Detailed information for compound 799148

Basic information

Technical information
  • TDR Targets ID: 799148
  • Name: 6-bromo-N-butan-2-yl-3-(4-ethylphenyl)-4-hydr oxy-2-oxo-1H-quinazoline-4-carboxamide
  • MW: 446.338 | Formula: C21H24BrN3O3
  • H donors: 3 H acceptors: 3 LogP: 3.84 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(NC(=O)C1(O)N(c2ccc(cc2)CC)C(=O)Nc2c1cc(Br)cc2)C
  • InChi: 1S/C21H24BrN3O3/c1-4-13(3)23-19(26)21(28)17-12-15(22)8-11-18(17)24-20(27)25(21)16-9-6-14(5-2)7-10-16/h6-13,28H,4-5H2,1-3H3,(H,23,26)(H,24,27)
  • InChiKey: DVSQOHIVWVJDHS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-bromo-3-(4-ethylphenyl)-4-hydroxy-2-oxo-N-sec-butyl-1H-quinazoline-4-carboxamide
  • 6-bromo-3-(4-ethylphenyl)-4-hydroxy-2-keto-N-sec-butyl-1H-quinazoline-4-carboxamide
  • EU-0055096

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0082 0.6172
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0133 1
Brugia malayi Cathepsin L-like precursor 0.0018 0.0036 0.0036
Leishmania major C-8 sterol isomerase-like protein 0.1912 1 1
Echinococcus multilocularis replication factor c subunit 1 0.0011 0.0000001646 0.00000034704
Schistosoma mansoni chromosome transmission fidelity factor 0.0011 0.0000001646 0.00000043386
Onchocerca volvulus 0.0018 0.0036 0.0095
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0036 0.2718
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0133 0.082
Echinococcus granulosus replication factor c subunit 1 0.0011 0.0000001646 0.00000043386
Onchocerca volvulus 0.0018 0.0036 0.0095
Brugia malayi Cathepsin L-like precursor 0.0018 0.0036 0.0036
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0011 0.0000001646 0.000004759
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0082 0.2373
Onchocerca volvulus 0.0012 0.0005 0.0013
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0036 0.2718
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0036 0.0076
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0036 0.2718
Brugia malayi Cathepsin L-like precursor 0.0018 0.0036 0.0036
Toxoplasma gondii cathepsin CPL 0.0018 0.0036 0.2718
Schistosoma mansoni hypothetical protein 0.0018 0.0035 0.0093
Loa Loa (eye worm) transcription factor SMAD2 0.0128 0.0615 0.0615
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0036 0.0095
Echinococcus multilocularis microtubule associated protein 2 0.0678 0.3511 0.7402
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0076 0.0076
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0082 0.6172
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0036 0.0076
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0082 0.2373
Loa Loa (eye worm) hypothetical protein 0.0036 0.0133 0.0133
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0133 0.0351
Onchocerca volvulus 0.0018 0.0036 0.0095
Brugia malayi Cathepsin L-like precursor 0.0018 0.0036 0.0036
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0011 0 0.5
Schistosoma mansoni hypothetical protein 0.0018 0.0035 0.0093
Brugia malayi beta-lactamase family protein 0.0036 0.0133 0.0133
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0732 0.3794 1
Onchocerca volvulus 0.0036 0.0133 0.0351
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0302 0.0302
Schistosoma mansoni hypothetical protein 0.0077 0.0346 0.0912
Mycobacterium tuberculosis Conserved protein 0.0036 0.0133 0.082
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0036 0.2718
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0002 0.0005
Echinococcus multilocularis tar DNA binding protein 0.013 0.0627 0.1321
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0036 0.2718
Schistosoma mansoni tar DNA-binding protein 0.013 0.0627 0.1652
Loa Loa (eye worm) hypothetical protein 0.0025 0.0076 0.0076
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.013 0.0627 0.0627
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0237 0.0237
Plasmodium vivax vivapain-2 0.0018 0.0036 0.2718
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0913 0.4743 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.0036 0.4779
Echinococcus granulosus vesicular acetylcholine transporter 0.0732 0.3794 1
Plasmodium vivax vivapain-2 0.0018 0.0036 0.2718
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0005
Loa Loa (eye worm) MH2 domain-containing protein 0.0128 0.0615 0.0615
Giardia lamblia Replication factor C, subunit 1 0.0011 0.0000001646 0.5
Leishmania major cathepsin L-like protease 0.0068 0.0302 0.0266
Loa Loa (eye worm) hypothetical protein 0.002 0.0047 0.0047
Trypanosoma cruzi cruzipain precursor, putative 0.0068 0.0302 0.0302
Echinococcus multilocularis vesicular acetylcholine transporter 0.0732 0.3794 0.7999
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0036 0.2718
Schistosoma mansoni transcription factor LCR-F1 0.0077 0.0346 0.0912
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0302 0.0302
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0076 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0036 0.2718
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0082 0.6172
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0133 0.0133
Brugia malayi hypothetical protein 0.0077 0.0346 0.0346
Brugia malayi cathepsin L-like precursor 0.0012 0.0005 0.0005
Brugia malayi Cathepsin L-like precursor 0.0012 0.0005 0.0005
Mycobacterium ulcerans lipase LipD 0.0036 0.0133 1
Brugia malayi RNA binding protein 0.013 0.0627 0.0627
Onchocerca volvulus 0.0036 0.0133 0.0351
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0047 0.3503
Onchocerca volvulus 0.0036 0.0133 0.0351
Echinococcus granulosus GPCR family 2 0.0018 0.0035 0.0093
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0036 0.0076
Trypanosoma cruzi major cysteine proteinase, putative 0.0054 0.0225 0.0225
Loa Loa (eye worm) hypothetical protein 0.0036 0.0133 0.0133
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0076 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0002 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0036 0.2718
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0076 0.5686
Brugia malayi vesicular acetylcholine transporter unc-17 0.0732 0.3794 0.3794
Mycobacterium ulcerans hypothetical protein 0.0027 0.0082 0.6172
Schistosoma mansoni microtubule-associated protein tau 0.0678 0.3511 0.9254
Brugia malayi Cathepsin L-like precursor 0.0018 0.0036 0.0036
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0036 0.1045
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0133 0.0133
Trypanosoma brucei C-8 sterol isomerase, putative 0.1912 1 1
Schistosoma mansoni hypothetical protein 0.0011 0.0002 0.0005
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.0036 0.4779
Schistosoma mansoni vesicular acetylcholine transporter 0.0732 0.3794 1
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0302 0.0302
Mycobacterium tuberculosis Conserved protein 0.0036 0.0133 0.082
Loa Loa (eye worm) hypothetical protein 0.0027 0.0082 0.0082
Leishmania major cathepsin L-like protease 0.0068 0.0302 0.0266
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0036 0.2718
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0082 0.0367
Entamoeba histolytica hypothetical protein 0.0077 0.0346 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0302 0.0302
Loa Loa (eye worm) cysteine protease 0.0018 0.0036 0.0036
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0237 0.0237
Loa Loa (eye worm) hypothetical protein 0.0018 0.0036 0.0036
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0036 0.2718
Brugia malayi Cathepsin L-like cysteine proteinase 0.0012 0.0005 0.0005
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0082 0.6172
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0036 0.0095
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0133 0.082
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0082 0.6172
Mycobacterium tuberculosis Conserved protein 0.0036 0.0133 0.082
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0133 0.082
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0133 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0035 0.0074
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0036 0.2718
Echinococcus multilocularis GPCR, family 2 0.0018 0.0035 0.0074
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0076 0.0076
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0133 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0082 0.0082
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0076 0.5686
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0302 0.0302
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0035 0.0035
Schistosoma mansoni cathepsin F (C01 family) 0.0012 0.0005 0.0013
Loa Loa (eye worm) TAR-binding protein 0.013 0.0627 0.0627
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0036 0.0095
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0302 0.0302
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0082 0.6172
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0047 0.3503
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0035 0.0035
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0732 0.3794 0.3794
Entamoeba histolytica hypothetical protein 0.0077 0.0346 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0036 0.0133 0.0133
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0035 0.0074
Echinococcus granulosus cathepsin l1 0.0012 0.0005 0.0013
Loa Loa (eye worm) hypothetical protein 0.0036 0.0133 0.0133
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0036 0.2718
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0036 0.0095
Onchocerca volvulus 0.0018 0.0036 0.0095
Entamoeba histolytica cysteine proteinase, putative 0.0012 0.0005 0.0142
Echinococcus granulosus tar DNA binding protein 0.013 0.0627 0.1652
Loa Loa (eye worm) hypothetical protein 0.0977 0.5083 0.5083
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0047 0.6161
Toxoplasma gondii ABC1 family protein 0.0036 0.0133 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0077 0.0346 0.0912
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0143 0.0143
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0133 1
Brugia malayi MH2 domain containing protein 0.0128 0.0615 0.0615
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0302 0.0302
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0036 0.2718
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0082 0.0082
Echinococcus multilocularis cysteine protease 0.0018 0.0036 0.0076
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0036 0.0095
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0036 0.2718
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0036 0.1045
Onchocerca volvulus 0.0027 0.0082 0.0216
Brugia malayi Cathepsin L-like precursor 0.0018 0.0036 0.0036
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0232 0.1164 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0133 0.0351
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.0036 0.4779
Onchocerca volvulus 0.0018 0.0036 0.0095
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0082 0.0367
Entamoeba histolytica hypothetical protein 0.0077 0.0346 1
Echinococcus granulosus microtubule associated protein 2 0.0678 0.3511 0.9254
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0133 0.0133
Brugia malayi TAR-binding protein 0.013 0.0627 0.0627
Schistosoma mansoni hypothetical protein 0.0018 0.0035 0.0093
Entamoeba histolytica cysteine protease, putative 0.0018 0.0036 0.1045
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0133 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0062 0.027 0.027
Leishmania major hypothetical protein, conserved 0.0025 0.0076 0.004
Entamoeba histolytica hypothetical protein 0.0077 0.0346 1
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0036 0.0095
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0005
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0082 0.0046
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0077 0.0346 0.0729
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0035 0.0035
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0302 0.0302
Echinococcus granulosus cathepsin l1 0.0018 0.0036 0.0095
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0133 1
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0082 0.0082
Schistosoma mansoni tar DNA-binding protein 0.013 0.0627 0.1652
Schistosoma mansoni tar DNA-binding protein 0.013 0.0627 0.1652
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0036 0.2718
Onchocerca volvulus 0.0018 0.0036 0.0095
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0302 0.0302
Treponema pallidum DNA ligase (lig) 0.0011 0 0.5
Brugia malayi beta-lactamase 0.0036 0.0133 0.0133
Loa Loa (eye worm) beta-lactamase 0.0036 0.0133 0.0133
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.0047 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0082 0.6172
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0082 0.0046
Loa Loa (eye worm) hypothetical protein 0.002 0.0047 0.0047
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0036 0.0036
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0302 0.0302
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0047 0.0051
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0035 0.0093
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0133 0.082
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.0082 0.2373
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0302 0.0302
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0036 0.0036
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0133 1
Mycobacterium ulcerans beta-lactamase 0.0036 0.0133 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0036 0.2718
Brugia malayi Cathepsin L-like precursor 0.0012 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0036 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.002 0.0047 0.0047
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0036 0.2718
Loa Loa (eye worm) hypothetical protein 0.1912 1 1
Echinococcus multilocularis cysteine protease 0.0018 0.0036 0.0076
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0036 0.2718
Brugia malayi hypothetical protein 0.0016 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0027 0.0082 0.0082
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0036 0.2718
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0133 0.0351
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0082 0.6172
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0036 0.2718
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0036 0.2718
Loa Loa (eye worm) ctsf protein 0.0018 0.0036 0.0036
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0036 0.2718
Schistosoma mansoni hypothetical protein 0.0038 0.0143 0.0378
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0005 0.037
Trypanosoma cruzi C-8 sterol isomerase, putative 0.1912 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0036 0.2718
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0036 0.0036
Leishmania major cathepsin L-like protease 0.0068 0.0302 0.0266
Schistosoma mansoni hypothetical protein 0.0018 0.0035 0.0093
Schistosoma mansoni tar DNA-binding protein 0.013 0.0627 0.1652
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0302 0.0302
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0133 0.0133
Loa Loa (eye worm) RNA binding protein 0.013 0.0627 0.0627
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.0035
Trichomonas vaginalis esterase, putative 0.0036 0.0133 1
Onchocerca volvulus 0.0018 0.0036 0.0095
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0036 0.2718
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0082 0.0082
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0133 1
Brugia malayi RNA recognition motif domain containing protein 0.013 0.0627 0.0627
Onchocerca volvulus Cathepsin F homolog 0.0018 0.0036 0.0095
Brugia malayi beta-lactamase family protein 0.0036 0.0133 0.0133
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0035 0.0093
Loa Loa (eye worm) hypothetical protein 0.0036 0.0133 0.0133
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0036 0.0036
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0082 0.6172
Loa Loa (eye worm) fibroinase 0.0018 0.0036 0.0036
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0082 0.0046
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0302 0.0302
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0133 0.082
Loa Loa (eye worm) hypothetical protein 0.0056 0.0237 0.0237
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0036 0.2718
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0133 0.028
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0005 0.037
Loa Loa (eye worm) hypothetical protein 0.002 0.0047 0.0047
Mycobacterium leprae Probable lipase LipE 0.0036 0.0133 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0237 0.0237
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0133 0.082
Schistosoma mansoni tar DNA-binding protein 0.013 0.0627 0.1652
Loa Loa (eye worm) hypothetical protein 0.002 0.0047 0.0047
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0302 0.0302
Brugia malayi hypothetical protein 0.0025 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0005
Leishmania major hypothetical protein, conserved 0.0036 0.0133 0.0097
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0133 0.082
Loa Loa (eye worm) hypothetical protein 0.0038 0.0143 0.0143
Mycobacterium ulcerans hypothetical protein 0.0036 0.0133 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0036 0.0076
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0133 0.0133
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0133 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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