Detailed information for compound 815365

Basic information

Technical information
  • TDR Targets ID: 815365
  • Name: [(6-methoxy-5-nitro-3,4-dihydro-2H-naphthalen -1-ylidene)amino] naphthalene-1-carboxylate
  • MW: 390.389 | Formula: C22H18N2O5
  • H donors: 0 H acceptors: 3 LogP: 5.1 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1[N+](=O)[O-])CCC/C/2=N/OC(=O)c1cccc2c1cccc2
  • InChi: 1S/C22H18N2O5/c1-28-20-13-12-16-17(21(20)24(26)27)9-5-11-19(16)23-29-22(25)18-10-4-7-14-6-2-3-8-15(14)18/h2-4,6-8,10,12-13H,5,9,11H2,1H3/b23-19-
  • InChiKey: QLSVHZCGJWDGPG-NMWGTECJSA-N  


Substructure search Similarity search

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Synonyms

  • [(6-methoxy-5-nitro-tetralin-1-ylidene)amino] naphthalene-1-carboxylate
  • 1-naphthalenecarboxylic acid [(6-methoxy-5-nitro-1-tetralinylidene)amino] ester
  • naphthalene-1-carboxylic acid [(6-methoxy-5-nitro-tetralin-1-ylidene)amino] ester
  • BIM-0010423.P001

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 2 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 19 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania major cytochrome p450-like protein cytochrome P450, family 2, subfamily C, polypeptide 19 490 aa 411 aa 23.1 %
Brugia malayi Cytochrome P450 family protein cytochrome P450, family 1, subfamily A, polypeptide 2 516 aa 470 aa 26.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus dnaJ subfamily B 0.0494 0.5888 0.5885
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.001 0.0031 0.0061
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.015 0.0142
Schistosoma mansoni hypothetical protein 0.0494 0.5888 0.5885
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.015 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0838 0.224
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0309 0.3652 0.9838
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.0838 0.224
Brugia malayi Cathepsin L-like precursor 0.002 0.015 0.0382
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0053 0.0044
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0314 0.3712 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.015 1
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0314 0.3712 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0053 0.0044
Onchocerca volvulus 0.002 0.015 0.0644
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0053 0.012
Plasmodium vivax vivapain-2 0.002 0.015 0.0328
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0053 0.0044
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0314 0.3712 0.5
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0053 0.012
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.015 0.0142
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.001 0.0031 0.0061
Entamoeba histolytica cysteine proteinase, putative 0.002 0.015 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0069 0.4593
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.007 0.0062
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0838 0.224
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.007 0.0062
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.015 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0838 0.224
Schistosoma mansoni cpg binding protein 0.0037 0.0349 0.0341
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0053 0.0044
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0053 0.0044
Entamoeba histolytica cysteine protease, putative 0.002 0.015 1
Echinococcus multilocularis cysteine protease 0.002 0.015 0.0142
Onchocerca volvulus 0.002 0.015 0.0644
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0053 0.012
Leishmania major cathepsin L-like protease 0.002 0.015 0.0382
Loa Loa (eye worm) hypothetical protein 0.0014 0.0069 0.0163
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.015 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0053 0.0044
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.015 0.0382
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0309 0.3652 1
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0137 0.156 0.4191
Trypanosoma cruzi cysteine proteinase, putative 0.001 0.0031 0.0061
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0053 0.012
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.015 0.0382
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0009 0.0001
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0142 0.162 0.4352
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0274 0.067
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0053 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0053 0.012
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0701 0.187
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0053 0.0044
Onchocerca volvulus 0.002 0.015 0.0644
Leishmania major cathepsin L-like protease 0.0077 0.0838 0.224
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0314 0.3712 0.3707
Brugia malayi nuclear hormone receptor 0.0012 0.0053 0.012
Echinococcus multilocularis cathepsin L 0.001 0.0031 0.0023
Onchocerca volvulus 0.0014 0.0069 0.0107
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0053 0.012
Brugia malayi nuclear receptor NHR-88 0.0012 0.0053 0.012
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.5888 0.5885
Loa Loa (eye worm) hypothetical protein 0.0014 0.0069 0.0163
Leishmania major cathepsin L-like protease 0.002 0.015 0.0382
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0031 0.0061
Brugia malayi GMP reductase 0.0137 0.156 0.4191
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.0031 0.2069
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0053 0.012
Loa Loa (eye worm) hypothetical protein 0.0012 0.0053 0.012
Echinococcus granulosus cathepsin L cysteine protease 0.001 0.0031 0.0023
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0053 0.0044
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.015 1
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0274 0.0716
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.015 1
Loa Loa (eye worm) cysteine protease 0.002 0.015 0.0382
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0838 0.224
Brugia malayi Papain family cysteine protease containing protein 0.001 0.0031 0.0061
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0838 0.224
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0053 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0053 0.012
Loa Loa (eye worm) fibroinase 0.002 0.015 0.0382
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0314 0.3712 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.015 0.0142
Onchocerca volvulus Cathepsin L homolog 0.002 0.015 0.0644
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0053 0.0044
Leishmania major cathepsin L-like protease 0.002 0.015 0.0382
Brugia malayi steroid hormone receptor 0.0012 0.0053 0.012
Brugia malayi Cathepsin L-like precursor 0.002 0.015 0.0382
Brugia malayi Cathepsin L-like precursor 0.002 0.015 0.0382
Brugia malayi Cathepsin L-like precursor 0.0014 0.0069 0.0163
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0053 0.0044
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0009 0.0001
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0053 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0053 0.012
Onchocerca volvulus Cathepsin L homolog 0.002 0.015 0.0644
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.015 0.0142
Onchocerca volvulus 0.002 0.015 0.0644
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0053 0.012
Brugia malayi CXXC zinc finger family protein 0.0035 0.0325 0.0855
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.015 1
Leishmania major guanosine monophosphate reductase 0.0314 0.3712 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.015 0.0328
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0309 0.3652 1
Trypanosoma cruzi cysteine peptidase, putative 0.001 0.0031 0.0061
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0838 0.224
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.015 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0838 0.224
Toxoplasma gondii IMP dehydrogenas 0.0314 0.3712 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0031 0.0023
Brugia malayi Cathepsin L-like precursor 0.002 0.015 0.0382
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0053 0.0044
Toxoplasma gondii cathepsin CPL 0.002 0.015 0.0382
Echinococcus granulosus cysteine protease 0.001 0.0031 0.0023
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.015 0.0382
Leishmania major cathepsin L-like protease 0.002 0.015 0.0382
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.001 0.0031 0.0061
Brugia malayi Cathepsin L-like cysteine proteinase 0.0014 0.0069 0.0163
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.015 0.0142
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0035 0.0026
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0053 0.012
Loa Loa (eye worm) hypothetical protein 0.0012 0.0053 0.012
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0053 0.0044
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0274 0.0716
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.015 1
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.015 0.0142
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.0757 0.2022
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0053 0.0044
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0173 0.1997 0.5368
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0053 0.012
Leishmania major cathepsin L-like protease 0.002 0.015 0.0382
Loa Loa (eye worm) hypothetical protein 0.002 0.015 0.0382
Loa Loa (eye worm) ctsf protein 0.002 0.015 0.0382
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0053 0.012
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0314 0.3712 1
Onchocerca volvulus 0.0035 0.0325 0.1806
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0053 0.0044
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0274 0.0716
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.015 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.015 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0838 0.224
Brugia malayi hypothetical protein 0.003 0.0274 0.0716
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0838 0.224
Leishmania major cathepsin L-like protease 0.0077 0.0838 0.224
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0009 0.0001
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0053 0.0044
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0838 0.224
Echinococcus granulosus cathepsin l1 0.002 0.015 0.0142
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0053 0.012
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0053 0.0044
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0053 0.012
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0142 0.162 0.4352
Trypanosoma cruzi cysteine protease, putative 0.001 0.0031 0.0061
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0287 0.0754
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.015 1
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0035 0.0071
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0053 0.012
Leishmania major hypothetical protein, conserved 0.003 0.0274 0.0716
Brugia malayi hypothetical protein 0.002 0.0143 0.0363
Onchocerca volvulus 0.002 0.015 0.0644
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0053 0.0044
Leishmania major cathepsin L-like protease 0.0077 0.0838 0.224
Onchocerca volvulus Putative GMP reductase 0.0137 0.156 1
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0314 0.3712 1
Brugia malayi Cytochrome P450 family protein 0.0032 0.0287 0.0754
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.015 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0009 0.0001
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0053 0.0044
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0838 0.224
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.015 1
Schistosoma mansoni coup transcription factor 0.0012 0.0053 0.0044
Loa Loa (eye worm) hypothetical protein 0.0012 0.0053 0.012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.015 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.015 0.0328
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0053 0.0044
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0053 0.0044
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.015 0.0142
Entamoeba histolytica cysteine proteinase, putative 0.0014 0.0069 0.3182
Brugia malayi Cathepsin L-like precursor 0.0014 0.0069 0.0163
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.015 1
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0314 0.3712 0.3707
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.015 0.0142
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0069 0.4593
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0638 0.1701
Loa Loa (eye worm) hypothetical protein 0.0012 0.0053 0.012
Loa Loa (eye worm) hypothetical protein 0.0012 0.0053 0.012
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0053 0.012
Trypanosoma cruzi GMP reductase 0.0314 0.3712 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0053 0.0044
Echinococcus granulosus cathepsin l1 0.0014 0.0069 0.006
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0033 0.0067
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0053 0.012
Onchocerca volvulus 0.002 0.015 0.0644
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0325 0.0855
Brugia malayi Cathepsin L-like precursor 0.002 0.015 0.0382
Echinococcus granulosus cathepsin L 0.001 0.0031 0.0023
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0314 0.3712 0.3707
Onchocerca volvulus Cathepsin F homolog 0.002 0.015 0.0644
Echinococcus multilocularis cpg binding protein 0.0037 0.0349 0.0341
Echinococcus multilocularis cysteine protease 0.002 0.015 0.0142
Loa Loa (eye worm) IMP dehydrogenase 1 0.0314 0.3712 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0053 0.012
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0053 0.012
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0173 0.1997 0.5368
Brugia malayi Papain family cysteine protease containing protein 0.002 0.015 0.0382
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0053 0.0044
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.015 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0796 0.0788
Leishmania major inosine-5-monophosphate dehydrogenase 0.0314 0.3712 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.015 1
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0274 0.067
Loa Loa (eye worm) hypothetical protein 0.0012 0.0053 0.012
Plasmodium vivax vivapain-2 0.002 0.015 0.0328
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0031 0.0023
Schistosoma mansoni cpg binding protein 0.0035 0.0325 0.0317
Brugia malayi ecdysteroid receptor 0.0012 0.0053 0.012
Trypanosoma brucei GMP reductase 0.0314 0.3712 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0053 0.012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0053 0.012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.015 1
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0274 0.0716
Trypanosoma cruzi cysteine proteinase, putative 0.001 0.0031 0.0061
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0838 0.224
Schistosoma mansoni hypothetical protein 0.0014 0.007 0.0062
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0053 0.012
Loa Loa (eye worm) hypothetical protein 0.003 0.0274 0.0716
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0053 0.0044
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.015 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0053 0.012
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0035 0.0026
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.015 1
Onchocerca volvulus 0.002 0.015 0.0644
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0274 0.067
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0053 0.0044
Loa Loa (eye worm) hypothetical protein 0.0012 0.0053 0.012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.001 0.0031 0.2069
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0838 0.224
Brugia malayi cathepsin L-like precursor 0.0014 0.0069 0.0163
Entamoeba histolytica cysteine proteinase, putative 0.002 0.015 1
Trypanosoma cruzi GMP reductase 0.0314 0.3712 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0053 0.0044
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.015 1
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0314 0.3712 1
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0137 0.156 0.4191
Loa Loa (eye worm) GMP reductase 0.0137 0.156 0.4191
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0314 0.3712 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.015 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0838 0.224
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.015 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0053 0.012
Schistosoma mansoni cpg binding protein 0.0037 0.0349 0.0341
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0009 0.0001
Schistosoma mansoni cathepsin F (C01 family) 0.0014 0.0069 0.006
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0053 0.0044
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.015 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.015 0.0328
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0031 0.0023
Loa Loa (eye worm) hypothetical protein 0.0014 0.0069 0.0163
Brugia malayi Cathepsin L-like precursor 0.002 0.015 0.0382
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0314 0.3712 1
Echinococcus granulosus cpg binding protein 0.0037 0.0349 0.0341
Leishmania major cysteine peptidase A (CPA) 0.002 0.015 0.0382
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0053 0.0044

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 0.794328235 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 12.58925412 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (functional) 1.5849 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 12.5893 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (binding) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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