Detailed information for compound 797528

Basic information

Technical information
  • TDR Targets ID: 797528
  • Name: 1-(2,5-diethoxyphenyl)sulfonyl-4-(4-fluorophe nyl)piperazine
  • MW: 408.487 | Formula: C20H25FN2O4S
  • H donors: 0 H acceptors: 2 LogP: 3.44 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1S(=O)(=O)N1CCN(CC1)c1ccc(cc1)F)OCC
  • InChi: 1S/C20H25FN2O4S/c1-3-26-18-9-10-19(27-4-2)20(15-18)28(24,25)23-13-11-22(12-14-23)17-7-5-16(21)6-8-17/h5-10,15H,3-4,11-14H2,1-2H3
  • InChiKey: SRUOTRXXGSELEL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • ZINC01025560
  • Oprea1_261609
  • A2170/0091165

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0014 0.0034 0.0032
Plasmodium vivax casein kinase II beta chain, putative 0.0071 0.0768 1
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.003 0.0001
Loa Loa (eye worm) hypothetical protein 0.0033 0.0286 0.1747
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.0449 0.5671
Mycobacterium ulcerans hypothetical protein 0.0046 0.0449 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0286 0.1747
Loa Loa (eye worm) Plcb4 protein 0.0018 0.0081 0.0355
Echinococcus multilocularis enteropeptidase 0.0014 0.0034 0.0005
Loa Loa (eye worm) PAN domain-containing protein 0.0033 0.0286 0.1747
Onchocerca volvulus 0.0014 0.0034 0.0064
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0071 0.0768 1
Onchocerca volvulus 0.0014 0.0034 0.0064
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0071 0.0768 1
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.003 0.0546
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0123 0.1253
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0123 0.1253
Brugia malayi Trypsin family protein 0.0014 0.0034 0.0225
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0071 0.0768 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0095 0.0447
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.003 0.0546
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0034 0.0439
Echinococcus multilocularis casein kinase ii subunit beta 0.0071 0.0768 0.0741
Trichomonas vaginalis casein kinase II beta chain, putative 0.0071 0.0768 1
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0034 0.0005
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0034 0.0439
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0046 0.0449 1
Plasmodium vivax casein kinase II beta chain, putative 0.0071 0.0768 1
Loa Loa (eye worm) trypsin family protein 0.0014 0.0034 0.0032
Loa Loa (eye worm) hypothetical protein 0.0033 0.0286 0.1747
Onchocerca volvulus 0.0014 0.003 0.0016
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0034 0.0439
Brugia malayi Trypsin family protein 0.0014 0.0034 0.0225
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0014 0.0034 0.0064
Toxoplasma gondii hypothetical protein 0.0033 0.0286 0.0672
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0019 0.0095 0.0631
Brugia malayi AMP-binding enzyme family protein 0.0014 0.003 0.0201
Brugia malayi PAN domain containing protein 0.0033 0.0286 0.1907
Loa Loa (eye worm) hypothetical protein 0.0014 0.0034 0.0032
Brugia malayi AMP-binding enzyme family protein 0.0046 0.0449 0.299
Onchocerca volvulus 0.0033 0.0286 0.3478
Loa Loa (eye worm) hypothetical protein 0.0014 0.0034 0.0032
Trypanosoma cruzi phosphoinositide-specific phospholipase C, putative 0.0019 0.0095 0.0875
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.003 0.0008
Trichomonas vaginalis casein kinase II beta chain, putative 0.0071 0.0768 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0034 0.0299 0.6617
Toxoplasma gondii PAN domain-containing protein 0.0033 0.0286 0.0672
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0275 0.6071
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.0449 1
Toxoplasma gondii microneme protein, putative 0.0033 0.0286 0.0672
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0034 0.0439
Brugia malayi PAN domain containing protein 0.0033 0.0286 0.1907
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0034 0.0439
Plasmodium vivax phospholipase C-like, putative 0.0018 0.0081 0.0692
Leishmania major hypothetical protein, conserved 0.0052 0.0521 0.6652
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.003 0.0201
Echinococcus granulosus tissue type plasminogen activator 0.0052 0.0521 0.6657
Mycobacterium ulcerans hypothetical protein 0.0014 0.0034 0.0085
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0071 0.0768 1
Brugia malayi AMP-binding enzyme family protein 0.0014 0.003 0.0201
Loa Loa (eye worm) hypothetical protein 0.0034 0.0299 0.1834
Onchocerca volvulus 0.0046 0.0449 0.5678
Trichomonas vaginalis casein kinase II beta chain, putative 0.0071 0.0768 1
Toxoplasma gondii kringle domain-containing protein 0.0052 0.0521 0.1285
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0123 0.1253
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0034 0.0439
Brugia malayi PAN domain containing protein 0.0033 0.0286 0.1907
Toxoplasma gondii propionate-CoA ligase 0.0014 0.003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0034 0.0299 0.1834
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.003 0.0546
Schistosoma mansoni egf-like domain protein 0.0013 0.0029 0.0378
Brugia malayi AMP-binding enzyme family protein 0.0046 0.0449 0.299
Onchocerca volvulus 0.0052 0.0521 0.6657
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0275 0.6071
Onchocerca volvulus 0.0019 0.0095 0.0889
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0046 0.0449 1
Leishmania major phosphatidylinositol-specific phospholipase-like protein 0.0018 0.0081 0.0692
Trichomonas vaginalis protein kinase ck2-beta, putative 0.0021 0.0123 0.1253
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0033 0.0286 0.0672
Onchocerca volvulus 0.0019 0.0095 0.0889
Trichomonas vaginalis casein kinase II beta chain, putative 0.0071 0.0768 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0095 0.0447
Onchocerca volvulus 0.0014 0.003 0.0016
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0034 0.0439
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0123 0.1253
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0071 0.0768 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.0449 0.5671
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.003 0.0546
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0123 0.1253
Loa Loa (eye worm) hypothetical protein 0.0014 0.0034 0.0032
Brugia malayi Variant SH3 domain containing protein 0.0128 0.15 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0008
Toxoplasma gondii PAN domain-containing protein 0.0033 0.0286 0.0672
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.0449 0.5671
Trichomonas vaginalis casein kinase II beta chain, putative 0.0071 0.0768 1
Plasmodium falciparum casein kinase II beta chain 0.0071 0.0768 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0046 0.0449 1
Onchocerca volvulus 0.0014 0.0034 0.0064
Toxoplasma gondii microneme protein MIC17A 0.0033 0.0286 0.0672
Trichomonas vaginalis casein kinase II beta chain, putative 0.0071 0.0768 1
Onchocerca volvulus 0.0033 0.0286 0.3478
Brugia malayi PAN domain containing protein 0.0033 0.0286 0.1907
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0014 0.0034 0.0439
Toxoplasma gondii PAN domain-containing protein 0.0312 0.3856 1
Brugia malayi Trypsin family protein 0.0014 0.0034 0.0225
Brugia malayi Calcium binding EGF domain containing protein 0.0013 0.0029 0.0193
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0123 0.1253
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.003 0.0393
Brugia malayi PAN domain containing protein 0.0033 0.0286 0.1907
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0052 0.0521 0.6652
Echinococcus granulosus transmembrane protease serine 3 0.0014 0.0034 0.0064
Loa Loa (eye worm) hypothetical protein 0.0052 0.0521 0.3343
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0123 0.1253
Trichomonas vaginalis casein kinase II beta chain, putative 0.0071 0.0768 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.0449 1
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.003 0.0546
Brugia malayi hypothetical protein 0.0014 0.0034 0.0225
Brugia malayi PAN domain containing protein 0.0033 0.0286 0.1907
Loa Loa (eye worm) oxidoreductase 0.0014 0.003 0.0008
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0123 0.1253
Loa Loa (eye worm) hypothetical protein 0.0018 0.0081 0.0355
Loa Loa (eye worm) hypothetical protein 0.0034 0.0299 0.1834
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0071 0.0768 1
Brugia malayi Trypsin-like protease protein 5 0.0014 0.0034 0.0225
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0034 0.0299 0.6421
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0034 0.0439
Loa Loa (eye worm) casein kinase II 0.0021 0.0123 0.0636
Trichomonas vaginalis casein kinase II beta chain, putative 0.0071 0.0768 1
Onchocerca volvulus 0.0014 0.0034 0.0064
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.003 0.0546
Toxoplasma gondii microneme protein MIC4 0.0033 0.0286 0.0672
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0021 0.0123 0.1253
Brugia malayi PAN domain containing protein 0.0033 0.0286 0.1907
Brugia malayi 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 0.0018 0.0081 0.0541
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.003 0.0008
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0071 0.0768 1
Echinococcus granulosus enteropeptidase 0.0014 0.0034 0.0064
Schistosoma mansoni casein kinase II beta subunit 0.0071 0.0768 1
Echinococcus multilocularis Mastin 0.0014 0.0034 0.0005
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0034 0.0439
Trichomonas vaginalis casein kinase II beta chain, putative 0.0071 0.0768 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0034 0.0032
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0034 0.0439
Plasmodium vivax acyl-CoA synthetase, putative 0.0034 0.0299 0.3642
Trichomonas vaginalis casein kinase II beta chain, putative 0.0071 0.0768 1
Onchocerca volvulus 0.0014 0.0034 0.0064
Loa Loa (eye worm) PAN domain-containing protein 0.0033 0.0286 0.1747
Plasmodium falciparum cysteine repeat modular protein 1 0.0052 0.0521 0.6652
Toxoplasma gondii microneme protein MIC17C 0.0033 0.0286 0.0672
Toxoplasma gondii PAN domain-containing protein 0.0033 0.0286 0.0672
Echinococcus multilocularis 1 phosphatidylinositol 4,5 bisphosphate 0.0019 0.0095 0.0066
Trichomonas vaginalis casein kinase II beta chain, putative 0.0071 0.0768 1
Brugia malayi Kringle domain containing protein 0.0052 0.0521 0.3472
Leishmania major phospholipase c-like protein 0.0019 0.0095 0.0875
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0071 0.0768 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.003 0.0008
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0034 0.0439
Trichomonas vaginalis casein kinase II beta chain, putative 0.0071 0.0768 1
Onchocerca volvulus 0.0033 0.0286 0.3478
Plasmodium falciparum phosphoinositide-specific phospholipase C 0.0018 0.0081 0.0692
Entamoeba histolytica acyl-CoA synthetase, putative 0.0046 0.0449 0.5671
Onchocerca volvulus 0.0033 0.0286 0.3478
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0123 0.1253
Brugia malayi Fibulin-1 precursor 0.0013 0.0029 0.0193
Toxoplasma gondii PAN domain-containing protein 0.0312 0.3856 1
Brugia malayi Protein kinase domain containing protein 0.0052 0.0521 0.3472
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0018 0.0081 0.0541
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0034 0.0439
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0046 0.0449 1
Trichomonas vaginalis protein kinase ck2-beta, putative 0.0021 0.0123 0.1253
Echinococcus granulosus 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 0.0019 0.0095 0.0889
Echinococcus granulosus glycoprotein Antigen 5 0.0014 0.0034 0.0064
Onchocerca volvulus 0.0033 0.0286 0.3478
Onchocerca volvulus 0.0033 0.0286 0.3478
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0034 0.0439
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0046 0.0449 1
Toxoplasma gondii ck2 beta subunit 0.0071 0.0768 0.1931
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0123 0.1253
Echinococcus multilocularis glycoprotein Antigen 5 0.0014 0.0034 0.0005
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.003 0.0546
Brugia malayi PAN domain containing protein 0.0033 0.0286 0.1907
Onchocerca volvulus 0.0014 0.003 0.0016
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0034 0.0439
Loa Loa (eye worm) phosphatidylinositol-specific phospholipase C 0.0019 0.0095 0.0447
Loa Loa (eye worm) Csnk2b protein 0.0071 0.0768 0.5022
Onchocerca volvulus 0.0033 0.0286 0.3478
Brugia malayi Trypsin family protein 0.0014 0.0034 0.0225
Entamoeba histolytica acyl-coA synthetase, putative 0.0046 0.0449 0.5671
Plasmodium falciparum acyl-CoA synthetase 0.0034 0.0299 0.3642
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.003 0.0546
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0014 0.0034 0.0005
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0123 0.1253
Toxoplasma gondii phosphoinositide phospholipase PIPLC 0.0019 0.0095 0.0172
Loa Loa (eye worm) PAN domain-containing protein 0.0033 0.0286 0.1747
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0046 0.0449 1
Toxoplasma gondii PAN domain-containing protein 0.0033 0.0286 0.0672
Trichomonas vaginalis casein kinase II beta chain, putative 0.0071 0.0768 1
Toxoplasma gondii subtilisin SUB12 0.0033 0.0286 0.0672
Echinococcus multilocularis transmembrane protease serine 3 0.0014 0.0034 0.0005
Loa Loa (eye worm) hypothetical protein 0.0014 0.0034 0.0032
Brugia malayi casein kinase II, putaitve 0.0021 0.0123 0.0817
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0123 0.1253
Trichomonas vaginalis casein kinase II beta chain, putative 0.0071 0.0768 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0021 0.0123 0.1253
Giardia lamblia Casein kinase II beta chain 0.0071 0.0768 1
Loa Loa (eye worm) PAN domain-containing protein 0.0033 0.0286 0.1747
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.003 0.0546
Entamoeba histolytica acyl-CoA synthetase, putative 0.0046 0.0449 0.5671
Toxoplasma gondii hypothetical protein 0.0033 0.0286 0.0672
Echinococcus granulosus casein kinase ii subunit beta 0.0071 0.0768 1
Loa Loa (eye worm) TK/ROR protein kinase 0.0052 0.0521 0.3343
Onchocerca volvulus 0.0033 0.0286 0.3478
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0014 0.003 0.0003
Brugia malayi PAN domain containing protein 0.0033 0.0286 0.1907
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0046 0.0449 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0275 0.6071
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.003 0.0546
Plasmodium falciparum casein kinase II beta chain 0.0071 0.0768 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.0449 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0034 0.0439
Loa Loa (eye worm) hypothetical protein 0.0033 0.0286 0.1747
Loa Loa (eye worm) hypothetical protein 0.0046 0.0449 0.2852
Brugia malayi AMP-binding enzyme family protein 0.0046 0.0449 0.299
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.003 0.0016
Echinococcus multilocularis tissue type plasminogen activator 0.0052 0.0521 0.0493
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0034 0.0439
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0034 0.0299 0.5
Loa Loa (eye worm) hypothetical protein 0.0033 0.0286 0.1747
Onchocerca volvulus 0.0014 0.003 0.0016
Trypanosoma brucei phosphoinositide-specific phospholipase C 0.0019 0.0095 0.0875
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0034 0.0439
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.003 0.0003
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0013 0.0029 0.0378
Loa Loa (eye worm) hypothetical protein 0.0046 0.0449 0.2852
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0013 0.0029 0.0193
Schistosoma mansoni phospholipase C beta 0.0018 0.0081 0.1058
Onchocerca volvulus 0.0033 0.0286 0.3478
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0014 0.0034 0.0064
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0046 0.0449 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0128 0.15 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0299 0.1834
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0014 0.0034 0.0225
Loa Loa (eye worm) hypothetical protein 0.0046 0.0449 0.2852
Trypanosoma cruzi hypothetical protein, conserved 0.0052 0.0521 0.6652
Loa Loa (eye worm) hypothetical protein 0.0033 0.0286 0.1747
Loa Loa (eye worm) hypothetical protein 0.0034 0.0299 0.1834
Trichomonas vaginalis casein kinase II beta chain, putative 0.0071 0.0768 1
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.003 0.0546
Schistosoma mansoni hypothetical protein 0.0014 0.0034 0.0439
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0071 0.0768 0.1931
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.003 0.0201
Schistosoma mansoni hypothetical protein 0.0014 0.0034 0.0439
Echinococcus granulosus Mastin 0.0014 0.0034 0.0064
Onchocerca volvulus 0.0014 0.0034 0.0064
Toxoplasma gondii microneme protein MIC17B 0.0033 0.0286 0.0672
Brugia malayi AMP-binding enzyme family protein 0.0014 0.003 0.0201
Toxoplasma gondii PAN/Apple domain-containing protein 0.0033 0.0286 0.0672
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0021 0.0123 0.1253
Onchocerca volvulus 0.0033 0.0286 0.3478
Onchocerca volvulus 0.0033 0.0286 0.3478
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0071 0.0768 1
Brugia malayi PAN domain containing protein 0.0033 0.0286 0.1907
Loa Loa (eye worm) hypothetical protein 0.0014 0.0034 0.0032
Leishmania major phosphoinositide-specific phospholipase C, putative 0.0018 0.0081 0.0692
Brugia malayi Csnk2b protein 0.0071 0.0768 0.5118
Loa Loa (eye worm) PAN domain-containing protein 0.0033 0.0286 0.1747
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0275 0.6071
Loa Loa (eye worm) hypothetical protein 0.0033 0.0286 0.1747
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0034 0.0439
Schistosoma mansoni hypothetical protein 0.0052 0.0521 0.6783
Brugia malayi AMP-binding enzyme family protein 0.0014 0.003 0.0201

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.