TDR Targets

Basic information

Technical information

TDR Targets ID: 829223
Name: N-(4-butylphenyl)-1-methylsulfonyl-2,3-dihydr oindole-5-carboxamide
MW: 372.481 | Formula: C20H24N2O3S
H donors: 1 H acceptors: 3 LogP: 3.82 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCCCc1ccc(cc1)NC(=O)c1ccc2c(c1)CCN2S(=O)(=O)C
InChi: 1S/C20H24N2O3S/c1-3-4-5-15-6-9-18(10-7-15)21-20(23)17-8-11-19-16(14-17)12-13-22(19)26(2,24)25/h6-11,14H,3-5,12-13H2,1-2H3,(H,21,23)
InChiKey: UZLWTFMYLVPQJE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(4-butylphenyl)-1-methylsulfonyl-indoline-5-carboxamide
N-(4-butylphenyl)-1-methylsulfonyl-5-indolinecarboxamide
N-(4-butylphenyl)-1-mesyl-indoline-5-carboxamide
ZINC06766475

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.007	0.043	0.2466
Treponema pallidum	glucose-6-phosphate 1-dehydrogenase	0.0108	0.0827	0.2073
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0041	0.013	0.0437
Trichomonas vaginalis	glucosamine-6-phosphate isomerase, putative	0.0118	0.0927	1
Trypanosoma brucei	heat shock protein, putative	0.0053	0.0257	0.1099
Toxoplasma gondii	glucose-6-phosphate 1-dehydrogenase	0.0071	0.0438	0.2405
Leishmania major	heat shock protein 83-1	0.0053	0.0257	0.1133
Leishmania major	heat shock protein 83-1	0.0053	0.0257	0.1133
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0268	0.2889
Mycobacterium leprae	PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)	0.007	0.043	0.0711
Leishmania major	heat shock protein 83-1	0.0053	0.0257	0.1133
Trichomonas vaginalis	CAMK family protein kinase	0.011	0.0842	0.908
Trypanosoma cruzi	heat shock protein 85, putative	0.0053	0.0257	0.1133
Trypanosoma brucei	hypothetical protein, conserved	0.0247	0.2265	1
Brugia malayi	hypothetical protein	0.007	0.043	0.2783
Brugia malayi	PHD-finger family protein	0.0034	0.0056	0.0314
Leishmania major	heat shock protein 83-1	0.0053	0.0257	0.1133
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0058	0.0305	0.1957
Plasmodium falciparum	protoporphyrinogen oxidase	0.007	0.043	0.1347
Mycobacterium tuberculosis	Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G)	0.005	0.0223	0.024
Echinococcus multilocularis	heat shock protein 90	0.0045	0.0177	0.1014
Trypanosoma brucei	heat shock protein, putative	0.0053	0.0257	0.1099
Loa Loa (eye worm)	hypothetical protein	0.007	0.043	0.2783
Trypanosoma cruzi	polo-like protein kinase, putative	0.011	0.0842	0.3717
Echinococcus granulosus	endoplasmin	0.005	0.0223	0.1277
Trypanosoma cruzi	Glucose-6-phosphate dehydrogenase, putative	0.0035	0.0066	0.0292
Plasmodium falciparum	heat shock protein 90, putative	0.0201	0.1795	0.5706
Trypanosoma brucei	Heat shock protein 83, putative	0.0053	0.0257	0.1099
Trypanosoma brucei	heat shock protein, putative	0.0053	0.0257	0.1099
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.007	0.043	0.1347
Echinococcus multilocularis		0.007	0.043	0.2466
Chlamydia trachomatis	glucose-6-phosphate 1-dehydrogenase	0.0108	0.0827	1
Schistosoma mansoni	heat shock protein	0.0053	0.0257	0.1188
Trypanosoma cruzi	heat shock protein 90, putative	0.0045	0.0177	0.0781
Onchocerca volvulus		0.007	0.043	0.255
Trichomonas vaginalis	heat shock protein, putative	0.0031	0.0026	0.0277
Loa Loa (eye worm)	hypothetical protein	0.007	0.043	0.2783
Trypanosoma cruzi	hypothetical protein, conserved	0.0247	0.2265	1
Toxoplasma gondii	histone lysine-specific demethylase	0.007	0.043	0.236
Toxoplasma gondii	Hsp90 domain-containing protein	0.0201	0.1795	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.007	0.043	0.2779
Toxoplasma gondii	glucose-6-phosphate 1-dehydrogenase	0.0118	0.0927	0.5143
Echinococcus granulosus	lysine specific histone demethylase 1A	0.007	0.043	0.2466
Leishmania major	heat shock protein 83-1	0.0053	0.0257	0.1133
Trypanosoma cruzi	UDP-galactopyranose mutase	0.007	0.043	0.1899
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0111	0.0854	0.4897
Echinococcus granulosus	lysine specific demethylase 5A	0.0041	0.013	0.0744
Trypanosoma brucei	heat shock protein, putative	0.0053	0.0257	0.1099
Entamoeba histolytica	hypothetical protein	0.0042	0.0138	0.0865
Echinococcus multilocularis	endoplasmin	0.005	0.0223	0.1277
Leishmania major	heat shock protein 83-1	0.0053	0.0257	0.1133
Trypanosoma brucei	glucose-6-phosphate 1-dehydrogenase	0.0108	0.0827	0.3628
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.0009	0.0038
Loa Loa (eye worm)	TAR-binding protein	0.0073	0.0467	0.3029
Toxoplasma gondii	PHD-finger domain-containing protein	0.0034	0.0056	0.0266
Mycobacterium ulcerans	heat shock protein 90	0.005	0.0223	0.0223
Toxoplasma gondii	histone lysine-specific demethylase LSD1/BHC110/KDMA1A	0.007	0.043	0.236
Leishmania major	heat shock protein 83-1	0.0053	0.0257	0.1133
Echinococcus multilocularis	jumonji domain containing protein	0.0047	0.0193	0.1109
Entamoeba histolytica	hypothetical protein	0.0042	0.0138	0.0865
Trichomonas vaginalis	endoplasmin, putative	0.0039	0.0105	0.1136
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0073	0.0467	0.3029
Entamoeba histolytica	heat shock protein 90, putative	0.0053	0.0257	0.2402
Brugia malayi	amine oxidase, flavin-containing family protein	0.007	0.043	0.2783
Giardia lamblia	Grp94/Hsp90	0.005	0.0223	0.1913
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.0467	0.2437
Brugia malayi	heat shock protein 90	0.0053	0.0257	0.1637
Echinococcus multilocularis	heat shock protein 90	0.0053	0.0257	0.1471
Entamoeba histolytica	heat shock protein 90, putative	0.0053	0.0257	0.2402
Plasmodium vivax	endoplasmin, putative	0.0053	0.0257	0.0792
Trichomonas vaginalis	CAMK family protein kinase	0.011	0.0842	0.908
Echinococcus multilocularis	protoporphyrinogen oxidase	0.007	0.043	0.2466
Trichomonas vaginalis	heat shock protein, putative	0.0045	0.0177	0.1908
Brugia malayi	SWIRM domain containing protein	0.007	0.043	0.2783
Entamoeba histolytica	hypothetical protein	0.0042	0.0138	0.0865
Schistosoma mansoni	heat shock protein	0.0053	0.0257	0.1188
Giardia lamblia	Glucose-6-phosphate 1-dehydrogenase	0.0118	0.0927	1
Plasmodium vivax	hypothetical protein, conserved	0.007	0.043	0.1347
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.011	0.0842	0.3717
Plasmodium falciparum	heat shock protein 90	0.0053	0.0257	0.0792
Plasmodium vivax	heat shock protein, putative	0.0201	0.1795	0.5706
Plasmodium vivax	heat shock protein 86, putative	0.0053	0.0257	0.0792
Echinococcus multilocularis	tar DNA binding protein	0.0073	0.0467	0.268
Echinococcus granulosus	glucose 6 phosphate 1 dehydrogenase	0.0108	0.0827	0.4743
Leishmania major	heat shock protein 83-1	0.0053	0.0257	0.1133
Brugia malayi	RNA binding protein	0.0073	0.0467	0.3029
Trypanosoma cruzi	glucose-6-phosphate 1-dehydrogenase, putative	0.0108	0.0827	0.3652
Giardia lamblia	Kinase, PLK	0.011	0.0842	0.902
Echinococcus granulosus	heat shock protein heat shock protein 90 alpha	0.0045	0.0177	0.1014
Echinococcus multilocularis	peregrin	0.0034	0.0056	0.0321
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0042	0.0138	0.0792
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0034	0.0056	0.0321
Trichomonas vaginalis	CAMK family protein kinase	0.011	0.0842	0.908
Leishmania major	heat shock protein 83-1	0.0053	0.0257	0.1133
Plasmodium vivax	hypothetical protein, conserved	0.007	0.043	0.1347
Plasmodium falciparum	endoplasmin, putative	0.0039	0.0105	0.0309
Plasmodium vivax	heat shock protein 90, putative	0.0035	0.0072	0.0201
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0053	0.0257	0.2302
Trypanosoma cruzi	UDP-galactopyranose mutase	0.007	0.043	0.1899
Echinococcus granulosus	heat shock protein 75 kDa mitochondrial	0.0035	0.0072	0.041
Brugia malayi	glucose-6-phosphate dehydrogenase	0.0108	0.0827	0.5405
Trichomonas vaginalis	heat shock protein, putative	0.005	0.0223	0.2402
Schistosoma mansoni	heat shock protein	0.0035	0.0072	0.0092
Leishmania major	heat shock protein 83-1	0.0053	0.0257	0.1133
Echinococcus multilocularis	geminin	0.0196	0.1744	1
Leishmania major	heat shock protein, putative	0.0035	0.0072	0.0316
Loa Loa (eye worm)	hypothetical protein	0.007	0.043	0.2783
Schistosoma mansoni	transcription factor LCR-F1	0.0042	0.0138	0.0486
Mycobacterium ulcerans	oxidoreductase	0.007	0.043	0.043
Loa Loa (eye worm)	jmjC domain-containing protein	0.0041	0.013	0.0801
Plasmodium falciparum	nicotinamide/nicotinic acid mononucleotide adenylyltransferase	0.0331	0.3139	1
Mycobacterium ulcerans	dehydrogenase	0.007	0.043	0.043
Leishmania major	UDP-galactopyranose mutase	0.007	0.043	0.1899
Loa Loa (eye worm)	hypothetical protein	0.007	0.043	0.2783
Trypanosoma brucei	heat shock protein 90, putative	0.0053	0.0257	0.1099
Leishmania major	heat shock protein 83-1	0.0053	0.0257	0.1133
Echinococcus multilocularis	heat shock protein	0.0053	0.0257	0.1471
Brugia malayi	TAR-binding protein	0.0073	0.0467	0.3029
Echinococcus granulosus	heat shock protein 90	0.0045	0.0177	0.1014
Trichomonas vaginalis	CAMK family protein kinase	0.011	0.0842	0.908
Echinococcus multilocularis	heat shock protein 75 kDa, mitochondrial	0.0035	0.0072	0.041
Trichomonas vaginalis	CAMK family protein kinase	0.011	0.0842	0.908
Brugia malayi	RNA recognition motif domain containing protein	0.0073	0.0467	0.3029
Trypanosoma cruzi	heat shock protein 90, putative	0.0053	0.0257	0.1133
Onchocerca volvulus		0.0175	0.1524	1
Schistosoma mansoni	hypothetical protein	0.004	0.0115	0.0351
Loa Loa (eye worm)	hypothetical protein	0.0175	0.1524	1
Trichomonas vaginalis	CAMK family protein kinase	0.011	0.0842	0.908
Echinococcus multilocularis	glucose 6 phosphate 1 dehydrogenase	0.0108	0.0827	0.4743
Loa Loa (eye worm)	heat shock protein 90	0.0053	0.0257	0.1637
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0992	1	1
Onchocerca volvulus	Serine\/threonine kinase homolog	0.011	0.0842	0.5355
Trichomonas vaginalis	glucosamine-6-phosphate isomerase, putative	0.0118	0.0927	1
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.0467	0.2437
Echinococcus granulosus	heat shock protein 90	0.0053	0.0257	0.1471
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.011	0.0842	0.5501
Mycobacterium tuberculosis	Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD)	0.0038	0.0094	0.0102
Leishmania major	heat shock protein 83-1	0.0053	0.0257	0.1133
Echinococcus granulosus	geminin	0.0196	0.1744	1
Trypanosoma cruzi	heat shock protein, putative	0.0035	0.0072	0.0316
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.0467	0.2437
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.0467	0.2437
Schistosoma mansoni	glucose-6-phosphate 1-dehydrogenase	0.0108	0.0827	0.4569
Brugia malayi	jmjC domain containing protein	0.0041	0.013	0.0801
Mycobacterium ulcerans	glucose-6-phosphate 1-dehydrogenase	0.0108	0.0827	0.0827
Schistosoma mansoni	kinase	0.0056	0.0283	0.1344
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.0467	0.2437
Leishmania major	heat shock protein 83-1	0.0053	0.0257	0.1133
Brugia malayi	Bromodomain containing protein	0.0034	0.0056	0.0314
Brugia malayi	Endoplasmin precursor	0.0053	0.0257	0.1637
Trypanosoma brucei	heat shock protein, putative	0.0053	0.0257	0.1099
Trypanosoma brucei	heat shock protein 90, putative	0.0053	0.0257	0.1099
Leishmania major	heat shock protein 83-1	0.0053	0.0257	0.1133
Toxoplasma gondii	PHD-finger domain-containing protein	0.0034	0.0056	0.0266
Mycobacterium ulcerans	bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein	0.0331	0.3139	0.3139
Trypanosoma cruzi	polo-like protein kinase, putative	0.011	0.0842	0.3717
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.007	0.043	0.1347
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0307	0.1968
Schistosoma mansoni	hypothetical protein	0.0042	0.0138	0.0486
Brugia malayi	Hsp90 protein	0.0035	0.0072	0.0416
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.0009	0.0038
Trypanosoma cruzi	heat shock protein 85, putative	0.0053	0.0257	0.1133
Plasmodium falciparum	phd finger protein, putative	0.0034	0.0056	0.0152
Echinococcus granulosus	tar DNA binding protein	0.0073	0.0467	0.268
Mycobacterium ulcerans	glucose-6-phosphate 1-dehydrogenase	0.0071	0.0438	0.0438
Toxoplasma gondii	heat shock protein 75, putative	0.0035	0.0072	0.0353
Echinococcus granulosus	PHD finger protein rhinoceros	0.0034	0.0056	0.0321
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0058	0.0305	0.1957
Leishmania major	heat shock protein 83-1	0.0053	0.0257	0.1133
Loa Loa (eye worm)	hypothetical protein	0.007	0.043	0.2783
Loa Loa (eye worm)	RNA binding protein	0.0073	0.0467	0.3029
Leishmania major	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	0.005	0.0223	0.0983
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0045	0.0177	0.1388
Schistosoma mansoni	serine/threonine protein kinase	0.011	0.0842	0.4655
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0111	0.0854	0.4897
Toxoplasma gondii	heat shock protein HSP90	0.0053	0.0257	0.1389
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.007	0.043	0.1347
Mycobacterium ulcerans	protoporphyrinogen oxidase	0.007	0.043	0.043
Trypanosoma brucei	heat shock protein 84, putative	0.0035	0.0072	0.0279
Mycobacterium tuberculosis	Possible oxidoreductase	0.007	0.043	0.0464
Loa Loa (eye worm)	heat shock protein 75	0.0035	0.0072	0.0416
Plasmodium vivax	nicotinate-nucleotide adenylyltransferase, putative	0.0331	0.3139	1
Trichomonas vaginalis	6-phosphogluconolactonase, putative	0.0118	0.0927	1
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.011	0.0842	0.4827
Mycobacterium tuberculosis	Conserved hypothetical protein	0.007	0.043	0.0464
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.011	0.0842	0.4827
Trypanosoma cruzi	Heat shock protein 83, putative	0.0053	0.0257	0.1133
Loa Loa (eye worm)	glucose-6-phosphate dehydrogenase	0.0108	0.0827	0.5405
Schistosoma mansoni	endoplasmin	0.0053	0.0257	0.1188
Brugia malayi	jmjC domain containing protein	0.0111	0.0854	0.5582
Schistosoma mansoni	amine oxidase	0.007	0.043	0.2216
Trichomonas vaginalis	heat shock protein, putative	0.005	0.0223	0.2402
Onchocerca volvulus	Heat shock protein 75 kDa, mitochondrial homolog	0.0035	0.0072	0.0106
Mycobacterium ulcerans	monoamine oxidase	0.007	0.043	0.043
Schistosoma mansoni	jumonji domain containing protein	0.0088	0.0618	0.3329
Brugia malayi	serine/threonine-protein kinase plk-2	0.011	0.0842	0.5501
Trichomonas vaginalis	CAMK family protein kinase	0.011	0.0842	0.908
Treponema pallidum	hypothetical protein	0.0331	0.3139	1
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.007	0.043	0.2216
Trypanosoma brucei	heat shock protein, putative	0.0053	0.0257	0.1099
Trypanosoma cruzi	glucose-6-phosphate 1-dehydrogenase, putative	0.0036	0.0077	0.034
Schistosoma mansoni	hypothetical protein	0.0196	0.1744	1
Trichomonas vaginalis	heat shock protein, putative	0.0053	0.0257	0.2767
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0058	0.0305	0.1957
Echinococcus granulosus	peregrin	0.0034	0.0056	0.0321
Leishmania major	hypothetical protein, conserved	0.0029	0.0009	0.0038
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.007	0.043	0.2216
Leishmania major	hypothetical protein, conserved	0.0247	0.2265	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0041	0.013	0.0437
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.007	0.043	0.1347
Loa Loa (eye worm)	endoplasmin	0.0053	0.0257	0.1637
Mycobacterium leprae	PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC	0.0331	0.3139	1
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	0.0922	0.9275	1
Toxoplasma gondii	heat shock protein 90, putative	0.0053	0.0257	0.1389
Mycobacterium tuberculosis	Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic	0.0331	0.3139	0.3384
Echinococcus multilocularis	lysine specific demethylase 5A	0.0041	0.013	0.0744
Leishmania major	glucose-6-phosphate 1-dehydrogenase, putative	0.0108	0.0827	0.3652
Schistosoma mansoni	endoplasmin	0.0053	0.0257	0.1188
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0305	0.1957
Trichomonas vaginalis	CAMK family protein kinase	0.0054	0.0268	0.2889
Trichomonas vaginalis	heat shock protein, putative	0.0039	0.0105	0.1136
Wolbachia endosymbiont of Brugia malayi	heat shock protein 90	0.005	0.0223	0.5
Brugia malayi	latrophilin 2 splice variant baaae	0.004	0.0115	0.0705
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0042	0.0138	0.0792
Plasmodium falciparum	heat shock protein 90, putative	0.0031	0.0026	0.0055
Echinococcus granulosus	lysine specific histone demethylase 1A	0.007	0.043	0.2466
Trypanosoma cruzi	heat shock protein 85, putative	0.0045	0.0177	0.0781
Brugia malayi	hypothetical protein	0.0042	0.0138	0.0856
Loa Loa (eye worm)	PHD-finger family protein	0.0034	0.0056	0.0314
Entamoeba histolytica	serine/threonine protein kinase, putative	0.011	0.0842	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0115	0.0705
Echinococcus granulosus	heat shock protein	0.0053	0.0257	0.1471
Trypanosoma brucei	heat shock protein, putative	0.0053	0.0257	0.1099
Plasmodium vivax	glucose-6-phosphate 1-dehydrogenase, putative	0.0118	0.0927	0.2935
Echinococcus granulosus	jumonji domain containing protein	0.0047	0.0193	0.1109
Schistosoma mansoni	hypothetical protein	0.0196	0.1744	1
Trypanosoma brucei	heat shock protein, putative	0.0053	0.0257	0.1099
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0056	0.0314
Trypanosoma cruzi	heat shock protein 85, putative	0.0053	0.0257	0.1133
Entamoeba histolytica	hypothetical protein	0.0042	0.0138	0.0865
Plasmodium vivax	hypothetical protein, conserved	0.0034	0.0056	0.0152
Plasmodium falciparum	glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0.0118	0.0927	0.2935
Trypanosoma cruzi	hypothetical protein, conserved	0.0247	0.2265	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.043	0.2783
Trypanosoma brucei	polo-like protein kinase	0.011	0.0842	0.3693
Leishmania major	heat shock protein 83-1	0.0053	0.0257	0.1133
Schistosoma mansoni	amine oxidase	0.007	0.043	0.2216
Leishmania major	heat shock protein 83-1	0.0053	0.0257	0.1133
Brugia malayi	hypothetical protein	0.0175	0.1524	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 829223