Detailed information for compound 794978

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 241.285 | Formula: C15H15NO2
  • H donors: 1 H acceptors: 1 LogP: 3.2 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1O)C=Nc1cccc(c1)C
  • InChi: 1S/C15H15NO2/c1-11-5-3-7-13(9-11)16-10-12-6-4-8-14(18-2)15(12)17/h3-10,17H,1-2H3/b16-10+
  • InChiKey: SRAOQWUHLRSHSQ-MHWRWJLKSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0055 0.3623 0.8262
Echinococcus multilocularis glycoprotein Antigen 5 0.001 0.0291 0.0663
Schistosoma mansoni cercarial elastase (S01 family) 0.001 0.0291 0.0291
Schistosoma mansoni hypothetical protein 0.001 0.0291 0.0291
Echinococcus multilocularis protein tyrosine phosphatase PRL 0.002 0.105 0.2394
Trypanosoma cruzi protein tyrosine phosphatase PRL 0.002 0.105 0.1357
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.001 0.0291 0.0291
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.001 0.0291 0.0663
Loa Loa (eye worm) hypothetical protein 0.001 0.0291 0.016
Trypanosoma brucei phosphatase of regenerating liver-type phosphatase, putative 0.002 0.105 0.3484
Echinococcus granulosus Endonuclease G 0.0039 0.245 0.5587
Brugia malayi Type I phosphodiesterase / nucleotide pyrophosphatase family protein 0.0065 0.4385 0.4385
Echinococcus multilocularis gpi ethanolamine phosphate transferase 1 0.001 0.0301 0.0686
Brugia malayi Immunoglobulin I-set domain containing protein 0.0008 0.0133 0.0133
Leishmania major tyrosine specific protein phosphatase, putative 0.0017 0.083 0.2461
Echinococcus multilocularis Alkaline phosphatase, core domain 0.001 0.0301 0.0686
Echinococcus multilocularis Endonuclease G 0.0039 0.245 0.5587
Trypanosoma cruzi protein tyrosine phosphatase, putative 0.002 0.105 0.1357
Loa Loa (eye worm) hypothetical protein 0.0065 0.4385 0.4309
Schistosoma mansoni cercarial elastase (S01 family) 0.001 0.0291 0.0291
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0065 0.4385 1
Schistosoma mansoni endonuclease related 0.0039 0.245 0.245
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0021 0.1102 0.0982
Loa Loa (eye worm) hypothetical protein 0.001 0.0291 0.016
Schistosoma mansoni hypothetical protein 0.0141 1 1
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0065 0.4385 1
Trypanosoma cruzi protein tyrosine phosphatase-like protein, putative 0.002 0.105 0.1357
Brugia malayi endonuclease G, mitochondrial precursor 0.0039 0.245 0.245
Brugia malayi Immunoglobulin I-set domain containing protein 0.0008 0.0133 0.0133
Trypanosoma brucei endonuclease G, putative 0.0039 0.245 1
Echinococcus granulosus transferase 0.001 0.0301 0.0686
Loa Loa (eye worm) hypothetical protein 0.0065 0.4385 0.4309
Echinococcus granulosus protein tyrosine phosphatase PRL 0.002 0.105 0.2394
Plasmodium falciparum protein tyrosine phosphatase 0.002 0.105 1
Plasmodium vivax protein tyrosine phosphatase, putative 0.002 0.105 0.5
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0021 0.1102 0.1102
Schistosoma mansoni cercarial elastase (S01 family) 0.001 0.0291 0.0291
Trypanosoma cruzi protein tyrosine phosphatase-like protein, putative 0.002 0.105 0.1357
Loa Loa (eye worm) hypothetical protein 0.001 0.0291 0.016
Brugia malayi Type I phosphodiesterase / nucleotide pyrophosphatase family protein 0.001 0.0301 0.0301
Schistosoma mansoni cell adhesion molecule 0.0008 0.0133 0.0133
Brugia malayi Trypsin family protein 0.001 0.0291 0.0291
Schistosoma mansoni cercarial elastase (S01 family) 0.001 0.0291 0.0291
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0097 0.6759 0.6759
Schistosoma mansoni nephrin 0.0008 0.0133 0.0133
Onchocerca volvulus Ectonucleotide pyrophosphatase\/phosphodiesterase family member 7 homolog 0.001 0.0301 0.0011
Schistosoma mansoni cercarial elastase (S01 family) 0.001 0.0291 0.0291
Loa Loa (eye worm) hypothetical protein 0.001 0.0301 0.017
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0025 0.1424 0.3248
Echinococcus granulosus transmembrane protease serine 3 0.001 0.0291 0.0663
Schistosoma mansoni hypothetical protein 0.001 0.0301 0.0301
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0065 0.4385 1
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0065 0.4385 1
Echinococcus multilocularis roundabout 2 0.0008 0.0133 0.0304
Brugia malayi Trypsin family protein 0.001 0.0291 0.0291
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0065 0.4385 1
Onchocerca volvulus 0.0087 0.6007 0.5888
Toxoplasma gondii DNA/RNA non-specific endonuclease 0.0039 0.245 1
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.002 0.1036 0.2363
Schistosoma mansoni cercarial elastase (S01 family) 0.001 0.0291 0.0291
Loa Loa (eye worm) hypothetical protein 0.001 0.0301 0.017
Loa Loa (eye worm) hypothetical protein 0.0016 0.0745 0.0621
Loa Loa (eye worm) hypothetical protein 0.0065 0.4385 0.4309
Onchocerca volvulus 0.0141 1 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.3623 0.3537
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0065 0.4385 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0781 0.0657
Leishmania major endonuclease G, putative 0.0039 0.245 1
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.002 0.1036 0.0915
Schistosoma mansoni hypothetical protein 0.001 0.0301 0.0301
Onchocerca volvulus 0.0065 0.4385 0.4217
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0008 0.0133 0.0304
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0017 0.083 0.083
Echinococcus multilocularis enteropeptidase 0.001 0.0291 0.0663
Trypanosoma cruzi protein tyrosine phosphatase-like protein, putative 0.002 0.105 0.1357
Onchocerca volvulus 0.0097 0.6759 0.6662
Trypanosoma brucei endonuclease G, putative 0.0039 0.245 1
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0055 0.3623 0.8262
Onchocerca volvulus 0.0017 0.083 0.0556
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0065 0.4385 0.4385
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.001 0.0291 0.0291
Schistosoma mansoni cercarial elastase (S01 family) 0.001 0.0291 0.0291
Brugia malayi hypothetical protein 0.001 0.0301 0.0301
Loa Loa (eye worm) hypothetical protein 0.0097 0.6759 0.6715
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.001 0.0301 0.0686
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.001 0.0291 0.0663
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.001 0.0301 0.0686
Loa Loa (eye worm) hypothetical protein 0.0097 0.6759 0.6715
Loa Loa (eye worm) thrombospondin type 1 domain-containing protein 0.0141 1 1
Echinococcus granulosus roundabout 2 0.0008 0.0133 0.0304
Brugia malayi Trypsin family protein 0.0097 0.6759 0.6759
Leishmania major protein tyrosine phosphatase-likie protein 0.002 0.105 0.3484
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.002 0.1036 0.2363
Schistosoma mansoni neuroglian 0.0008 0.0133 0.0133
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.002 0.1036 0.1036
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0017 0.083 0.1893
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0065 0.4385 0.4385
Loa Loa (eye worm) hypothetical protein 0.001 0.0301 0.017
Loa Loa (eye worm) trypsin family protein 0.001 0.0291 0.016
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0065 0.4385 1
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0065 0.4385 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0291 0.016
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.001 0.0291 0.0291
Echinococcus multilocularis ectonucleotide 0.0055 0.3623 0.8262
Mycobacterium ulcerans hypothetical protein 0.001 0.0301 1
Echinococcus multilocularis roundabout 2 0.0008 0.0133 0.0304
Echinococcus granulosus roundabout 2 0.0008 0.0133 0.0304
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.001 0.0291 0.0663
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0023 0.1207 0.2752
Leishmania major protein tyrosine phosphatase-like protein 0.002 0.105 0.3484
Echinococcus multilocularis roundabout 2 0.0008 0.0133 0.0304
Loa Loa (eye worm) type I phosphodiesterase/nucleotide pyrophosphatase 0.001 0.0301 0.017
Brugia malayi Trypsin family protein 0.001 0.0291 0.0291
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0017 0.083 0.1893
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0025 0.1424 0.1424
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.001 0.0301 0.0301
Echinococcus granulosus Mastin 0.001 0.0291 0.0663
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0065 0.4385 0.4385
Schistosoma mansoni protein tyrosine phosphatase prl 0.002 0.105 0.105
Echinococcus granulosus gpi ethanolamine phosphate transferase 3 0.001 0.0301 0.0686
Schistosoma mansoni cercarial elastase (S01 family) 0.001 0.0291 0.0291
Schistosoma mansoni hypothetical protein 0.001 0.0291 0.0291
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.0039 0.245 1
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.001 0.0291 0.0663
Schistosoma mansoni cercarial elastase (S01 family) 0.001 0.0291 0.0291
Onchocerca volvulus 0.0065 0.4385 0.4217
Onchocerca volvulus GPI ethanolamine phosphate transferase 1 homolog 0.001 0.0301 0.0011
Giardia lamblia Phosphatidylinositol-glycan biosynthesis, class O protein 0.001 0.0301 0.5
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.001 0.0291 0.0291
Echinococcus multilocularis transmembrane protease serine 3 0.001 0.0291 0.0663
Echinococcus granulosus neuroglian 0.0008 0.0133 0.0304
Leishmania major DNA/RNA non-specific endonuclease-like protein 0.0039 0.245 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0301 0.017
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0065 0.4385 1
Schistosoma mansoni cercarial elastase (S01 family) 0.001 0.0291 0.0291
Echinococcus granulosus contactin 0.0008 0.0133 0.0304
Echinococcus multilocularis Mastin 0.001 0.0291 0.0663
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0017 0.083 0.1893
Trypanosoma cruzi protein tyrosine phosphatase, putative 0.002 0.105 0.1357
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0025 0.1424 0.3248
Trypanosoma brucei endonuclease G, putative 0.0039 0.245 1
Echinococcus granulosus enteropeptidase 0.001 0.0291 0.0663
Echinococcus granulosus ectonucleotide 0.0055 0.3623 0.8262
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0847 0.5
Brugia malayi AEL166Cp 0.001 0.0301 0.0301
Echinococcus multilocularis transferase 0.001 0.0301 0.0686
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0025 0.1424 0.3248
Schistosoma mansoni cell adhesion molecule 0.0008 0.0133 0.0133
Schistosoma mansoni cercarial elastase (S01 family) 0.001 0.0291 0.0291
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0065 0.4385 1
Onchocerca volvulus GPI ethanolamine phosphate transferase 2 homolog 0.001 0.0301 0.0011
Onchocerca volvulus Ectonucleotide pyrophosphatase\/phosphodiesterase family member 6 homolog 0.001 0.0301 0.0011
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0097 0.6759 0.6759
Onchocerca volvulus GPI ethanolamine phosphate transferase 3 homolog 0.001 0.0301 0.0011
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.002 0.1036 0.1036
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.001 0.0291 0.0291
Loa Loa (eye worm) hypothetical protein 0.001 0.0291 0.016
Echinococcus granulosus glycoprotein Antigen 5 0.001 0.0291 0.0663
Brugia malayi hypothetical protein 0.001 0.0291 0.0291
Schistosoma mansoni protein tyrosine phosphatase prl 0.002 0.105 0.105
Trypanosoma cruzi endonuclease G, putative 0.0039 0.245 1
Trypanosoma cruzi protein tyrosine phosphatase, putative 0.002 0.105 0.1357
Mycobacterium leprae hypothetical protein 0.001 0.0301 0.5
Brugia malayi Trypsin-like protease protein 5 0.001 0.0291 0.0291
Trypanosoma cruzi protein tyrosine phosphatase-like protein, putative 0.002 0.105 0.1357
Brugia malayi hypothetical protein 0.001 0.0301 0.0301
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.001 0.0291 0.0291
Schistosoma mansoni hypothetical protein 0.001 0.0301 0.0301
Echinococcus granulosus roundabout 2 0.0008 0.0133 0.0304
Trypanosoma cruzi endonuclease G, putative 0.0039 0.245 1
Echinococcus multilocularis sortilin receptor 0.0014 0.0575 0.1311
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.001 0.0301 0.0686
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0065 0.4385 1
Echinococcus multilocularis neuroglian 0.0008 0.0133 0.0304
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.0039 0.245 1
Echinococcus multilocularis gpi ethanolamine phosphate transferase 3 0.001 0.0301 0.0686
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.001 0.0291 0.0291
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0065 0.4385 0.4385
Brugia malayi Immunoglobulin I-set domain containing protein 0.0008 0.0133 0.0133
Entamoeba histolytica protein tyrosine phosphatase, putative 0.002 0.105 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0025 0.1424 0.3248
Schistosoma mansoni hypothetical protein 0.001 0.0301 0.0301

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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