TDR Targets

Basic information

Technical information

TDR Targets ID: 834306
Name: 2,5-dimethyl-N-[[3-(4-methylphenyl)-1,2,4-oxa diazol-5-yl]methyl]-N-propan-2-ylbenzamide
MW: 363.453 | Formula: C22H25N3O2
H donors: 0 H acceptors: 3 LogP: 4.68 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(cc1)c1noc(n1)CN(C(=O)c1cc(C)ccc1C)C(C)C
InChi: 1S/C22H25N3O2/c1-14(2)25(22(26)19-12-16(4)6-9-17(19)5)13-20-23-21(24-27-20)18-10-7-15(3)8-11-18/h6-12,14H,13H2,1-5H3
InChiKey: IJZVIBMCVZGRIW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-isopropyl-2,5-dimethyl-N-[[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]benzamide
2,5-dimethyl-N-[[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]-N-propan-2-yl-benzamide
ZINC04958793
STK266784

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	fibropellin Ia	0.0053	0.098	0.098
Schistosoma mansoni	notch	0.0053	0.098	0.098
Onchocerca volvulus		0.0246	0.6182	1
Loa Loa (eye worm)	hypothetical protein	0.0246	0.6182	0.6182
Echinococcus granulosus	delta-like protein 1	0.0053	0.098	0.098
Schistosoma mansoni	hypothetical protein	0.0053	0.098	0.098
Echinococcus multilocularis	lipoxygenase domain containing protein	0.004	0.0647	0.0647
Loa Loa (eye worm)	hypothetical protein	0.0053	0.098	0.098
Echinococcus granulosus	slit 2 protein	0.0053	0.098	0.098
Onchocerca volvulus		0.0053	0.098	0.1586
Brugia malayi	Calcium binding EGF domain containing protein	0.0053	0.098	0.098
Loa Loa (eye worm)	hypothetical protein	0.0053	0.098	0.098
Loa Loa (eye worm)	hypothetical protein	0.0053	0.098	0.098
Brugia malayi	Blistered cuticle protein 3	0.0246	0.6182	0.6182
Brugia malayi	Calcium binding EGF domain containing protein	0.0053	0.098	0.098
Echinococcus granulosus	protein jagged 1	0.0053	0.098	0.098
Echinococcus granulosus	protein jagged 2	0.0053	0.098	0.098
Onchocerca volvulus	Neurogenic locus notch homolog	0.0053	0.098	0.1586
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.024	0.6033	0.6033
Loa Loa (eye worm)	hypothetical protein	0.0246	0.6182	0.6182
Brugia malayi	hypothetical protein	0.004	0.0647	0.0647
Brugia malayi	EGF-like domain containing protein	0.0053	0.098	0.098
Brugia malayi	Animal haem peroxidase family protein	0.0246	0.6182	0.6182
Schistosoma mansoni	rab6-interacting	0.004	0.0647	0.0647
Loa Loa (eye worm)	Notch2	0.0053	0.098	0.098
Echinococcus granulosus	Polycystic kidney disease protein	0.004	0.0647	0.0647
Brugia malayi	hypothetical protein	0.0246	0.6182	0.6182
Schistosoma mansoni	slit	0.0053	0.098	0.098
Onchocerca volvulus		0.0246	0.6182	1
Brugia malayi	EGF-like domain containing protein	0.0053	0.098	0.098
Schistosoma mansoni	hypothetical protein	0.0053	0.098	0.098
Echinococcus multilocularis	neurogenic locus protein delta	0.0053	0.098	0.098
Echinococcus multilocularis	protein jagged 1	0.0053	0.098	0.098
Loa Loa (eye worm)	hypothetical protein	0.0053	0.098	0.098
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0142	0.3397	0.3397
Loa Loa (eye worm)	hypothetical protein	0.0053	0.098	0.098
Brugia malayi	Cadherin domain containing protein	0.0053	0.098	0.098
Brugia malayi	EGF-like domain containing protein	0.0053	0.098	0.098
Toxoplasma gondii	EGF family domain-containing protein	0.0053	0.098	0.5
Mycobacterium ulcerans	hypothetical protein	0.0112	0.2572	0.5
Schistosoma mansoni	notch	0.0053	0.098	0.098
Echinococcus multilocularis	neurogenic locus protein delta	0.0053	0.098	0.098
Loa Loa (eye worm)	hypothetical protein	0.0246	0.6182	0.6182
Echinococcus multilocularis	fibropellin Ia	0.0053	0.098	0.098
Echinococcus multilocularis	notch	0.0053	0.098	0.098
Schistosoma mansoni	lipoxygenase	0.0168	0.4087	0.4087
Brugia malayi	Cadherin domain containing protein	0.0053	0.098	0.098
Schistosoma mansoni	hypothetical protein	0.0053	0.098	0.098
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0053	0.098	0.098
Onchocerca volvulus		0.004	0.0647	0.1047
Plasmodium falciparum	LCCL domain-containing protein	0.004	0.0647	0.5
Brugia malayi	Animal haem peroxidase family protein	0.0246	0.6182	0.6182
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0388	1	1
Loa Loa (eye worm)	hypothetical protein	0.0246	0.6182	0.6182
Onchocerca volvulus		0.0246	0.6182	1
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.0053	0.098	0.1586
Brugia malayi	Animal haem peroxidase family protein	0.0246	0.6182	0.6182
Echinococcus granulosus	notch	0.0053	0.098	0.098
Loa Loa (eye worm)	hypothetical protein	0.0053	0.098	0.098
Brugia malayi	Calcium binding EGF domain containing protein	0.0053	0.098	0.098
Loa Loa (eye worm)	doublecortin family protein	0.004	0.0647	0.0647
Schistosoma mansoni	hypothetical protein	0.0053	0.098	0.098
Schistosoma mansoni	cell polarity protein	0.0053	0.098	0.098
Loa Loa (eye worm)	hypothetical protein	0.0053	0.098	0.098
Loa Loa (eye worm)	hypothetical protein	0.0053	0.098	0.098
Loa Loa (eye worm)	hypothetical protein	0.0246	0.6182	0.6182
Loa Loa (eye worm)	hypothetical protein	0.0053	0.098	0.098
Loa Loa (eye worm)	hypothetical protein	0.0246	0.6182	0.6182
Echinococcus multilocularis	protein jagged 2	0.0053	0.098	0.098
Trichomonas vaginalis	pten, drome, putative	0.0016	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0053	0.098	0.098
Entamoeba histolytica	Pten 3-phosphoinositide phosphatase, putative	0.0016	0	0.5
Echinococcus granulosus	lipoxygenase domain containing protein	0.004	0.0647	0.0647
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0016	0	0.5
Brugia malayi	EGF-like domain containing protein	0.0053	0.098	0.098
Echinococcus granulosus	protein jagged 2	0.0053	0.098	0.098
Onchocerca volvulus	Peroxidase homolog	0.0246	0.6182	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.098	0.098
Echinococcus granulosus	neurogenic locus protein delta	0.0053	0.098	0.098
Echinococcus multilocularis	neural cadherin	0.0053	0.098	0.098
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0053	0.098	0.098
Schistosoma mansoni	notch	0.0053	0.098	0.098
Echinococcus multilocularis	slit 2 protein	0.0053	0.098	0.098
Echinococcus multilocularis	neurogenic locus notch protein	0.0053	0.098	0.098
Loa Loa (eye worm)	hypothetical protein	0.0246	0.6182	0.6182
Loa Loa (eye worm)	hypothetical protein	0.0053	0.098	0.098
Echinococcus granulosus	protein jagged 1	0.0053	0.098	0.098
Echinococcus multilocularis	protein jagged 1	0.0053	0.098	0.098
Loa Loa (eye worm)	hypothetical protein	0.0246	0.6182	0.6182
Loa Loa (eye worm)	animal heme peroxidase	0.0246	0.6182	0.6182
Brugia malayi	Doublecortin family protein	0.004	0.0647	0.0647
Schistosoma mansoni	polycystin 1-related	0.004	0.0647	0.0647
Loa Loa (eye worm)	hypothetical protein	0.0053	0.098	0.098
Onchocerca volvulus		0.0053	0.098	0.1586
Loa Loa (eye worm)	hypothetical protein	0.0246	0.6182	0.6182
Echinococcus multilocularis	RUN	0.004	0.0647	0.0647
Brugia malayi	notch-like transmembrane receptor	0.0053	0.098	0.098
Brugia malayi	EGF-like domain containing protein	0.0053	0.098	0.098
Loa Loa (eye worm)	hypothetical protein	0.0053	0.098	0.098
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0142	0.3397	0.3397
Brugia malayi	GCC2 and GCC3 family protein	0.0053	0.098	0.098
Loa Loa (eye worm)	hypothetical protein	0.0246	0.6182	0.6182
Schistosoma mansoni	peroxidasin	0.0246	0.6182	0.6182
Loa Loa (eye worm)	hypothetical protein	0.0246	0.6182	0.6182
Brugia malayi	hypothetical protein	0.004	0.0647	0.0647
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.0388	1	1
Echinococcus granulosus	peroxidasin	0.0246	0.6182	0.6182
Brugia malayi	EGF-like domain containing protein	0.0053	0.098	0.098
Schistosoma mansoni	hypothetical protein	0.004	0.0647	0.0647
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0053	0.098	0.098
Onchocerca volvulus	Putative cubilin	0.0053	0.098	0.1586
Loa Loa (eye worm)	hypothetical protein	0.0053	0.098	0.098
Onchocerca volvulus	Peroxidasin homolog	0.0246	0.6182	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0142	0.3397	0.3397
Loa Loa (eye worm)	animal heme peroxidase	0.0246	0.6182	0.6182
Schistosoma mansoni	lipoxygenase	0.024	0.6033	0.6033
Schistosoma mansoni	laminin gamma-3 chain	0.0053	0.098	0.098
Echinococcus multilocularis	peroxidasin	0.0246	0.6182	0.6182
Trypanosoma brucei	protein tyrosine phosphatase 1	0.0016	0	0.5
Plasmodium vivax	multidomain scavenger receptor, putative	0.004	0.0647	0.5
Onchocerca volvulus	Dual oxidase homolog	0.0246	0.6182	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0142	0.3397	0.3397
Loa Loa (eye worm)	hypothetical protein	0.0053	0.098	0.098
Onchocerca volvulus		0.0053	0.098	0.1586
Echinococcus granulosus	neurogenic locus notch protein	0.0053	0.098	0.098
Echinococcus granulosus	neurogenic locus notch protein 4	0.0053	0.098	0.098
Loa Loa (eye worm)	hypothetical protein	0.0246	0.6182	0.6182
Brugia malayi	Animal haem peroxidase family protein	0.0246	0.6182	0.6182
Schistosoma mansoni	loxhd1	0.004	0.0647	0.0647
Schistosoma mansoni	peroxidasin	0.0246	0.6182	0.6182
Loa Loa (eye worm)	hypothetical protein	0.0053	0.098	0.098
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0142	0.3397	0.3397
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0388	1	1
Leishmania major	protein-tyrosine phosphatase 1-like protein	0.0016	0	0.5
Echinococcus granulosus	neural cadherin	0.0053	0.098	0.098
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0016	0	0.5
Brugia malayi	Muscle positioning protein 4	0.0053	0.098	0.098
Echinococcus multilocularis	Polycystic kidney disease protein	0.004	0.0647	0.0647
Echinococcus multilocularis	neurogenic locus notch protein	0.0053	0.098	0.098
Onchocerca volvulus		0.0053	0.098	0.1586
Giardia lamblia	High cysteine protein	0.0053	0.098	1
Leishmania major	tyrosine specific protein phosphatase, putative	0.0016	0	0.5
Schistosoma mansoni	hypothetical protein	0.0053	0.098	0.098
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0142	0.3397	0.3397
Loa Loa (eye worm)	hypothetical protein	0.004	0.0647	0.0647
Schistosoma mansoni	notch	0.0053	0.098	0.098
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0016	0	0.5
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0142	0.3397	0.3397
Brugia malayi	Animal haem peroxidase family protein	0.0246	0.6182	0.6182
Loa Loa (eye worm)	animal heme peroxidase	0.0246	0.6182	0.6182
Onchocerca volvulus	Peroxidase homolog	0.0246	0.6182	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0388	1	1
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0016	0	0.5
Loa Loa (eye worm)	animal heme peroxidase	0.0246	0.6182	0.6182
Onchocerca volvulus	Slit protein homolog	0.0053	0.098	0.1586
Brugia malayi	Peroxidasin	0.0246	0.6182	0.6182
Onchocerca volvulus		0.0053	0.098	0.1586
Loa Loa (eye worm)	hypothetical protein	0.0246	0.6182	0.6182
Schistosoma mansoni	hypothetical protein	0.0053	0.098	0.098
Schistosoma mansoni	hypothetical protein	0.0053	0.098	0.098
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.024	0.6033	0.6033
Brugia malayi	EGF-like domain containing protein	0.0053	0.098	0.098
Onchocerca volvulus		0.004	0.0647	0.1047
Schistosoma mansoni	notch	0.0053	0.098	0.098
Loa Loa (eye worm)	notch protein	0.0053	0.098	0.098
Loa Loa (eye worm)	hypothetical protein	0.0053	0.098	0.098
Onchocerca volvulus	Peroxidasin homolog	0.0246	0.6182	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.098	0.098
Loa Loa (eye worm)	hypothetical protein	0.0053	0.098	0.098
Loa Loa (eye worm)	hypothetical protein	0.0053	0.098	0.098
Echinococcus multilocularis	lipoxygenase domain containing protein	0.004	0.0647	0.0647
Echinococcus granulosus	neurogenic locus notch protein	0.0053	0.098	0.098
Loa Loa (eye worm)	hypothetical protein	0.004	0.0647	0.0647
Brugia malayi	Delta serrate ligand family protein	0.0053	0.098	0.098
Echinococcus granulosus	lipoxygenase domain containing protein	0.004	0.0647	0.0647
Onchocerca volvulus	Chorion peroxidase homolog	0.0246	0.6182	1
Schistosoma mansoni	notch	0.0053	0.098	0.098
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0053	0.098	0.098
Schistosoma mansoni	rab6-interacting	0.004	0.0647	0.0647
Loa Loa (eye worm)	blistered cuticle protein 3	0.0246	0.6182	0.6182
Schistosoma mansoni	septate junction protein	0.0053	0.098	0.098
Loa Loa (eye worm)	hypothetical protein	0.0053	0.098	0.098
Loa Loa (eye worm)	hypothetical protein	0.0246	0.6182	0.6182
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0016	0	0.5
Echinococcus granulosus	RUN	0.004	0.0647	0.0647

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 834306