Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0305 | 0.8207 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.1433 | 0.2321 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0848 | 0.1179 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.009 | 0.2023 | 0.2023 |
Loa Loa (eye worm) | inositol-1 | 0.0036 | 0.0486 | 0.0755 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0149 | 0.3729 | 0.8059 |
Echinococcus multilocularis | geminin | 0.0367 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0305 | 0.8207 | 1 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.0036 | 0.0488 | 0.0488 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0026 | 0.0206 | 0.0206 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0083 | 0.0083 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0029 | 0.0289 | 0.0429 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0036 | 0.0488 | 0.0002 |
Loa Loa (eye worm) | intermediate filament protein | 0.0054 | 0.1015 | 0.1629 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.009 | 0.2023 | 0.2023 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0036 | 0.0486 | 0.0486 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.0036 | 0.0488 | 0.0488 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0022 | 0.0083 | 0.0083 |
Echinococcus granulosus | intermediate filament protein | 0.0054 | 0.1015 | 0.1015 |
Echinococcus granulosus | lamin dm0 | 0.0054 | 0.1015 | 0.1015 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0459 | 0.0459 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0231 | 0.6076 | 0.6076 |
Echinococcus granulosus | lamin | 0.0054 | 0.1015 | 0.1015 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0406 | 0.0433 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0177 | 0.0244 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0305 | 0.8207 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.009 | 0.2023 | 0.2023 |
Brugia malayi | Bromodomain containing protein | 0.0037 | 0.0525 | 0.0633 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0149 | 0.3729 | 0.8059 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.009 | 0.2023 | 0.2023 |
Brugia malayi | Inositol-1 | 0.0036 | 0.0486 | 0.0568 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0406 | 0.0623 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0036 | 0.0486 | 0.0486 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0406 | 0.0406 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.009 | 0.2023 | 0.2023 |
Schistosoma mansoni | lamin | 0.0054 | 0.1015 | 0.1015 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0305 | 0.8207 | 1 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0036 | 0.0488 | 0.0002 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0231 | 0.6076 | 0.6076 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0149 | 0.3729 | 0.8007 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0305 | 0.8207 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.0486 | 0.0486 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.0036 | 0.0488 | 0.0488 |
Onchocerca volvulus | 0.0054 | 0.1015 | 1 | |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0848 | 0.1354 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0646 | 0.102 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0036 | 0.0488 | 0.0002 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0803 | 0.0803 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.1015 | 0.1629 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0848 | 0.1179 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0177 | 0.4536 | 0.5261 |
Schistosoma mansoni | hypothetical protein | 0.0367 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0177 | 0.4536 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.6076 | 1 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0305 | 0.8207 | 0.5 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0036 | 0.0488 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0054 | 0.1015 | 0.1629 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0459 | 0.0523 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0022 | 0.0083 | 0.0083 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.003 | 0.003 |
Onchocerca volvulus | 0.0054 | 0.1015 | 1 | |
Brugia malayi | hypothetical protein | 0.0231 | 0.6076 | 1 |
Echinococcus multilocularis | musashi | 0.0054 | 0.1015 | 0.1015 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0036 | 0.0488 | 0.0036 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0305 | 0.8207 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0058 | 0.1124 | 0.1124 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0459 | 0.0459 |
Mycobacterium ulcerans | hypothetical protein | 0.0177 | 0.4536 | 1 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0029 | 0.0289 | 0.0236 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.0036 | 0.0488 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.009 | 0.2023 | 0.3297 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0035 | 0.0458 | 0.0458 |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.0036 | 0.0488 | 0.0488 |
Mycobacterium tuberculosis | Conserved protein | 0.0177 | 0.4536 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0986 | 0.1582 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.0486 | 0.0486 |
Mycobacterium leprae | conserved hypothetical protein | 0.0177 | 0.4536 | 1 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0036 | 0.0486 | 0.0035 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.0036 | 0.0488 | 0.0488 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0305 | 0.8207 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0054 | 0.1015 | 0.1015 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0305 | 0.8207 | 1 |
Schistosoma mansoni | bromodomain containing protein | 0.0062 | 0.1224 | 0.1224 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0036 | 0.0488 | 1 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.0036 | 0.0488 | 0.0488 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0593 | 0.0931 |
Schistosoma mansoni | lamin | 0.0054 | 0.1015 | 0.1015 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0488 | 0.0757 |
Brugia malayi | Bromodomain containing protein | 0.0073 | 0.1553 | 0.2368 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.0036 | 0.0488 | 1 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0036 | 0.0486 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0177 | 0.4536 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0367 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0848 | 0.1354 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0459 | 0.0459 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0305 | 0.8207 | 1 |
Brugia malayi | intermediate filament protein | 0.0054 | 0.1015 | 0.146 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0047 | 0.0803 | 0.1102 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.0036 | 0.0488 | 0.0488 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.0036 | 0.0488 | 0.057 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0026 | 0.0206 | 0.0206 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0054 | 0.1015 | 0.146 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0459 | 0.0459 |
Echinococcus multilocularis | lamin | 0.0054 | 0.1015 | 0.1015 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.0036 | 0.0488 | 0.0488 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0527 | 0.0822 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0305 | 0.8207 | 1 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0036 | 0.0486 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0058 | 0.1124 | 0.1124 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.009 | 0.2023 | 0.2023 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0305 | 0.8207 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0206 | 0.0292 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.009 | 0.2023 | 0.3161 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0177 | 0.0244 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.009 | 0.2023 | 0.2023 |
Schistosoma mansoni | survival motor neuron protein | 0.0047 | 0.0803 | 0.0803 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0035 | 0.0458 | 0.0458 |
Echinococcus multilocularis | lamin dm0 | 0.0054 | 0.1015 | 0.1015 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.36 mg kg-1 | Compound was tested for the antagonistic activity against amphetamine-induced stereotypy in rat. | ChEMBL. | 3941416 |
IC50 (binding) | = 140 nM | Inhibition of [3H]-spiroperidol (0.5 nM) binding to dopamine receptor from rat striatal membrane. | ChEMBL. | 3941416 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.