Detailed information for compound 829058

Basic information

Technical information
  • TDR Targets ID: 829058
  • Name: 5-chloro-N-[4-(difluoromethoxy)phenyl]-2-[(3- methylphenyl)methylsulfonyl]pyrimidine-4-carb oxamide
  • MW: 467.874 | Formula: C20H16ClF2N3O4S
  • H donors: 1 H acceptors: 5 LogP: 4.35 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: FC(Oc1ccc(cc1)NC(=O)c1nc(ncc1Cl)S(=O)(=O)Cc1cccc(c1)C)F
  • InChi: 1S/C20H16ClF2N3O4S/c1-12-3-2-4-13(9-12)11-31(28,29)20-24-10-16(21)17(26-20)18(27)25-14-5-7-15(8-6-14)30-19(22)23/h2-10,19H,11H2,1H3,(H,25,27)
  • InChiKey: VMGJGEZZLNOLSC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-chloro-N-[4-(difluoromethoxy)phenyl]-2-[(3-methylphenyl)methylsulfonyl]-4-pyrimidinecarboxamide
  • 5-chloro-N-[4-(difluoromethoxy)phenyl]-2-(3-methylbenzyl)sulfonyl-pyrimidine-4-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus low density lipoprotein receptor ldl 0.0077 0.0957 0.0957
Onchocerca volvulus 0.0077 0.0957 0.1419
Loa Loa (eye worm) hypothetical protein 0.0077 0.0957 0.1419
Schistosoma mansoni cercarial elastase (S01 family) 0.0083 0.1045 0.1045
Schistosoma mansoni hypothetical protein 0.0018 0.0018 0.0018
Schistosoma mansoni hypothetical protein 0.0076 0.0939 0.0939
Onchocerca volvulus 0.0086 0.1095 0.1624
Schistosoma mansoni cercarial elastase (S01 family) 0.0083 0.1045 0.1045
Loa Loa (eye worm) hypothetical protein 0.0044 0.0426 0.0632
Echinococcus multilocularis isocitrate dehydrogenase 0.0033 0.0253 0.0253
Loa Loa (eye worm) glutaminase 0.0255 0.3798 0.5632
Echinococcus granulosus Low density lipoprotein receptor class A cysteine rich 0.0077 0.0957 0.0957
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0077 0.0957 0.0957
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0033 0.0253 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0105 0.1403 0.1403
Onchocerca volvulus 0.0083 0.1045 0.155
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0077 0.0957 0.1419
Onchocerca volvulus 0.0423 0.6473 0.9598
Loa Loa (eye worm) trypsin family protein 0.0083 0.1045 0.155
Echinococcus granulosus Tolloid protein 1 0.0044 0.0426 0.0426
Brugia malayi Muscle positioning protein 4 0.044 0.6744 1
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0044 0.0426 0.0632
Brugia malayi SEA domain containing protein 0.0423 0.6473 0.9598
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.0641 0.0951
Schistosoma mansoni hypothetical protein 0.0044 0.0426 0.0426
Schistosoma mansoni hypothetical protein 0.0018 0.0018 0.0018
Toxoplasma gondii kringle domain-containing protein 0.0076 0.0939 1
Giardia lamblia High cysteine protein 0.0017 0 0.5
Toxoplasma gondii Erv1 / Alr family protein 0.0032 0.024 0.2553
Loa Loa (eye worm) hypothetical protein 0.0083 0.1045 0.155
Schistosoma mansoni hypothetical protein 0.0018 0.0018 0.0018
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0253 0.0194
Schistosoma mansoni microtubule-associated protein tau 0.0644 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0105 0.1403 0.1403
Brugia malayi Nematode astacin protease protein 30 0.0044 0.0426 0.0632
Brugia malayi Nematode astacin protease protein 30 0.0044 0.0426 0.0632
Echinococcus granulosus glycoprotein Antigen 5 0.0083 0.1045 0.1045
Brugia malayi Trypsin family protein 0.0083 0.1045 0.155
Brugia malayi CUB domain containing protein 0.0044 0.0426 0.0632
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0083 0.1045 0.1045
Onchocerca volvulus 0.0077 0.0957 0.1419
Echinococcus granulosus low density lipoprotein receptor protein 0.0077 0.0957 0.0957
Echinococcus multilocularis Mastin 0.0083 0.1045 0.1045
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0077 0.0957 0.1419
Brugia malayi Trypsin family protein 0.0083 0.1045 0.155
Brugia malayi MH2 domain containing protein 0.0111 0.1506 0.2233
Onchocerca volvulus 0.0423 0.6473 0.9598
Echinococcus granulosus geminin 0.0158 0.2251 0.2251
Loa Loa (eye worm) hypothetical protein 0.0083 0.1045 0.155
Loa Loa (eye worm) hypothetical protein 0.0044 0.0426 0.0632
Echinococcus granulosus CUB 0.0044 0.0426 0.0426
Brugia malayi Augmenter of liver regeneration 0.0032 0.024 0.0355
Brugia malayi hypoxia-induced factor 1 0.0141 0.197 0.2921
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0105 0.1403 0.1403
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0033 0.0253 0.0253
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0083 0.1045 0.1045
Loa Loa (eye worm) isocitrate dehydrogenase 0.0033 0.0253 0.0376
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0032 0.024 0.024
Echinococcus multilocularis dnaJ subfamily B 0.0469 0.7212 0.7212
Echinococcus multilocularis cubilin 0.0044 0.0426 0.0426
Loa Loa (eye worm) hypothetical protein 0.0152 0.2158 0.32
Toxoplasma gondii Erv1 / Alr family protein 0.0032 0.024 0.2553
Schistosoma mansoni cercarial elastase (S01 family) 0.0083 0.1045 0.1045
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0018 0.0018
Echinococcus multilocularis enteropeptidase 0.0083 0.1045 0.1045
Loa Loa (eye worm) hypothetical protein 0.0044 0.0426 0.0632
Echinococcus multilocularis CUB 0.0044 0.0426 0.0426
Loa Loa (eye worm) hypothetical protein 0.0044 0.0426 0.0632
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0083 0.1045 0.1045
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0044 0.0426 0.0632
Loa Loa (eye worm) hypothetical protein 0.044 0.6744 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0111 0.1506 0.2233
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0033 0.0253 0.0194
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0253 0.2698
Brugia malayi Trypsin family protein 0.0168 0.2411 0.3575
Loa Loa (eye worm) hypothetical protein 0.0077 0.0957 0.1419
Loa Loa (eye worm) hypothetical protein 0.0077 0.0957 0.1419
Loa Loa (eye worm) zinc metalloproteinase toh-2 0.0044 0.0426 0.0632
Echinococcus multilocularis Tolloid protein 1 0.0044 0.0426 0.0426
Loa Loa (eye worm) hypothetical protein 0.0044 0.0426 0.0632
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0033 0.0253 0.0194
Echinococcus granulosus low density lipoprotein receptor ldl 0.0077 0.0957 0.0957
Echinococcus multilocularis GPCR, family 2 0.0018 0.0018 0.0018
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0044 0.0426 0.2666
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0253 0.0194
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0077 0.0957 0.1419
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0032 0.024 0.024
Brugia malayi CXXC zinc finger family protein 0.0033 0.0255 0.0377
Loa Loa (eye worm) hypothetical protein 0.0168 0.2411 0.3575
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0077 0.0957 0.1419
Echinococcus granulosus 5'partial|Low density lipoprotein receptor class A cysteine rich 0.0077 0.0957 0.0957
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0033 0.0253 0.0253
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0044 0.0426 0.2666
Loa Loa (eye worm) hypothetical protein 0.0077 0.0957 0.1419
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0077 0.0957 0.1419
Onchocerca volvulus 0.0044 0.0426 0.0632
Loa Loa (eye worm) CUB domain-containing protein 0.0044 0.0426 0.0632
Echinococcus multilocularis microtubule associated protein 2 0.0644 1 1
Schistosoma mansoni hypothetical protein 0.0044 0.0426 0.0426
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0077 0.0957 0.1419
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0105 0.1403 0.208
Loa Loa (eye worm) hypothetical protein 0.0077 0.0957 0.1419
Schistosoma mansoni single-minded 0.0045 0.0453 0.0453
Onchocerca volvulus 0.0077 0.0957 0.1419
Brugia malayi hypothetical protein 0.0044 0.0426 0.0632
Schistosoma mansoni cercarial elastase (S01 family) 0.0083 0.1045 0.1045
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0105 0.1403 0.1403
Echinococcus granulosus neuropilin nrp and tolloid tll 0.0044 0.0426 0.0426
Brugia malayi CUB domain containing protein 0.0044 0.0426 0.0632
Onchocerca volvulus 0.0077 0.0957 0.1419
Loa Loa (eye worm) hypothetical protein 0.0057 0.0641 0.0951
Schistosoma mansoni aryl hydrocarbon receptor 0.0045 0.0453 0.0453
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0018 0.0026
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0121 0.1654 0.2453
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0044 0.0426 1
Schistosoma mansoni hypothetical protein 0.0044 0.0426 0.0426
Loa Loa (eye worm) hypothetical protein 0.0077 0.0957 0.1419
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0126 0.1742 0.1742
Trichomonas vaginalis glutaminase, putative 0.0255 0.3798 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0957 0.1419
Loa Loa (eye worm) hypothetical protein 0.0061 0.0697 0.1033
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0083 0.1045 0.155
Brugia malayi CUB domain containing protein 0.0044 0.0426 0.0632
Echinococcus multilocularis transmembrane protease serine 3 0.0083 0.1045 0.1045
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0289 0.4336 0.4336
Onchocerca volvulus 0.0423 0.6473 0.9598
Echinococcus granulosus transmembrane protease serine 3 0.0083 0.1045 0.1045
Schistosoma mansoni hypothetical protein 0.0083 0.1045 0.1045
Plasmodium falciparum cysteine repeat modular protein 1 0.0076 0.0939 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0083 0.1045 0.1045
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0077 0.0957 0.1419
Loa Loa (eye worm) hypothetical protein 0.0121 0.1654 0.2453
Loa Loa (eye worm) hypothetical protein 0.0083 0.1045 0.155
Schistosoma mansoni cpg binding protein 0.0035 0.0284 0.0284
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0077 0.0957 0.0957
Schistosoma mansoni cercarial elastase (S01 family) 0.0083 0.1045 0.1045
Schistosoma mansoni cpg binding protein 0.0035 0.0284 0.0284
Echinococcus granulosus cubilin 0.0044 0.0426 0.0426
Loa Loa (eye worm) hypothetical protein 0.0044 0.0426 0.0632
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0044 0.0426 0.0426
Brugia malayi CUB domain containing protein 0.0044 0.0426 0.0632
Echinococcus multilocularis transfer RNA-Lys 0.0034 0.0265 0.0265
Brugia malayi glutaminase DH11.1 0.0255 0.3798 0.5632
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0083 0.1045 0.1045
Echinococcus multilocularis tissue type plasminogen activator 0.0076 0.0939 0.0939
Schistosoma mansoni hypothetical protein 0.0039 0.0353 0.0353
Loa Loa (eye worm) hypothetical protein 0.0076 0.0939 0.1392
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0724 0.7717
Brugia malayi Calcium binding EGF domain containing protein 0.0061 0.0697 0.1033
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0077 0.0957 0.0957
Schistosoma mansoni neuropilin (nrp) and tolloid (tll)-like 0.0044 0.0426 0.0426
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0077 0.0957 0.1419
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0253 0.0253
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0077 0.0957 0.0957
Onchocerca volvulus 0.0044 0.0426 0.0632
Brugia malayi zinc metalloproteinase toh-2 precursor 0.0044 0.0426 0.0632
Loa Loa (eye worm) hypothetical protein 0.0039 0.0353 0.0523
Brugia malayi Protein kinase domain containing protein 0.0076 0.0939 0.1392
Brugia malayi Isocitrate dehydrogenase 0.0033 0.0253 0.0376
Loa Loa (eye worm) hypothetical protein 0.0077 0.0957 0.1419
Leishmania major hypothetical protein, conserved 0.0076 0.0939 1
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0083 0.1045 0.1045
Onchocerca volvulus 0.0034 0.0265 0.0393
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.0641 0.0951
Brugia malayi Low-density lipoprotein receptor-related protein, putative 0.0077 0.0957 0.1419
Brugia malayi PAS domain containing protein 0.0045 0.0453 0.0672
Loa Loa (eye worm) DPY-31 protein 0.0044 0.0426 0.0632
Echinococcus granulosus cubilin 0.0044 0.0426 0.0426
Brugia malayi Suppressor of lurcher protein 1 precursor 0.0044 0.0426 0.0632
Onchocerca volvulus 0.0077 0.0957 0.1419
Brugia malayi Lectin C-type domain containing protein 0.0044 0.0426 0.0632
Loa Loa (eye worm) hypothetical protein 0.0018 0.0018 0.0026
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0083 0.1045 0.155
Loa Loa (eye worm) transcription factor SMAD2 0.0111 0.1506 0.2233
Mycobacterium ulcerans hypothetical protein 0.0083 0.1045 0.2208
Schistosoma mansoni mixed-lineage leukemia protein mll 0.007 0.0844 0.0844
Echinococcus multilocularis glycoprotein Antigen 5 0.0083 0.1045 0.1045
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0077 0.0957 0.1419
Echinococcus granulosus cpg binding protein 0.0035 0.0284 0.0284
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0105 0.1403 0.1403
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0033 0.0253 0.0194
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0077 0.0957 0.1419
Brugia malayi hypothetical protein 0.0083 0.1045 0.155
Onchocerca volvulus 0.0083 0.1045 0.155
Onchocerca volvulus Arrow homolog 0.0077 0.0957 0.1419
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0033 0.0253 0.0253
Loa Loa (eye worm) hypothetical protein 0.0423 0.6473 0.9598
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0105 0.1403 0.208
Loa Loa (eye worm) hypoxia-induced factor 1 0.0141 0.197 0.2921
Schistosoma mansoni cpg binding protein 0.0033 0.0255 0.0255
Schistosoma mansoni glutaminase 0.0255 0.3798 0.3798
Echinococcus multilocularis low density lipoprotein receptor protein 0.0077 0.0957 0.0957
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0083 0.1045 0.1045
Loa Loa (eye worm) CUB domain-containing protein 0.0044 0.0426 0.0632
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0077 0.0957 0.0957
Onchocerca volvulus 0.0083 0.1045 0.155
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0083 0.1045 0.1045
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0138 0.193 0.193
Echinococcus multilocularis cubilin 0.0044 0.0426 0.0426
Schistosoma mansoni hypothetical protein 0.0083 0.1045 0.1045
Schistosoma mansoni hypothetical protein 0.0077 0.0957 0.0957
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0077 0.0957 0.0957
Loa Loa (eye worm) TK/ROR protein kinase 0.0076 0.0939 0.1392
Brugia malayi Kringle domain containing protein 0.0076 0.0939 0.1392
Brugia malayi enteropeptidase precursor 0.0077 0.0957 0.1419
Schistosoma mansoni hypothetical protein 0.0018 0.0018 0.0018
Echinococcus multilocularis geminin 0.0158 0.2251 0.2251
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0076 0.0939 1
Echinococcus granulosus enteropeptidase 0.0083 0.1045 0.1045
Brugia malayi basement membrane proteoglycan precursor 0.0077 0.0957 0.1419
Echinococcus granulosus Mastin 0.0083 0.1045 0.1045
Brugia malayi Trypsin family protein 0.0083 0.1045 0.155
Loa Loa (eye worm) hypothetical protein 0.0044 0.0426 0.0632
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0353 0.0523
Onchocerca volvulus 0.0423 0.6473 0.9598
Onchocerca volvulus Terribly reduced optic lobes homolog 0.0077 0.0957 0.1419
Schistosoma mansoni hypothetical protein 0.0158 0.2251 0.2251
Onchocerca volvulus 0.0076 0.0939 0.1392
Echinococcus granulosus tissue type plasminogen activator 0.0076 0.0939 0.0939
Schistosoma mansoni hypothetical protein 0.0044 0.0426 0.0426
Echinococcus multilocularis neuropilin (nrp) and tolloid (tll) 0.0044 0.0426 0.0426
Onchocerca volvulus Putative cubilin 0.0061 0.0697 0.1033
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0255 0.0377
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0077 0.0957 0.0957
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0033 0.0253 0.0729
Echinococcus granulosus dnaJ subfamily B 0.0469 0.7212 0.7212
Schistosoma mansoni cercarial elastase (S01 family) 0.0083 0.1045 0.1045
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0253 0.0729
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.0641 0.0951
Echinococcus granulosus basement membrane specific heparan sulfate 0.0077 0.0957 0.0957
Brugia malayi CUB domain containing protein 0.0121 0.1654 0.2453
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0083 0.1045 0.1045
Brugia malayi bHLH-PAS transcription factor 0.0034 0.0265 0.0393
Schistosoma mansoni cercarial elastase (S01 family) 0.0083 0.1045 0.1045
Mycobacterium ulcerans glutaminase 0.0255 0.3798 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0018 0.0026
Brugia malayi Kelch motif family protein 0.0044 0.0426 0.0632
Loa Loa (eye worm) glutaminase 2 0.0255 0.3798 0.5632
Echinococcus granulosus basement membrane specific heparan sulfate 0.0077 0.0957 0.0957
Loa Loa (eye worm) hypothetical protein 0.0077 0.0957 0.1419
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0018 0.0018
Onchocerca volvulus 0.0083 0.1045 0.155
Onchocerca volvulus 0.0168 0.2411 0.3575
Loa Loa (eye worm) hypothetical protein 0.0077 0.0957 0.1419
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0939 1
Brugia malayi astacin protease protein 30 0.0044 0.0426 0.0632
Brugia malayi hypothetical protein 0.0152 0.2158 0.32
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0077 0.0957 0.0957
Loa Loa (eye worm) hypothetical protein 0.0083 0.1045 0.155
Loa Loa (eye worm) hypothetical protein 0.0077 0.0957 0.1419
Loa Loa (eye worm) hepatopoietin HPO2 0.0032 0.024 0.0355
Onchocerca volvulus 0.0077 0.0957 0.1419
Schistosoma mansoni hypothetical protein 0.0423 0.6473 0.6473
Loa Loa (eye worm) calcium binding EGF domain-containing protein 0.0077 0.0957 0.1419
Onchocerca volvulus 0.044 0.6744 1
Loa Loa (eye worm) lectin C-type domain-containing protein 0.0044 0.0426 0.0632
Schistosoma mansoni hypothetical protein 0.0044 0.0426 0.0426
Schistosoma mansoni hypothetical protein 0.0469 0.7212 0.7212
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0253 0.0253
Schistosoma mansoni cercarial elastase (S01 family) 0.0083 0.1045 0.1045
Onchocerca volvulus 0.0044 0.0426 0.0632
Brugia malayi Zinc metalloproteinase toh-2 precursor 0.0044 0.0426 0.0632
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0077 0.0957 0.1419
Loa Loa (eye worm) hypothetical protein 0.0044 0.0426 0.0632
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0253 0.2698
Brugia malayi Trypsin-like protease protein 5 0.0083 0.1045 0.155
Schistosoma mansoni hypothetical protein 0.0077 0.0957 0.0957
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0077 0.0957 0.1419
Schistosoma mansoni neuropilin (nrp) and tolloid (tll)-like 0.0044 0.0426 0.0426
Brugia malayi Calcium binding EGF domain containing protein 0.0077 0.0957 0.1419
Schistosoma mansoni hypothetical protein 0.0158 0.2251 0.2251
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0105 0.1403 0.1403
Onchocerca volvulus 0.0033 0.0255 0.0377
Schistosoma mansoni cercarial elastase (S01 family) 0.0083 0.1045 0.1045
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0105 0.1403 0.1403
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0253 0.0253
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0077 0.0957 0.0957
Loa Loa (eye worm) hypothetical protein 0.0168 0.2411 0.3575
Brugia malayi isocitrate dehydrogenase 0.0033 0.0253 0.0376
Echinococcus multilocularis cpg binding protein 0.0035 0.0284 0.0284
Onchocerca volvulus 0.0083 0.1045 0.155
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0018 0.0026
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0168 0.2411 0.2411
Echinococcus granulosus GPCR family 2 0.0018 0.0018 0.0018
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0083 0.1045 0.1045
Loa Loa (eye worm) hypothetical protein 0.0077 0.0957 0.1419
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0077 0.0957 0.1419
Schistosoma mansoni cercarial elastase (S01 family) 0.0083 0.1045 0.1045
Onchocerca volvulus 0.0044 0.0426 0.0632
Echinococcus granulosus single minded 2 0.0034 0.0265 0.0265
Loa Loa (eye worm) DOMON domain-containing protein 0.0423 0.6473 0.9598
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0077 0.0957 0.0957

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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