Detailed information for compound 797498

Basic information

Technical information
  • TDR Targets ID: 797498
  • Name: N'-(2-cyanoacetyl)-8-methoxy-2-oxochromene-3- carbohydrazide
  • MW: 301.254 | Formula: C14H11N3O5
  • H donors: 2 H acceptors: 4 LogP: 1.32 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc2c1oc(=O)c(c2)C(=O)NNC(=O)CC#N
  • InChi: 1S/C14H11N3O5/c1-21-10-4-2-3-8-7-9(14(20)22-12(8)10)13(19)17-16-11(18)5-6-15/h2-4,7H,5H2,1H3,(H,16,18)(H,17,19)
  • InChiKey: SUURMIPZRPRUFD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N'-(2-cyanoacetyl)-8-methoxy-2-oxo-chromene-3-carbohydrazide
  • N'-(2-cyano-1-oxoethyl)-8-methoxy-2-oxo-3-chromenecarbohydrazide
  • N'-(2-cyanoacetyl)-2-keto-8-methoxy-chromene-3-carbohydrazide
  • N'-(2-cyanoethanoyl)-8-methoxy-2-oxo-chromene-3-carbohydrazide
  • A2195/0092372
  • ZINC03670942

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Fibulin-1 precursor 0.0014 0.0029 0.0193
Brugia malayi PAN domain containing protein 0.0034 0.0287 0.1907
Toxoplasma gondii propionate-CoA ligase 0.0014 0.003 0.0003
Trichomonas vaginalis casein kinase II beta chain, putative 0.0072 0.0769 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0123 0.1252
Toxoplasma gondii kringle domain-containing protein 0.0053 0.0522 0.1285
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0123 0.1252
Trichomonas vaginalis casein kinase II beta chain, putative 0.0072 0.0769 1
Trypanosoma brucei phosphoinositide-specific phospholipase C 0.0019 0.0095 0.0877
Toxoplasma gondii PAN domain-containing protein 0.0034 0.0287 0.0672
Loa Loa (eye worm) hypothetical protein 0.0019 0.0095 0.0447
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.0449 1
Leishmania major phosphoinositide-specific phospholipase C, putative 0.0018 0.0081 0.0693
Onchocerca volvulus 0.0053 0.0522 0.6662
Toxoplasma gondii microneme protein MIC17C 0.0034 0.0287 0.0672
Loa Loa (eye worm) hypothetical protein 0.0035 0.0299 0.1832
Brugia malayi Trypsin family protein 0.0014 0.0034 0.0225
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0449 0.2988
Schistosoma mansoni hypothetical protein 0.0014 0.0034 0.0439
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0014 0.0034 0.0225
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0123 0.1252
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0449 0.5672
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0123 0.1252
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.003 0.0546
Schistosoma mansoni hypothetical protein 0.0014 0.0034 0.0439
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0019 0.0095 0.0631
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0072 0.0769 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0072 0.0769 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0034 0.0439
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0034 0.0287 0.0672
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0449 0.5672
Loa Loa (eye worm) hypothetical protein 0.0014 0.0034 0.0032
Brugia malayi Variant SH3 domain containing protein 0.013 0.1503 1
Echinococcus granulosus transmembrane protease serine 3 0.0014 0.0034 0.0064
Toxoplasma gondii PAN domain-containing protein 0.0317 0.3863 1
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.003 0.0546
Schistosoma mansoni egf-like domain protein 0.0014 0.0029 0.0378
Brugia malayi PAN domain containing protein 0.0034 0.0287 0.1907
Trichomonas vaginalis casein kinase II beta chain, putative 0.0072 0.0769 1
Toxoplasma gondii microneme protein MIC4 0.0034 0.0287 0.0672
Toxoplasma gondii microneme protein MIC17B 0.0034 0.0287 0.0672
Plasmodium falciparum casein kinase II beta chain 0.0072 0.0769 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0449 1
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.003 0.0546
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0123 0.1252
Trichomonas vaginalis casein kinase II beta chain, putative 0.0072 0.0769 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0449 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0522 0.3343
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0123 0.1252
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0007
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0053 0.0522 0.6657
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0014 0.0034 0.0064
Loa Loa (eye worm) PAN domain-containing protein 0.0034 0.0287 0.1747
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0072 0.0769 1
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.003 0.0001
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0299 0.6421
Plasmodium vivax phospholipase C-like, putative 0.0018 0.0081 0.0693
Loa Loa (eye worm) hypothetical protein 0.0035 0.0299 0.1832
Loa Loa (eye worm) PAN domain-containing protein 0.0034 0.0287 0.1747
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0007
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0123 0.1252
Echinococcus multilocularis Mastin 0.0014 0.0034 0.0005
Loa Loa (eye worm) hypothetical protein 0.0014 0.0034 0.0032
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0034 0.0005
Onchocerca volvulus 0.0014 0.0034 0.0064
Trichomonas vaginalis casein kinase II beta chain, putative 0.0072 0.0769 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0034 0.0439
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0123 0.1252
Mycobacterium ulcerans hypothetical protein 0.0047 0.0449 1
Toxoplasma gondii PAN/Apple domain-containing protein 0.0034 0.0287 0.0672
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0018 0.0081 0.0541
Echinococcus multilocularis transmembrane protease serine 3 0.0014 0.0034 0.0005
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0014 0.0029 0.0193
Loa Loa (eye worm) hypothetical protein 0.0034 0.0287 0.1747
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0449 0.5672
Plasmodium vivax casein kinase II beta chain, putative 0.0072 0.0769 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0034 0.0439
Brugia malayi AMP-binding enzyme family protein 0.0014 0.003 0.02
Echinococcus multilocularis enteropeptidase 0.0014 0.0034 0.0005
Onchocerca volvulus 0.0014 0.003 0.0014
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0072 0.0769 1
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0072 0.0769 1
Loa Loa (eye worm) PAN domain-containing protein 0.0034 0.0287 0.1747
Trichomonas vaginalis casein kinase II beta chain, putative 0.0072 0.0769 1
Onchocerca volvulus 0.0014 0.003 0.0014
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0034 0.0439
Onchocerca volvulus 0.0014 0.0034 0.0064
Echinococcus multilocularis casein kinase ii subunit beta 0.0072 0.0769 0.0742
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0072 0.0769 1
Trypanosoma cruzi phosphoinositide-specific phospholipase C, putative 0.0019 0.0095 0.0877
Loa Loa (eye worm) casein kinase II 0.0021 0.0123 0.0635
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0123 0.1252
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.003 0.0546
Brugia malayi Trypsin family protein 0.0014 0.0034 0.0225
Echinococcus granulosus Mastin 0.0014 0.0034 0.0064
Brugia malayi PAN domain containing protein 0.0034 0.0287 0.1907
Loa Loa (eye worm) trypsin family protein 0.0014 0.0034 0.0032
Brugia malayi PAN domain containing protein 0.0034 0.0287 0.1907
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0014 0.0034 0.0005
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0034 0.0439
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.0449 1
Plasmodium vivax casein kinase II beta chain, putative 0.0072 0.0769 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0034 0.0439
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0449 0.2988
Onchocerca volvulus 0.0034 0.0287 0.3481
Brugia malayi PAN domain containing protein 0.0034 0.0287 0.1907
Loa Loa (eye worm) hypothetical protein 0.0014 0.0034 0.0032
Brugia malayi AMP-binding enzyme family protein 0.0014 0.003 0.02
Onchocerca volvulus 0.0019 0.0095 0.089
Loa Loa (eye worm) phosphatidylinositol-specific phospholipase C 0.0019 0.0095 0.0447
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.003 0.0007
Loa Loa (eye worm) hypothetical protein 0.0014 0.0034 0.0032
Onchocerca volvulus 0.0034 0.0287 0.3481
Loa Loa (eye worm) hypothetical protein 0.0014 0.0034 0.0032
Onchocerca volvulus 0.0034 0.0287 0.3481
Echinococcus granulosus enteropeptidase 0.0014 0.0034 0.0064
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0449 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0275 0.6071
Loa Loa (eye worm) hypothetical protein 0.0034 0.0287 0.1747
Trichomonas vaginalis casein kinase II beta chain, putative 0.0072 0.0769 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0299 0.6617
Loa Loa (eye worm) hypothetical protein 0.0035 0.0299 0.1832
Onchocerca volvulus 0.0047 0.0449 0.5678
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.003 0.02
Echinococcus granulosus tissue type plasminogen activator 0.0053 0.0522 0.6662
Onchocerca volvulus 0.0014 0.0034 0.0064
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0072 0.0769 1
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.003 0.0546
Leishmania major hypothetical protein, conserved 0.0053 0.0522 0.6657
Plasmodium falciparum phosphoinositide-specific phospholipase C 0.0018 0.0081 0.0693
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.003 0.0546
Loa Loa (eye worm) hypothetical protein 0.0014 0.0034 0.0032
Trichomonas vaginalis protein kinase ck2-beta, putative 0.0021 0.0123 0.1252
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0123 0.1252
Trichomonas vaginalis casein kinase II beta chain, putative 0.0072 0.0769 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0449 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0275 0.6071
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0275 0.6071
Trichomonas vaginalis casein kinase II beta chain, putative 0.0072 0.0769 1
Echinococcus granulosus 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 0.0019 0.0095 0.089
Loa Loa (eye worm) hypothetical protein 0.0034 0.0287 0.1747
Brugia malayi casein kinase II, putaitve 0.0021 0.0123 0.0816
Toxoplasma gondii hypothetical protein 0.0034 0.0287 0.0672
Loa Loa (eye worm) TK/ROR protein kinase 0.0053 0.0522 0.3343
Echinococcus granulosus casein kinase ii subunit beta 0.0072 0.0769 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0449 0.5672
Giardia lamblia Casein kinase II beta chain 0.0072 0.0769 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0123 0.1252
Loa Loa (eye worm) PAN domain-containing protein 0.0034 0.0287 0.1747
Onchocerca volvulus 0.0014 0.0034 0.0064
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0034 0.0439
Plasmodium falciparum casein kinase II beta chain 0.0072 0.0769 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0449 1
Brugia malayi PAN domain containing protein 0.0034 0.0287 0.1907
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.003 0.0546
Onchocerca volvulus 0.0034 0.0287 0.3481
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0014 0.003 0.0003
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0449 1
Brugia malayi PAN domain containing protein 0.0034 0.0287 0.1907
Loa Loa (eye worm) hypothetical protein 0.0047 0.0449 0.2849
Toxoplasma gondii PAN domain-containing protein 0.0034 0.0287 0.0672
Loa Loa (eye worm) hypothetical protein 0.0047 0.0449 0.2849
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0034 0.0439
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.003 0.0546
Brugia malayi PAN domain containing protein 0.0034 0.0287 0.1907
Onchocerca volvulus 0.0019 0.0095 0.089
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.003 0.0003
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0014 0.0034 0.0439
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.003 0.0007
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0034 0.0439
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.0299 0.5
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0449 0.2988
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0034 0.0439
Echinococcus multilocularis tissue type plasminogen activator 0.0053 0.0522 0.0494
Loa Loa (eye worm) hypothetical protein 0.0035 0.0299 0.1832
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.003 0.0546
Loa Loa (eye worm) hypothetical protein 0.0047 0.0449 0.2849
Echinococcus granulosus glycoprotein Antigen 5 0.0014 0.0034 0.0064
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.0449 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.013 0.1503 1
Onchocerca volvulus 0.0034 0.0287 0.3481
Loa Loa (eye worm) hypothetical protein 0.0018 0.0081 0.0355
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0034 0.0439
Onchocerca volvulus 0.0014 0.003 0.0014
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0014 0.0034 0.0064
Onchocerca volvulus 0.0034 0.0287 0.3481
Loa Loa (eye worm) hypothetical protein 0.0034 0.0287 0.1747
Brugia malayi AMP-binding enzyme family protein 0.0014 0.003 0.02
Onchocerca volvulus 0.0014 0.003 0.0014
Trichomonas vaginalis casein kinase II beta chain, putative 0.0072 0.0769 1
Brugia malayi AMP-binding enzyme family protein 0.0014 0.003 0.02
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0034 0.0439
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0072 0.0769 0.1929
Trypanosoma cruzi hypothetical protein, conserved 0.0053 0.0522 0.6657
Toxoplasma gondii microneme protein, putative 0.0034 0.0287 0.0672
Loa Loa (eye worm) hypothetical protein 0.0035 0.0299 0.1832
Brugia malayi PAN domain containing protein 0.0034 0.0287 0.1907
Loa Loa (eye worm) hypothetical protein 0.0034 0.0287 0.1747
Loa Loa (eye worm) hypothetical protein 0.0014 0.0034 0.0032
Schistosoma mansoni hypothetical protein 0.0053 0.0522 0.6788
Brugia malayi Trypsin family protein 0.0014 0.0034 0.0225
Brugia malayi Csnk2b protein 0.0072 0.0769 0.5115
Loa Loa (eye worm) oxidoreductase 0.0014 0.003 0.0007
Leishmania major phosphatidylinositol-specific phospholipase-like protein 0.0018 0.0081 0.0693
Toxoplasma gondii PAN domain-containing protein 0.0034 0.0287 0.0672
Loa Loa (eye worm) hypothetical protein 0.0034 0.0287 0.1747
Onchocerca volvulus 0.0034 0.0287 0.3481
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0021 0.0123 0.1252
Onchocerca volvulus 0.0034 0.0287 0.3481
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0072 0.0769 1
Mycobacterium ulcerans hypothetical protein 0.0014 0.0034 0.0087
Schistosoma mansoni casein kinase II beta subunit 0.0072 0.0769 1
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0072 0.0769 1
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0021 0.0123 0.1252
Toxoplasma gondii microneme protein MIC17A 0.0034 0.0287 0.0672
Brugia malayi PAN domain containing protein 0.0034 0.0287 0.1907
Schistosoma mansoni phospholipase C beta 0.0018 0.0081 0.1058
Brugia malayi hypothetical protein 0.0014 0.0034 0.0225
Onchocerca volvulus 0.0014 0.0034 0.0064
Trichomonas vaginalis casein kinase II beta chain, putative 0.0072 0.0769 1
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.003 0.0392
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0034 0.0439
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0299 0.3642
Brugia malayi Calcium binding EGF domain containing protein 0.0014 0.0029 0.0193
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0014 0.0029 0.0378
Trichomonas vaginalis casein kinase II beta chain, putative 0.0072 0.0769 1
Brugia malayi Kringle domain containing protein 0.0053 0.0522 0.3472
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0072 0.0769 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0095 0.0447
Loa Loa (eye worm) PAN domain-containing protein 0.0034 0.0287 0.1747
Loa Loa (eye worm) hypothetical protein 0.0034 0.0287 0.1747
Plasmodium falciparum cysteine repeat modular protein 1 0.0053 0.0522 0.6657
Toxoplasma gondii phosphoinositide phospholipase PIPLC 0.0019 0.0095 0.0172
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0275 0.6071
Trichomonas vaginalis casein kinase II beta chain, putative 0.0072 0.0769 1
Loa Loa (eye worm) Plcb4 protein 0.0018 0.0081 0.0355
Onchocerca volvulus 0.0034 0.0287 0.3481
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0449 0.5672
Trichomonas vaginalis casein kinase II beta chain, putative 0.0072 0.0769 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0034 0.0439
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0034 0.0439
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0034 0.0439
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.0449 1
Trichomonas vaginalis protein kinase ck2-beta, putative 0.0021 0.0123 0.1252
Brugia malayi 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 0.0018 0.0081 0.0541
Brugia malayi Protein kinase domain containing protein 0.0053 0.0522 0.3472
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0123 0.1252
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.003 0.02
Toxoplasma gondii PAN domain-containing protein 0.0317 0.3863 1
Toxoplasma gondii PAN domain-containing protein 0.0034 0.0287 0.0672
Toxoplasma gondii subtilisin SUB12 0.0034 0.0287 0.0672
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0449 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0034 0.0439
Toxoplasma gondii ck2 beta subunit 0.0072 0.0769 0.1929
Onchocerca volvulus 0.0034 0.0287 0.3481
Echinococcus multilocularis 1 phosphatidylinositol 4,5 bisphosphate 0.0019 0.0095 0.0066
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.003 0.0014
Brugia malayi Trypsin-like protease protein 5 0.0014 0.0034 0.0225
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.003 0.0546
Toxoplasma gondii hypothetical protein 0.0034 0.0287 0.0672
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0034 0.0439
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0123 0.1252
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.003 0.0546
Echinococcus multilocularis glycoprotein Antigen 5 0.0014 0.0034 0.0005
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0299 0.3642
Onchocerca volvulus 0.0014 0.0034 0.0064
Brugia malayi Trypsin family protein 0.0014 0.0034 0.0225
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.0449 0.5672
Onchocerca volvulus 0.0034 0.0287 0.3481
Leishmania major phospholipase c-like protein 0.0019 0.0095 0.0877
Loa Loa (eye worm) Csnk2b protein 0.0072 0.0769 0.5018

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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