TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 445.489 | Formula: C21H23N3O6S
H donors: 3 H acceptors: 5 LogP: 1.06 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)c1ccc(cc1)NC(=O)CCNS(=O)(=O)c1ccc2c(c1)CCC(=O)N2
InChi: 1S/C21H23N3O6S/c1-2-30-21(27)14-3-6-16(7-4-14)23-20(26)11-12-22-31(28,29)17-8-9-18-15(13-17)5-10-19(25)24-18/h3-4,6-9,13,22H,2,5,10-12H2,1H3,(H,23,26)(H,24,25)
InChiKey: ZYHBAQJOWJDPFN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0031	0.0582	0.1051
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0032	0.0597	0.0597
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Echinococcus granulosus	solute carrier family 22	0.0015	0.0201	0.0364
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0032	0.0597	0.0903
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0031	0.0582	0.1481
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0606	0.8067
Echinococcus multilocularis	calcium dependent protein kinase	0.003	0.0552	0.0996
Leishmania major	protein kinase, putative	0.0032	0.0597	0.7943
Leishmania major	myo-inositol/proton symporter (MIT)	0.0015	0.0201	0.268
Entamoeba histolytica	protein kinase, putative	0.0032	0.0597	0.7943
Echinococcus granulosus	solute carrier family 22	0.0015	0.0201	0.0364
Schistosoma mansoni	sugar transporter	0.0015	0.0201	0.0513
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0399	0.5305
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0023	0.0399	0.1769
Trypanosoma cruzi	glucose transporter, putative	0.0015	0.0201	0.268
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0606	0.8067
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.002	0.0318	0.4833
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0201	0.0894
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0032	0.0597	0.1078
Loa Loa (eye worm)	sugar transporter	0.0104	0.2253	0.407
Trypanosoma brucei	glucose transporter 1E	0.0032	0.0606	0.8067
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Echinococcus granulosus	solute carrier family 22	0.0015	0.0201	0.0364
Schistosoma mansoni	inositol monophosphatase	0.0039	0.0751	0.1912
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0035	0.0659	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Leishmania major	lysyl-tRNA synthetase, putative	0.0023	0.0399	0.5305
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0606	0.8067
Trichomonas vaginalis	myo-inositol transporter, putative	0.0015	0.0201	0.0894
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0201	0.0364
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0015	0.0201	0.0201
Trypanosoma cruzi	sugar transporter, putative	0.0015	0.0201	0.268
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0032	0.0597	0.0597
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0032	0.0597	0.0597
Brugia malayi	Sugar transporter family protein	0.0015	0.0201	0.0364
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Onchocerca volvulus		0.005	0.1022	1
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0201	0.0894
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0013	0.016	0.0288
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Brugia malayi	hypothetical protein	0.0015	0.0201	0.0364
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0201	0.0364
Schistosoma mansoni	serine/threonine protein kinase	0.0032	0.0597	0.1519
Schistosoma mansoni	inositol monophosphatase	0.0039	0.0751	0.1912
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0701	0.9325
Schistosoma mansoni	sugar transporter	0.0015	0.0201	0.0513
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0606	0.8067
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0032	0.0597	0.0597
Leishmania major	hypothetical protein, conserved	0.0015	0.0201	0.268
Trypanosoma cruzi	hexose transporter, putative	0.0018	0.027	0.3599
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.002	0.0318	0.4833
Trichomonas vaginalis	glucose transporter, putative	0.0015	0.0201	0.0894
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0606	0.8067
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0399	0.5305
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0031	0.0582	0.8837
Mycobacterium ulcerans	sugar transporter	0.0015	0.0201	0.268
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0039	0.0751	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0364
Echinococcus multilocularis	inositol monophosphatase 1	0.0039	0.0751	0.1357
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0032	0.0597	0.0597
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0039	0.0751	0.1136
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0104	0.2253	0.407
Trichomonas vaginalis	sugar transport protein, putative	0.0015	0.0201	0.0894
Toxoplasma gondii	sugar transporter ST3	0.0015	0.0201	0.0305
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0036	0.0701	0.106
Giardia lamblia	Hexose transporter	0.0015	0.0201	0.346
Loa Loa (eye worm)	sugar transporter	0.0015	0.0201	0.0364
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0039	0.0751	0.3334
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0031	0.0582	0.7746
Brugia malayi	Sugar transporter family protein	0.0015	0.0201	0.0364
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0364
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0364
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Echinococcus granulosus	solute carrier family 22	0.0015	0.0201	0.0364
Echinococcus granulosus	inositol monophosphatase 1	0.0039	0.0751	0.1357
Brugia malayi	hypothetical protein	0.0247	0.5536	1
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0032	0.0597	0.0903
Trypanosoma cruzi	hexose transporter	0.0032	0.0606	0.8067
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0039	0.0751	0.3334
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0399	0.1015
Brugia malayi	Sugar transporter family protein	0.0104	0.2253	0.407
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0104	0.2253	0.407
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0364
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0201	0.0364
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Brugia malayi	Cam kinase protein 1	0.0032	0.0597	0.1078
Leishmania major	glucose transporter, lmgt2	0.0032	0.0606	0.8067
Plasmodium falciparum	lysine--tRNA ligase	0.0023	0.0399	0.0399
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0201	0.0364
Brugia malayi	hypothetical protein	0.0015	0.0201	0.0364
Plasmodium vivax	hexose transporter	0.0104	0.2253	0.2253
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0015	0.0201	0.0364
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0606	0.269
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0597	0.1078
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0104	0.2253	0.407
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0597	0.1078
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0032	0.0597	0.0597
Leishmania major	glucose transporter, lmgt1	0.0032	0.0606	0.8067
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0606	0.8067
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0606	0.8067
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0597	0.1078
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0606	0.8067
Schistosoma mansoni	glucose transport protein	0.0104	0.2253	0.5735
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0036	0.0701	0.9325
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0104	0.2253	0.407
Echinococcus granulosus	geminin	0.0177	0.3929	0.7097
Brugia malayi	Inositol-1	0.0039	0.0751	0.1357
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0606	0.269
Schistosoma mansoni	hypothetical protein	0.005	0.1022	0.2602
Schistosoma mansoni	sugar transporter	0.0015	0.0201	0.0513
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0039	0.0751	1
Toxoplasma gondii	protein kinase, putative	0.0294	0.6612	1
Schistosoma mansoni	hypothetical protein	0.0177	0.3929	1
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0039	0.0751	1
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0039	0.0751	1
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0015	0.0201	0.0364
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0201	0.0364
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0035	0.0659	1
Leishmania major	glucose transporter, lmgt3	0.0032	0.0606	0.8067
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0168	0.3724	0.3724
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0201	0.0894
Echinococcus multilocularis	General substrate transporter	0.0089	0.1918	0.3464
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0031	0.0582	0.1481
Trypanosoma brucei	sugar transporter, putative	0.0015	0.0201	0.268
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0364
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0015	0.0201	0.268
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0597	0.1078
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0031	0.0582	0.1051
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0104	0.2253	0.407
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0448	0.0809
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0201	0.0894
Echinococcus granulosus	lysyl tRNA synthetase	0.0023	0.0399	0.072
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0036	0.0701	0.9325
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0606	0.8067
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0032	0.0597	0.0597
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0168	0.3724	0.3724
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0606	0.269
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Brugia malayi	major facilitator superfamily protein	0.0015	0.0201	0.0364
Giardia lamblia	Lysyl-tRNA synthetase	0.0023	0.0399	0.6849
Schistosoma mansoni	protein kinase	0.0032	0.0597	0.1519
Trichomonas vaginalis	CAMK family protein kinase	0.0032	0.0597	0.2648
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0399	0.072
Toxoplasma gondii	sugar transporter ST1	0.0015	0.0201	0.0305
Schistosoma mansoni	glucose transport protein	0.0104	0.2253	0.5735
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0031	0.0582	0.1051
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0606	0.269
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0364
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0364
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0104	0.2253	0.407
Schistosoma mansoni	glucose transporter	0.0015	0.0201	0.0513
Schistosoma mansoni	sugar transporter	0.0015	0.0201	0.0513
Trypanosoma brucei	glucose transporter 2A	0.0032	0.0606	0.8067
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0032	0.0597	0.1078
Trichomonas vaginalis	sugar transporter, putative	0.0032	0.0606	0.269
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0597	0.1078
Echinococcus granulosus	synaptic vesicle 2 protein	0.0015	0.0201	0.0364
Entamoeba histolytica	protein kinase, putative	0.0032	0.0597	0.7943
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0032	0.0606	0.8067
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0032	0.0597	0.1078
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0364
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0015	0.0201	0.3058
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0032	0.0606	0.8067
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0032	0.0597	0.1078
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0015	0.0201	0.3058
Trypanosoma cruzi	hexose transporter, putative	0.0032	0.0606	0.8067
Echinococcus granulosus	calcium dependent protein kinase	0.003	0.0552	0.0996
Trichomonas vaginalis	inositol monophosphatase, putative	0.0039	0.0751	0.3334
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0364
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0039	0.0751	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0364
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0701	0.9325
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0023	0.0399	0.5305
Plasmodium vivax	sugar transporter, putative	0.0015	0.0201	0.0201
Giardia lamblia	Prolyl-tRNA synthetase	0.0031	0.0582	1
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0032	0.0597	0.0903
Schistosoma mansoni	hypothetical protein	0.0177	0.3929	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Trypanosoma cruzi	hexose transporter, putative	0.0015	0.0201	0.268
Plasmodium vivax	proline--tRNA ligase, putative	0.0036	0.0701	0.0701
Trichomonas vaginalis	conserved hypothetical protein	0.0104	0.2253	1
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0201	0.0364
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0168	0.3724	0.5632
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Brugia malayi	major facilitator superfamily protein	0.0015	0.0201	0.0364
Schistosoma mansoni	glucose transport protein	0.0104	0.2253	0.5735
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0015	0.0201	0.268
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0441	1	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0364
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0364
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0104	0.2253	0.407
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.002	0.0318	0.4833
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0597	0.1078
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0606	0.8067
Treponema pallidum	prolyl-tRNA synthetase	0.0011	0.0119	1
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0606	0.8067
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0036	0.0701	0.9325
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0247	0.5536	1
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0023	0.0399	0.5305
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Giardia lamblia	Sugar-proton symporter	0.0015	0.0201	0.346
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0023	0.0399	0.6053
Toxoplasma gondii	lysine-tRNA ligase	0.0023	0.0399	0.0603
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0201	0.0364
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Trichomonas vaginalis	glucose transporter, putative	0.0032	0.0606	0.269
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0011	0.0119	0.158
Chlamydia trachomatis	lysine--tRNA ligase	0.0023	0.0399	1
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0104	0.2253	0.407
Chlamydia trachomatis	proline--tRNA ligase	0.0011	0.0119	0.2978
Toxoplasma gondii	transporter, major facilitator family protein	0.0015	0.0201	0.0305
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0032	0.0597	0.0597
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0039	0.0751	1
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0039	0.0751	1
Echinococcus granulosus	survival motor neuron protein 1	0.0247	0.5536	1
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0597	0.1078
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0364
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0582	0.1051
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Brugia malayi	hypothetical protein	0.0015	0.0201	0.0364
Echinococcus granulosus	General substrate transporter	0.0089	0.1918	0.3464
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0597	0.1078
Plasmodium vivax	lysine--tRNA ligase, putative	0.0023	0.0399	0.0399
Toxoplasma gondii	sugar transporter ST2	0.0015	0.0201	0.0305
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0201	0.0364
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.005	0.1022	0.1847
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0582	0.1051
Plasmodium falciparum	proline--tRNA ligase	0.0036	0.0701	0.0701
Schistosoma mansoni	survival motor neuron protein	0.005	0.1022	0.2602
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0032	0.0597	0.0597
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0031	0.0582	0.2583
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0364
Echinococcus multilocularis	geminin	0.0177	0.3929	0.7097
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0399	0.1015
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.002	0.0333	0.1477
Schistosoma mansoni	hypothetical protein	0.0104	0.2253	0.5735
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0015	0.0201	0.0364
Echinococcus multilocularis	survival motor neuron protein 1	0.0247	0.5536	1
Schistosoma mansoni	protein kinase	0.0032	0.0597	0.1519
Plasmodium falciparum	hexose transporter	0.0104	0.2253	0.2253
Trypanosoma brucei	glucose transporter, putative	0.0032	0.0606	0.8067
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Echinococcus multilocularis	lysyl tRNA synthetase	0.0023	0.0399	0.072
Toxoplasma gondii	facilitative glucose transporter GT1	0.0104	0.2253	0.3408
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0015	0.0201	0.268
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0032	0.0597	0.7943
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0364
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0031	0.0582	0.1051
Entamoeba histolytica	hypothetical protein	0.0023	0.0399	0.5305
Schistosoma mansoni	protein kinase	0.0032	0.0597	0.1519
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0201	0.0364
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0015	0.0201	0.0513
Plasmodium falciparum	protein kinase 7	0.0294	0.6612	0.6612
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0606	0.269
Brugia malayi	lysyl-tRNA synthetase	0.0023	0.0399	0.072
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0015	0.0201	0.268
Mycobacterium ulcerans	integral membrane transport protein	0.0015	0.0201	0.268
Loa Loa (eye worm)	inositol-1	0.0039	0.0751	0.1357

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 794024