Detailed information for compound 79897

Basic information

Technical information
  • TDR Targets ID: 79897
  • Name: 5-[[4-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)p ropyl]phenyl]methyl]-1,3-thiazolidine-2,4-dio ne
  • MW: 406.497 | Formula: C23H22N2O3S
  • H donors: 1 H acceptors: 3 LogP: 5.15 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1NC(=O)C(S1)Cc1ccc(cc1)CCCc1nc(oc1C)c1ccccc1
  • InChi: 1S/C23H22N2O3S/c1-15-19(24-22(28-15)18-7-3-2-4-8-18)9-5-6-16-10-12-17(13-11-16)14-20-21(26)25-23(27)29-20/h2-4,7-8,10-13,20H,5-6,9,14H2,1H3,(H,25,26,27)
  • InChiKey: QHTULCIAIDWQKP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-[[4-[3-(5-methyl-2-phenyl-oxazol-4-yl)propyl]phenyl]methyl]thiazolidine-2,4-dione
  • 5-[[4-[3-(5-methyl-2-phenyl-4-oxazolyl)propyl]phenyl]methyl]thiazolidine-2,4-dione
  • 5-[4-[3-(5-methyl-2-phenyl-oxazol-4-yl)propyl]benzyl]thiazolidine-2,4-quinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Na:K ATPase alpha subunit 0.0039 0.0585 0.0585
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0041 0.0143
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0041 0.0143
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0041 0.0041
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0017 0.0171 0.0473
Echinococcus granulosus cyclin B 0.0042 0.0645 0.0645
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0523 1 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0041 0.0041
Echinococcus multilocularis cyclin B 0.0042 0.0645 0.0645
Mycobacterium ulcerans cation-transporter ATPase I CtpI 0.0012 0.0064 0.0984
Echinococcus granulosus plasma membrane calcium transporting ATPase 0.0014 0.0105 0.0105
Trichomonas vaginalis cyclins, putative 0.0042 0.0645 1
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0011 0.005 0.2929
Echinococcus multilocularis cyclins 0.0017 0.0174 0.0174
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0017 0.0171 0.2653
Trypanosoma brucei calcium-translocating P-type ATPase 0.0014 0.0105 0.0289
Trichomonas vaginalis cation-transporting ATPase, putative 0.0017 0.0171 0.2653
Trichomonas vaginalis cyclins, putative 0.0028 0.039 0.604
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0174 0.2698
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0017 0.0171 0.2653
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0041 0.0143
Brugia malayi Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0014 0.0105 0.036
Brugia malayi nuclear hormone receptor 0.0011 0.0041 0.0143
Echinococcus granulosus Ca2 transporting ATPase plasma membrane 0.0014 0.0105 0.0105
Echinococcus multilocularis cyclins 0.0017 0.0174 0.0174
Trichomonas vaginalis cyclin B, putative 0.0042 0.0645 1
Trypanosoma cruzi P-type H+-ATPase, putative 0.0011 0.005 0.0771
Onchocerca volvulus 0.0011 0.0041 0.0041
Brugia malayi Membrane calcium atpase protein 3 0.0014 0.0105 0.036
Leishmania major calcium-translocating P-type ATPase 0.0017 0.0171 0.0466
Leishmania major calcium-transporting ATPase, putative 0.0014 0.0105 0.0285
Echinococcus multilocularis Na+:K+ ATPase alpha subunit 0.0039 0.0585 0.0585
Echinococcus multilocularis sodium:potassium transporting ATPase subunit 0.0523 1 1
Echinococcus granulosus cyclin b3 0.0017 0.0174 0.0174
Chlamydia trachomatis oxoacy-ACP reductase 0.0008 0 0.5
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0041 0.0041
Brugia malayi nuclear receptor NHR-88 0.0011 0.0041 0.0143
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0041 0.0041
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0036 0.0544 0.1875
Loa Loa (eye worm) hypothetical protein 0.0024 0.0308 0.0308
Mycobacterium ulcerans short chain dehydrogenase 0.0011 0.005 0.077
Onchocerca volvulus 0.0042 0.0645 0.0645
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0041 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0041 0.0143
Entamoeba histolytica plasma membrane calcium-transporting ATPase 1, putative 0.001 0.0025 0.0393
Loa Loa (eye worm) hypothetical protein 0.003 0.0423 0.0423
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0041 0.0041
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0017 0.0171 0.2653
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0523 1 1
Echinococcus multilocularis geminin 0.0166 0.3053 0.3053
Loa Loa (eye worm) hypothetical protein 0.0025 0.0318 0.0318
Loa Loa (eye worm) hypothetical protein 0.0011 0.0041 0.0041
Trichomonas vaginalis cyclin B, putative 0.0017 0.0174 0.2698
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0042 0.0645 0.0645
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0041 0.0041
Trichomonas vaginalis cyclin B, putative 0.0042 0.0645 1
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0014 0.0105 0.162
Entamoeba histolytica cyclin, putative 0.0042 0.0645 1
Echinococcus granulosus cyclins 0.0017 0.0174 0.0174
Echinococcus multilocularis nervana 2 0.0523 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0011 0.005 0.077
Loa Loa (eye worm) calcium ATPase 0.001 0.0025 0.0025
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0041 0.0041
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0017 0.0171 0.0466
Echinococcus granulosus nervana 2 0.0523 1 1
Schistosoma mansoni transmemberane protein 0.0523 1 1
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0014 0.0105 0.0105
Brugia malayi Cyclin, N-terminal domain containing protein 0.0042 0.0645 0.2223
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0017 0.0171 0.0171
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0017 0.0171 0.0171
Schistosoma mansoni coup transcription factor 0.0011 0.0041 0.0041
Trichomonas vaginalis cyclin A, putative 0.0042 0.0645 1
Trypanosoma brucei calcium motive p-type ATPase, putative 0.0014 0.0105 0.0289
Schistosoma mansoni hypothetical protein 0.0166 0.3053 0.3053
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0041 0.0041
Echinococcus granulosus nervana 2 0.0322 0.6084 0.6084
Trypanosoma cruzi cyclin 6, putative 0.0042 0.0645 1
Echinococcus granulosus cyclin B3 1 0.0017 0.0174 0.0174
Giardia lamblia Potassium-transporting ATPase alpha chain 1 0.0039 0.0585 0.8883
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0017 0.0171 0.2653
Echinococcus granulosus cyclins 0.0017 0.0174 0.0174
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.0017 0.0171 1
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0014 0.0105 0.0105
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0041 0.0041
Leishmania major P-type H -ATPase, putative 0.0011 0.005 0.0135
Loa Loa (eye worm) STAT protein 0.0158 0.2903 0.2903
Schistosoma mansoni calcium-transporting atpase 2 (atpase 2) 0.0014 0.0105 0.0105
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0011 0.005 0.0777
Trypanosoma brucei mitotic cyclin 6 0.0042 0.0645 0.1781
Loa Loa (eye worm) hypothetical protein 0.0011 0.0041 0.0041
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0017 0.0171 0.9833
Trichomonas vaginalis cation-transporting ATPase, putative 0.0011 0.005 0.0771
Toxoplasma gondii plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 0.0014 0.0105 0.6105
Giardia lamblia Cyclin A 0.0017 0.0174 0.1287
Plasmodium vivax P-type ATPase4, putative 0.0017 0.0171 1
Leishmania major P-type ATPase, putative 0.0014 0.0105 0.0285
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0017 0.0171 0.0473
Echinococcus multilocularis cyclin B3 1 0.0017 0.0174 0.0174
Echinococcus multilocularis Ca2+ transporting ATPase plasma membrane 0.0014 0.0105 0.0105
Schistosoma mansoni sodium / potassium ATPase beta chain 0.0322 0.6084 0.6084
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0042 0.0645 0.1757
Echinococcus granulosus nervana 2 0.0523 1 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.0017 0.0174 0.06
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.001 0.0025 0.0087
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0041 0.0041
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0042 0.0652 0.0652
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0523 1 1
Echinococcus multilocularis cyclin b3 0.0017 0.0174 0.0174
Mycobacterium tuberculosis Probable oxidoreductase 0.0011 0.005 0.7824
Leishmania major cyclin 0.0042 0.0645 0.1757
Loa Loa (eye worm) hypothetical protein 0.0011 0.0041 0.0041
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0041 0.0143
Trypanosoma brucei P-type H+-ATPase, putative 0.0011 0.005 0.0137
Trypanosoma cruzi cyclin, putative 0.0042 0.0645 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0041 0.0041
Trichomonas vaginalis cyclins, putative 0.0042 0.0645 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0011 0.005 0.077
Trypanosoma brucei P-type H+-ATPase, putative 0.0011 0.005 0.0137
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0041 0.0143
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0017 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0011 0.0041 0.0041
Giardia lamblia G2/mitotic-specific cyclin B 0.0042 0.0645 1
Entamoeba histolytica cyclin family protein 0.0017 0.0174 0.2698
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0041 0.0143
Trichomonas vaginalis cyclin B3, putative 0.0017 0.0174 0.2698
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0017 0.0171 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0041 0.0041
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0017 0.0171 0.2653
Trypanosoma cruzi CYC2-like cyclin, putative 0.0042 0.0645 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0041 0.0143
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.0042 0.0652 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0041 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0041 0.0143
Echinococcus multilocularis nervana 2 0.0322 0.6084 0.6084
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0017 0.0171 0.2653
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0041 0.0041
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0041 0.0041
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0041 0.0041
Brugia malayi Na,K-ATPase alpha subunit 0.0042 0.0652 0.2244
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0011 0.005 0.077
Loa Loa (eye worm) hypothetical protein 0.0523 1 1
Echinococcus multilocularis calcium transporting atpase 0.0014 0.0105 0.0105
Schistosoma mansoni cyclin B 0.0042 0.0645 0.0645
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0041 0.0041
Trypanosoma cruzi P-type H+-ATPase, putative 0.0011 0.005 0.0771
Leishmania major oxidoreductase-like protein 0.0011 0.005 0.0137
Schistosoma mansoni cyclin B3 0.0017 0.0174 0.0174
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0041 0.0143
Leishmania major calcium motive p-type ATPase, putative 0.0014 0.0105 0.0285
Echinococcus multilocularis cyclins 0.0017 0.0174 0.0174
Loa Loa (eye worm) cyclin domain-containing protein 0.0017 0.0174 0.0174
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0041 0.0041
Mycobacterium tuberculosis Possible metal cation transporting P-type ATPase CtpH 0.0012 0.0064 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0041 0.0143
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0041 0.0041
Toxoplasma gondii hypothetical protein 0.0013 0.0093 0.5422
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0014 0.0105 0.0105
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0041 0.0041
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0322 0.6084 0.6084
Brugia malayi steroid hormone receptor 0.0011 0.0041 0.0143
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0017 0.0171 0.0466
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.001 0.0025 0.0393
Loa Loa (eye worm) hypothetical protein 0.0011 0.0041 0.0041
Echinococcus multilocularis cyclins 0.0017 0.0174 0.0174
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0042 0.0652 0.0652
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0041 0.0041
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0523 1 1
Plasmodium falciparum calcium-transporting ATPase 0.0014 0.0105 0.6003
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0017 0.0171 0.0171
Echinococcus granulosus geminin 0.0166 0.3053 0.3053
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0041 0.0041
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0036 0.0544 0.0544
Onchocerca volvulus 0.0322 0.6084 0.6084
Onchocerca volvulus 0.0523 1 1
Trichomonas vaginalis cation-transporting ATPase, putative 0.0017 0.0171 0.2653
Brugia malayi E1-E2 ATPase family protein 0.0011 0.005 0.0171
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0042 0.0652 0.0652
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0008 0 0.5
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0017 0.0174 0.0174
Loa Loa (eye worm) hypothetical protein 0.0017 0.0171 0.0171
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0017 0.0171 0.2653
Trichomonas vaginalis cyclin B, putative 0.0042 0.0645 1
Trypanosoma brucei oxidoreductase-like protein 0.0011 0.005 0.0138
Entamoeba histolytica cyclin family protein 0.0017 0.0174 0.2698
Loa Loa (eye worm) hypothetical protein 0.0042 0.0645 0.0645
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0041 0.0041
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0041 0.0041
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0017 0.0171 0.2653
Trichomonas vaginalis cyclins, putative 0.0017 0.0174 0.2698
Leishmania major P-type H -ATPase, putative 0.0011 0.005 0.0135
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0041 0.0041
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0041 0.0041
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0008 0 0.5
Schistosoma mansoni hypothetical protein 0.0166 0.3053 0.3053
Brugia malayi STAT protein, DNA binding domain containing protein 0.0158 0.2903 1
Echinococcus granulosus cyclins 0.0017 0.0174 0.0174
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0017 0.0171 0.2653
Echinococcus multilocularis nervana 2 0.0322 0.6084 0.6084
Giardia lamblia Hypothetical protein 0.0017 0.0174 0.1287
Echinococcus granulosus cyclins 0.0017 0.0174 0.0174
Trichomonas vaginalis cyclin B, putative 0.0042 0.0645 1
Echinococcus granulosus calcium transporting atpase 0.0014 0.0105 0.0105
Mycobacterium ulcerans metal cation-transporting p-type ATPase F, CtpF 0.0017 0.0171 0.2627
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0041 0.0041
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0041 0.0041
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0041 0.0041
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0041 0.0041
Schistosoma mansoni ATPase 0.0017 0.0171 0.0171
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0041 0.0041
Loa Loa (eye worm) E1-E2 ATPase 0.0011 0.005 0.005
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0014 0.0105 0.162
Echinococcus multilocularis cyclins 0.0017 0.0174 0.0174
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0041 0.0143
Toxoplasma gondii P-type ATPase4, putative 0.0017 0.0171 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0041 0.0041
Echinococcus multilocularis cyclins 0.0017 0.0174 0.0174
Brugia malayi Cyclin, N-terminal domain containing protein 0.0042 0.0645 0.2223
Loa Loa (eye worm) hypothetical protein 0.0011 0.0041 0.0041
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0008 0 0.5
Echinococcus multilocularis plasma membrane calcium transporting ATPase 0.0014 0.0105 0.0105
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0041 0.0041
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0041 0.0143
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0041 0.0143
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0017 0.0171 0.1233
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0523 1 1
Entamoeba histolytica cyclin, putative 0.0017 0.0174 0.2698
Trichomonas vaginalis cyclin D, putative 0.0017 0.0174 0.2698
Trichomonas vaginalis cation-transporting ATPase, putative 0.0017 0.0171 0.2653
Echinococcus multilocularis cyclins 0.0017 0.0174 0.0174
Echinococcus granulosus nervana 2 0.0322 0.6084 0.6084
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0041 0.0041
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0322 0.6084 0.6084
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0017 0.0171 0.0171
Onchocerca volvulus 0.0011 0.005 0.005
Trichomonas vaginalis cyclins, putative 0.0042 0.0645 1
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0017 0.0174 0.0174
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0017 0.0171 0.2653
Trypanosoma brucei pteridine reductase 1 0.0195 0.3622 1
Leishmania major pteridine reductase 1 0.0198 0.3672 1
Schistosoma mansoni ATPase 0.0017 0.0171 0.0171
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0017 0.0171 0.0473
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0041 0.0041
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0041 0.0041
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0041 0.0041
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0014 0.0105 0.162
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0017 0.0171 0.2653
Echinococcus multilocularis nervana 2 0.0523 1 1
Brugia malayi ecdysteroid receptor 0.0011 0.0041 0.0143
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0041 0.0041
Onchocerca volvulus 0.0042 0.0652 0.0652
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0017 0.0171 0.2653
Trypanosoma cruzi cyclin, putative 0.0042 0.0645 1
Schistosoma mansoni na+/k+ atpase alpha subunit 0.0039 0.0585 0.0585
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0017 0.0171 0.2653
Echinococcus granulosus sodium:potassium transporting ATPase subunit 0.0523 1 1
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0523 1 1
Plasmodium falciparum cyclin 0.0017 0.0174 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0041 0.0143
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0014 0.0105 0.0105
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0017 0.0171 0.0171
Echinococcus granulosus cyclins 0.0017 0.0174 0.0174
Loa Loa (eye worm) hypothetical protein 0.0031 0.0439 0.0439
Trichomonas vaginalis cyclin D, putative 0.0017 0.0174 0.2698
Plasmodium vivax calcium-transporting ATPase, putative 0.0017 0.0171 1
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0041 0.0143
Schistosoma mansoni cyclins 0.0017 0.0174 0.0174
Mycobacterium leprae PROBABLE CATION-TRANSPORTER ATPASE I CTPI 0.0036 0.0544 1
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0322 0.6084 0.6084
Toxoplasma gondii P-type ATPase PMA1 0.0011 0.005 0.2907
Loa Loa (eye worm) hypothetical protein 0.0011 0.0041 0.0041
Trichomonas vaginalis cyclins, putative 0.0042 0.0645 1

Activities

Activity type Activity value Assay description Source Reference
Normalization (functional) = 37 % In vivo euglycemic activity (administered by oral gavage) in C57/6J-ob/ob mice by normalization of blood glucose levels at a dose of 0.5 mg/kg. ChEMBL. 1588563
Normalization (functional) = 37 % In vivo euglycemic activity (administered by oral gavage) in C57/6J-ob/ob mice by normalization of blood glucose levels at a dose of 0.5 mg/kg. ChEMBL. 1588563

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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