Detailed information for compound 814289

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 473.63 | Formula: C28H31N3O2S
  • H donors: 0 H acceptors: 3 LogP: 5.08 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSc1ccc(cc1)C(=O)N1CCC(CC1)C(N(C(=O)c1ccccn1)C)Cc1ccccc1
  • InChi: 1S/C28H31N3O2S/c1-30(28(33)25-10-6-7-17-29-25)26(20-21-8-4-3-5-9-21)22-15-18-31(19-16-22)27(32)23-11-13-24(34-2)14-12-23/h3-14,17,22,26H,15-16,18-20H2,1-2H3
  • InChiKey: PANBYJIDXJKHLG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.1039 1
Trichomonas vaginalis importin beta-1, putative 0.0045 0.0369 0.1322
Schistosoma mansoni DNA polymerase eta 0.0038 0.0267 0.032
Brugia malayi Calcitonin receptor-like protein seb-1 0.0197 0.2576 0.2576
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0046 0.0389 0.2958
Echinococcus granulosus Smad4 0.0024 0.0061 0.0073
Schistosoma mansoni hypothetical protein 0.0086 0.0959 0.1149
Brugia malayi jmjC domain containing protein 0.0028 0.0115 0.0115
Schistosoma mansoni tar DNA-binding protein 0.0186 0.2421 0.2899
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0028 0.0121 0.0007
Leishmania major DNA polymerase eta, putative 0.0038 0.0267 0.1646
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0267 0.1823
Plasmodium falciparum ataxin-2 like protein, putative 0.0074 0.0791 0.0867
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.1297 0.1348
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.1297 0.1348
Echinococcus multilocularis jumonji domain containing protein 0.0119 0.1447 0.1733
Brugia malayi jmjC domain containing protein 0.0028 0.0115 0.0115
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0267 0.1823
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0595 0.835 0.835
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0267 0.1823
Trypanosoma brucei importin beta-1 subunit, putative 0.0056 0.0522 0.4527
Echinococcus granulosus jumonji domain containing protein 0.0119 0.1447 0.1733
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0028 0.0115 0.0138
Schistosoma mansoni tar DNA-binding protein 0.0186 0.2421 0.2899
Entamoeba histolytica hypothetical protein 0.0106 0.1251 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0024 0.0061 0.0061
Echinococcus multilocularis tar DNA binding protein 0.0186 0.2421 0.2899
Onchocerca volvulus 0.0292 0.3953 0.3953
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0041 0.0309 0.037
Echinococcus multilocularis importin subunit beta 1 0.0056 0.0522 0.0626
Schistosoma mansoni hypothetical protein 0.0106 0.1251 0.1498
Echinococcus granulosus phd:f box containing protein 0.0028 0.0115 0.0138
Brugia malayi isocitrate dehydrogenase 0.0046 0.0389 0.0389
Loa Loa (eye worm) hypothetical protein 0.0183 0.2364 0.2364
Schistosoma mansoni terminal deoxycytidyl transferase 0.0038 0.0267 0.032
Loa Loa (eye worm) transcription factor SMAD2 0.0351 0.4816 0.4816
Brugia malayi Thioredoxin reductase 0.0048 0.0408 0.0408
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0028 0.0115 0.0213
Loa Loa (eye worm) hypothetical protein 0.0197 0.2576 0.2576
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.0267 0.0267
Toxoplasma gondii isocitrate dehydrogenase 0.0046 0.0389 0.3236
Schistosoma mansoni smad1 5 8 and 0.0024 0.0061 0.0073
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0408 0.0488
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.1039 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0033 0.0196 0.0235
Schistosoma mansoni jumonji/arid domain-containing protein 0.0104 0.1222 0.1463
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0028 0.0115 0.0138
Loa Loa (eye worm) hypothetical protein 0.0028 0.0115 0.0115
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0028 0.0121 0.006
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0046 0.0389 0.2958
Leishmania major hypothetical protein, conserved 0.0074 0.0791 0.7314
Schistosoma mansoni hypothetical protein 0.0062 0.0619 0.0741
Brugia malayi AF-10 protein 0.0028 0.0121 0.0121
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0024 0.0061 0.0073
Leishmania major GTP-binding protein, putative 0.0041 0.0309 0.2094
Echinococcus granulosus TGF beta signal transducer SmadC 0.0024 0.0061 0.0073
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0267 0.1823
Schistosoma mansoni hypothetical protein 0.0033 0.0196 0.0235
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0045 0.0369 0.1322
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0355 0.0425
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0267 0.1646
Brugia malayi F/Y-rich N-terminus family protein 0.0028 0.0121 0.0121
Schistosoma mansoni smad 0.0024 0.0061 0.0073
Echinococcus granulosus GPCR family 2 0.0062 0.0619 0.0741
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0267 0.1823
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.0564 0.7906 1
Echinococcus multilocularis dna polymerase eta 0.0038 0.0267 0.032
Onchocerca volvulus Alhambra homolog 0.0086 0.0959 0.0959
Schistosoma mansoni hypothetical protein 0.0499 0.6956 0.833
Schistosoma mansoni kinase 0.0046 0.0387 0.0463
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0267 0.1823
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.0564 0.7906 1
Loa Loa (eye worm) pax transcription factor protein 2 0.0708 1 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.1297 0.1348
Echinococcus granulosus snurportin 1 0.0595 0.835 1
Brugia malayi jmjC domain containing protein 0.0028 0.0115 0.0115
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0041 0.0309 0.0248
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0121 0.006
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0408 0.0183
Loa Loa (eye worm) RNA binding protein 0.0186 0.2421 0.2421
Schistosoma mansoni hypothetical protein 0.0595 0.835 1
Brugia malayi jmjC domain containing protein 0.0281 0.3794 0.3794
Loa Loa (eye worm) TAR-binding protein 0.0186 0.2421 0.2421
Brugia malayi N-terminal motif family protein 0.0183 0.2364 0.2364
Echinococcus multilocularis snurportin 1 0.0595 0.835 1
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0183 0.2364 0.2364
Schistosoma mansoni tar DNA-binding protein 0.0186 0.2421 0.2899
Trypanosoma brucei polo-like protein kinase 0.0091 0.1039 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0267 0.1646
Brugia malayi MH1 domain containing protein 0.0024 0.0061 0.0061
Echinococcus granulosus lysine specific demethylase 5A 0.0104 0.1222 0.1463
Plasmodium vivax importin-beta 2, putative 0.0056 0.0522 0.0522
Loa Loa (eye worm) hypothetical protein 0.0056 0.0522 0.0522
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0041 0.0309 0.2094
Echinococcus multilocularis lysine specific demethylase 6a 0.0028 0.0115 0.0138
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0267 0.1646
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0046 0.0389 0.0159
Schistosoma mansoni smad1 5 8 and 0.0024 0.0061 0.0073
Entamoeba histolytica serine/threonine protein kinase, putative 0.0091 0.1039 0.784
Echinococcus granulosus smad 0.0024 0.0061 0.0073
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.1039 1
Trypanosoma brucei DNA polymerase eta, putative 0.0038 0.0267 0.1823
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.1039 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0041 0.0309 0.2094
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0062 0.0619 0.0741
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0038 0.0267 0.1646
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.1039 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0091 0.1039 1
Leishmania major trypanothione reductase 0.0048 0.0408 0.3164
Plasmodium falciparum importin beta, putative 0.0056 0.0522 0.0522
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.1474 0.1579
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0091 0.1039 0.1039
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0041 0.0309 0.0248
Loa Loa (eye worm) jmjC domain-containing protein 0.0104 0.1222 0.1222
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0197 0.2576 0.2576
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0355 0.0425
Schistosoma mansoni Smad4 0.0024 0.0061 0.0073
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0086 0.0959 0.1149
Brugia malayi hypothetical protein 0.0074 0.0791 0.0791
Giardia lamblia Kinase, PLK 0.0091 0.1039 1
Plasmodium vivax hypothetical protein, conserved 0.0086 0.0959 0.1083
Brugia malayi MH2 domain containing protein 0.0024 0.0061 0.0061
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.1039 1
Plasmodium vivax glutathione reductase, putative 0.0048 0.0408 0.0375
Echinococcus multilocularis jumonji domain containing 1A 0.0028 0.0115 0.0138
Brugia malayi RNA recognition motif domain containing protein 0.0186 0.2421 0.2421
Loa Loa (eye worm) jmjC domain-containing protein 0.0028 0.0115 0.0115
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0267 0.1823
Schistosoma mansoni tar DNA-binding protein 0.0186 0.2421 0.2899
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0028 0.0121 0.0267
Echinococcus multilocularis GPCR, family 2 0.0062 0.0619 0.0741
Echinococcus multilocularis peregrin 0.0086 0.0959 0.1149
Schistosoma mansoni transcription factor LCR-F1 0.0106 0.1251 0.1498
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.1474 0.1579
Loa Loa (eye worm) MH1 domain-containing protein 0.0024 0.0061 0.0061
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0267 0.1823
Loa Loa (eye worm) MH2 domain-containing protein 0.0351 0.4816 0.4816
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0355 0.0425
Echinococcus granulosus GTP binding nuclear protein Ran 0.0041 0.0309 0.037
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.0564 0.7906 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0038 0.0267 0.0267
Loa Loa (eye worm) hypothetical protein 0.0135 0.167 0.167
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0046 0.0389 0.3108
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0267 0.1646
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0028 0.0121 0.0144
Schistosoma mansoni hypothetical protein 0.0499 0.6956 0.833
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0062 0.0619 0.0619
Leishmania major importin beta-1 subunit, putative 0.0045 0.0369 0.275
Trypanosoma brucei importin beta-1 subunit, putative 0.0056 0.0522 0.4527
Entamoeba histolytica hypothetical protein 0.0106 0.1251 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0062 0.0619 0.0619
Echinococcus multilocularis dna polymerase kappa 0.0038 0.0267 0.032
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0046 0.0389 0.035
Echinococcus granulosus importin subunit beta 1 0.0056 0.0522 0.0626
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0091 0.1039 0.1244
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0186 0.2421 0.2421
Loa Loa (eye worm) hypothetical protein 0.0028 0.0121 0.0121
Schistosoma mansoni tar DNA-binding protein 0.0186 0.2421 0.2899
Loa Loa (eye worm) Smad1 0.0024 0.0061 0.0061
Brugia malayi jmjC domain containing protein 0.0104 0.1222 0.1222
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0355 0.0425
Loa Loa (eye worm) hypothetical protein 0.0074 0.0791 0.0791
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0038 0.0267 0.032
Trypanosoma brucei PAB1-binding protein , putative 0.0074 0.0791 0.7372
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0091 0.1039 1
Schistosoma mansoni protein phosphatase 2C 0.0028 0.0115 0.0138
Toxoplasma gondii LsmAD domain-containing protein 0.0074 0.0791 0.8001
Loa Loa (eye worm) hypothetical protein 0.0038 0.0267 0.0267
Schistosoma mansoni jumonji/arid domain-containing protein 0.0104 0.1222 0.1463
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0106 0.1251 0.1498
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.0267 0.0267
Plasmodium vivax ataxin-2 like protein, putative 0.0074 0.0791 0.0867
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0408 0.3164
Leishmania major DNA polymerase kappa, putative 0.0038 0.0267 0.1646
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0355 0.0425
Schistosoma mansoni hypothetical protein 0.0062 0.0619 0.0741
Echinococcus granulosus mothers against decapentaplegic 5 0.0024 0.0061 0.0073
Entamoeba histolytica hypothetical protein 0.0106 0.1251 1
Schistosoma mansoni ran 0.0041 0.0309 0.037
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0062 0.0619 0.0741
Schistosoma mansoni hypothetical protein 0.0062 0.0619 0.0741
Brugia malayi glutathione reductase 0.0048 0.0408 0.0408
Loa Loa (eye worm) hypothetical protein 0.0028 0.0115 0.0115
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0046 0.0389 0.0465
Brugia malayi jmjC domain containing protein 0.0028 0.0115 0.0115
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0033 0.0196 0.0235
Toxoplasma gondii thioredoxin reductase 0.0048 0.0408 0.3461
Onchocerca volvulus 0.0708 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0267 0.1823
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0028 0.0115 0.0138
Brugia malayi hypothetical protein 0.0292 0.3953 0.3953
Echinococcus multilocularis mothers against decapentaplegic 5 0.0024 0.0061 0.0073
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0267 0.1823
Schistosoma mansoni hypothetical protein 0.0028 0.0121 0.0144
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0281 0.3794 0.4544
Brugia malayi hypothetical protein 0.0106 0.1251 0.1251
Loa Loa (eye worm) jmjC domain-containing protein 0.0177 0.2286 0.2286
Brugia malayi Latrophilin receptor protein 2 0.0062 0.0619 0.0619
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0355 0.0425
Treponema pallidum hypothetical protein 0.0564 0.7906 0.5
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0038 0.0267 0.032
Brugia malayi MH2 domain containing protein 0.0351 0.4816 0.4816
Echinococcus granulosus jumonji domain containing 1A 0.0028 0.0115 0.0138
Loa Loa (eye worm) hypothetical protein 0.0292 0.3953 0.3953
Loa Loa (eye worm) hypothetical protein 0.0147 0.185 0.185
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0062 0.0619 0.0741
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0041 0.0309 0.0309
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0355 0.0425
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0046 0.0389 0.0465
Entamoeba histolytica Ran family GTPase 0.0041 0.0309 0.0421
Brugia malayi latrophilin 2 splice variant baaae 0.0135 0.167 0.167
Loa Loa (eye worm) glutathione reductase 0.0048 0.0408 0.0408
Plasmodium falciparum glutathione reductase 0.0048 0.0408 0.0375
Trypanosoma cruzi importin beta-1 subunit, putative 0.0045 0.0369 0.275
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0281 0.3794 0.4544
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.1039 0.1244
Echinococcus granulosus lysine specific demethylase 6a 0.0028 0.0115 0.0138
Trypanosoma cruzi PAB1-binding protein , putative 0.0074 0.0791 0.7314
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0267 0.1646
Echinococcus granulosus JmjC domain containing protein 4 0.0028 0.0115 0.0138
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0121 0.0007
Loa Loa (eye worm) jmjC domain-containing protein 0.0028 0.0115 0.0115
Brugia malayi PHD-finger family protein 0.0028 0.0121 0.0121
Toxoplasma gondii isocitrate dehydrogenase 0.0046 0.0389 0.3236
Brugia malayi MH1 domain containing protein 0.0024 0.0061 0.0061
Schistosoma mansoni ran 0.0041 0.0309 0.037
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0408 0.0488
Plasmodium falciparum ataxin-2 like protein, putative 0.0074 0.0791 0.0867
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.1297 0.1348
Brugia malayi Isocitrate dehydrogenase 0.0046 0.0389 0.0389
Trypanosoma cruzi polo-like protein kinase, putative 0.0091 0.1039 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0091 0.1039 0.1039
Echinococcus granulosus dna polymerase kappa 0.0038 0.0267 0.032
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0045 0.0369 0.1322
Toxoplasma gondii PHD-finger domain-containing protein 0.0086 0.0959 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.1297 0.1348
Trypanosoma brucei unspecified product 0.0038 0.0267 0.1823
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0041 0.0309 0.0309
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0046 0.0389 0.2958
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0046 0.0389 0.0465
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.1474 0.1579
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0028 0.0121 0.0267
Schistosoma mansoni smad1 5 8 and 0.0024 0.0061 0.0073
Echinococcus granulosus PHD finger protein rhinoceros 0.0086 0.0959 0.1149
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0369 0.1322
Echinococcus multilocularis smad 0.0024 0.0061 0.0073
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0046 0.0389 0.3108
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0355 0.0355
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.0564 0.7906 1
Mycobacterium tuberculosis Probable reductase 0.0109 0.1297 0.1348
Echinococcus multilocularis JmjC domain containing protein 4 0.0028 0.0115 0.0138
Echinococcus granulosus tar DNA binding protein 0.0186 0.2421 0.2899
Loa Loa (eye worm) PHD-finger family protein 0.0086 0.0959 0.0959
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0024 0.0061 0.0073
Echinococcus granulosus geminin 0.0499 0.6956 0.833
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.1039 1
Schistosoma mansoni jumonji domain containing protein 0.0223 0.2956 0.3539
Onchocerca volvulus Serine\/threonine kinase homolog 0.0091 0.1039 0.1039
Brugia malayi Smad1 0.0024 0.0061 0.0061
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0369 0.1322
Echinococcus multilocularis geminin 0.0499 0.6956 0.833
Schistosoma mansoni hypothetical protein 0.0062 0.0619 0.0741
Brugia malayi MH2 domain containing protein 0.0024 0.0061 0.0061
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0046 0.0389 0.0465
Loa Loa (eye worm) isocitrate dehydrogenase 0.0046 0.0389 0.0389
Brugia malayi TAR-binding protein 0.0186 0.2421 0.2421
Echinococcus multilocularis PHD finger protein rhinoceros 0.0086 0.0959 0.1149
Schistosoma mansoni phd/f-box containing protein 0.0028 0.0115 0.0138
Trypanosoma cruzi PAB1-binding protein , putative 0.0074 0.0791 0.7314
Brugia malayi RNA binding protein 0.0186 0.2421 0.2421
Brugia malayi PHD-finger family protein 0.0086 0.0959 0.0959
Trypanosoma brucei trypanothione reductase 0.0048 0.0408 0.3309
Toxoplasma gondii HEAT repeat-containing protein 0.0056 0.0522 0.4821
Loa Loa (eye worm) jmjC domain-containing protein 0.0028 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0086 0.0959 0.0959
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0046 0.0389 0.0465
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0062 0.0619 0.0741
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.0564 0.7906 1
Echinococcus multilocularis phd:f box containing protein 0.0028 0.0115 0.0138
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0038 0.0267 0.032
Brugia malayi hypothetical protein 0.0048 0.0409 0.0409
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0408 0.0408
Entamoeba histolytica hypothetical protein 0.0106 0.1251 1
Entamoeba histolytica hypothetical protein 0.0045 0.0369 0.1037
Schistosoma mansoni importin beta-1 0.0056 0.0522 0.0626
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0408 0.0375
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0267 0.1823
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0091 0.1039 0.1244
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0041 0.0309 0.229
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0355 0.0355
Brugia malayi RNA, U transporter 1 0.0158 0.2014 0.2014
Trichomonas vaginalis ran, putative 0.0041 0.0309 0.0536
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0267 0.1823
Toxoplasma gondii PHD-finger domain-containing protein 0.0086 0.0959 1
Echinococcus granulosus peregrin 0.0086 0.0959 0.1149
Schistosoma mansoni jumonji domain containing protein 0.0028 0.0115 0.0138
Brugia malayi Importin beta-1 subunit 0.0056 0.0522 0.0522
Schistosoma mansoni hypothetical protein 0.0135 0.167 0.2
Brugia malayi Bromodomain containing protein 0.0086 0.0959 0.0959
Giardia lamblia PHD finger protein 15 0.0086 0.0959 0.8974
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0041 0.0309 0.2262
Echinococcus multilocularis Smad4 0.0024 0.0061 0.0073
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0197 0.2576 0.2576
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0046 0.0389 0.0465
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.1474 0.0267
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0267 0.1823
Echinococcus multilocularis isocitrate dehydrogenase 0.0046 0.0389 0.0465
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0106 0.1251 0.1498
Loa Loa (eye worm) hypothetical protein 0.0062 0.0619 0.0619
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0041 0.0309 0.0536
Echinococcus granulosus dna polymerase eta 0.0038 0.0267 0.032
Echinococcus multilocularis lysine specific demethylase 5A 0.0104 0.1222 0.1463
Plasmodium falciparum phd finger protein, putative 0.0086 0.0959 0.1083
Schistosoma mansoni phosphatidylserine receptor 0.0028 0.0115 0.0138
Plasmodium falciparum thioredoxin reductase 0.0048 0.0408 0.0375
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0046 0.0389 0.035

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.