Detailed information for compound 791897

Basic information

Technical information
  • TDR Targets ID: 791897
  • Name: N-(2,5-dimethoxyphenyl)-[1,2,4]triazolo[4,3-c ]quinazolin-5-amine
  • MW: 321.333 | Formula: C17H15N5O2
  • H donors: 1 H acceptors: 3 LogP: 3.68 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1Nc1nc2ccccc2c2n1cnn2)OC
  • InChi: 1S/C17H15N5O2/c1-23-11-7-8-15(24-2)14(9-11)20-17-19-13-6-4-3-5-12(13)16-21-18-10-22(16)17/h3-10H,1-2H3,(H,19,20)
  • InChiKey: TWFHIOTZUWVMIG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2,5-dimethoxyphenyl)-([1,2,4]triazolo[4,3-c]quinazolin-5-yl)amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Glycosyl hydrolases family 31 protein 0.0163 0.22 0.6795
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0024 0.0157 0.0115
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0334 0.0801
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0043 0.0103
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0043 0.0103
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0334 0.4107
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0047 0.0489 0.1173
Loa Loa (eye worm) glutathione reductase 0.0047 0.0498 0.1546
Onchocerca volvulus 0.0024 0.0157 0.0486
Echinococcus multilocularis JmjC domain containing protein 4 0.0047 0.0489 0.0448
Mycobacterium ulcerans aminopeptidase N PepN 0.0024 0.0157 0.0554
Loa Loa (eye worm) hypothetical protein 0.0045 0.0458 0.1421
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0334 0.0292
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0024 0.0157 0.0115
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0082 0.1009 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.055 0.132
Toxoplasma gondii aminopeptidase N, putative 0.0024 0.0157 0.0554
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0069 0.0813 0.0774
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.22 0.2167
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0043 0.0103
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0024 0.0157 0.0378
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0334 0.1037
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0108 0.139 0.6542
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0334 0.4107
Schistosoma mansoni jumonji/arid domain-containing protein 0.0177 0.2402 0.2369
Echinococcus multilocularis lysine specific demethylase 5A 0.0175 0.2378 0.2345
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0463 0.0422
Loa Loa (eye worm) hypothetical protein 0.0045 0.0458 0.1421
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0043 0.0529
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0416 0.0997
Mycobacterium tuberculosis Probable dehydrogenase 0.0108 0.139 0.6542
Onchocerca volvulus 0.0029 0.0225 0.0694
Brugia malayi hypothetical protein 0.0232 0.322 0.9945
Brugia malayi jmjC domain containing protein 0.0047 0.0489 0.1509
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0334 0.4107
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0334 0.1409
Toxoplasma gondii hypothetical protein 0.0054 0.0597 0.268
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0069 0.0813 0.0774
Echinococcus multilocularis phd:f box containing protein 0.0047 0.0489 0.0448
Loa Loa (eye worm) jmjC domain-containing protein 0.0047 0.0489 0.1518
Brugia malayi Probable ClpP-like protease 0.0157 0.2109 0.6513
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0334 0.1032
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0069 0.0813 0.0774
Toxoplasma gondii hypothetical protein 0.0048 0.0506 0.2241
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0103 0.1314 0.4744
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0069 0.0813 0.0774
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.22 0.2167
Trypanosoma cruzi aminopeptidase, putative 0.0024 0.0157 0.0378
Loa Loa (eye worm) jmjC domain-containing protein 0.0177 0.2402 0.7459
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0024 0.0157 0.0115
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0024 0.0157 0.0115
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0103 0.1314 0.6174
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0054 0.0597 0.268
Schistosoma mansoni cpg binding protein 0.0029 0.0225 0.0182
Echinococcus multilocularis dnaJ subfamily B 0.0409 0.5823 0.5805
Schistosoma mansoni hypothetical protein 0.0169 0.2296 0.2263
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0157 0.2109 1
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0047 0.0489 0.2158
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0463 0.0422
Schistosoma mansoni peptidase Clp (S14 family) 0.0157 0.2109 0.2075
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0416 0.0997
Echinococcus multilocularis jumonji domain containing 1A 0.0047 0.0489 0.0448
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0334 0.4107
Brugia malayi glutathione reductase 0.0047 0.0498 0.1538
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0054 0.0597 0.268
Brugia malayi jmjC domain containing protein 0.0177 0.2402 0.7418
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0463 0.1438
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0043 0.0103
Brugia malayi Thioredoxin reductase 0.0047 0.0498 0.1538
Brugia malayi jmjC domain containing protein 0.0047 0.0489 0.1509
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0334 0.4107
Mycobacterium tuberculosis Conserved hypothetical protein 0.0156 0.2101 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0157 0.2109 1
Schistosoma mansoni alpha-glucosidase 0.014 0.1866 0.1831
Echinococcus granulosus cpg binding protein 0.003 0.0249 0.0207
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0069 0.0813 0.0774
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0043 0.0133
Schistosoma mansoni alpha-glucosidase 0.014 0.1866 0.1831
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0157 0.2109 0.2075
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0498 0.0457
Brugia malayi jmjC domain containing protein 0.0175 0.2378 0.7343
Toxoplasma gondii aminopeptidase N protein 0.0024 0.0157 0.0554
Trypanosoma brucei glucosidase, putative 0.0036 0.0334 0.0801
Schistosoma mansoni cpg binding protein 0.003 0.0249 0.0207
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0069 0.0813 0.0774
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0108 0.139 0.6542
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0047 0.0489 0.1173
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0175 0.2378 0.2345
Toxoplasma gondii aminopeptidase n, putative 0.0024 0.0157 0.0554
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.014 0.1868 0.4482
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.012 0.1567 0.7403
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0108 0.139 0.6542
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0024 0.0157 0.0378
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0296 0.4168 1
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0024 0.0157 0.0378
Loa Loa (eye worm) peptidase family M1 containing protein 0.0189 0.2582 0.8019
Echinococcus granulosus dnaJ subfamily B 0.0409 0.5823 0.5805
Echinococcus granulosus JmjC domain containing protein 4 0.0047 0.0489 0.0448
Echinococcus multilocularis cpg binding protein 0.003 0.0249 0.0207
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0048 0.0513 0.0472
Echinococcus granulosus jumonji domain containing 1A 0.0047 0.0489 0.0448
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0699 0.0658
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0163 0.22 0.6833
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0024 0.0157 0.1935
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0157 0.2109 1
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0498 0.2202
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0048 0.0513 0.0472
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0498 0.1546
Mycobacterium tuberculosis Probable oxidoreductase 0.012 0.1567 0.7403
Loa Loa (eye worm) hypothetical protein 0.0047 0.0489 0.1518
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0024 0.0157 0.0378
Schistosoma mansoni phd/f-box containing protein 0.0047 0.0489 0.0448
Echinococcus multilocularis geminin 0.0169 0.2296 0.2263
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0082 0.1009 1
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0069 0.0813 0.1951
Loa Loa (eye worm) hypothetical protein 0.0024 0.0157 0.0489
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0043 0.0103
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0069 0.0813 0.0774
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0024 0.0157 0.0554
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.012 0.1567 0.6417
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0225 0.0697
Schistosoma mansoni alpha glucosidase 0.0036 0.0334 0.0292
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0334 0.4107
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0043 0.0103
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.322 0.3191
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.322 0.3191
Schistosoma mansoni cpg binding protein 0.003 0.0249 0.0207
Mycobacterium ulcerans aminopeptidase N PepN 0.0069 0.0813 0.3729
Echinococcus multilocularis peptidase Clp (S14 family) 0.0103 0.1314 0.1276
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0043 0.0103
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0334 0.4107
Trypanosoma brucei Aminopeptidase M1, putative 0.0069 0.0813 0.1951
Toxoplasma gondii thioredoxin reductase 0.0047 0.0498 0.2202
Onchocerca volvulus 0.0094 0.1189 0.3672
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0069 0.0813 0.0774
Brugia malayi Peptidase family M1 containing protein 0.0069 0.0813 0.2512
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0463 0.0422
Trypanosoma brucei trypanothione reductase 0.0047 0.0498 0.1195
Echinococcus multilocularis microtubule associated protein 2 0.0692 1 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.1009 0.3135
Leishmania major mitochondrial DNA polymerase beta 0.0296 0.4168 1
Echinococcus granulosus aminopeptidase N 0.0233 0.3238 0.3209
Leishmania major trypanothione reductase 0.0047 0.0498 0.1195
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0069 0.0813 0.0774
Loa Loa (eye worm) hypothetical protein 0.0047 0.0489 0.1518
Loa Loa (eye worm) TATA binding protein associated factor 0.0024 0.0157 0.0489
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0498 0.0457
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0296 0.4168 1
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0047 0.0489 0.1173
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0024 0.0157 0.0554
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0334 0.4107
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0047 0.0489 0.2158
Echinococcus granulosus phd:f box containing protein 0.0047 0.0489 0.0448
Trypanosoma cruzi aminopeptidase, putative 0.0069 0.0813 0.1951
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0175 0.2378 0.2345
Trypanosoma brucei Aminopeptidase M1, putative 0.0069 0.0813 0.1951
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0334 0.0292
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0334 0.0801
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0047 0.0489 0.0448
Loa Loa (eye worm) hypothetical protein 0.0024 0.0157 0.0489
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0069 0.0813 0.1951
Plasmodium vivax glutathione reductase, putative 0.0047 0.0498 0.2202
Loa Loa (eye worm) hypothetical protein 0.0047 0.0489 0.1518
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0045 0.0458 0.0416
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0463 0.143
Schistosoma mansoni hypothetical protein 0.0047 0.0499 0.0458
Schistosoma mansoni aminopeptidase A (M01 family) 0.0024 0.0157 0.0115
Echinococcus granulosus lysine specific demethylase 5A 0.0177 0.2402 0.2369
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0334 0.3309
Trypanosoma brucei aminopeptidase, putative 0.0024 0.0157 0.0378
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.014 0.1868 0.4482
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0024 0.0157 0.0489
Echinococcus granulosus lysine specific demethylase 6a 0.0047 0.0489 0.0448
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0108 0.139 0.6542
Echinococcus granulosus peptidase Clp S14 family 0.0103 0.1314 0.1276
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0416 0.0997
Schistosoma mansoni hypothetical protein 0.0409 0.5823 0.5805
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0463 0.0422
Schistosoma mansoni jumonji domain containing protein 0.0047 0.0489 0.0448
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0334 0.0801
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0045 0.0458 0.0416
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0043 0.0103
Onchocerca volvulus 0.0069 0.0813 0.2512
Mycobacterium ulcerans hypothetical protein 0.0156 0.2101 0.9965
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.012 0.1567 0.7403
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0603 0.271
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0069 0.0813 0.1951
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0334 0.4107
Plasmodium falciparum thioredoxin reductase 0.0047 0.0498 0.2202
Brugia malayi Peptidase family M1 containing protein 0.0233 0.3238 1
Echinococcus multilocularis aminopeptidase N 0.0233 0.3238 0.3209
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0334 0.3309
Loa Loa (eye worm) aminopeptidase N 0.0069 0.0813 0.2526
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0157 0.2109 1
Schistosoma mansoni survival motor neuron protein 0.0047 0.0499 0.0458
Schistosoma mansoni jumonji/arid domain-containing protein 0.0177 0.2402 0.2369
Loa Loa (eye worm) hypothetical protein 0.0232 0.322 1
Onchocerca volvulus 0.0047 0.0499 0.1541
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0103 0.1314 0.6174
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0045 0.0458 0.1098
Echinococcus granulosus lysosomal alpha glucosidase 0.0163 0.22 0.2167
Schistosoma mansoni hypothetical protein 0.0169 0.2296 0.2263
Schistosoma mansoni phosphatidylserine receptor 0.0047 0.0489 0.0448
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0024 0.0157 0.0378
Brugia malayi jmjC domain containing protein 0.0047 0.0489 0.1509
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0043 0.0103
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0463 0.0422
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0069 0.0813 1
Onchocerca volvulus 0.0233 0.3238 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0157 0.2109 1
Echinococcus granulosus geminin 0.0169 0.2296 0.2263
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0157 0.2109 0.2075
Echinococcus multilocularis lysine specific demethylase 6a 0.0047 0.0489 0.0448
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.014 0.1868 0.4482
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0024 0.0157 0.0378
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0296 0.4168 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0463 0.0422
Loa Loa (eye worm) hypothetical protein 0.0165 0.2226 0.6914
Schistosoma mansoni microtubule-associated protein tau 0.0692 1 1
Mycobacterium tuberculosis Probable reductase 0.0108 0.139 0.6542
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0043 0.0529
Brugia malayi TATA binding protein associated factor 0.0024 0.0157 0.0486
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0069 0.0813 0.1951
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0157 0.2109 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0054 0.0597 0.268
Plasmodium vivax JmjC domain containing protein 0.0047 0.0489 0.2158
Brugia malayi hypothetical protein 0.0069 0.0813 0.2512
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0157 0.2109 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0043 0.0103
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0108 0.139 0.5245
Brugia malayi Peptidase family M1 containing protein 0.0024 0.0157 0.0486
Loa Loa (eye worm) jmjC domain-containing protein 0.0047 0.0489 0.1518
Plasmodium falciparum JmjC domain-containing protein, putative 0.0047 0.0489 0.2158
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0024 0.0157 0.0554
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0043 0.0103
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0157 0.2109 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0416 0.0997
Brugia malayi hypothetical protein 0.0024 0.0157 0.0486
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0024 0.0157 0.0554
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0043 0.0103
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0043 0.0103
Brugia malayi jmjC domain containing protein 0.0047 0.0489 0.1509
Leishmania major hypothetical protein, conserved 0.0047 0.0489 0.1173
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0499 0.1541
Schistosoma mansoni jumonji domain containing protein 0.0175 0.2378 0.2345
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0069 0.0813 0.0774
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0498 0.1195
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0157 0.2109 1
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0069 0.0813 0.0774
Entamoeba histolytica aminopeptidase, putative 0.0069 0.0813 0.8057
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0157 0.2109 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0463 0.0422
Brugia malayi CXXC zinc finger family protein 0.0029 0.0225 0.0694
Loa Loa (eye worm) jmjC domain-containing protein 0.0047 0.0489 0.1518
Schistosoma mansoni protein phosphatase 2C 0.0047 0.0489 0.0448
Loa Loa (eye worm) hypothetical protein 0.0157 0.2109 0.6549
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0069 0.0813 1
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0024 0.0157 0.0115
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.0043 0.5
Loa Loa (eye worm) hypothetical protein 0.0209 0.2882 0.8951
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0069 0.0813 0.0774
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0498 0.221
Loa Loa (eye worm) hypothetical protein 0.0024 0.0157 0.0489
Trypanosoma cruzi Aminopeptidase M1, putative 0.0069 0.0813 0.1951
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0043 0.0103
Echinococcus granulosus leukotriene A 4 hydrolase 0.0024 0.0157 0.0115
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0157 0.2109 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0043 0.0103
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0043 0.0103
Plasmodium falciparum glutathione reductase 0.0047 0.0498 0.2202
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0043 0.0103

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.