Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | cyclin dependent kinase 5 activator 1 | 0.0247 | 0.0691 | 0.0987 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.005 | 0.003 | 0.0023 |
Entamoeba histolytica | protein kinase, putative | 0.0095 | 0.018 | 0.1018 |
Brugia malayi | serine/threonine kinase 12 | 0.0488 | 0.1497 | 0.2141 |
Echinococcus granulosus | roundabout 2 | 0.0045 | 0.0014 | 0.0002 |
Echinococcus granulosus | dual specificity protein kinase clk2 | 0.0067 | 0.0086 | 0.0107 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0067 | 0.0086 | 0.0082 |
Trichomonas vaginalis | AGC family protein kinase | 0.0488 | 0.1497 | 1 |
Schistosoma mansoni | leukocyte receptor cluster (lrc) member 4 protein | 0.0092 | 0.0169 | 0.0202 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.0169 | 0.0245 |
Schistosoma mansoni | tyrosine kinase | 0.0888 | 0.2841 | 0.4102 |
Schistosoma mansoni | tyrosine kinase | 0.1164 | 0.3764 | 0.545 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0092 | 0.0169 | 0.0945 |
Schistosoma mansoni | tyrosine kinase | 0.1179 | 0.3817 | 0.5527 |
Loa Loa (eye worm) | CMGC/MAPK/P38 protein kinase | 0.0901 | 0.2885 | 0.4192 |
Schistosoma mansoni | o-acyltransferase (membrane bound) domain containing protein | 0.0092 | 0.0169 | 0.0202 |
Trypanosoma brucei | kinetoplastid kinetochore protein 19 | 0.0067 | 0.0086 | 0.0197 |
Leishmania major | glycerol uptake protein, putative | 0.0092 | 0.0169 | 0.0486 |
Echinococcus multilocularis | o acyltransferase (membrane bound) domain | 0.0092 | 0.0169 | 0.0225 |
Echinococcus multilocularis | cyclin dependent kinase | 0.005 | 0.003 | 0.0023 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.005 | 0.003 | 0.0044 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.005 | 0.003 | 0.0025 |
Brugia malayi | MBOAT family protein | 0.0092 | 0.0169 | 0.0202 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.005 | 0.003 | 0.0044 |
Schistosoma mansoni | tyrosine kinase | 0.1164 | 0.3764 | 0.545 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0067 | 0.0086 | 0.0082 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0481 | 0.1474 | 0.2142 |
Leishmania major | mitogen-activated protein kinase 3, putative,map kinase 3, putative | 0.0901 | 0.2885 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0149 | 0.0217 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.005 | 0.003 | 0.0023 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0095 | 0.018 | 0.0523 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0901 | 0.2885 | 0.418 |
Plasmodium falciparum | diacylglycerol O-acyltransferase | 0.0092 | 0.0169 | 0.0945 |
Echinococcus multilocularis | aurora kinase A | 0.0488 | 0.1497 | 0.2159 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 10, putative | 0.0067 | 0.0086 | 0.0197 |
Brugia malayi | MBOAT family protein | 0.0092 | 0.0169 | 0.0202 |
Giardia lamblia | Kinase, CMGC CLK | 0.0067 | 0.0086 | 0.0383 |
Schistosoma mansoni | diacylglycerol O-acyltransferase 1 | 0.0092 | 0.0169 | 0.0202 |
Loa Loa (eye worm) | membrane bound O-acyltransferase domain containing 1 | 0.0092 | 0.0169 | 0.0245 |
Echinococcus granulosus | insulin receptor | 0.0888 | 0.2841 | 0.4117 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.0488 | 0.1497 | 1 |
Echinococcus granulosus | o acyltransferase membrane bound domain | 0.0092 | 0.0169 | 0.0227 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.0169 | 0.0245 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.045 | 0.1371 | 1 |
Mycobacterium ulcerans | bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase | 0.3023 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0901 | 0.2885 | 0.418 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.2093 | 0.6882 | 1 |
Brugia malayi | hypothetical protein | 0.0118 | 0.0259 | 0.0333 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 19, putative | 0.0067 | 0.0086 | 0.0197 |
Echinococcus granulosus | hypothetical protein | 0.0058 | 0.0056 | 0.0063 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.0488 | 0.1497 | 1 |
Echinococcus granulosus | epidermal growth factor receptor | 0.1179 | 0.3817 | 0.5539 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.0259 | 0.0376 |
Loa Loa (eye worm) | hhat protein | 0.0092 | 0.0169 | 0.0245 |
Entamoeba histolytica | protein kinase, putative | 0.0488 | 0.1497 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0014 | 0.0021 |
Echinococcus multilocularis | insulin receptor | 0.0888 | 0.2841 | 0.4116 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.0488 | 0.1497 | 1 |
Toxoplasma gondii | acyl-CoA:diacylglycerol acyltransferase 1-related enzyme | 0.0092 | 0.0169 | 0.082 |
Brugia malayi | diacylglycerol acyltransferase | 0.0092 | 0.0169 | 0.0202 |
Echinococcus granulosus | diacylglycerol O acyltransferase 1 | 0.0092 | 0.0169 | 0.0227 |
Brugia malayi | Protein kinase domain containing protein | 0.0067 | 0.0086 | 0.0082 |
Trichomonas vaginalis | AGC family protein kinase | 0.0488 | 0.1497 | 1 |
Echinococcus granulosus | Membrane bound O acyl transferase MBOAT | 0.0092 | 0.0169 | 0.0227 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.0488 | 0.1497 | 1 |
Entamoeba histolytica | membrane-bound O-acyltransferase (MBOAT ) family protein | 0.0092 | 0.0169 | 0.0945 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.005 | 0.003 | 0.0025 |
Echinococcus granulosus | cyclin dependent kinase | 0.005 | 0.003 | 0.0025 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.1179 | 0.3817 | 0.5539 |
Onchocerca volvulus | 0.0427 | 0.1293 | 0.9352 | |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0901 | 0.2885 | 1 |
Echinococcus granulosus | o acyltransferase membrane bound domain | 0.0092 | 0.0169 | 0.0227 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0095 | 0.018 | 0.0218 |
Entamoeba histolytica | protein kinase , putative | 0.0488 | 0.1497 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.2093 | 0.6882 | 1 |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.005 | 0.003 | 0.0023 |
Leishmania major | glycerol uptake protein, putative | 0.0092 | 0.0169 | 0.0486 |
Echinococcus multilocularis | 0.0058 | 0.0056 | 0.0061 | |
Echinococcus multilocularis | dual specificity | 0.0095 | 0.018 | 0.0241 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0901 | 0.2885 | 1 |
Plasmodium vivax | diacylglycerol O-acyltransferase, putative | 0.0092 | 0.0169 | 0.0945 |
Echinococcus granulosus | sterol O acyltransferase 1 | 0.0938 | 0.3006 | 0.4358 |
Loa Loa (eye worm) | hypothetical protein | 0.0938 | 0.3006 | 0.4369 |
Leishmania major | protein kinase, putative | 0.0067 | 0.0086 | 0.0197 |
Trichomonas vaginalis | AGC family protein kinase | 0.0488 | 0.1497 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 14 | 0.0901 | 0.2885 | 0.4181 |
Brugia malayi | MBOAT family protein | 0.0092 | 0.0169 | 0.0202 |
Brugia malayi | Protein kinase domain containing protein | 0.0888 | 0.2841 | 0.4102 |
Entamoeba histolytica | membrane-bound O-acyltransferase (MBOAT ) family protein | 0.0092 | 0.0169 | 0.0945 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.0488 | 0.1497 | 0.2161 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0888 | 0.2841 | 0.4116 |
Brugia malayi | Protein kinase domain containing protein | 0.0095 | 0.018 | 0.0218 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0901 | 0.2885 | 0.418 |
Trypanosoma brucei | CMGC/DYRK protein kinase, putative | 0.0095 | 0.018 | 0.0523 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.2093 | 0.6882 | 1 |
Leishmania major | glycerol uptake protein, putative | 0.0092 | 0.0169 | 0.0486 |
Echinococcus multilocularis | o acyltransferase (membrane bound) domain | 0.0092 | 0.0169 | 0.0225 |
Loa Loa (eye worm) | hypothetical protein | 0.0846 | 0.2699 | 0.3922 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0067 | 0.0086 | 0.0383 |
Treponema pallidum | licC protein (licC) | 0.0554 | 0.1721 | 1 |
Echinococcus granulosus | aurora kinase A | 0.0488 | 0.1497 | 0.2161 |
Loa Loa (eye worm) | MBOAT family protein | 0.0092 | 0.0169 | 0.0245 |
Schistosoma mansoni | hypothetical protein | 0.0092 | 0.0169 | 0.0202 |
Echinococcus granulosus | mitogen activated protein kinase 11 | 0.0901 | 0.2885 | 0.4181 |
Plasmodium falciparum | protein serine/threonine kinase-1 | 0.0067 | 0.0086 | 0.0383 |
Loa Loa (eye worm) | AUR protein kinase | 0.0488 | 0.1497 | 0.2176 |
Toxoplasma gondii | acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha | 0.0092 | 0.0169 | 0.082 |
Brugia malayi | P38 map kinase family protein 2 | 0.0901 | 0.2885 | 0.4166 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0888 | 0.2841 | 0.4128 |
Giardia lamblia | Aurora kinase | 0.0488 | 0.1497 | 1 |
Schistosoma mansoni | membrane-bound acyltransferase/hhat | 0.0092 | 0.0169 | 0.0202 |
Echinococcus multilocularis | 0.0644 | 0.2023 | 0.2925 | |
Echinococcus multilocularis | epidermal growth factor receptor | 0.1179 | 0.3817 | 0.5538 |
Echinococcus granulosus | lysophospholipid acyltransferase 7 | 0.0092 | 0.0169 | 0.0227 |
Toxoplasma gondii | eukaryotic initiation factor-2B, gamma subunit, putative | 0.0554 | 0.1721 | 1 |
Trypanosoma cruzi | glycerol uptake protein, putative | 0.0092 | 0.0169 | 0.0486 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.0488 | 0.1497 | 0.2159 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.0169 | 0.0245 |
Loa Loa (eye worm) | CMGC/CLK protein kinase | 0.0067 | 0.0086 | 0.0125 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 19, putative | 0.0067 | 0.0086 | 0.0197 |
Schistosoma mansoni | protein kinase | 0.0488 | 0.1497 | 0.2141 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.0259 | 0.0376 |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | 0.3023 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU | 0.3023 | 1 | 1 |
Echinococcus granulosus | epidermal growth factor receptor | 0.2093 | 0.6882 | 1 |
Brugia malayi | MBOAT family protein | 0.0092 | 0.0169 | 0.0202 |
Brugia malayi | MBOAT family protein | 0.0092 | 0.0169 | 0.0202 |
Schistosoma mansoni | tyrosine kinase | 0.1164 | 0.3764 | 0.545 |
Brugia malayi | Protein kinase domain containing protein | 0.0155 | 0.038 | 0.0511 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0092 | 0.0169 | 0.0945 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0014 | 0.0021 |
Loa Loa (eye worm) | MBOAT family protein | 0.0092 | 0.0169 | 0.0245 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.2093 | 0.6882 | 1 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.0488 | 0.1497 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.0149 | 0.0217 |
Plasmodium vivax | serine/threonine kinase-1, putative | 0.0067 | 0.0086 | 0.0383 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.005 | 0.003 | 0.0044 |
Trypanosoma cruzi | glycerol uptake protein, putative | 0.0092 | 0.0169 | 0.0486 |
Loa Loa (eye worm) | AUR protein kinase | 0.0488 | 0.1497 | 0.2176 |
Trypanosoma cruzi | GUP1, putative | 0.0092 | 0.0169 | 0.0486 |
Echinococcus multilocularis | cyclin dependent kinase 5 activator 1 | 0.0247 | 0.0691 | 0.0985 |
Loa Loa (eye worm) | hypothetical protein | 0.0247 | 0.0691 | 0.1004 |
Schistosoma mansoni | sterol O-acyltransferase 1 | 0.0938 | 0.3006 | 0.4344 |
Leishmania major | serine/threonine-protein kinase, putative,protein kinase, putative | 0.0095 | 0.018 | 0.0523 |
Echinococcus granulosus | protein cysteine N palmitoyltransferase | 0.0092 | 0.0169 | 0.0227 |
Trypanosoma cruzi | glycerol uptake protein, putative | 0.0092 | 0.0169 | 0.0486 |
Leishmania major | glycerol uptake protein, putative | 0.0092 | 0.0169 | 0.0486 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0488 | 0.1497 | 0.2141 |
Echinococcus multilocularis | o acyltransferase (membrane bound) domain | 0.0092 | 0.0169 | 0.0225 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0092 | 0.0169 | 0.0945 |
Schistosoma mansoni | tyrosine kinase | 0.0888 | 0.2841 | 0.4102 |
Echinococcus granulosus | dual specificity | 0.0095 | 0.018 | 0.0242 |
Schistosoma mansoni | cyclin-dependent kinase 5 activator | 0.0247 | 0.0691 | 0.0964 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0327 | 0.0475 |
Trypanosoma brucei | kinetoplastid kinetochore protein 10 | 0.0067 | 0.0086 | 0.0197 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 10, putative | 0.0067 | 0.0086 | 0.0197 |
Loa Loa (eye worm) | AUR protein kinase | 0.0488 | 0.1497 | 0.2176 |
Echinococcus multilocularis | protein cysteine N palmitoyltransferase | 0.0092 | 0.0169 | 0.0225 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0488 | 0.1497 | 0.2141 |
Leishmania major | hypothetical protein, conserved | 0.0092 | 0.0169 | 0.0486 |
Trypanosoma brucei | glycerol uptake protein, putative | 0.0092 | 0.0169 | 0.0486 |
Echinococcus multilocularis | diacylglycerol O acyltransferase 1 | 0.0092 | 0.0169 | 0.0225 |
Trypanosoma cruzi | aurora B kinase, putative | 0.0488 | 0.1497 | 0.5139 |
Entamoeba histolytica | protein kinase, putative | 0.0095 | 0.018 | 0.1018 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0888 | 0.2841 | 0.4117 |
Trypanosoma cruzi | GUP1, putative | 0.0092 | 0.0169 | 0.0486 |
Entamoeba histolytica | protein kinase, putative | 0.0488 | 0.1497 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0092 | 0.0169 | 0.0945 |
Entamoeba histolytica | vacuolar protein sorting 26 | 0.0092 | 0.0169 | 0.0945 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0095 | 0.018 | 0.1018 |
Trypanosoma brucei | mitogen-activated protein kinase 3, putative | 0.0901 | 0.2885 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0092 | 0.0169 | 0.0202 |
Schistosoma mansoni | tyrosine kinase | 0.1179 | 0.3817 | 0.5527 |
Leishmania major | glycerol uptake protein, putative | 0.0092 | 0.0169 | 0.0486 |
Trypanosoma brucei | aurora B kinase | 0.0488 | 0.1497 | 0.5139 |
Entamoeba histolytica | membrane-bound O-acyltransferase (MBOAT ) family protein | 0.0092 | 0.0169 | 0.0945 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0901 | 0.2885 | 0.418 |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.005 | 0.003 | 0.0025 |
Entamoeba histolytica | hypothetical protein | 0.0092 | 0.0169 | 0.0945 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0488 | 0.1497 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0488 | 0.1497 | 1 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK1 protein kinase | 0.0095 | 0.018 | 0.0261 |
Loa Loa (eye worm) | diacylglycerol acyltransferase | 0.0092 | 0.0169 | 0.0245 |
Trichomonas vaginalis | transmembrane protein nessy, putative | 0.0092 | 0.0169 | 0.0945 |
Toxoplasma gondii | cell-cycle-associated protein kinase CLK, putative | 0.0067 | 0.0086 | 0.0332 |
Loa Loa (eye worm) | hhat protein | 0.0092 | 0.0169 | 0.0245 |
Echinococcus multilocularis | membrane bound acyltransferase:hhat | 0.0092 | 0.0169 | 0.0225 |
Echinococcus multilocularis | dual specificity protein kinase clk2 | 0.0067 | 0.0086 | 0.0105 |
Leishmania major | protein kinase, putative | 0.0067 | 0.0086 | 0.0197 |
Leishmania major | protein kinase, putative | 0.0488 | 0.1497 | 0.5139 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.0095 | 0.018 | 0.0523 |
Trypanosoma brucei | glycerol uptake protein, putative | 0.0092 | 0.0169 | 0.0486 |
Trichomonas vaginalis | porcupine, putative | 0.0092 | 0.0169 | 0.0945 |
Echinococcus multilocularis | sterol O acyltransferase 1 | 0.0938 | 0.3006 | 0.4357 |
Schistosoma mansoni | o-acyltransferase (membrane bound) domain containing protein | 0.0092 | 0.0169 | 0.0202 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0056 | 0.0082 |
Loa Loa (eye worm) | MBOAT family protein | 0.0092 | 0.0169 | 0.0245 |
Entamoeba histolytica | hypothetical protein | 0.0095 | 0.018 | 0.1018 |
Toxoplasma gondii | aurora kinase | 0.0488 | 0.1497 | 0.8678 |
Toxoplasma gondii | hypothetical protein | 0.0092 | 0.0169 | 0.082 |
Echinococcus multilocularis | lysophospholipid acyltransferase 7 | 0.0092 | 0.0169 | 0.0225 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0481 | 0.1474 | 0.2107 |
Echinococcus granulosus | o acyltransferase membrane bound domain | 0.0092 | 0.0169 | 0.0227 |
Brugia malayi | Hhat protein | 0.0092 | 0.0169 | 0.0202 |
Schistosoma mansoni | o-acyltransferase (membrane bound) domain containing protein | 0.0092 | 0.0169 | 0.0202 |
Echinococcus granulosus | membrane bound acyltransferase:hhat | 0.0092 | 0.0169 | 0.0227 |
Brugia malayi | serine/threonine protein kinase 6 | 0.0488 | 0.1497 | 0.2141 |
Echinococcus multilocularis | Membrane bound O acyl transferase, MBOAT | 0.0092 | 0.0169 | 0.0225 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.