TDR Targets

Basic information

Technical information

TDR Targets ID: 790732
Name: N-(4-methoxyphenyl)-2-[(2-phenyl-1,4-diazaspi ro[4.5]deca-1,3-dien-3-yl)sulfanyl]acetamide
MW: 407.529 | Formula: C23H25N3O2S
H donors: 1 H acceptors: 1 LogP: 4.53 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)NC(=O)CSC1=NC2(N=C1c1ccccc1)CCCCC2
InChi: 1S/C23H25N3O2S/c1-28-19-12-10-18(11-13-19)24-20(27)16-29-22-21(17-8-4-2-5-9-17)25-23(26-22)14-6-3-7-15-23/h2,4-5,8-13H,3,6-7,14-16H2,1H3,(H,24,27)
InChiKey: SQFOTHUXARRVKB-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(4-methoxyphenyl)-2-[(2-phenyl-1,4-diazaspiro[4.5]deca-1,3-dien-3-yl)thio]acetamide
N-(4-methoxyphenyl)-2-[(2-phenyl-1,4-diazaspiro[4.5]deca-1,3-dien-3-yl)sulfanyl]ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0031	0.0117	0.0297
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0031	0.0117	0.0511
Entamoeba histolytica	acyl-coA synthetase, putative	0.0059	0.0465	0.3577
Echinococcus granulosus	muscleblind protein	0.0129	0.135	0.1824
Onchocerca volvulus		0.0031	0.0117	0.0297
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0026	0.005	0.0017
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0068	0.0576	0.5
Echinococcus granulosus	Protein patched homolog 1	0.0043	0.0261	0.031
Schistosoma mansoni	patched 1	0.0043	0.0261	0.031
Onchocerca volvulus		0.0031	0.0117	0.0297
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0026	0.005	0.0877
Schistosoma mansoni	hypothetical protein	0.0041	0.0242	0.0283
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.005	0.035	0.0433
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0306	0.0371
Plasmodium vivax	hypothetical protein, conserved	0.0031	0.0117	0.2038
Loa Loa (eye worm)	hypothetical protein	0.0026	0.005	0.022
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0465	0.2025
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0068	0.0576	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0306	0.0371
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.0261	0.0659
Brugia malayi	AMP-binding enzyme family protein	0.0059	0.0465	0.2025
Echinococcus multilocularis	geminin	0.0171	0.1873	0.1832
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0042	0.0248	0.062
Echinococcus granulosus	geminin	0.0171	0.1873	0.2552
Brugia malayi	Muscleblind-like protein	0.0129	0.135	0.5878
Echinococcus multilocularis	survival motor neuron protein 1	0.0205	0.2296	0.2257
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0044	0.0278	0.3507
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0117	0.0511
Entamoeba histolytica	kinesin, putative	0.0051	0.0362	0.2274
Echinococcus multilocularis	tar DNA binding protein	0.0064	0.0529	0.0481
Loa Loa (eye worm)	beta-lactamase	0.0031	0.0117	0.0511
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0059	0.0465	0.758
Echinococcus multilocularis	kinesin family 1	0.039	0.462	0.4593
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0576	0.2508
Echinococcus multilocularis	expressed conserved protein	0.0093	0.0898	0.0852
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0068	0.0576	1
Echinococcus granulosus	microtubule associated protein 2	0.0597	0.7227	1
Loa Loa (eye worm)	hypothetical protein	0.0129	0.135	0.5878
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0099	0.0973	1
Brugia malayi	AMP-binding enzyme family protein	0.0059	0.0465	0.2025
Echinococcus granulosus	Niemann Pick C1 protein	0.0099	0.0973	0.1301
Schistosoma mansoni	hypothetical protein	0.0042	0.025	0.0294
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0059	0.0465	0.8008
Brugia malayi	RNA recognition motif domain containing protein	0.0064	0.0529	0.2302
Schistosoma mansoni	metabotropic glutamate receptor	0.0043	0.0263	0.0312
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.005	0.035	0.7517
Echinococcus granulosus	metabotropic glutamate receptor 2	0.0043	0.0263	0.0313
Brugia malayi	beta-lactamase	0.0031	0.0117	0.0511
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0031	0.0117	0.011
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0042	0.0248	0.062
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0529	0.0682
Echinococcus granulosus	kinesin family 1	0.039	0.462	0.6374
Schistosoma mansoni	hypothetical protein	0.0339	0.3985	0.549
Echinococcus multilocularis	microtubule associated protein 2	0.0597	0.7227	0.7213
Echinococcus granulosus	histone lysine methyltransferase setb	0.0026	0.005	0.0017
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0042	0.025	0.109
Brugia malayi	Pre-SET motif family protein	0.018	0.1988	0.8658
Echinococcus granulosus	survival motor neuron protein 1	0.0205	0.2296	0.3141
Giardia lamblia	Kinesin-5	0.0051	0.0362	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.005	0.035	0.1101
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0278	0.1212
Mycobacterium leprae	conserved hypothetical protein	0.0031	0.0117	0.1768
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0306	0.0371
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0306	0.0371
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0043	0.0268	0.1167
Loa Loa (eye worm)	RNA binding protein	0.0064	0.0529	0.2302
Brugia malayi	AMP-binding enzyme family protein	0.0059	0.0465	0.2025
Toxoplasma gondii	hypothetical protein	0.0023	0.0019	0.0328
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0973	0.4239
Echinococcus multilocularis	protein dispatched 1	0.0049	0.0337	0.0288
Loa Loa (eye worm)	glutamate receptor	0.0051	0.0367	0.16
Onchocerca volvulus		0.0059	0.0465	0.1842
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0182	0.0199
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.005	0.035	0.5063
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0101	0.0993	0.1327
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0023	0.0019	0.0328
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.005	0.035	0.1522
Leishmania major	4-coumarate:coa ligase-like protein	0.0059	0.0465	1
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0031	0.0117	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0117	0.0511
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0059	0.0465	0.758
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0068	0.0576	1
Onchocerca volvulus		0.0042	0.025	0.0888
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0068	0.0576	1
Schistosoma mansoni	hypothetical protein	0.0171	0.1873	0.2552
Brugia malayi	Pre-SET motif family protein	0.0026	0.005	0.022
Echinococcus multilocularis	metabotropic glutamate receptor 2	0.0043	0.0263	0.0214
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0529	0.0682
Echinococcus multilocularis	Niemann Pick C1 protein	0.0142	0.1509	0.1466
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0068	0.0576	1
Echinococcus granulosus	tar DNA binding protein	0.0064	0.0529	0.0682
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0044	0.0283	0.0786
Schistosoma mansoni	hypothetical protein	0.0171	0.1873	0.2552
Echinococcus granulosus	Niemann Pick C1 protein	0.0142	0.1509	0.2045
Schistosoma mansoni	peptidase Clp (S14 family)	0.0068	0.0576	0.0748
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0026	0.005	0.0017
Brugia malayi	metabotropic glutamate receptor type 2	0.0025	0.0039	0.0168
Entamoeba histolytica	Acid sphingomyelinase-like phosphodiesterase, putative	0.0071	0.0624	0.5582
Brugia malayi	TAR-binding protein	0.0064	0.0529	0.2302
Echinococcus multilocularis	sterol regulatory element binding protein	0.0043	0.0261	0.0212
Schistosoma mansoni	microtubule-associated protein tau	0.0597	0.7227	1
Loa Loa (eye worm)	TAR-binding protein	0.0064	0.0529	0.2302
Brugia malayi	hypothetical protein	0.0036	0.0182	0.0792
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0278	0.1212
Echinococcus multilocularis	protein patched	0.0043	0.0261	0.0212
Echinococcus multilocularis	tumor protein p63	0.0341	0.4007	0.3977
Echinococcus granulosus	peptidase Clp S14 family	0.0044	0.0283	0.034
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0306	0.1331
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0064	0.0529	0.2302
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0529	0.0682
Brugia malayi	RNA binding protein	0.0064	0.0529	0.2302
Brugia malayi	latrophilin 2 splice variant baaae	0.003	0.0096	0.042
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0529	0.0682
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0046	0.0308	0.1339
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0068	0.0576	0.0528
Loa Loa (eye worm)	DEAH box polypeptide 35	0.0033	0.0144	0.0627
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0044	0.0283	0.4744
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0023	0.0019	0.0328
Schistosoma mansoni	hypothetical protein	0.003	0.0096	0.008
Brugia malayi	Kinesin motor domain containing protein	0.0051	0.0362	0.1576
Echinococcus granulosus	tumor protein p63	0.0341	0.4007	0.5521
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.018	0.1988	0.8658
Mycobacterium leprae	Probable lipase LipE	0.0031	0.0117	0.1768
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0382	0.1663
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0117	0.0511
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0068	0.0576	1
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.0063	0.0516	0.0467
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0117	0.0511
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0068	0.0576	0.0748
Plasmodium vivax	acyl-CoA synthetase, putative	0.0044	0.0278	0.483
Toxoplasma gondii	kinesin motor domain-containing protein	0.0051	0.0362	0.6282
Echinococcus multilocularis	Niemann Pick C1 protein	0.0099	0.0973	0.0928
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0043	0.0261	0.1138
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0026	0.005	0.0017
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0059	0.0465	0.758
Plasmodium vivax	SET domain protein, putative	0.0026	0.005	0.0877
Plasmodium falciparum	acyl-CoA synthetase	0.0044	0.0278	0.483
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0624	0.2716
Mycobacterium ulcerans	hypothetical protein	0.0059	0.0465	0.758
Echinococcus granulosus	beta LACTamase domain containing family member	0.0031	0.0117	0.011
Schistosoma mansoni	survival motor neuron protein	0.0042	0.025	0.0294
Mycobacterium ulcerans	acyl-CoA synthetase	0.0059	0.0465	0.758
Brugia malayi	CHE-14 protein	0.0043	0.0261	0.1138
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0059	0.0465	0.1649
Loa Loa (eye worm)	kinesin-like protein KLP2	0.0051	0.0362	0.1576
Echinococcus granulosus	expressed conserved protein	0.0093	0.0898	0.1195
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0268	0.1167
Schistosoma mansoni	hypothetical protein	0.0041	0.0242	0.0283
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0465	0.2025
Leishmania major	4-coumarate:coa ligase-like protein	0.0059	0.0465	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0031	0.0117	1
Schistosoma mansoni	kinesin eg-5	0.0051	0.0362	0.045
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0278	0.1212
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0026	0.005	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0278	0.1212
Brugia malayi	metabotropic glutamate receptor subtype 5a (mGluR5a), putative	0.0046	0.0307	0.1337
Echinococcus granulosus	metabotropic glutamate receptor 5	0.0063	0.0516	0.0664
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0516	0.2245
Schistosoma mansoni	hypothetical protein	0.0041	0.0242	0.0283
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0068	0.0576	1
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0044	0.0283	0.0786
Schistosoma mansoni	hypothetical protein	0.0041	0.0242	0.0283
Echinococcus multilocularis	muscleblind protein 1	0.0129	0.135	0.1306
Toxoplasma gondii	ABC1 family protein	0.0031	0.0117	0.2038
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0031	0.0117	0.011
Plasmodium vivax	kinesin-5	0.0051	0.0362	0.6282
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.005	0.035	0.0433
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0068	0.0576	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0199	0.2226	1
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0278	0.1212
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	0.0058	0.0455	0.058
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0306	0.0256
Brugia malayi	hypothetical protein	0.0205	0.2296	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0059	0.0465	0.3577
Loa Loa (eye worm)	hypothetical protein	0.0129	0.135	0.5878
Brugia malayi	beta-lactamase family protein	0.0031	0.0117	0.0511
Brugia malayi	Niemann-Pick C1 protein precursor	0.0099	0.0973	0.4239
Onchocerca volvulus		0.005	0.0353	0.1343
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.0529	0.0682
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0059	0.0465	0.3577
Mycobacterium ulcerans	acyl-CoA synthetase	0.0059	0.0465	0.758
Loa Loa (eye worm)	hypothetical protein	0.0205	0.2296	1
Schistosoma mansoni	hypothetical protein	0.0036	0.0182	0.0199
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0059	0.0465	0.8008
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0117	0.0511
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0144	0.0627
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0117	0.0511
Trypanosoma brucei	hypothetical protein, conserved	0.0031	0.0117	1
Loa Loa (eye worm)	hypothetical protein	0.005	0.0353	0.1536
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0044	0.0278	0.0763
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0068	0.0576	1
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0182	0.0199
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0031	0.0117	0.0511
Brugia malayi	Probable ATP-dependent helicase DHX35	0.0033	0.0144	0.0627
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0261	0.1138
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0059	0.0465	0.1649
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.005	0.035	0.0301
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0043	0.0268	0.1167
Trichomonas vaginalis	set domain proteins, putative	0.0205	0.2301	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0306	0.0371
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0051	0.0367	0.16
Trypanosoma cruzi	hypothetical protein, conserved	0.0031	0.0117	1
Brugia malayi	beta-lactamase family protein	0.0031	0.0117	0.0511
Schistosoma mansoni	cellular tumor antigen P53	0.005	0.0353	0.0437
Echinococcus multilocularis	muscleblind protein	0.0129	0.135	0.1306
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0042	0.0248	0.062
Leishmania major	4-coumarate:coa ligase-like protein	0.0059	0.0465	1
Echinococcus granulosus	sterol regulatory element binding protein	0.0043	0.0261	0.031
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0465	0.2025
Loa Loa (eye worm)	hypothetical protein	0.003	0.0096	0.042
Brugia malayi	Probable ClpP-like protease	0.0068	0.0576	0.2508
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0306	0.0256
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0044	0.0283	0.0234
Entamoeba histolytica	Acid sphingomyelinase-like phosphodiesterase, putative	0.0071	0.0624	0.5582
Plasmodium falciparum	kinesin-5	0.0051	0.0362	0.6282
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0043	0.0268	0.1167
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0059	0.0465	0.758
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.005	0.035	0.5063
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0068	0.0576	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0059	0.0465	0.758
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0042	0.0248	0.062
Onchocerca volvulus		0.0205	0.2301	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0306	0.1331
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0182	0.0132
Leishmania major	hypothetical protein, conserved	0.0031	0.0117	0.2524

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 790732