Detailed information for compound 81281

Basic information

Technical information
  • TDR Targets ID: 81281
  • Name: 5-(2-imidazol-1-ylethyl)-5,6,7,8-tetrahydroqu inoline
  • MW: 227.305 | Formula: C14H17N3
  • H donors: 0 H acceptors: 2 LogP: 1.95 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: c1cnc2c(c1)C(CCC2)CCn1cncc1
  • InChi: 1S/C14H17N3/c1-3-12(6-9-17-10-8-15-11-17)13-4-2-7-16-14(13)5-1/h2,4,7-8,10-12H,1,3,5-6,9H2
  • InChiKey: VPDLANZEXFQJSQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-[2-(1-imidazolyl)ethyl]-5,6,7,8-tetrahydroquinoline

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cytochrome P450, family 19, subfamily A, polypeptide 1 Starlite/ChEMBL References
Homo sapiens thromboxane A synthase 1 (platelet) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi cytochrome P450, putative cytochrome P450, family 19, subfamily A, polypeptide 1 503 aa 425 aa 18.8 %
Trypanosoma brucei cytochrome P450, putative thromboxane A synthase 1 (platelet) 534 aa 498 aa 21.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis orexin receptor type 2 0.014 0.0852 0.1506
Schistosoma mansoni neuropeptide F-like receptor 0.014 0.0852 0.3048
Loa Loa (eye worm) hypothetical protein 0.0056 0.0199 0.0199
Schistosoma mansoni adenoreceptor 0.014 0.0852 0.3048
Onchocerca volvulus Neuropeptide F receptor homolog 0.014 0.0852 0.0848
Brugia malayi hypothetical protein 0.017 0.108 0.1076
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.014 0.0852 0.1506
Echinococcus multilocularis rhodopsin orphan GPCR 0.014 0.0852 0.1506
Onchocerca volvulus 0.014 0.0852 0.0848
Loa Loa (eye worm) hypothetical protein 0.014 0.0852 0.0852
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0056 0.0199 0.0195
Loa Loa (eye worm) hypothetical protein 0.0054 0.0188 0.0188
Echinococcus granulosus thyrotropin releasing hormone receptor 0.014 0.0852 0.0919
Echinococcus multilocularis thyroid hormone receptor alpha 0.0054 0.0188 0.0327
Brugia malayi ecdysteroid receptor 0.0054 0.0188 0.0184
Echinococcus multilocularis ecdysone induced protein 78C 0.0054 0.0188 0.0327
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.017 0.108 0.1912
Loa Loa (eye worm) hypothetical protein 0.014 0.0852 0.0852
Brugia malayi hypoxia-induced factor 1 0.017 0.1086 0.1082
Echinococcus granulosus regulator of G protein signaling 3 0.0039 0.0069 0.0071
Loa Loa (eye worm) hypothetical protein 0.017 0.108 0.108
Onchocerca volvulus 0.0432 0.3108 0.3105
Echinococcus granulosus neuropeptide receptor 0.014 0.0852 0.0919
Echinococcus granulosus 7tm_1 domain containing protein 0.014 0.0852 0.0919
Onchocerca volvulus 0.014 0.0852 0.0848
Entamoeba histolytica hypothetical protein 0.0039 0.0069 0.5
Loa Loa (eye worm) hypothetical protein 0.0039 0.0069 0.0069
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.014 0.0852 0.1506
Onchocerca volvulus 0.014 0.0852 0.0848
Echinococcus multilocularis rhodopsin orphan GPCR 0.014 0.0852 0.1506
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0054 0.0188 0.0184
Brugia malayi nuclear hormone receptor 0.0054 0.0188 0.0184
Schistosoma mansoni rhodopsin-like orphan GPCR 0.014 0.0852 0.3048
Echinococcus multilocularis G protein coupled receptor 139 0.014 0.0852 0.1506
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.014 0.0852 0.1506
Loa Loa (eye worm) hypothetical protein 0.017 0.108 0.108
Echinococcus granulosus tm gpcr rhodopsin 0.014 0.0852 0.0919
Brugia malayi Regulator of G protein signaling domain containing protein 0.0039 0.0069 0.0065
Echinococcus multilocularis fmrfamide receptor 0.014 0.0852 0.1506
Loa Loa (eye worm) hypothetical protein 0.0039 0.0069 0.0069
Schistosoma mansoni neuropeptide F-like receptor 0.014 0.0852 0.3048
Brugia malayi Serotonin receptor 0.014 0.0852 0.0848
Onchocerca volvulus 0.014 0.0852 0.0848
Onchocerca volvulus Putative organic anion transporter 0.017 0.108 0.1076
Echinococcus multilocularis axis inhibition protein axin 0.0039 0.0069 0.0116
Echinococcus multilocularis Protein lozenge 0.0054 0.0187 0.0325
Brugia malayi Tachykinin-like peptides receptor 99D 0.014 0.0852 0.0848
Loa Loa (eye worm) hypothetical protein 0.014 0.0852 0.0852
Echinococcus granulosus mitogen activated protein kinase 0.0118 0.068 0.0732
Echinococcus granulosus sex peptide receptor 0.014 0.0852 0.0919
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.014 0.0852 0.0852
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.014 0.0852 0.3048
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0056 0.0199 0.0195
Schistosoma mansoni biogenic amine (5HT) receptor 0.014 0.0852 0.3048
Brugia malayi G-protein coupled receptor 0.014 0.0852 0.0848
Schistosoma mansoni axis inhibition protein axin 0.0039 0.0069 0.0234
Brugia malayi Dopamine receptor protein 2 0.014 0.0852 0.0848
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0054 0.0188 0.0661
Schistosoma mansoni biogenic amine receptor 0.014 0.0852 0.3048
Echinococcus granulosus somatostatin receptor 0.014 0.0852 0.0919
Brugia malayi Cytochrome P450 family protein 0.0034 0.0032 0.0028
Brugia malayi putative neuropeptide receptor 0.014 0.0852 0.0848
Brugia malayi Regulator of G protein signaling domain containing protein 0.0039 0.0069 0.0065
Echinococcus multilocularis regulator of G protein signaling 0.0039 0.0069 0.0116
Loa Loa (eye worm) hypothetical protein 0.0054 0.0188 0.0188
Brugia malayi larval opioid receptor 0.014 0.0852 0.0848
Loa Loa (eye worm) hypothetical protein 0.014 0.0852 0.0852
Schistosoma mansoni rhodopsin-like orphan GPCR 0.014 0.0852 0.3048
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.014 0.0852 0.1506
Brugia malayi A-kinase anchor protein 10, precursor 0.0039 0.0069 0.0065
Loa Loa (eye worm) hypothetical protein 0.0056 0.0199 0.0199
Brugia malayi neuropeptide F receptor 0.014 0.0852 0.0848
Echinococcus granulosus 7TM GPCR rhodopsin 0.014 0.0852 0.0919
Loa Loa (eye worm) hypothetical protein 0.0432 0.3108 0.3108
Loa Loa (eye worm) sodium-independent organic anion transporter 0.017 0.108 0.108
Trichomonas vaginalis CMGC family protein kinase 0.0118 0.068 1
Brugia malayi hypothetical protein 0.017 0.108 0.1076
Loa Loa (eye worm) hypothetical protein 0.014 0.0852 0.0852
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0118 0.068 1
Schistosoma mansoni aryl hydrocarbon receptor 0.0055 0.0194 0.0682
Brugia malayi G-protein coupled receptor 0.014 0.0852 0.0848
Brugia malayi regulator of G-protein signaling rgs-7 0.0039 0.0069 0.0065
Loa Loa (eye worm) hypothetical protein 0.014 0.0852 0.0852
Entamoeba histolytica hypothetical protein 0.0039 0.0069 0.5
Brugia malayi AKH receptor 0.014 0.0852 0.0848
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.014 0.0852 0.1506
Loa Loa (eye worm) hypothetical protein 0.014 0.0852 0.0852
Echinococcus multilocularis tachykinin peptides receptor 99D 0.014 0.0852 0.1506
Echinococcus multilocularis rhodopsin orphan GPCR 0.014 0.0852 0.1506
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0226 0.0394
Echinococcus multilocularis g protein coupled receptor 0.014 0.0852 0.1506
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0039 0.0069 0.0234
Loa Loa (eye worm) hypothetical protein 0.014 0.0852 0.0852
Echinococcus multilocularis g protein coupled receptor 0.014 0.0852 0.1506
Schistosoma mansoni organic anion transporter 0.017 0.108 0.387
Echinococcus granulosus neuropeptides capa receptor 0.014 0.0852 0.0919
Echinococcus multilocularis serotonin receptor 0.014 0.0852 0.1506
Loa Loa (eye worm) hypothetical protein 0.014 0.0852 0.0852
Schistosoma mansoni biogenic amine receptor 0.014 0.0852 0.3048
Brugia malayi gonadotropin-releasing hormone receptor 2 0.014 0.0852 0.0848
Trichomonas vaginalis CMGC family protein kinase 0.0118 0.068 1
Echinococcus granulosus hypothetical protein 0.014 0.0852 0.0919
Brugia malayi Steroid receptor seven-up type 2 0.0054 0.0188 0.0184
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0004 0.0004
Brugia malayi G protein-coupled receptor F59B2.13 0.014 0.0852 0.0848
Echinococcus multilocularis g protein coupled receptor 0.014 0.0852 0.1506
Schistosoma mansoni peptide (allatostatin)-like receptor 0.014 0.0852 0.3048
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0054 0.0188 0.0327
Loa Loa (eye worm) hypothetical protein 0.014 0.0852 0.0852
Loa Loa (eye worm) hypothetical protein 0.014 0.0852 0.0852
Brugia malayi hypothetical protein 0.014 0.0852 0.0848
Schistosoma mansoni amine GPCR 0.014 0.0852 0.3048
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0054 0.0188 0.0184
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0054 0.0188 0.0199
Loa Loa (eye worm) hypothetical protein 0.014 0.0852 0.0852
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0069 0.0234
Schistosoma mansoni opsin-like receptor 0.014 0.0852 0.3048
Loa Loa (eye worm) hypothetical protein 0.014 0.0852 0.0852
Onchocerca volvulus 0.014 0.0852 0.0848
Onchocerca volvulus Putative organic anion transporter 0.1324 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.014 0.0852 0.0919
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0054 0.0188 0.0188
Brugia malayi ORL1-like opioid receptor 0.014 0.0852 0.0848
Loa Loa (eye worm) hypothetical protein 0.0054 0.0188 0.0188
Schistosoma mansoni RAR-like nuclear receptor 0.0054 0.0188 0.0661
Echinococcus granulosus biogenic amine 5HT receptor 0.014 0.0852 0.0919
Loa Loa (eye worm) hypothetical protein 0.0054 0.0188 0.0188
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0069 0.0234
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0054 0.0188 0.0184
Brugia malayi hypothetical protein 0.014 0.0852 0.0848
Schistosoma mansoni lozenge 0.0054 0.0187 0.0658
Echinococcus multilocularis allatostatin A receptor 0.014 0.0852 0.1506
Echinococcus granulosus follistatin 0.0056 0.0199 0.0211
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0054 0.0188 0.0188
Echinococcus granulosus ecdysone induced protein 78C 0.0054 0.0188 0.0199
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0039 0.0069 0.0234
Echinococcus granulosus regulator of G protein signaling 7 0.0039 0.0069 0.0071
Schistosoma mansoni axis inhibition protein axin 0.0039 0.0069 0.0234
Echinococcus granulosus g protein coupled receptor 0.014 0.0852 0.0919
Echinococcus multilocularis rhodopsin orphan GPCR 0.014 0.0852 0.1506
Loa Loa (eye worm) hypothetical protein 0.014 0.0852 0.0852
Echinococcus multilocularis fmrfamide receptor 0.014 0.0852 0.1506
Echinococcus granulosus rhodopsin orphan GPCR 0.014 0.0852 0.0919
Loa Loa (eye worm) hypothetical protein 0.014 0.0852 0.0852
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0004 0.0004
Brugia malayi hypothetical protein 0.014 0.0852 0.0848
Echinococcus granulosus rhodopsin orphan GPCR 0.014 0.0852 0.0919
Loa Loa (eye worm) hypothetical protein 0.0031 0.0004 0.0004
Echinococcus granulosus agrin 0.0056 0.0199 0.0211
Brugia malayi bHLH-PAS transcription factor 0.0041 0.0083 0.0079
Echinococcus granulosus allatostatin A receptor 0.014 0.0852 0.0919
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0056 0.0199 0.0195
Onchocerca volvulus 0.017 0.108 0.1076
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0054 0.0188 0.0184
Loa Loa (eye worm) hypothetical protein 0.0432 0.3108 0.3108
Echinococcus granulosus neuropeptide Y receptor 0.014 0.0852 0.0919
Trypanosoma cruzi MFS transporter, putative 0.017 0.108 1
Schistosoma mansoni thyroid hormone receptor 0.0054 0.0188 0.0661
Schistosoma mansoni neuropeptide receptor 0.014 0.0852 0.3048
Schistosoma mansoni amine GPCR 0.014 0.0852 0.3048
Loa Loa (eye worm) hypothetical protein 0.0054 0.0188 0.0188
Trichomonas vaginalis CMGC family protein kinase 0.0118 0.068 1
Onchocerca volvulus 0.014 0.0852 0.0848
Loa Loa (eye worm) agrin synaptic family protein 0.0056 0.0199 0.0199
Loa Loa (eye worm) hypoxia-induced factor 1 0.017 0.1086 0.1086
Echinococcus granulosus Solute carrier family 22 5 0.1224 0.923 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.014 0.0852 0.0848
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.014 0.0852 0.1506
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0054 0.0188 0.0661
Brugia malayi photoreceptor-specific nuclear receptor 0.0054 0.0188 0.0184
Echinococcus multilocularis rhodopsin orphan GPCR 0.014 0.0852 0.1506
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.014 0.0852 0.3048
Echinococcus granulosus tm gpcr rhodopsin 0.014 0.0852 0.0919
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.014 0.0852 0.0919
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.004 0.0078 0.0078
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0069 0.0234
Brugia malayi regulator of G-protein signaling egl-10 0.0039 0.0069 0.0065
Brugia malayi hypothetical protein 0.014 0.0852 0.0848
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0226 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0054 0.0188 0.0327
Onchocerca volvulus 0.014 0.0852 0.0848
Echinococcus granulosus g protein coupled receptor 0.014 0.0852 0.0919
Schistosoma mansoni rhodopsin-like orphan GPCR 0.014 0.0852 0.3048
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0054 0.0188 0.0184
Onchocerca volvulus 0.014 0.0852 0.0848
Loa Loa (eye worm) G-protein coupled receptor 0.014 0.0852 0.0852
Loa Loa (eye worm) hypothetical protein 0.014 0.0852 0.0852
Loa Loa (eye worm) hypothetical protein 0.014 0.0852 0.0852
Echinococcus multilocularis beta adrenergic receptor kinase 0.004 0.0078 0.013
Loa Loa (eye worm) neuropeptide F receptor 0.014 0.0852 0.0852
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0226 0.5
Echinococcus granulosus G protein coupled receptor 139 0.014 0.0852 0.0919
Schistosoma mansoni hypothetical protein 0.014 0.0852 0.3048
Schistosoma mansoni steroid hormone receptor ad4bp 0.0054 0.0188 0.0661
Loa Loa (eye worm) hypothetical protein 0.0056 0.0199 0.0199
Loa Loa (eye worm) melatonin receptor type 1A 0.014 0.0852 0.0852
Onchocerca volvulus Putative organic anion transporter 0.017 0.108 0.1076
Loa Loa (eye worm) hypothetical protein 0.014 0.0852 0.0852
Brugia malayi putative neuropeptide receptor NPR1 0.014 0.0852 0.0848
Echinococcus multilocularis axis inhibition protein axin 0.0039 0.0069 0.0116
Echinococcus granulosus rhodopsin orphan GPCR 0.014 0.0852 0.0919
Echinococcus granulosus tachykinin peptides receptor 99D 0.014 0.0852 0.0919
Schistosoma mansoni neuropeptide receptor 0.014 0.0852 0.3048
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0054 0.0188 0.0327
Loa Loa (eye worm) hypothetical protein 0.014 0.0852 0.0852
Onchocerca volvulus 0.017 0.108 0.1076
Loa Loa (eye worm) hypothetical protein 0.0039 0.0069 0.0069
Giardia lamblia Kinase, CMGC MAPK 0.0118 0.068 0.5
Loa Loa (eye worm) hypothetical protein 0.014 0.0852 0.0852
Echinococcus multilocularis neuropeptides capa receptor 0.014 0.0852 0.1506
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.014 0.0852 0.0919
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0226 0.0798
Schistosoma mansoni retinoic acid receptor RXR 0.0054 0.0188 0.0661
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0673 0.4968 0.4968
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0054 0.0188 0.0184
Onchocerca volvulus 0.0054 0.0188 0.0184
Onchocerca volvulus 0.014 0.0852 0.0848
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.014 0.0852 0.1506
Schistosoma mansoni amine GPCR 0.014 0.0852 0.3048
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0054 0.0188 0.0199
Brugia malayi hypothetical protein 0.0185 0.1197 0.1193
Brugia malayi hypothetical protein 0.014 0.0852 0.0848
Schistosoma mansoni growth hormone secretagogue receptor 0.014 0.0852 0.3048
Echinococcus multilocularis neuropeptide receptor A26 0.014 0.0852 0.1506
Brugia malayi hypothetical protein 0.014 0.0852 0.0848
Brugia malayi sulfakinin receptor protein 0.014 0.0852 0.0848
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0054 0.0188 0.0184
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.014 0.0852 0.3048
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.014 0.0852 0.3048
Schistosoma mansoni histamine h1 receptor 0.014 0.0852 0.3048
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.014 0.0852 0.3048
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0054 0.0188 0.0199
Schistosoma mansoni z-protein (S1r protein) 0.0039 0.0069 0.0234
Onchocerca volvulus 0.014 0.0852 0.0848
Echinococcus multilocularis sex peptide receptor 0.014 0.0852 0.1506
Echinococcus multilocularis alpha 1A adrenergic receptor 0.014 0.0852 0.1506
Loa Loa (eye worm) hypothetical protein 0.1324 1 1
Schistosoma mansoni nuclear hormone receptor 0.0054 0.0188 0.0661
Echinococcus granulosus biogenic amine 5HT receptor 0.014 0.0852 0.0919
Echinococcus multilocularis biogenic amine (5HT) receptor 0.014 0.0852 0.1506
Loa Loa (eye worm) hypothetical protein 0.014 0.0852 0.0852
Onchocerca volvulus 0.014 0.0852 0.0848
Echinococcus multilocularis rhodopsin orphan GPCR 0.014 0.0852 0.1506
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.014 0.0852 0.0848
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.0032 0.0032
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.014 0.0852 0.1506
Schistosoma mansoni hypothetical protein 0.014 0.0852 0.3048
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0054 0.0188 0.0661
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0056 0.0199 0.0195
Echinococcus granulosus regulator of G protein signaling 7 0.0039 0.0069 0.0071
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.014 0.0852 0.0848
Loa Loa (eye worm) hypothetical protein 0.014 0.0852 0.0852
Echinococcus multilocularis FTZ F1 alpha 0.0054 0.0188 0.0327
Echinococcus granulosus neuropeptide s receptor 0.014 0.0852 0.0919
Echinococcus granulosus neuropeptide FF receptor 2 0.014 0.0852 0.0919
Brugia malayi nuclear receptor NHR-88 0.0054 0.0188 0.0184
Echinococcus multilocularis Regulator of G protein signaling 20 0.0039 0.0069 0.0116
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0054 0.0188 0.0327
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.014 0.0852 0.0919
Schistosoma mansoni rhodopsin-like orphan GPCR 0.014 0.0852 0.3048
Loa Loa (eye worm) hypothetical protein 0.014 0.0852 0.0852
Echinococcus granulosus dro:myosuppressin receptor 0.014 0.0852 0.0919
Loa Loa (eye worm) hypothetical protein 0.014 0.0852 0.0852
Onchocerca volvulus 0.017 0.108 0.1076
Schistosoma mansoni amine GPCR 0.014 0.0852 0.3048
Echinococcus granulosus fmrfamide receptor 0.014 0.0852 0.0919
Echinococcus granulosus mitogen activated protein kinase 3 0.0118 0.068 0.0732
Loa Loa (eye worm) hypothetical protein 0.0039 0.0069 0.0069
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0078 0.0264
Echinococcus multilocularis regulator of G protein signaling 7 0.0039 0.0069 0.0116
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0054 0.0188 0.0184
Entamoeba histolytica hypothetical protein 0.0039 0.0069 0.5
Echinococcus multilocularis neuropeptides capa receptor 0.014 0.0852 0.1506
Echinococcus granulosus Solute carrier organic anion transporter family 0.017 0.108 0.1166
Echinococcus multilocularis g-protein coupled receptor 0.014 0.0852 0.1506
Schistosoma mansoni myosin xvIII 0.014 0.0852 0.3048
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.014 0.0852 0.3048
Loa Loa (eye worm) hypothetical protein 0.017 0.108 0.108
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.014 0.0852 0.1506
Loa Loa (eye worm) RGS-3 protein 0.0039 0.0069 0.0069
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0054 0.0188 0.0188
Echinococcus granulosus alpha 1A adrenergic receptor 0.014 0.0852 0.0919
Echinococcus granulosus rhodopsin orphan GPCR 0.014 0.0852 0.0919
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0039 0.0069 0.0069
Schistosoma mansoni biogenic amine (dopamine) receptor 0.014 0.0852 0.3048
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.014 0.0852 0.3048
Loa Loa (eye worm) hypothetical protein 0.017 0.108 0.108
Loa Loa (eye worm) TYRA-2 protein 0.014 0.0852 0.0852
Brugia malayi hypothetical protein 0.014 0.0852 0.0848
Echinococcus multilocularis rhodopsin orphan GPCR 0.014 0.0852 0.1506
Onchocerca volvulus 0.0056 0.0199 0.0195
Loa Loa (eye worm) runx1 0.0054 0.0187 0.0187
Brugia malayi MAP kinase sur-1 0.0118 0.068 0.0676
Schistosoma mansoni biogenic amine (5HT) receptor 0.014 0.0852 0.3048
Brugia malayi steroid hormone receptor 0.0054 0.0188 0.0184
Echinococcus multilocularis agrin 0.0056 0.0199 0.0346
Loa Loa (eye worm) hypothetical protein 0.014 0.0852 0.0852
Brugia malayi hypothetical protein 0.014 0.0852 0.0848
Schistosoma mansoni serine/threonine protein kinase 0.0118 0.068 0.243
Echinococcus multilocularis mitogen activated protein kinase 3 0.0118 0.068 0.1201
Schistosoma mansoni organic anion transporter 0.017 0.108 0.387
Brugia malayi PAS domain containing protein 0.0055 0.0194 0.019
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0039 0.0069 0.0071
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.014 0.0852 0.0852
Echinococcus multilocularis Solute carrier organic anion transporter family 0.017 0.108 0.1912
Echinococcus multilocularis neuropeptide s receptor 0.014 0.0852 0.1506
Loa Loa (eye worm) hypothetical protein 0.014 0.0852 0.0852
Brugia malayi Nuclear hormone receptor-like 1 0.0054 0.0188 0.0184
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0054 0.0188 0.0199
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.014 0.0852 0.3048
Loa Loa (eye worm) G-protein coupled receptor 0.014 0.0852 0.0852
Echinococcus multilocularis neuropeptide receptor 0.014 0.0852 0.1506
Brugia malayi sodium-independent organic anion transporter family protein 0.017 0.108 0.1076
Echinococcus granulosus axis inhibition protein axin 0.0039 0.0069 0.0071
Onchocerca volvulus 0.014 0.0852 0.0848
Schistosoma mansoni biogenic amine (dopamine) receptor 0.014 0.0852 0.3048
Onchocerca volvulus 0.017 0.108 0.1076
Loa Loa (eye worm) hypothetical protein 0.014 0.0852 0.0852
Loa Loa (eye worm) hypothetical protein 0.014 0.0852 0.0852
Onchocerca volvulus 0.014 0.0852 0.0848
Loa Loa (eye worm) hypothetical protein 0.0039 0.0069 0.0069
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.014 0.0852 0.1506
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0054 0.0188 0.0184
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0078 0.0264
Toxoplasma gondii transporter, major facilitator family protein 0.017 0.108 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.014 0.0852 0.3048
Loa Loa (eye worm) hypothetical protein 0.014 0.0852 0.0852
Echinococcus granulosus single minded 2 0.0041 0.0083 0.0086
Echinococcus multilocularis expressed protein 0.0056 0.0199 0.0346
Loa Loa (eye worm) hypothetical protein 0.014 0.0852 0.0852
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0054 0.0188 0.0199
Loa Loa (eye worm) hypothetical protein 0.0039 0.0069 0.0069
Echinococcus granulosus serotonin receptor 0.014 0.0852 0.0919
Brugia malayi hypothetical protein 0.0432 0.3108 0.3105
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0054 0.0188 0.0327
Echinococcus granulosus neuropeptide receptor A26 0.014 0.0852 0.0919
Schistosoma mansoni follistatin 0.0056 0.0199 0.07
Echinococcus granulosus regulator of G protein signaling 3 0.0039 0.0069 0.0071
Loa Loa (eye worm) hypothetical protein 0.014 0.0852 0.0852
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0054 0.0188 0.0199
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0069 0.0234
Echinococcus multilocularis expressed protein 0.0758 0.5632 1
Onchocerca volvulus 0.014 0.0852 0.0848
Brugia malayi PXA domain containing protein 0.0039 0.0069 0.0065
Echinococcus granulosus beta-adrenergic receptor kinase 0.004 0.0078 0.008
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0118 0.068 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.014 0.0852 0.0848
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0054 0.0188 0.0327
Schistosoma mansoni thyroid hormone receptor 0.0054 0.0188 0.0661
Brugia malayi follicle stimulating hormone receptor 0.0673 0.4968 0.4965
Brugia malayi SPARC precursor 0.0056 0.0199 0.0195
Echinococcus multilocularis transfer RNA-Lys 0.0041 0.0083 0.0141
Loa Loa (eye worm) hypothetical protein 0.014 0.0852 0.0852
Loa Loa (eye worm) hypothetical protein 0.014 0.0852 0.0852
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0054 0.0188 0.0184
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0226 1
Echinococcus granulosus g-protein coupled receptor 0.014 0.0852 0.0919
Brugia malayi G protein-coupled receptor 0.014 0.0852 0.0848
Loa Loa (eye worm) hypothetical protein 0.017 0.108 0.108
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0054 0.0188 0.0184
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0054 0.0188 0.0661
Brugia malayi hypothetical protein 0.0039 0.0069 0.0065
Loa Loa (eye worm) hypothetical protein 0.0054 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.014 0.0852 0.0852
Echinococcus multilocularis rhodopsin orphan GPCR 0.014 0.0852 0.1506
Brugia malayi Dopamine receptor 0.014 0.0852 0.0848
Echinococcus multilocularis neuropeptide Y receptor 0.014 0.0852 0.1506
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0054 0.0188 0.0661
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0226 1
Loa Loa (eye worm) steroid hormone receptor 0.0054 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.0054 0.0188 0.0188
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0054 0.0188 0.0188
Loa Loa (eye worm) PXA domain-containing protein 0.0039 0.0069 0.0069
Schistosoma mansoni rhodopsin-like orphan GPCR 0.014 0.0852 0.3048
Echinococcus multilocularis neuropeptide receptor 0.014 0.0852 0.1506
Echinococcus granulosus orexin receptor type 2 0.014 0.0852 0.0919
Onchocerca volvulus 0.0041 0.0083 0.0079
Echinococcus granulosus neuropeptide receptor 0.014 0.0852 0.0919
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.014 0.0852 0.0852
Schistosoma mansoni neuropeptide receptor 0.014 0.0852 0.3048
Onchocerca volvulus 0.014 0.0852 0.0848
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0054 0.0188 0.0188
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0056 0.0199 0.0199
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0118 0.068 0.068
Loa Loa (eye worm) hypothetical protein 0.0185 0.1197 0.1197
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.014 0.0852 0.0919
Echinococcus granulosus rhodopsin orphan GPCR 0.014 0.0852 0.0919
Loa Loa (eye worm) hypothetical protein 0.014 0.0852 0.0852
Loa Loa (eye worm) hypothetical protein 0.0054 0.0188 0.0188
Brugia malayi RE15519p 0.014 0.0852 0.0848
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0039 0.0069 0.0234
Brugia malayi sodium-independent organic anion transporter family protein 0.017 0.108 0.1076
Echinococcus granulosus FTZ F1 alpha 0.0054 0.0188 0.0199
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0039 0.0069 0.0116
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0054 0.0188 0.0184
Loa Loa (eye worm) hypothetical protein 0.014 0.0852 0.0852
Schistosoma mansoni biogenic amine (dopamine) receptor 0.014 0.0852 0.3048
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0054 0.0188 0.0188
Schistosoma mansoni hypothetical protein 0.014 0.0852 0.3048
Brugia malayi secreted modular calcium-binding protein 1 0.0056 0.0199 0.0195
Brugia malayi neuropeptide F receptor 0.014 0.0852 0.0848
Echinococcus multilocularis dro:myosuppressin receptor 0.014 0.0852 0.1506
Echinococcus multilocularis follistatin 0.0056 0.0199 0.0346
Brugia malayi hypothetical protein 0.0039 0.0069 0.0065
Echinococcus granulosus expressed protein 0.0758 0.5632 0.61
Brugia malayi Melatonin receptor type 1A 0.014 0.0852 0.0848
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0069 0.0234
Loa Loa (eye worm) hypothetical protein 0.014 0.0852 0.0852
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0054 0.0188 0.0184
Trichomonas vaginalis CMGC family protein kinase 0.0118 0.068 1
Loa Loa (eye worm) hypothetical protein 0.014 0.0852 0.0852
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.014 0.0852 0.3048
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0226 0.0798
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0054 0.0188 0.0184
Echinococcus multilocularis regulator of G protein signaling 7 0.0039 0.0069 0.0116
Schistosoma mansoni biogenic amine receptor 0.014 0.0852 0.3048
Echinococcus granulosus axis inhibition protein axin 0.0039 0.0069 0.0071
Schistosoma mansoni single-minded 0.0055 0.0194 0.0682
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0078 0.0264
Echinococcus multilocularis neuropeptide FF receptor 2 0.014 0.0852 0.1506
Echinococcus granulosus g protein coupled receptor 0.014 0.0852 0.0919
Brugia malayi Serotonin receptor 0.014 0.0852 0.0848
Echinococcus granulosus Regulator of G protein signaling 20 0.0039 0.0069 0.0071
Loa Loa (eye worm) hypothetical protein 0.014 0.0852 0.0852
Schistosoma mansoni agrin 0.0056 0.0199 0.07
Schistosoma mansoni opsin-like receptor 0.014 0.0852 0.3048
Brugia malayi Dopamine receptor protein 1 0.014 0.0852 0.0848
Loa Loa (eye worm) hypothetical protein 0.014 0.0852 0.0852
Schistosoma mansoni neuropeptide receptor 0.014 0.0852 0.3048
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.004 0.0078 0.0073
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0118 0.068 0.5458
Brugia malayi GnHR receptor homolog 0.014 0.0852 0.0848
Schistosoma mansoni rhodopsin-like orphan GPCR 0.014 0.0852 0.3048
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.014 0.0852 0.0852
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.014 0.0852 0.1506
Schistosoma mansoni coup transcription factor 0.0054 0.0188 0.0661
Onchocerca volvulus 0.014 0.0852 0.0848
Onchocerca volvulus 0.014 0.0852 0.0848
Schistosoma mansoni alpha-1 adrenergic receptor 0.014 0.0852 0.3048
Echinococcus multilocularis G-protein coupled receptor, putative 0.014 0.0852 0.1506
Schistosoma mansoni neuropeptide f receptor 76f 0.014 0.0852 0.3048
Trypanosoma brucei protein kinase, putative 0.0118 0.068 0.5
Echinococcus multilocularis regulator of G protein signaling 3 0.0039 0.0069 0.0116
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.014 0.0852 0.0919
Loa Loa (eye worm) hypothetical protein 0.017 0.108 0.108
Echinococcus granulosus neuropeptides capa receptor 0.014 0.0852 0.0919
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0054 0.0188 0.0661
Brugia malayi hypothetical protein 0.014 0.0852 0.0848
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0226 0.024
Onchocerca volvulus Protein ultraspiracle homolog 0.0054 0.0188 0.0184
Onchocerca volvulus Bile acid receptor homolog 0.0054 0.0188 0.0184
Loa Loa (eye worm) hypothetical protein 0.014 0.0852 0.0852
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0118 0.068 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.014 0.0852 0.0919
Loa Loa (eye worm) hypothetical protein 0.014 0.0852 0.0852
Echinococcus multilocularis regulator of G protein signaling 3 0.0039 0.0069 0.0116
Schistosoma mansoni rhodopsin-like orphan GPCR 0.014 0.0852 0.3048
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0226 0.0309
Brugia malayi hypothetical protein 0.014 0.0852 0.0848
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.004 0.0078 0.0078
Schistosoma mansoni hypothetical protein 0.014 0.0852 0.3048
Echinococcus granulosus neuropeptide Y receptor 0.014 0.0852 0.0919
Echinococcus granulosus rhodopsin orphan GPCR 0.014 0.0852 0.0919
Echinococcus granulosus peptide allatostatin:somatostatin 0.014 0.0852 0.0919
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.039 0.2785 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0199 0.0199
Onchocerca volvulus 0.017 0.108 0.1076
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0054 0.0188 0.0188
Loa Loa (eye worm) hypothetical protein 0.014 0.0852 0.0852
Schistosoma mansoni rhodopsin-like orphan GPCR 0.014 0.0852 0.3048
Brugia malayi PXA domain containing protein 0.0039 0.0069 0.0065
Schistosoma mansoni opsin-like receptor 0.014 0.0852 0.3048
Schistosoma mansoni amine GPCR 0.014 0.0852 0.3048
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0054 0.0188 0.0199
Echinococcus multilocularis neuropeptide Y receptor 0.014 0.0852 0.1506
Echinococcus multilocularis mitogen activated protein kinase 0.0118 0.068 0.1201
Loa Loa (eye worm) hypothetical protein 0.014 0.0852 0.0852
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.014 0.0852 0.0848
Brugia malayi sodium-independent organic anion transporter family protein 0.017 0.108 0.1076
Loa Loa (eye worm) neuropeptide F receptor 0.014 0.0852 0.0852
Echinococcus multilocularis somatostatin receptor 0.014 0.0852 0.1506
Echinococcus multilocularis serotonin receptor 0.014 0.0852 0.1506
Echinococcus granulosus organic anion transporting polypeptide 30B 0.017 0.108 0.1166
Loa Loa (eye worm) hypothetical protein 0.014 0.0852 0.0852

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.38 uM 50% in vitro inhibitory concentration against Cytochrome P450 19A1 from human placental microsomes by thiobarbituric acid assay ChEMBL. 10794700
IC50 (binding) = 0.38 uM 50% in vitro inhibitory concentration against Cytochrome P450 19A1 from human placental microsomes by thiobarbituric acid assay ChEMBL. 10794700
IC50 (binding) = 0.63 uM 50% in vitro inhibitory concentration against Thromboxane-A synthase from human whole blood by thiobarbituric acid assay ChEMBL. 10794700
IC50 (binding) = 0.63 uM 50% in vitro inhibitory concentration against Thromboxane-A synthase from human whole blood by thiobarbituric acid assay ChEMBL. 10794700
IC50 (binding) = 125 uM Inhibition of Cytochrome P450 17 enzyme of rat testicular microsomes ChEMBL. 10794700
IC50 (binding) = 125 uM Inhibition of Cytochrome P450 17 enzyme of rat testicular microsomes ChEMBL. 10794700
Inhibition (functional) = 6 % Percent inhibition of TXB2 in rat serum at 4.2 mg/kg dose after 8 hr ChEMBL. 10794700
Inhibition (functional) = 6 % Percent inhibition of TXB2 in rat serum at 4.2 mg/kg dose after 8 hr ChEMBL. 10794700
Inhibition (binding) = 49 % % inhibition, at 125 microM concentration, against Cytochrome P450 17 enzyme in rat testicular microsomes ChEMBL. 10794700
Inhibition (binding) = 49 % % inhibition, at 125 microM concentration, against Cytochrome P450 17 enzyme in rat testicular microsomes ChEMBL. 10794700
Inhibition (functional) = 51 % Percent inhibition of TXB2 in rat serum at 8.5 mg/kg dose after 8 hr ChEMBL. 10794700
Inhibition (functional) = 51 % Percent inhibition of TXB2 in rat serum at 8.5 mg/kg dose after 8 hr ChEMBL. 10794700
Inhibition (functional) = 56 % Percent inhibition of TXB2 in rat serum at 4.2 mg/kg dose after 3 hr ChEMBL. 10794700
Inhibition (functional) = 56 % Percent inhibition of TXB2 in rat serum at 4.2 mg/kg dose after 3 hr ChEMBL. 10794700
Inhibition (functional) = 71 % Percent inhibition of TXB2 in rat serum at 8.5 mg/kg dose after 5 hr ChEMBL. 10794700
Inhibition (functional) = 71 % Percent inhibition of TXB2 in rat serum at 8.5 mg/kg dose after 5 hr ChEMBL. 10794700
Inhibition (functional) = 77 % Percent inhibition of TXB2 in rat serum at 8.5 mg/kg dose after 2 hr ChEMBL. 10794700
Inhibition (functional) = 77 % Percent inhibition of TXB2 in rat serum at 8.5 mg/kg dose after 2 hr ChEMBL. 10794700
Inhibition (functional) = 78 % Percent inhibition of TXB2 in rat serum at 8.5 mg/kg dose after 3 hr ChEMBL. 10794700
Inhibition (functional) = 78 % Percent inhibition of TXB2 in rat serum at 8.5 mg/kg dose after 3 hr ChEMBL. 10794700

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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