TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 320.817 | Formula: C16H21ClN4O
H donors: 1 H acceptors: 3 LogP: 2.4 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(c(c1)CN1CCn2c(CC1)nnc2C(C)C)O
InChi: 1S/C16H21ClN4O/c1-11(2)16-19-18-15-5-6-20(7-8-21(15)16)10-12-9-13(17)3-4-14(12)22/h3-4,9,11,22H,5-8,10H2,1-2H3
InChiKey: DEHJNOBPFCNWGW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	sphingosine kinase 1	0.0463	0.5336	0.5314
Entamoeba histolytica	hypothetical protein	0.0038	0.03	0.0449
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0053	0.0473	0.2788
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0071	0.0046
Schistosoma mansoni	hypothetical protein	0.0537	0.6218	1
Leishmania major	DNA polymerase kappa, putative	0.0019	0.0071	0.0427
Schistosoma mansoni	diacylglycerol kinase theta	0.0018	0.0063	0.0026
Plasmodium falciparum	glutathione reductase	0.005	0.0441	1
Echinococcus multilocularis	dna polymerase kappa	0.0019	0.0071	0.0024
Brugia malayi	RNA, U transporter 1	0.0094	0.0963	0.5672
Brugia malayi	Eye-specific diacylglycerol kinase	0.0018	0.0063	0.0371
Trichomonas vaginalis	diacylglycerol kinase, zeta, iota, putative	0.0018	0.0063	0.0765
Plasmodium vivax	thioredoxin reductase, putative	0.005	0.0441	1
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0024	0.0138	0.0091
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0071	0.0418
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0063	0.0031
Trichomonas vaginalis	diacylglycerol kinase, putative	0.0018	0.0063	0.0765
Leishmania major	trypanothione reductase	0.005	0.0441	1
Schistosoma mansoni	ran	0.0024	0.0138	0.0147
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0114	0.12	0.2168
Leishmania major	importin beta-1 subunit, putative	0.0027	0.0167	0.2906
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0642	0.0965
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0024	0.0138	0.2148
Brugia malayi	MH2 domain containing protein	0.0132	0.1409	0.8302
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0019	0.0071	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0063	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0463	0.5336	1
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0019	0.0071	0.0039
Echinococcus multilocularis	Diacylglycerol kinase zeta	0.0018	0.0063	0.0016
Entamoeba histolytica	hypothetical protein	0.0038	0.03	0.0449
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0071	0.1567
Entamoeba histolytica	hypothetical protein	0.0038	0.03	0.0449
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0156	0.1698	0.2675
Brugia malayi	Importin beta-1 subunit	0.0033	0.0241	0.1419
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0071	0.0427
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0067	0.0642	0.1126
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0071	0.1567
Echinococcus granulosus	ceramide kinase	0.0018	0.0063	0.0026
Plasmodium vivax	glutathione reductase, putative	0.005	0.0441	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0036	0.0276	0.1625
Trypanosoma brucei	hypothetical protein, conserved	0.0018	0.0063	0.1386
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0156	0.1698	0.2675
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0017	0.0054	0.0008
Trypanosoma cruzi	Sphingosine kinase	0.0018	0.0063	0.0222
Trypanosoma brucei	DNA polymerase eta, putative	0.0019	0.0071	0.1567
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0019	0.0071	0.0039
Entamoeba histolytica	hypothetical protein, conserved	0.0463	0.5336	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0071	0.1567
Loa Loa (eye worm)	glutathione reductase	0.005	0.0441	0.0746
Echinococcus multilocularis	dna polymerase eta	0.0019	0.0071	0.0024
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0024	0.0138	0.081
Trichomonas vaginalis	sphingosine kinase, putative	0.0018	0.0063	0.0765
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0019	0.0071	0.0015
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0642	0.0965
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0071	0.1567
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0156	0.1698	0.3121
Schistosoma mansoni	DNA polymerase eta	0.0019	0.0071	0.0039
Echinococcus granulosus	tar DNA binding protein	0.0067	0.0642	0.0965
Trichomonas vaginalis	bmru protein, putative	0.0018	0.0063	0.0765
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0024	0.0138	0.2148
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0024	0.0138	0.3083
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.0047	0.0276
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0019	0.0071	0.0427
Schistosoma mansoni	diacylglycerol kinase theta	0.0018	0.0063	0.0026
Trypanosoma brucei	diacylglycerol kinase, putative	0.0018	0.0063	0.1386
Loa Loa (eye worm)	TAR-binding protein	0.0067	0.0642	0.1126
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0017	0.0054	0.119
Trichomonas vaginalis	diacylglycerol kinase, putative	0.0018	0.0063	0.0765
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0024	0.0138	0.2148
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0156	0.1698	0.1659
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0071	0.1567
Echinococcus granulosus	importin subunit beta 1	0.0033	0.0241	0.0315
Mycobacterium tuberculosis	Probable dehydrogenase	0.0114	0.12	0.2168
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0027	0.0167	0.2906
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0071	0.0031
Plasmodium vivax	importin-beta 2, putative	0.0033	0.0241	0.4821
Trichomonas vaginalis	DNA polymerase eta, putative	0.0019	0.0071	0.1471
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0024	0.0138	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0156	0.1698	0.2675
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0017	0.0054	0.119
Toxoplasma gondii	diacylglycerol kinase, putative	0.0018	0.0063	0.0222
Brugia malayi	diacylglycerol kinase	0.0018	0.0063	0.0371
Schistosoma mansoni	hypothetical protein	0.0036	0.0276	0.0371
Trypanosoma cruzi	Sphingosine kinase	0.0018	0.0063	0.0222
Trypanosoma cruzi	Diacylglycerol kinase catalytic domain containing protein, putative	0.0018	0.0063	0.0222
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0071	0.1567
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0024	0.0138	0.2148
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0127	0.135	0.2453
Plasmodium falciparum	diacylglycerol kinase, putative	0.0018	0.0063	0.0222
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.0047	0.0276
Schistosoma mansoni	hypothetical protein	0.0352	0.403	0.6454
Trypanosoma brucei	importin beta-1 subunit, putative	0.0033	0.0241	0.5437
Entamoeba histolytica	Ran family GTPase	0.0024	0.0138	0.0141
Brugia malayi	RNA binding protein	0.0067	0.0642	0.3784
Leishmania major	diacylglycerol kinase, putative	0.0018	0.0063	0.0222
Brugia malayi	hypothetical protein	0.0018	0.0063	0.0371
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0473	0.0806
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0276	0.0433
Schistosoma mansoni	hypothetical protein	0.0537	0.6218	1
Echinococcus multilocularis	thioredoxin glutathione reductase	0.005	0.0441	0.0396
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0071	0.0427
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0017	0.0054	0.5
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0156	0.1698	0.2675
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0038	0.03	0.0254
Trichomonas vaginalis	importin beta-1, putative	0.0027	0.0167	1
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0642	0.0965
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0071	0.1567
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0019	0.0071	0.0039
Trypanosoma cruzi	diacylglycerol kinase, putative	0.0018	0.0063	0.0222
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0053	0.0473	0.2788
Trypanosoma cruzi	trypanothione reductase, putative	0.005	0.0441	1
Echinococcus multilocularis	geminin	0.0537	0.6218	0.62
Trichomonas vaginalis	diacylglycerol kinase, zeta, iota, putative	0.0018	0.0063	0.0765
Trypanosoma brucei	unspecified product	0.0019	0.0071	0.1567
Schistosoma mansoni	hypothetical protein	0.0018	0.0063	0.0026
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0019	0.0071	0.1471
Loa Loa (eye worm)	eye-specific diacylglycerol kinase	0.0018	0.0063	0.0031
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0071	0.1567
Schistosoma mansoni	hypothetical protein	0.0038	0.03	0.041
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0019	0.0071	0.0031
Echinococcus multilocularis	snurportin 1	0.0352	0.403	0.4001
Trichomonas vaginalis	sphingosine kinase, putative	0.0018	0.0063	0.0765
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0017	0.0054	0.5
Loa Loa (eye worm)	RNA binding protein	0.0067	0.0642	0.1126
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0114	0.12	0.2168
Brugia malayi	Thioredoxin reductase	0.005	0.0441	0.2599
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0053	0.0473	0.0806
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0024	0.0138	0.0172
Trichomonas vaginalis	bmru protein, putative	0.0018	0.0063	0.0765
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0027	0.0167	1
Plasmodium falciparum	diacylglycerol kinase, putative	0.0018	0.0063	0.0222
Leishmania major	sphingosine kinase A, B, putative	0.0018	0.0063	0.0222
Schistosoma mansoni	transcription factor LCR-F1	0.0038	0.03	0.041
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0024	0.0138	0.0147
Mycobacterium ulcerans	hypothetical protein	0.0463	0.5336	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0156	0.1698	1
Plasmodium falciparum	thioredoxin reductase	0.005	0.0441	1
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0017	0.0054	0.0012
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0017	0.0054	0.119
Brugia malayi	Diacylglycerol kinase protein 2	0.0018	0.0063	0.0371
Mycobacterium tuberculosis	Probable oxidoreductase	0.0127	0.135	0.2453
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0114	0.12	0.2168
Onchocerca volvulus	Ceramide kinase 1 homolog	0.0018	0.0063	0.5
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0127	0.135	1
Echinococcus granulosus	Diacylglycerol kinase theta	0.0018	0.0063	0.0026
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0642	0.0965
Echinococcus granulosus	snurportin 1	0.0352	0.403	0.6454
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0071	0.0427
Mycobacterium ulcerans	diacylglycerol kinase	0.0018	0.0063	0.0016
Loa Loa (eye worm)	diacylglycerol kinase 2	0.0018	0.0063	0.0031
Echinococcus multilocularis	importin subunit beta 1	0.0033	0.0241	0.0195
Loa Loa (eye worm)	transcription factor SMAD2	0.0132	0.1409	0.2576
Brugia malayi	RNA recognition motif domain containing protein	0.0067	0.0642	0.3784
Trypanosoma cruzi	DNA polymerase eta, putative	0.0019	0.0071	0.0427
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0071	0.1567
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0071	0.0418
Mycobacterium tuberculosis	Diacylglycerol kinase	0.0018	0.0063	0.0016
Leishmania major	diacylglycerol kinase-like protein	0.0018	0.0063	0.0222
Echinococcus granulosus	Diacylglycerol kinase zeta	0.0018	0.0063	0.0026
Loa Loa (eye worm)	MH2 domain-containing protein	0.0132	0.1409	0.2576
Mycobacterium tuberculosis	Probable reductase	0.0114	0.12	0.2168
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0114	0.12	0.2168
Echinococcus granulosus	acylglycerol kinase mitochondrial	0.0018	0.0063	0.0026
Trypanosoma brucei	importin beta-1 subunit, putative	0.0033	0.0241	0.5437
Toxoplasma gondii	diacylglycerol kinase accessory domain (presumed) domain-containing protein	0.0018	0.0063	0.0222
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0017	0.0054	0.0012
Schistosoma mansoni	importin beta-1	0.0033	0.0241	0.0315
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0156	0.1698	0.1659
Trypanosoma cruzi	hypothetical protein, conserved	0.0018	0.0063	0.0222
Echinococcus multilocularis	acylglycerol kinase, mitochondrial	0.0018	0.0063	0.0016
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0024	0.0138	0.2148
Brugia malayi	Ceramide kinase	0.0018	0.0063	0.0371
Entamoeba histolytica	hypothetical protein	0.0038	0.03	0.0449
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.005	0.0441	0.0732
Plasmodium vivax	diacylglycerol kinase, putative	0.0018	0.0063	0.0222
Echinococcus granulosus	sphingosine kinase 1	0.0463	0.5336	0.8571
Trypanosoma brucei	Diacylglycerol kinase catalytic domain containing protein, putative	0.0018	0.0063	0.1386
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0241	0.0367
Schistosoma mansoni	sphingoid long chain base kinase	0.0463	0.5336	0.8571
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0352	0.403	0.753
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0063	0.0765
Giardia lamblia	DINP protein human, muc B family	0.0019	0.0071	0.199
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0017	0.0054	0.0321
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0071	0.0031
Echinococcus granulosus	dna polymerase eta	0.0019	0.0071	0.0039
Leishmania major	hypothetical protein, conserved	0.0018	0.0063	0.0222
Brugia malayi	hypothetical protein	0.0038	0.03	0.1765
Trypanosoma brucei	Sphingosine kinase	0.0018	0.0063	0.1386
Toxoplasma gondii	HEAT repeat-containing protein	0.0033	0.0241	0.4821
Toxoplasma gondii	thioredoxin reductase	0.005	0.0441	1
Trypanosoma cruzi	diacylglycerol kinase-like protein, putative	0.0018	0.0063	0.0222
Trypanosoma brucei	trypanothione reductase	0.005	0.0441	1
Trichomonas vaginalis	ran, putative	0.0024	0.0138	0.7391
Brugia malayi	diacylglycerol kinase	0.0018	0.0063	0.0371
Plasmodium vivax	diacylglycerol kinase, putative	0.0018	0.0063	0.0222
Trypanosoma cruzi	diacylglycerol kinase, putative	0.0018	0.0063	0.0222
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0156	0.1698	0.2675
Schistosoma mansoni	tar DNA-binding protein	0.0067	0.0642	0.0965
Mycobacterium tuberculosis	Conserved protein	0.0463	0.5336	1
Trypanosoma cruzi	diacylglycerol kinase-like protein, putative	0.0018	0.0063	0.0222
Brugia malayi	TAR-binding protein	0.0067	0.0642	0.3784
Loa Loa (eye worm)	ceramide kinase	0.0018	0.0063	0.0031
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0071	0.1567
Schistosoma mansoni	diacylglycerol kinase zeta iota	0.0018	0.0063	0.0026
Schistosoma mansoni	proteasome subunit alpha 6 (T01 family)	0.0018	0.0063	0.0026
Leishmania major	hypothetical protein, conserved	0.0018	0.0063	0.0222
Echinococcus granulosus	dna polymerase kappa	0.0019	0.0071	0.0039
Trichomonas vaginalis	diacylglycerol kinase, epsilon, putative	0.0018	0.0063	0.0765
Leishmania major	GTP-binding protein, putative	0.0024	0.0138	0.2148
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0038	0.03	0.041
Schistosoma mansoni	ran	0.0024	0.0138	0.0147
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0071	0.1567
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0071	0.1567
Toxoplasma gondii	diacylglycerol kinase catalytic domain-containing protein	0.0018	0.0063	0.0222
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0127	0.135	0.2453
Plasmodium falciparum	importin beta, putative	0.0033	0.0241	0.4821
Brugia malayi	glutathione reductase	0.005	0.0441	0.2599
Schistosoma mansoni	sphingosine kinase A B	0.0463	0.5336	0.8571
Onchocerca volvulus		0.0018	0.0063	0.5
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0071	0.0427
Entamoeba histolytica	hypothetical protein	0.0027	0.0167	0.0197
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0017	0.0054	0.5
Echinococcus multilocularis	Diacylglycerol kinase theta	0.0018	0.0063	0.0016
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0017	0.0054	0.119
Loa Loa (eye worm)	thioredoxin reductase	0.005	0.0441	0.0746
Echinococcus granulosus	thioredoxin glutathione reductase	0.005	0.0441	0.0639
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0027	0.0167	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0071	0.1567
Treponema pallidum	NADH oxidase	0.0017	0.0054	0.5
Echinococcus multilocularis	ceramide kinase	0.0018	0.0063	0.0016
Echinococcus multilocularis	tar DNA binding protein	0.0067	0.0642	0.0598
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0019	0.0071	0.0046
Echinococcus granulosus	geminin	0.0537	0.6218	1
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0019	0.0071	0.0024
Leishmania major	DNA polymerase eta, putative	0.0019	0.0071	0.0427
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0063	0.0031

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Detailed information for compound 819088