Detailed information for compound 824063

Basic information

Technical information
  • TDR Targets ID: 824063
  • Name: N-(3-chloro-4-methylphenyl)-2-(5-ethyl-1-benz ofuran-3-yl)acetamide
  • MW: 327.805 | Formula: C19H18ClNO2
  • H donors: 1 H acceptors: 1 LogP: 4.89 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1ccc2c(c1)c(co2)CC(=O)Nc1ccc(c(c1)Cl)C
  • InChi: 1S/C19H18ClNO2/c1-3-13-5-7-18-16(8-13)14(11-23-18)9-19(22)21-15-6-4-12(2)17(20)10-15/h4-8,10-11H,3,9H2,1-2H3,(H,21,22)
  • InChiKey: NHKUBSQQYVTBLD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-chloro-4-methyl-phenyl)-2-(5-ethylbenzofuran-3-yl)acetamide
  • N-(3-chloro-4-methylphenyl)-2-(5-ethyl-3-benzofuranyl)acetamide
  • N-(3-chloro-4-methyl-phenyl)-2-(5-ethyl-1-benzofuran-3-yl)ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Treponema pallidum methionyl-tRNA synthetase 0.0099 0.0136 0.5
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0031 0.0033
Schistosoma mansoni hypothetical protein 0.0152 0.0278 0.0289
Loa Loa (eye worm) hypothetical protein 0.194 0.5049 0.5049
Schistosoma mansoni survival motor neuron protein 0.0058 0.0027 0.0028
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0027 0.0027
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0152 0.0278 0.0289
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0077 0.0077 0.0077
Schistosoma mansoni hypothetical protein 0.0058 0.0027 0.0028
Schistosoma mansoni thyroid hormone receptor 0.0164 0.031 0.0322
Chlamydia trachomatis methionine--tRNA ligase 0.0099 0.0136 0.5
Entamoeba histolytica methionyl-tRNA synthetase, putative 0.0099 0.0136 0.5
Brugia malayi glycyl-tRNA synthetase 0.0077 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.006 0.0033 0.0033
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0077 0.0077 0.0077
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.2095 0.2178
Echinococcus granulosus tumor protein p63 0.0408 0.0961 0.0999
Brugia malayi MH2 domain containing protein 0.0144 0.0257 0.0257
Echinococcus granulosus methionyl tRNA synthetase cytoplasmic 0.0099 0.0136 0.0141
Echinococcus multilocularis methionyl tRNA synthetase, cytoplasmic 0.0099 0.0136 0.0141
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.3653 0.962 0.962
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.2095 0.2178
Brugia malayi vesicular acetylcholine transporter unc-17 0.3653 0.962 0.962
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0033 0.0033
Schistosoma mansoni glycyl-tRNA synthetase 0.0077 0.0077 0.008
Echinococcus multilocularis tumor protein p63 0.0408 0.0961 0.0999
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0257 0.0257
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0033 0.0033
Onchocerca volvulus 0.0058 0.0027 0.0028
Trypanosoma cruzi C-8 sterol isomerase, putative 0.3796 1 0.5
Loa Loa (eye worm) hypothetical protein 0.3796 1 1
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.3653 0.962 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0031 0.0031
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.0634 0.0659
Brugia malayi hypothetical protein 0.0286 0.0634 0.0634
Echinococcus granulosus microtubule associated protein 2 0.0833 0.2095 0.2178
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0033 0.0033
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0152 0.0278 0.0289
Loa Loa (eye worm) hypothetical protein 0.0099 0.0136 0.0136
Schistosoma mansoni vesicular acetylcholine transporter 0.3653 0.962 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0164 0.031 0.0322
Schistosoma mansoni methionine-tRNA synthetase 0.0099 0.0136 0.0141
Leishmania major C-8 sterol isomerase-like protein 0.3796 1 0.5
Onchocerca volvulus 0.006 0.0031 0.0033
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.0634 0.0659
Echinococcus granulosus vesicular acetylcholine transporter 0.3653 0.962 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0257 0.0257
Loa Loa (eye worm) multisynthetase complex auxiliary component p43 0.0083 0.0094 0.0094
Schistosoma mansoni thyroid hormone receptor 0.0164 0.031 0.0322
Loa Loa (eye worm) hypothetical protein 0.0286 0.0634 0.0634
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0077 0.0077 0.0077
Trypanosoma brucei C-8 sterol isomerase, putative 0.3796 1 0.5
Echinococcus granulosus glycyl tRNA synthetase 0.0077 0.0077 0.008
Echinococcus multilocularis glycyl tRNA synthetase 0.0077 0.0077 0.008
Brugia malayi methionyl-tRNA synthetase 0.0099 0.0136 0.0136
Echinococcus multilocularis vesicular acetylcholine transporter 0.3653 0.962 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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