Detailed information for compound 821897

Basic information

Technical information
  • TDR Targets ID: 821897
  • Name: N,N'-bis(4-methoxyphenyl)-2,2-bis(propylsulfo nyl)ethene-1,1-diamine
  • MW: 482.613 | Formula: C22H30N2O6S2
  • H donors: 2 H acceptors: 4 LogP: 5.32 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCS(=O)(=O)C(=C(Nc1ccc(cc1)OC)Nc1ccc(cc1)OC)S(=O)(=O)CCC
  • InChi: 1S/C22H30N2O6S2/c1-5-15-31(25,26)22(32(27,28)16-6-2)21(23-17-7-11-19(29-3)12-8-17)24-18-9-13-20(30-4)14-10-18/h7-14,23-24H,5-6,15-16H2,1-4H3
  • InChiKey: NXHNYTMBKZAILR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (4-methoxyphenyl)-[1-[(4-methoxyphenyl)amino]-2,2-bis(propylsulfonyl)vinyl]amine
  • (4-methoxyphenyl)[1-[(4-methoxyphenyl)amino]-2,2-bis(propylsulfonyl)vinyl]amine
  • MLS000532349
  • SMR000137308
  • CBMicro_006537
  • BIM-0006432.P001
  • ZINC03001520

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens RecQ helicase-like Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Giardia lamblia U5 small nuclear ribonucleoprotein 200 kDa helicase, putative RecQ helicase-like 649 aa 521 aa 19.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0118 0.0334 0.0334
Plasmodium falciparum plasmepsin IV 0.0275 0.0967 0.1338
Plasmodium vivax aspartyl protease, putative 0.0404 0.1487 0.2805
Echinococcus granulosus integrin alpha ps 0.0067 0.013 0.0229
Loa Loa (eye worm) TK/ROR protein kinase 0.0377 0.1379 0.1379
Toxoplasma gondii kringle domain-containing protein 0.0377 0.1379 0.3762
Loa Loa (eye worm) PAN domain-containing protein 0.0074 0.0156 0.0156
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0129 0.0378 0.0332
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0128 0.0376 0.1125
Onchocerca volvulus 0.0129 0.0378 0.1813
Brugia malayi Trypsin family protein 0.0219 0.074 0.0697
Trypanosoma cruzi prolyl endopeptidase 0.0128 0.0376 0.2368
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.006 0.0101 0.0595
Schistosoma mansoni cercarial elastase (S01 family) 0.0129 0.0378 0.1131
Loa Loa (eye worm) hypothetical protein 0.0047 0.0047 0.0047
Loa Loa (eye worm) PAN domain-containing protein 0.0074 0.0156 0.0156
Brugia malayi PAN domain containing protein 0.0074 0.0156 0.0109
Loa Loa (eye worm) aspartyl protease 6 0.0157 0.0493 0.0493
Loa Loa (eye worm) integrin beta-2 0.0307 0.1098 0.1098
Loa Loa (eye worm) hypothetical protein 0.0129 0.0378 0.0378
Onchocerca volvulus 0.0129 0.0378 0.1813
Echinococcus granulosus prolyl endopeptidase 0.0128 0.0376 0.215
Schistosoma mansoni hypothetical protein 0.0129 0.0378 0.1131
Plasmodium vivax aspartyl protease, putative 0.0404 0.1487 0.2805
Schistosoma mansoni hypothetical protein 0.0377 0.1379 0.4129
Loa Loa (eye worm) PAN domain-containing protein 0.0074 0.0156 0.0156
Plasmodium vivax plasmepsin V, putative 0.1037 0.404 1
Plasmodium falciparum plasmepsin IX 0.0404 0.1487 0.2805
Toxoplasma gondii aspartyl protease ASP5 0.0879 0.3406 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0157 0.0493 0.1475
Echinococcus multilocularis integrin alpha ps 0.0067 0.013 0.0811
Loa Loa (eye worm) hypothetical protein 0.0074 0.0156 0.0156
Echinococcus multilocularis glycoprotein Antigen 5 0.0129 0.0378 0.2632
Brugia malayi PAN domain containing protein 0.0074 0.0156 0.0109
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0157 0.0493 0.1475
Mycobacterium ulcerans hypothetical protein 0.0129 0.0378 1
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.006 0.0101 0.0302
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0275 0.0967 0.6781
Brugia malayi Trypsin family protein 0.0129 0.0378 0.0332
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0275 0.0967 0.2897
Brugia malayi Protein kinase domain containing protein 0.0377 0.1379 0.1338
Plasmodium falciparum plasmepsin V 0.1037 0.404 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0219 0.074 0.2217
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0219 0.074 0.2217
Loa Loa (eye worm) hypothetical protein 0.0275 0.0967 0.0967
Schistosoma mansoni cathepsin D (A01 family) 0.0863 0.3339 1
Brugia malayi Trypsin-like protease protein 5 0.0129 0.0378 0.0332
Schistosoma mansoni memapsin-2 (A01 family) 0.0157 0.0493 0.1475
Brugia malayi Trypsin family protein 0.0129 0.0378 0.0332
Echinococcus granulosus integrin beta 2 0.0228 0.0777 0.5292
Echinococcus multilocularis enteropeptidase 0.0129 0.0378 0.2632
Brugia malayi Integrin alpha pat-2 precursor 0.015 0.0464 0.0419
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0129 0.0378 0.2632
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0054 0.0078 0.0232
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0129 0.0378 0.1131
Plasmodium falciparum plasmepsin I 0.0275 0.0967 0.1338
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0129 0.0378 0.2166
Onchocerca volvulus 0.0129 0.0378 0.1813
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0129 0.0378 0.1131
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0275 0.0967 0.5
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0157 0.0493 0.1036
Echinococcus multilocularis transmembrane protease serine 3 0.0129 0.0378 0.2632
Loa Loa (eye worm) hypothetical protein 0.0074 0.0156 0.0156
Schistosoma mansoni cercarial elastase (S01 family) 0.0129 0.0378 0.1131
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0128 0.0376 0.2368
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0129 0.0378 0.2166
Brugia malayi Pepsin A precursor 0.0157 0.0493 0.0448
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0157 0.0493 0.1475
Brugia malayi aspartic protease BmAsp-2, identical 0.0157 0.0493 0.0448
Loa Loa (eye worm) hypothetical protein 0.0157 0.0493 0.0493
Brugia malayi prolyl oligopeptidase family protein 0.0128 0.0376 0.033
Echinococcus multilocularis prolyl endopeptidase 0.0128 0.0376 0.2618
Schistosoma mansoni cathepsin D (A01 family) 0.0863 0.3339 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0156 0.0156
Echinococcus multilocularis integrin alpha 3 0.0115 0.0323 0.2228
Brugia malayi calpain family protein 1 0.0054 0.0078 0.0031
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0157 0.0493 0.1475
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.2514 1 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0156 0.0156
Brugia malayi hypothetical protein 0.0157 0.0493 0.0448
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0275 0.0967 0.6972
Echinococcus multilocularis integrin beta 2 0.0228 0.0777 0.5572
Trypanosoma cruzi hypothetical protein, conserved 0.0377 0.1379 1
Onchocerca volvulus 0.009 0.0222 0.0537
Onchocerca volvulus 0.0377 0.1379 1
Toxoplasma gondii aspartyl protease 0.0157 0.0493 0.1036
Brugia malayi aspartic protease BmAsp-1, identical 0.0157 0.0493 0.0448
Loa Loa (eye worm) hypothetical protein 0.0219 0.074 0.074
Echinococcus multilocularis tissue type plasminogen activator 0.0377 0.1379 1
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0377 0.1379 0.2498
Loa Loa (eye worm) PAN domain-containing protein 0.0074 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0219 0.074 0.074
Schistosoma mansoni integrin alpha-ps 0.0067 0.013 0.0389
Schistosoma mansoni cercarial elastase (S01 family) 0.0129 0.0378 0.1131
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0129 0.0378 0.2632
Brugia malayi PAN domain containing protein 0.0074 0.0156 0.0109
Loa Loa (eye worm) hypothetical protein 0.0074 0.0156 0.0156
Loa Loa (eye worm) trypsin family protein 0.0129 0.0378 0.0378
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0157 0.0493 0.1475
Plasmodium vivax plasmepsin IV, putative 0.0275 0.0967 0.1338
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0113 0.0316 0.0271
Echinococcus granulosus Mastin 0.0129 0.0378 0.2166
Brugia malayi PAN domain containing protein 0.0074 0.0156 0.0109
Plasmodium vivax aspartyl proteinase, putative 0.0275 0.0967 0.1338
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0129 0.0378 0.1131
Echinococcus granulosus integrin alpha 3 0.0115 0.0323 0.1737
Onchocerca volvulus 0.0219 0.074 0.478
Brugia malayi hypothetical protein 0.0157 0.0493 0.0448
Onchocerca volvulus 0.0157 0.0493 0.2754
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0129 0.0378 0.1131
Loa Loa (eye worm) hypothetical protein 0.0377 0.1379 0.1379
Toxoplasma gondii aspartyl protease ASP3 0.0404 0.1487 0.4097
Brugia malayi hypothetical protein 0.0129 0.0378 0.0332
Loa Loa (eye worm) hypothetical protein 0.0074 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0157 0.0493 0.0493
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0051 0.0064 0.5
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0128 0.0376 0.1125
Brugia malayi Kringle domain containing protein 0.0377 0.1379 0.1338
Onchocerca volvulus 0.0129 0.0378 0.1813
Schistosoma mansoni integrin beta subunit 0.0181 0.0589 0.1763
Schistosoma mansoni cercarial elastase (S01 family) 0.0129 0.0378 0.1131
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.006 0.0101 0.0302
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0275 0.0967 0.2496
Brugia malayi PAN domain containing protein 0.0074 0.0156 0.0109
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0157 0.0493 0.0493
Echinococcus granulosus calpain A 0.006 0.0102 0.0007
Brugia malayi Eukaryotic aspartyl protease family protein 0.0157 0.0493 0.0448
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0157 0.0493 0.1475
Loa Loa (eye worm) hypothetical protein 0.0128 0.0376 0.0376
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0115 0.0321 1
Loa Loa (eye worm) calpain family protein 1 0.004 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0113 0.0316 0.0316
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0129 0.0378 0.1131
Echinococcus granulosus enteropeptidase 0.0129 0.0378 0.2166
Loa Loa (eye worm) hypothetical protein 0.0129 0.0378 0.0378
Loa Loa (eye worm) hypothetical protein 0.0074 0.0156 0.0156
Echinococcus multilocularis calpain A 0.006 0.0102 0.0602
Plasmodium falciparum plasmepsin VI 0.0275 0.0967 0.1338
Schistosoma mansoni integrin alpha 0.015 0.0464 0.1389
Brugia malayi PAN domain containing protein 0.0074 0.0156 0.0109
Brugia malayi calpain family protein 1 0.0054 0.0078 0.0031
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0047 0.0047 0.0047
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0157 0.0493 0.1475
Brugia malayi PAN domain containing protein 0.0074 0.0156 0.0109
Schistosoma mansoni cercarial elastase (S01 family) 0.0129 0.0378 0.1131
Loa Loa (eye worm) hypothetical protein 0.0048 0.0053 0.0053
Echinococcus multilocularis Mastin 0.0129 0.0378 0.2632
Loa Loa (eye worm) calpain family protein 1 0.0054 0.0078 0.0078
Leishmania major hypothetical protein, conserved 0.0377 0.1379 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0129 0.0378 0.1131
Loa Loa (eye worm) hypothetical protein 0.0129 0.0378 0.0378
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0157 0.0493 0.1475
Toxoplasma gondii aspartyl protease ASP1 0.0275 0.0967 0.2496
Schistosoma mansoni cercarial elastase (S01 family) 0.0129 0.0378 0.1131
Brugia malayi Integrin beta pat-3 precursor 0.0307 0.1098 0.1056
Echinococcus granulosus tissue type plasminogen activator 0.0377 0.1379 1
Loa Loa (eye worm) hypothetical protein 0.0129 0.0378 0.0378
Onchocerca volvulus Prolyl endopeptidase homolog 0.0128 0.0376 0.1797
Schistosoma mansoni cercarial elastase (S01 family) 0.0129 0.0378 0.1131
Loa Loa (eye worm) hypothetical protein 0.0054 0.0078 0.0078
Trypanosoma brucei prolyl endopeptidase 0.0128 0.0376 1
Plasmodium falciparum cysteine repeat modular protein 1 0.0377 0.1379 0.2498
Echinococcus multilocularis integrin alpha ps 0.0067 0.013 0.0811
Loa Loa (eye worm) integrin alpha pat-2 0.0231 0.0792 0.0792
Brugia malayi Trypsin family protein 0.0129 0.0378 0.0332
Schistosoma mansoni cercarial elastase (S01 family) 0.0129 0.0378 0.1131
Echinococcus granulosus transmembrane protease serine 3 0.0129 0.0378 0.2166
Brugia malayi PAN domain containing protein 0.0074 0.0156 0.0109
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0275 0.0967 0.0967
Onchocerca volvulus 0.0129 0.0378 0.1813
Loa Loa (eye worm) hypothetical protein 0.0083 0.0193 0.0193
Schistosoma mansoni cercarial elastase (S01 family) 0.0129 0.0378 0.1131
Onchocerca volvulus 0.0157 0.0493 0.2754
Loa Loa (eye worm) hypothetical protein 0.0129 0.0378 0.0378
Plasmodium falciparum plasmepsin II 0.0275 0.0967 0.1338
Brugia malayi PAN domain containing protein 0.0074 0.0156 0.0109
Brugia malayi PAN domain containing protein 0.0074 0.0156 0.0109
Echinococcus granulosus glycoprotein Antigen 5 0.0129 0.0378 0.2166
Schistosoma mansoni cercarial elastase (S01 family) 0.0129 0.0378 0.1131
Loa Loa (eye worm) hypothetical protein 0.004 0.002 0.002
Schistosoma mansoni cercarial elastase (S01 family) 0.0129 0.0378 0.1131
Plasmodium falciparum plasmepsin X 0.0404 0.1487 0.2805
Toxoplasma gondii prolyl endopeptidase 0.0128 0.0376 0.0676
Loa Loa (eye worm) PAN domain-containing protein 0.0074 0.0156 0.0156
Schistosoma mansoni hypothetical protein 0.0129 0.0378 0.1131

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.1585 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1). (Class of assay: confirmatory) [Related pubchem assays: 594 (Rhodamine region spectral profiling screen), 593 (Fluorescein region spectral profiling screen), 2367 (Probe Development Summary for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1)), 2353 (qHTS Validation Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1))] ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.