania major hypothetical protein, conserved 0.0035 0.008 0.018
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0356 0.2976
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0111 0.0649 0.3835
Echinococcus granulosus JmjC domain containing protein 4 0.0031 0.0043 0.0027
Brugia malayi RNA binding protein 0.0063 0.0288 0.0614
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0052 0.0207 0.1445
Giardia lamblia Kinesin-5 0.0058 0.0247 0.5
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0045 0.0002
Entamoeba histolytica acyl-coA synthetase, putative 0.0072 0.0356 0.4874
Mycobacterium tuberculosis Conserved hypothetical protein 0.0158 0.1008 0.6418
Loa Loa (eye worm) hypothetical protein 0.0054 0.0219 0.0453
Brugia malayi beta-lactamase family protein 0.0035 0.008 0.0148
Schistosoma mansoni alpha-glucosidase 0.0136 0.0843 0.0803
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0356 0.2976
Onchocerca volvulus 0.0031 0.0045 0.0101
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0052 0.0207 0.1788
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0111 0.0649 0.3835
Loa Loa (eye worm) jmjC domain-containing protein 0.0119 0.0716 0.157
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0142 0.0886 0.4135
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.008 0.0037
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.008 0.018
Loa Loa (eye worm) hypothetical protein 0.0035 0.008 0.0142
Trypanosoma brucei glucosidase, putative 0.0035 0.0078 0.0168
Onchocerca volvulus 0.0111 0.0649 0.1451
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0262 0.1957
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0262 0.0219
Schistosoma mansoni cpg binding protein 0.0089 0.0484 0.0443
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.007 0.0269
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0045 0.0002
Schistosoma mansoni cpg binding protein 0.0084 0.0448 0.0406
Loa Loa (eye worm) hypothetical protein 0.0054 0.0219 0.0453
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0288 0.0246
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0078 0.0137
Trichomonas vaginalis cdc25c, putative 0.0111 0.0649 0.3835
Loa Loa (eye worm) hypothetical protein 0.0054 0.0219 0.0453
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0262 0.1957
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0072 0.0356 0.2976
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0152 0.0959 0.9327
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0356 0.1534
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0045 0.0029
Schistosoma mansoni hypothetical protein 0.0385 0.2728 0.2697
Schistosoma mansoni hypothetical protein 0.0067 0.0316 0.0274
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0262 0.0245
Brugia malayi jmjC domain containing protein 0.0031 0.0043 0.0065
Loa Loa (eye worm) hypothetical protein 0.0072 0.0356 0.0762
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0131 0.043
Plasmodium falciparum acyl-CoA synthetase 0.0054 0.0219 0.1914
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0152 0.0959 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.008 0.0142
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0196 0.0805
Trypanosoma brucei mitochondrial DNA polymerase beta 0.03 0.2082 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0072 0.0356 0.3142
Entamoeba histolytica acyl-CoA synthetase, putative 0.0072 0.0356 0.4874
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0045 0.0029
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.068 0.0665
Loa Loa (eye worm) hypothetical protein 0.0031 0.0043 0.006
Onchocerca volvulus 0.0035 0.008 0.0179
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0196 0.0805
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.03 0.2082 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0158 0.101 0.2229
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.03 0.2082 1
Schistosoma mansoni cpg binding protein 0.0089 0.0484 0.0443
Echinococcus multilocularis cpg binding protein 0.0089 0.0484 0.0468
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0152 0.0959 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0072 0.0356 0.2976
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0078 0.0061
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0131 0.043
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0201 0.0773
Brugia malayi jmjC domain containing protein 0.0115 0.068 0.1493
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0045 0.007
Entamoeba histolytica acyl-CoA synthetase, putative 0.0072 0.0356 0.4874
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0078 0.0061
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.101 0.0995
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0152 0.0959 0.9474
Echinococcus multilocularis dnaJ subfamily B 0.1197 0.8873 0.8871
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0152 0.0959 0.5
Toxoplasma gondii kinesin motor domain-containing protein 0.0058 0.0247 0.2077
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0152 0.0959 1
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0034 0.007 0.0129
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0152 0.0959 1
Brugia malayi Probable ClpP-like protease 0.0152 0.0959 0.2119
Schistosoma mansoni hypothetical protein 0.1197 0.8873 0.8868
Echinococcus multilocularis peptidase Clp (S14 family) 0.0099 0.0564 0.0548
Onchocerca volvulus 0.0232 0.1568 0.3505
Loa Loa (eye worm) hypothetical protein 0.0054 0.0219 0.0453
Loa Loa (eye worm) RNA binding protein 0.0063 0.0288 0.0609
Echinococcus multilocularis kinesin family 1 0.0443 0.3164 0.3152
Loa Loa (eye worm) CXXC zinc finger family protein 0.0084 0.0448 0.0968
Loa Loa (eye worm) hypothetical protein 0.0031 0.0045 0.0064
Brugia malayi jmjC domain containing protein 0.0031 0.0043 0.0065
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.008 0.0063
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0045 0.0029
Schistosoma mansoni microtubule-associated protein tau 0.1345 1 1
Onchocerca volvulus 0.0616 0.4473 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0045 0.0029
Onchocerca volvulus 0.0111 0.0649 0.1451
Echinococcus granulosus dnaJ subfamily B 0.1197 0.8873 0.8871
Plasmodium vivax SET domain protein, putative 0.0031 0.0045 0.0021
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0356 0.0767
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0356 0.0767
Toxoplasma gondii hypothetical protein 0.0052 0.0207 0.1667
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.008 0.018
Echinococcus multilocularis phd:f box containing protein 0.0031 0.0043 0.0027
Echinococcus multilocularis JmjC domain containing protein 4 0.0031 0.0043 0.0027
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0045 0.0029
Echinococcus granulosus jumonji domain containing 1A 0.0031 0.0043 0.0027
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0034 0.007 0.0053
Loa Loa (eye worm) hypothetical protein 0.0035 0.008 0.0142
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0078 0.0168
Loa Loa (eye worm) hypothetical protein 0.0031 0.0043 0.006
Loa Loa (eye worm) hypothetical protein 0.0054 0.0219 0.0453
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0034 0.007 0.0053
Echinococcus granulosus GPCR family 2 0.0031 0.0045 0.0029
Echinococcus granulosus lysosomal alpha glucosidase 0.0158 0.101 0.0995
Loa Loa (eye worm) hypothetical protein 0.0031 0.0043 0.006
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0111 0.0649 0.3835
Brugia malayi Kinesin motor domain containing protein 0.0058 0.0247 0.0523
Echinococcus granulosus peptidase Clp S14 family 0.0099 0.0564 0.0548
Trichomonas vaginalis cdc25b, putative 0.0111 0.0649 0.3835
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0152 0.0959 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0152 0.0959 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0179 0.1169 0.1131
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0078 0.0168
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0288 0.0246
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0045 0.0029
Echinococcus multilocularis lysine specific demethylase 5A 0.0115 0.068 0.0665
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0262 0.2224
Brugia malayi Pre-SET motif family protein 0.0204 0.1356 0.301
Trichomonas vaginalis esterase, putative 0.0035 0.008 0.0016
Schistosoma mansoni hypothetical protein 0.0031 0.0045 0.0002
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0054 0.0219 0.1493
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.0886 0.4135
Loa Loa (eye worm) hypothetical protein 0.0111 0.0649 0.1419
Entamoeba histolytica rodhanase-like domain containing protein 0.0111 0.0649 1
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0111 0.0649 0.3835
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.068 0.0665
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0072 0.0356 0.191
Echinococcus granulosus phd:f box containing protein 0.0031 0.0043 0.0027
Echinococcus granulosus tar DNA binding protein 0.0063 0.0288 0.0272
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0023 0.0007
Brugia malayi hypothetical protein 0.0616 0.4473 1
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0034 0.007 0.0129
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0152 0.0959 0.0944
Loa Loa (eye worm) hypothetical protein 0.0031 0.0045 0.0064
Onchocerca volvulus 0.0084 0.0448 0.1001
Echinococcus multilocularis lysine specific demethylase 6a 0.0031 0.0043 0.0027
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0045 0.007
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.008 0.0016
Echinococcus granulosus cpg binding protein 0.0089 0.0484 0.0468
Loa Loa (eye worm) hypothetical protein 0.0035 0.008 0.0142
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0152 0.0959 0.0944
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0052 0.0207 0.1788
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.008 0.0016
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0045 0.0064
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0288 0.0246
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0131 0.043
Loa Loa (eye worm) hypothetical protein 0.0111 0.0649 0.1419
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0316 0.0677
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0152 0.0959 0.9327
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.0549 0.1195
Loa Loa (eye worm) hypothetical protein 0.0035 0.008 0.0142
Echinococcus multilocularis jumonji domain containing 1A 0.0031 0.0043 0.0027
Leishmania major mitochondrial DNA polymerase beta 0.03 0.2082 1
Brugia malayi TAR-binding protein 0.0063 0.0288 0.0614
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0262 0.1957
Echinococcus multilocularis m phase inducer phosphatase(cdc25) 0.0111 0.0649 0.0634
Schistosoma mansoni jumonji/arid domain-containing protein 0.0119 0.0716 0.0676
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0034 0.007 0.0288
Loa Loa (eye worm) hepatopoietin HPO2 0.0034 0.007 0.0119
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0152 0.0959 0.9474
Loa Loa (eye worm) hypothetical protein 0.0072 0.0356 0.0762
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0288 0.0272
Brugia malayi Pre-SET motif family protein 0.0031 0.0045 0.007
Loa Loa (eye worm) hypothetical protein 0.0035 0.008 0.0142
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.008 0.0016
Schistosoma mansoni jumonji/arid domain-containing protein 0.0119 0.0716 0.0676
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0196 0.0805
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0078 0.0142
Trichomonas vaginalis set domain proteins, putative 0.0232 0.1568 1
Loa Loa (eye worm) hypothetical protein 0.0616 0.4473 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0078 0.035
Onchocerca volvulus 0.0111 0.0649 0.1451
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0072 0.0356 0.2976
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0262 0.1256
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.0549 0.12
Echinococcus granulosus lysine specific demethylase 6a 0.0031 0.0043 0.0027
Schistosoma mansoni peptidase Clp (S14 family) 0.0152 0.0959 0.092
Loa Loa (eye worm) hypothetical protein 0.0102 0.0584 0.1272
Toxoplasma gondii ABC1 family protein 0.0035 0.008 0.0374
Echinococcus granulosus lysine specific demethylase 5A 0.0119 0.0716 0.0701
Brugia malayi Glycosyl hydrolases family 31 protein 0.0158 0.101 0.2233
Entamoeba histolytica rodhanase-like domain containing protein 0.0111 0.0649 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0262 0.0245
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0288 0.0246
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0356 0.2976
Onchocerca volvulus 0.0072 0.0356 0.0796
Onchocerca volvulus 0.0035 0.008 0.0179
Onchocerca volvulus 0.0092 0.0505 0.1129
Leishmania major hypothetical protein, conserved 0.0034 0.007 0.0129
Loa Loa (eye worm) hypothetical protein 0.0102 0.0584 0.1272
Brugia malayi Rhodanese-like domain containing protein 0.0111 0.0649 0.1424
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.0549 0.12
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0099 0.0564 0.3346
Brugia malayi jmjC domain containing protein 0.0031 0.0043 0.0065
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0356 0.0767
Brugia malayi beta-lactamase family protein 0.0035 0.008 0.0148
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0262 0.0219
Echinococcus granulosus m phase inducer phosphatasecdc25 0.0111 0.0649 0.0634
Toxoplasma gondii hypothetical protein 0.0048 0.0178 0.1372
Loa Loa (eye worm) jmjC domain-containing protein 0.0031 0.0043 0.006
Toxoplasma gondii Erv1 / Alr family protein 0.0034 0.007 0.0269
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0288 0.0246
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.008 0.0148

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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