Detailed information for compound 808089

Basic information

Technical information
  • TDR Targets ID: 808089
  • Name: (4-phenylphenyl) methyl butanedioate
  • MW: 284.307 | Formula: C17H16O4
  • H donors: 0 H acceptors: 2 LogP: 3.06 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)CCC(=O)Oc1ccc(cc1)c1ccccc1
  • InChi: 1S/C17H16O4/c1-20-16(18)11-12-17(19)21-15-9-7-14(8-10-15)13-5-3-2-4-6-13/h2-10H,11-12H2,1H3
  • InChiKey: MSHPPRCEXZALPL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • butanedioic acid (4-phenylphenyl) ester methyl ester
  • succinic acid (4-phenylphenyl) ester methyl ester
  • ST040293
  • BIM-0014377.P001
  • CBMicro_014316
  • Oprea1_409674
  • AN-329/09394012
  • Oprea1_035444
  • ZINC00125244
  • ARONIS016835

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0056 0.0746 0.0746
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0043 0.0109
Echinococcus multilocularis GPCR, family 2 0.0016 0.0019 0.0048
Echinococcus granulosus Ankyrin 0.0015 0.0002 0.0006
Echinococcus multilocularis nuclear receptor nhr 48 0.0027 0.0214 0.0543
Echinococcus multilocularis thyroid hormone receptor alpha 0.0185 0.3035 0.7703
Brugia malayi hypothetical protein 0.0036 0.0378 0.0378
Brugia malayi nuclear receptor RXR 0.003 0.0271 0.0271
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0043 0.5
Onchocerca volvulus 0.0032 0.0301 0.1428
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0898 0.5
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0056 0.0746 0.0746
Loa Loa (eye worm) hypothetical protein 0.0027 0.0214 0.0214
Schistosoma mansoni hypothetical protein 0.0036 0.0378 0.1245
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0202 0.3349 0.3349
Brugia malayi secreted modular calcium-binding protein 1 0.0022 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0022 0.0123 0.0123
Brugia malayi sodium-independent organic anion transporter family protein 0.0032 0.0301 0.0301
Schistosoma mansoni hypothetical protein 0.0048 0.0596 0.1962
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0056 0.0746 0.1894
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0898 0.5
Schistosoma mansoni organic anion transporter 0.0032 0.0301 0.0992
Brugia malayi prostaglandin transporter 0.0032 0.0301 0.0301
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0043 0.5
Onchocerca volvulus Protein ultraspiracle homolog 0.0056 0.0746 0.3537
Brugia malayi tailless protein 0.0027 0.0214 0.0214
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0043 0.5
Schistosoma mansoni follistatin 0.0022 0.0123 0.0404
Loa Loa (eye worm) hypothetical protein 0.003 0.0271 0.0271
Brugia malayi hypothetical protein 0.003 0.0271 0.0271
Loa Loa (eye worm) hypothetical protein 0.0027 0.0214 0.0214
Schistosoma mansoni RAR-like nuclear receptor 0.0056 0.0746 0.2458
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0043 0.0043
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0043 0.5
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0127 0.2006 0.5092
Brugia malayi photoreceptor-specific nuclear receptor 0.0056 0.0746 0.0746
Schistosoma mansoni thyroid hormone receptor 0.0185 0.3035 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0043 0.0109
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0056 0.0746 0.0746
Schistosoma mansoni jun-related protein 0.0137 0.2192 0.7222
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0056 0.0746 0.1894
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0043 0.5
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.003 0.0271 0.0892
Loa Loa (eye worm) hypothetical protein 0.0027 0.0214 0.0214
Schistosoma mansoni thyroid hormone receptor 0.0185 0.3035 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0746 0.0746
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0022 0.0123 0.0123
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0043 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0043 0.5
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0056 0.0746 0.2458
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0022 0.0123 0.0123
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0271 0.0271
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0019
Echinococcus granulosus ecdysone induced protein 78C 0.0056 0.0746 0.1894
Trypanosoma cruzi cruzipain precursor, putative 0.0065 0.0898 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0056 0.0746 0.0746
Brugia malayi nuclear receptor NHR-88 0.0056 0.0746 0.0746
Schistosoma mansoni hypothetical protein 0.0128 0.2027 0.668
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0027 0.0214 0.0214
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0043 0.5
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.003 0.0271 0.0271
Schistosoma mansoni organic anion transporter 0.0032 0.0301 0.0992
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0043 0.0204
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0043 0.5
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.003 0.0271 0.0687
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0043 0.0142
Loa Loa (eye worm) hypothetical protein 0.0034 0.0344 0.0344
Echinococcus granulosus Nuclear hormone receptor HR96 0.0027 0.0214 0.0543
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0056 0.0746 0.0746
Loa Loa (eye worm) hypothetical protein 0.0022 0.0123 0.0123
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0056 0.0746 0.3537
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0056 0.0746 0.1894
Loa Loa (eye worm) hypothetical protein 0.0027 0.0214 0.0214
Toxoplasma gondii transporter, major facilitator family protein 0.0032 0.0301 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0301 0.0301
Echinococcus multilocularis Ankyrin 0.0015 0.0002 0.0006
Echinococcus multilocularis FTZ F1 alpha 0.0056 0.0746 0.1894
Schistosoma mansoni nuclear receptor 0.0027 0.0214 0.0705
Onchocerca volvulus Bile acid receptor homolog 0.0056 0.0746 0.3537
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0019 0.0019
Echinococcus multilocularis cysteine protease 0.0017 0.0043 0.0109
Schistosoma mansoni hypothetical protein 0.0016 0.0019 0.0062
Echinococcus granulosus Solute carrier organic anion transporter family 0.0032 0.0301 0.0764
Onchocerca volvulus Putative organic anion transporter 0.0032 0.0301 0.1428
Echinococcus granulosus Nuclear hormone receptor HR96 0.0027 0.0214 0.0543
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0056 0.0746 0.0746
Brugia malayi nuclear receptor RXR 0.0027 0.0214 0.0214
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0027 0.0214 0.1014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0898 0.5
Loa Loa (eye worm) nuclear hormone receptor 0.0027 0.0214 0.0214
Entamoeba histolytica hypothetical protein 0.0036 0.0378 1
Entamoeba histolytica hypothetical protein 0.0036 0.0378 1
Onchocerca volvulus Putative organic anion transporter 0.0032 0.0301 0.1428
Onchocerca volvulus 0.0017 0.0043 0.0204
Echinococcus multilocularis cysteine protease 0.0017 0.0043 0.0109
Loa Loa (eye worm) hypothetical protein 0.003 0.0271 0.0271
Schistosoma mansoni steroid hormone receptor ad4bp 0.0056 0.0746 0.2458
Echinococcus granulosus cathepsin l1 0.0017 0.0043 0.0109
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.0214 0.0543
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0027 0.0214 0.0705
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0043 0.0109
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0157 0.2538 0.6443
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0056 0.0746 0.2458
Leishmania major cathepsin L-like protease 0.0065 0.0898 1
Echinococcus granulosus agrin 0.0022 0.0123 0.0311
Loa Loa (eye worm) hypothetical protein 0.0032 0.0301 0.0301
Loa Loa (eye worm) hypothetical protein 0.0575 1 1
Brugia malayi Nuclear hormone receptor E75 0.0027 0.0214 0.0214
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0043 0.0109
Loa Loa (eye worm) hypothetical protein 0.0164 0.2674 0.2674
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0043 0.5
Brugia malayi steroid hormone receptor 0.0056 0.0746 0.0746
Brugia malayi hypothetical protein 0.0027 0.0214 0.0214
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0056 0.0746 0.0746
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0056 0.0746 0.2458
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0043 0.5
Loa Loa (eye worm) cysteine protease 0.0017 0.0043 0.0043
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0898 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0043 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0056 0.0746 0.0746
Loa Loa (eye worm) hypothetical protein 0.0027 0.0214 0.0214
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0056 0.0746 0.0746
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0056 0.0746 0.0746
Schistosoma mansoni nuclear receptor nhr-48 0.0027 0.0214 0.0705
Brugia malayi nuclear receptor NHR-88 0.0027 0.0214 0.0214
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0624 0.0624
Loa Loa (eye worm) hypothetical protein 0.0032 0.0301 0.0301
Echinococcus granulosus nuclear receptor nhr 48 0.0027 0.0214 0.0543
Loa Loa (eye worm) hypothetical protein 0.0027 0.0214 0.0214
Entamoeba histolytica hypothetical protein 0.0036 0.0378 1
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0043 0.0043
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0624 0.0624
Plasmodium vivax vivapain-2 0.0017 0.0043 0.5
Onchocerca volvulus Putative organic anion transporter 0.0032 0.0301 0.1428
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0043 0.5
Loa Loa (eye worm) DR-78 0.0027 0.0214 0.0214
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0032 0.0301 0.0764
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0056 0.0746 0.1894
Brugia malayi nuclear hormone receptor 0.0056 0.0746 0.0746
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0043 0.0204
Brugia malayi hypothetical protein 0.0027 0.0214 0.0214
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0.000000015154 0.000000038465
Brugia malayi Cathepsin L-like precursor 0.0017 0.0043 0.0043
Brugia malayi Cathepsin L-like precursor 0.0017 0.0043 0.0043
Loa Loa (eye worm) nuclear receptor NHR-67 0.0027 0.0214 0.0214
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0056 0.0746 0.0746
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0056 0.0746 0.1894
Brugia malayi Steroid receptor seven-up type 2 0.0056 0.0746 0.0746
Loa Loa (eye worm) hypothetical protein 0.003 0.0271 0.0271
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0056 0.0746 0.2458
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0056 0.0746 0.1894
Brugia malayi Protein kinase domain containing protein 0.0015 0.000000015154 0.000000015154
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0022 0.0123 0.0123
Onchocerca volvulus 0.0017 0.0043 0.0204
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0168 0.2743 0.6963
Schistosoma mansoni hypothetical protein 0.0016 0.0019 0.0062
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0898 0.5
Plasmodium vivax vivapain-2 0.0017 0.0043 0.5
Entamoeba histolytica hypothetical protein 0.0036 0.0378 1
Schistosoma mansoni hypothetical protein 0.0034 0.0344 0.1134
Loa Loa (eye worm) hypothetical protein 0.0027 0.0214 0.0214
Loa Loa (eye worm) hypothetical protein 0.0202 0.3349 0.3349
Brugia malayi Nuclear hormone receptor E75 0.0027 0.0214 0.0214
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0169 0.2757 0.6998
Brugia malayi conserved hypotetical protein 0.0027 0.0214 0.0214
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0898 0.5
Onchocerca volvulus 0.0032 0.0301 0.1428
Loa Loa (eye worm) hypothetical protein 0.0032 0.0301 0.0301
Loa Loa (eye worm) hypothetical protein 0.0027 0.0214 0.0214
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0019 0.0019
Schistosoma mansoni hypothetical protein 0.0137 0.2192 0.7222
Brugia malayi Cathepsin L-like precursor 0.0017 0.0043 0.0043
Brugia malayi ecdysteroid receptor 0.0056 0.0746 0.0746
Schistosoma mansoni hypothetical protein 0.0016 0.0019 0.0062
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0027 0.0214 0.0705
Loa Loa (eye worm) hypothetical protein 0.0027 0.0214 0.0214
Loa Loa (eye worm) hypothetical protein 0.003 0.0271 0.0271
Loa Loa (eye worm) hypothetical protein 0.0056 0.0746 0.0746
Schistosoma mansoni nuclear hormone receptor 0.0027 0.0214 0.0705
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0056 0.0746 0.0746
Loa Loa (eye worm) hypothetical protein 0.0027 0.0214 0.0214
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0043 0.0109
Schistosoma mansoni ankyrin 23/unc44 0.0015 0.000000015154 0.000000049937
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0056 0.0746 0.0746
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.065 0.7098
Onchocerca volvulus 0.0032 0.0301 0.1428
Loa Loa (eye worm) hypothetical protein 0.0032 0.0301 0.0301
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0.000000015154 0.000000038465
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0056 0.0746 0.2458
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.0798 0.8824
Schistosoma mansoni zinc finger protein 0.0027 0.0214 0.0705
Brugia malayi hypothetical protein 0.0133 0.2109 0.2109
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0056 0.0746 0.1894
Brugia malayi sodium-independent organic anion transporter family protein 0.0032 0.0301 0.0301
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0027 0.0214 0.0543
Loa Loa (eye worm) agrin synaptic family protein 0.0022 0.0123 0.0123
Echinococcus granulosus follistatin 0.0022 0.0123 0.0311
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0271 0.0271
Loa Loa (eye worm) fibroinase 0.0017 0.0043 0.0043
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0043 0.5
Loa Loa (eye worm) steroid hormone receptor 0.0056 0.0746 0.0746
Trypanosoma cruzi MFS transporter, putative 0.0032 0.0301 0.3017
Loa Loa (eye worm) hypothetical protein 0.0027 0.0214 0.0214
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0019 0.0048
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0596 0.0596
Loa Loa (eye worm) hypothetical protein 0.0017 0.0043 0.0043
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0056 0.0746 0.1894
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0056 0.0746 0.0746
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0022 0.0123 0.0123
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0056 0.0746 0.0746
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0043 0.5
Brugia malayi sodium-independent organic anion transporter family protein 0.0032 0.0301 0.0301
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0043 0.0142
Onchocerca volvulus 0.0017 0.0043 0.0204
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0378 0.1245
Echinococcus granulosus jun protein 0.0169 0.2757 0.6998
Onchocerca volvulus 0.0027 0.0214 0.1014
Loa Loa (eye worm) hypothetical protein 0.0056 0.0746 0.0746
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0019 0.0048
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0898 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0746 0.0746
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0378 0.0959
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0022 0.0123 0.3086
Loa Loa (eye worm) hypothetical protein 0.0027 0.0214 0.0214
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0032 0.0301 0.0764
Echinococcus multilocularis follistatin 0.0022 0.0123 0.0311
Echinococcus granulosus GPCR family 2 0.0016 0.0019 0.0048
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0898 0.5
Onchocerca volvulus 0.0017 0.0043 0.0204
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0043 0.5
Loa Loa (eye worm) hypothetical protein 0.0056 0.0746 0.0746
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0056 0.0746 0.0746
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0056 0.0746 0.0746
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0032 0.0301 0.0301
Echinococcus multilocularis jun protein 0.0169 0.2757 0.6998
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0027 0.0214 0.1014
Onchocerca volvulus 0.0027 0.0214 0.1014
Loa Loa (eye worm) hypothetical protein 0.0235 0.394 0.394
Brugia malayi orphan nuclear receptor NR2E1 0.0027 0.0214 0.0214
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.003 0.0271 0.0687
Leishmania major cathepsin L-like protease 0.0065 0.0898 1
Brugia malayi nuclear receptor NHR-67 0.0027 0.0214 0.0214
Toxoplasma gondii protease inhibitor PI2 0.0022 0.0123 0.3086
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0075 0.1077 0.2735
Brugia malayi Cathepsin L-like precursor 0.0017 0.0043 0.0043
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0344 0.0344
Brugia malayi Nuclear hormone receptor-like 1 0.0056 0.0746 0.0746
Loa Loa (eye worm) hypothetical protein 0.0056 0.0746 0.0746
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0056 0.0746 0.2458
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0043 0.5
Schistosoma mansoni nuclear receptor 0.0027 0.0214 0.0705
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0043 0.5
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0043 0.5
Brugia malayi nuclear hormone receptor family member odr-7 0.0027 0.0214 0.0214
Echinococcus granulosus survival motor neuron protein 1 0.0235 0.394 1
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0022 0.0123 0.3086
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0032 0.0301 0.0764
Schistosoma mansoni survival motor neuron protein 0.0048 0.0596 0.1962
Echinococcus multilocularis ecdysone induced protein 78C 0.0056 0.0746 0.1894
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0056 0.0746 0.1894
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0056 0.0746 0.0746
Schistosoma mansoni nuclear hormone receptor 0.0056 0.0746 0.2458
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0898 0.5
Onchocerca volvulus 0.0017 0.0043 0.0204
Loa Loa (eye worm) hypothetical protein 0.003 0.0271 0.0271
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0169 0.2757 0.6998
Brugia malayi hypothetical protein 0.0032 0.0301 0.0301
Brugia malayi nuclear hormone receptor 0.0027 0.0214 0.0214
Loa Loa (eye worm) hypothetical protein 0.0056 0.0746 0.0746
Brugia malayi Cathepsin L-like precursor 0.0017 0.0043 0.0043
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0898 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0056 0.0746 0.1894
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0043 0.5
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0168 0.2743 0.6963
Leishmania major cathepsin L-like protease 0.0065 0.0898 1
Brugia malayi hypothetical protein 0.0032 0.0301 0.0301
Brugia malayi ecdysone receptor 0.0027 0.0214 0.0214
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0027 0.0214 0.0543
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0128 0.2027 0.5146
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0271 0.0892
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0043 0.5
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0056 0.0746 0.0746
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0019 0.0019
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0027 0.0214 0.0543
Echinococcus granulosus thyroid hormone receptor alpha 0.0027 0.0214 0.0543
Echinococcus multilocularis expressed protein 0.0022 0.0123 0.0311
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0056 0.0746 0.0746
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0043 0.5
Echinococcus granulosus nuclear factor of activated T cells 5 0.0075 0.1077 0.2735
Onchocerca volvulus 0.0022 0.0123 0.0582
Brugia malayi hypothetical protein 0.0235 0.394 0.394
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0022 0.0123 0.0123
Loa Loa (eye worm) STAT protein 0.0329 0.5611 0.5611
Loa Loa (eye worm) hypothetical protein 0.0056 0.0746 0.0746
Brugia malayi follicle stimulating hormone receptor 0.0236 0.3949 0.3949
Onchocerca volvulus 0.0017 0.0043 0.0204
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0027 0.0214 0.0543
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0043 0.0109
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0043 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0043 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0043 0.5
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0378 0.0959
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0022 0.0123 0.3086
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0022 0.0123 0.3086
Echinococcus multilocularis survival motor neuron protein 1 0.0235 0.394 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0056 0.0746 0.1894
Brugia malayi Uncoordinated protein 44 0.0015 0.000000015154 0.000000015154
Brugia malayi bZIP transcription factor family protein 0.0169 0.2757 0.2757
Loa Loa (eye worm) hypothetical protein 0.0032 0.0301 0.0301
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0898 0.5
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0236 0.3949 0.3949
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0898 0.5
Schistosoma mansoni coup transcription factor 0.0056 0.0746 0.2458
Schistosoma mansoni nuclear hormone receptor 0.0027 0.0214 0.0705
Brugia malayi Death domain containing protein 0.0015 0.000000015154 0.000000015154
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0032 0.0301 0.0301
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0128 0.2027 0.5146
Brugia malayi STAT protein, DNA binding domain containing protein 0.0329 0.5611 0.5611
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0898 0.5
Schistosoma mansoni retinoic acid receptor RXR 0.0157 0.2538 0.8364
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0898 1
Schistosoma mansoni hypothetical protein 0.0016 0.0019 0.0062
Onchocerca volvulus 0.0032 0.0301 0.1428
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0056 0.0746 0.1894
Loa Loa (eye worm) hypothetical protein 0.0022 0.0123 0.0123
Echinococcus granulosus FTZ F1 alpha 0.0056 0.0746 0.1894
Loa Loa (eye worm) hypothetical protein 0.0022 0.0123 0.0123
Onchocerca volvulus 0.0133 0.2109 1
Echinococcus multilocularis agrin 0.0022 0.0123 0.0311
Onchocerca volvulus 0.0032 0.0301 0.1428
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0043 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0043 0.5
Schistosoma mansoni agrin 0.0022 0.0123 0.0404
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.0214 0.0543
Brugia malayi SPARC precursor 0.0022 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0027 0.0214 0.0214
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0027 0.0214 0.0214
Brugia malayi Cathepsin L-like precursor 0.0017 0.0043 0.0043
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0043 0.0204
Onchocerca volvulus 0.0017 0.0043 0.0204
Brugia malayi hypothetical protein 0.003 0.0271 0.0271
Onchocerca volvulus 0.0056 0.0746 0.3537
Onchocerca volvulus 0.0048 0.0596 0.2824
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0043 0.0043
Loa Loa (eye worm) ctsf protein 0.0017 0.0043 0.0043
Brugia malayi nuclear hormone receptor family member nhr-6 0.0027 0.0214 0.0214
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0043 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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